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Liu, D. HNRNPK Gene. Encyclopedia. Available online: (accessed on 23 June 2024).
Liu D. HNRNPK Gene. Encyclopedia. Available at: Accessed June 23, 2024.
Liu, Dean. "HNRNPK Gene" Encyclopedia, (accessed June 23, 2024).
Liu, D. (2020, December 23). HNRNPK Gene. In Encyclopedia.
Liu, Dean. "HNRNPK Gene." Encyclopedia. Web. 23 December, 2020.

Heterogeneous nuclear ribonucleoprotein K


1. Introduction

The HNRNPK gene provides instructions for making a protein called heterogenous nuclear ribonucleoprotein K (hnRNP K). This protein attaches (binds) to DNA or its chemical cousin RNA and to other proteins. It acts as a docking site to bring together different molecules in the cell, which is important for relaying signals and controlling cellular functions. By bringing certain proteins together with DNA or RNA, the hnRNP K protein helps control the activity of genes and the production of proteins. By regulating gene activity and protein production, hnRNP K is involved in many cellular processes, including growth and division (proliferation) of cells, maturation of cells to take on specialized function (differentiation), and self-destruction (apoptosis) of cells when they are no longer needed.

The hnRNP K protein plays a role in the normal development or function of many body systems. In the brain, the protein may be involved in a process called synaptic plasticity, which is the ability of the connections between neurons (synapses) to change and adapt over time in response to experience. This process is critical for learning and memory. Another process in the brain involving the hnRNP K protein is the growth of nerve cell extensions called axons, which are essential for transmission of nerve impulses. While the protein is likely critical in other systems and processes, its role is not well understood.

2. Health Conditions Related to Genetic Changes

2.1. Au-Kline Syndrome

More than 20 mutations in the HNRNPK gene have been found to cause Au-Kline syndrome. This condition is characterized by weak muscle tone (hypotonia), intellectual disability, delayed development of speech and walking, and distinctive facial features. Other body systems, such as the heart, kidneys, and bones, may also be affected.

The HNRNPK gene mutations that cause Au-Kline syndrome alter the blueprint for making hnRNP K protein, which results in the production of little or no hnRNP K protein from one copy of the gene. A shortage of this protein changes gene activity and protein production in cells. As a result, the normal development or function of cells, tissues, and organs in many parts of the body is disrupted, leading to the varied features of Au-Kline syndrome. In particular, problems with brain development likely contribute to intellectual disability, delayed development, and other neurological problems in people with the condition.

2.2. Cancers

Loss of the HNRNPK gene is thought to be involved in the development of a blood cancer known as acute myeloid leukemia (AML). A mutation that removes (deletes) DNA from the long (q) arm of chromosome 9 occurs in about 2 percent of AML cases. Such cases are referred to as del(9q) AML. The missing region of DNA includes the HNRNPK gene, among other genes. Researchers suspect that a shortage of hnRNP K protein alters the activity of genes that control cell growth, resulting in an excess of abnormal cells. When the del(9q) mutation occurs in certain blood cells, the shortage of hnRNP K may contribute to the uncontrolled cell growth that underlies AML.

Individuals with Au-Kline syndrome (described above) do not appear to have a higher risk of developing AML than does the general population.

3. Other Names for This Gene

  • CSBP


  • transformation upregulated nuclear protein

  • TUNP


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  7. Naarmann-de Vries IS, Sackmann Y, Klein F, Ostareck-Lederer A, Ostareck DH,Jost E, Ehninger G, Brümmendorf TH, Marx G, Röllig C, Thiede C, Crysandt M.Characterization of acute myeloid leukemia with del(9q) - Impact of the genes in the minimally deleted region. Leuk Res. 2019 Jan;76:15-23. doi:10.1016/j.leukres.2018.11.007.
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  10. Xu Y, Wu W, Han Q, Wang Y, Li C, Zhang P, Xu H. New Insights into theInterplay between Non-Coding RNAs and RNA-Binding Protein HnRNPK in RegulatingCellular Functions. Cells. 2019 Jan 17;8(1). pii: E62. doi: 10.3390/cells8010062.Review.
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