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Xu, C. HNSCC. Encyclopedia. Available online: https://encyclopedia.pub/entry/4095 (accessed on 13 July 2024).
Xu C. HNSCC. Encyclopedia. Available at: https://encyclopedia.pub/entry/4095. Accessed July 13, 2024.
Xu, Camila. "HNSCC" Encyclopedia, https://encyclopedia.pub/entry/4095 (accessed July 13, 2024).
Xu, C. (2020, December 23). HNSCC. In Encyclopedia. https://encyclopedia.pub/entry/4095
Xu, Camila. "HNSCC." Encyclopedia. Web. 23 December, 2020.
HNSCC
Edit

Squamous cell carcinoma is a cancer that arises from particular cells called squamous cells. Squamous cells are found in the outer layer of skin and in the mucous membranes, which are the moist tissues that line body cavities such as the airways and intestines. Head and neck squamous cell carcinoma (HNSCC) develops in the mucous membranes of the mouth, nose, and throat.

genetic conditions

1. Introduction

HNSCC is classified by its location: it can occur in the mouth (oral cavity), the middle part of the throat near the mouth (oropharynx), the space behind the nose (nasal cavity and paranasal sinuses), the upper part of the throat near the nasal cavity (nasopharynx), the voicebox (larynx), or the lower part of the throat near the larynx (hypopharynx). Depending on the location, the cancer can cause abnormal patches or open sores (ulcers) in the mouth and throat, unusual bleeding or pain in the mouth, sinus congestion that does not clear, sore throat, earache, pain when swallowing or difficulty swallowing, a hoarse voice, difficulty breathing, or enlarged lymph nodes.

HNSCC can spread (metastasize) to other parts of the body, such as the lymph nodes or lungs. If it spreads, the cancer has a worse prognosis and can be fatal. About half of affected individuals survive more than five years after diagnosis.

2. Frequency

HNSCC is the seventh most common cancer worldwide. Approximately 600,000 new cases are diagnosed each year, including about 50,000 in the United States. HNSCC occurs most often in men in their 50s or 60s, although the incidence among younger individuals is increasing.

3. Causes

HNSCC is caused by a variety of factors that can alter the DNA in cells. The strongest risk factors for developing this form of cancer are tobacco use (including smoking or using chewing tobacco) and heavy alcohol consumption. In addition, studies have shown that infection with certain strains of human papillomavirus (HPV) is linked to the development of HNSCC. HPV infection accounts for the increasing incidence of HNSCC in younger people.

Researchers have identified mutations in many genes in people with HNSCC; however, it is not yet clear what role most of these mutations play in the development or progression of cancer. The proteins produced from several of the genes associated with HNSCC, including TP53, NOTCH1, and CDKN2A, function as tumor suppressors, which means they normally keep cells from growing and dividing too rapidly or in an uncontrolled way. When tumor suppressors are impaired, cells can grow and divide without control, leading to tumor formation. It is likely that a series of changes in multiple genes is involved in the development and progression of HNSCC.

4. Inheritance

HNSCC is generally not inherited; it typically arises from mutations in the body's cells that occur during an individual's lifetime. This type of alteration is called a somatic mutation.

Rarely, HNSCC is found in several members of a family. These families have inherited disorders that increase the risk of multiple types of cancer.

5. Other Names for This Condition

  • HNSCC

  • SCCHN

  • squamous cell carcinoma of the head and neck

References

  1. Agrawal N, Frederick MJ, Pickering CR, Bettegowda C, Chang K, Li RJ, Fakhry C,Xie TX, Zhang J, Wang J, Zhang N, El-Naggar AK, Jasser SA, Weinstein JN, Treviño L, Drummond JA, Muzny DM, Wu Y, Wood LD, Hruban RH, Westra WH, Koch WM, Califano JA, Gibbs RA, Sidransky D, Vogelstein B, Velculescu VE, Papadopoulos N, WheelerDA, Kinzler KW, Myers JN. Exome sequencing of head and neck squamous cellcarcinoma reveals inactivating mutations in NOTCH1. Science. 2011 Aug26;333(6046):1154-7. doi: 10.1126/science.1206923.
  2. Lim AM, Do H, Young RJ, Wong SQ, Angel C, Collins M, Takano EA, Corry J,Wiesenfeld D, Kleid S, Sigston E, Lyons B, Fox SB, Rischin D, Dobrovic A, SolomonB. Differential mechanisms of CDKN2A (p16) alteration in oral tongue squamouscell carcinomas and correlation with patient outcome. Int J Cancer. 2014 Aug15;135(4):887-95. doi: 10.1002/ijc.28727.
  3. Mountzios G, Rampias T, Psyrri A. The mutational spectrum of squamous-cellcarcinoma of the head and neck: targetable genetic events and clinical impact.Ann Oncol. 2014 Oct;25(10):1889-1900. doi: 10.1093/annonc/mdu143.
  4. Rothenberg SM, Ellisen LW. The molecular pathogenesis of head and necksquamous cell carcinoma. J Clin Invest. 2012 Jun;122(6):1951-7. Review.
  5. Stransky N, Egloff AM, Tward AD, Kostic AD, Cibulskis K, Sivachenko A, KryukovGV, Lawrence MS, Sougnez C, McKenna A, Shefler E, Ramos AH, Stojanov P, CarterSL, Voet D, Cortés ML, Auclair D, Berger MF, Saksena G, Guiducci C, Onofrio RC,Parkin M, Romkes M, Weissfeld JL, Seethala RR, Wang L, Rangel-Escareño C,Fernandez-Lopez JC, Hidalgo-Miranda A, Melendez-Zajgla J, Winckler W, Ardlie K,Gabriel SB, Meyerson M, Lander ES, Getz G, Golub TR, Garraway LA, Grandis JR. Themutational landscape of head and neck squamous cell carcinoma. Science. 2011 Aug 26;333(6046):1157-60. doi: 10.1126/science.1208130.
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