HNSCC

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Xu, C. HNSCC. Encyclopedia. Available online: https://encyclopedia.pub/entry/4095 (accessed on 25 September 2026).

Xu C. HNSCC. Encyclopedia. Available at: https://encyclopedia.pub/entry/4095. Accessed September 25, 2026.

Xu, Camila. "HNSCC" Encyclopedia, https://encyclopedia.pub/entry/4095 (accessed September 25, 2026).

Xu, C. (2020, December 23). HNSCC. In Encyclopedia. https://encyclopedia.pub/entry/4095

Xu, Camila. "HNSCC." Encyclopedia. Web. 23 December, 2020.

HNSCC

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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/head-and-neck-squamous-cell-carcinoma

Squamous cell carcinoma is a cancer that arises from particular cells called squamous cells. Squamous cells are found in the outer layer of skin and in the mucous membranes, which are the moist tissues that line body cavities such as the airways and intestines. Head and neck squamous cell carcinoma (HNSCC) develops in the mucous membranes of the mouth, nose, and throat.

genetic conditions

References

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Lim AM, Do H, Young RJ, Wong SQ, Angel C, Collins M, Takano EA, Corry J,Wiesenfeld D, Kleid S, Sigston E, Lyons B, Fox SB, Rischin D, Dobrovic A, SolomonB. Differential mechanisms of CDKN2A (p16) alteration in oral tongue squamouscell carcinomas and correlation with patient outcome. Int J Cancer. 2014 Aug15;135(4):887-95. doi: 10.1002/ijc.28727.
Mountzios G, Rampias T, Psyrri A. The mutational spectrum of squamous-cellcarcinoma of the head and neck: targetable genetic events and clinical impact.Ann Oncol. 2014 Oct;25(10):1889-1900. doi: 10.1093/annonc/mdu143.
Rothenberg SM, Ellisen LW. The molecular pathogenesis of head and necksquamous cell carcinoma. J Clin Invest. 2012 Jun;122(6):1951-7. Review.
Stransky N, Egloff AM, Tward AD, Kostic AD, Cibulskis K, Sivachenko A, KryukovGV, Lawrence MS, Sougnez C, McKenna A, Shefler E, Ramos AH, Stojanov P, CarterSL, Voet D, Cortés ML, Auclair D, Berger MF, Saksena G, Guiducci C, Onofrio RC,Parkin M, Romkes M, Weissfeld JL, Seethala RR, Wang L, Rangel-Escareño C,Fernandez-Lopez JC, Hidalgo-Miranda A, Melendez-Zajgla J, Winckler W, Ardlie K,Gabriel SB, Meyerson M, Lander ES, Getz G, Golub TR, Garraway LA, Grandis JR. Themutational landscape of head and neck squamous cell carcinoma. Science. 2011 Aug 26;333(6046):1157-60. doi: 10.1126/science.1208130.

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Subjects: Genetics & Heredity

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Entry Collection: MedlinePlus

Update Date: 23 Dec 2020

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