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Xu, C. Generalized Pustular Psoriasis. Encyclopedia. Available online: https://encyclopedia.pub/entry/3988 (accessed on 28 September 2026).
Xu C. Generalized Pustular Psoriasis. Encyclopedia. Available at: https://encyclopedia.pub/entry/3988. Accessed September 28, 2026.
Xu, Camila. "Generalized Pustular Psoriasis" Encyclopedia, https://encyclopedia.pub/entry/3988 (accessed September 28, 2026).
Xu, C. (2020, December 23). Generalized Pustular Psoriasis. In Encyclopedia. https://encyclopedia.pub/entry/3988
Xu, Camila. "Generalized Pustular Psoriasis." Encyclopedia. Web. 23 December, 2020.
Generalized Pustular Psoriasis
Edit

Generalized pustular psoriasis (GPP) is a severe form of a skin disorder called psoriasis.

genetic conditions

References

  1. Hussain S, Berki DM, Choon SE, Burden AD, Allen MH, Arostegui JI, Chaves A,Duckworth M, Irvine AD, Mockenhaupt M, Navarini AA, Seyger MM, Soler-Palacin P,Prins C, Valeyrie-Allanore L, Vicente MA, Trembath RC, Smith CH, Barker JN, CaponF. IL36RN mutations define a severe autoinflammatory phenotype of generalizedpustular psoriasis. J Allergy Clin Immunol. 2015 Apr;135(4):1067-70.e9. doi:10.1016/j.jaci.2014.09.043.
  2. Jordan CT, Cao L, Roberson ED, Duan S, Helms CA, Nair RP, Duffin KC, StuartPE, Goldgar D, Hayashi G, Olfson EH, Feng BJ, Pullinger CR, Kane JP, Wise CA,Goldbach-Mansky R, Lowes MA, Peddle L, Chandran V, Liao W, Rahman P, Krueger GG, Gladman D, Elder JT, Menter A, Bowcock AM. Rare and common variants in CARD14,encoding an epidermal regulator of NF-kappaB, in psoriasis. Am J Hum Genet. 2012 May 4;90(5):796-808. doi: 10.1016/j.ajhg.2012.03.013.
  3. Körber A, Mössner R, Renner R, Sticht H, Wilsmann-Theis D, Schulz P,Sticherling M, Traupe H, Hüffmeier U. Mutations in IL36RN in patients withgeneralized pustular psoriasis. J Invest Dermatol. 2013 Nov;133(11):2634-2637.doi: 10.1038/jid.2013.214.
  4. Marrakchi S, Guigue P, Renshaw BR, Puel A, Pei XY, Fraitag S, Zribi J, Bal E, Cluzeau C, Chrabieh M, Towne JE, Douangpanya J, Pons C, Mansour S, Serre V, MakniH, Mahfoudh N, Fakhfakh F, Bodemer C, Feingold J, Hadj-Rabia S, Favre M, Genin E,Sahbatou M, Munnich A, Casanova JL, Sims JE, Turki H, Bachelez H, Smahi A.Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis.N Engl J Med. 2011 Aug 18;365(7):620-8. doi: 10.1056/NEJMoa1013068.
  5. Onoufriadis A, Simpson MA, Pink AE, Di Meglio P, Smith CH, Pullabhatla V,Knight J, Spain SL, Nestle FO, Burden AD, Capon F, Trembath RC, Barker JN.Mutations in IL36RN/IL1F5 are associated with the severe episodic inflammatoryskin disease known as generalized pustular psoriasis. Am J Hum Genet. 2011 Sep9;89(3):432-7. doi: 10.1016/j.ajhg.2011.07.022.
  6. Setta-Kaffetzi N, Simpson MA, Navarini AA, Patel VM, Lu HC, Allen MH,Duckworth M, Bachelez H, Burden AD, Choon SE, Griffiths CE, Kirby B, Kolios A,Seyger MM, Prins C, Smahi A, Trembath RC, Fraternali F, Smith CH, Barker JN,Capon F. AP1S3 mutations are associated with pustular psoriasis and impairedToll-like receptor 3 trafficking. Am J Hum Genet. 2014 May 1;94(5):790-7. doi:10.1016/j.ajhg.2014.04.005.
  7. Sugiura K, Takemoto A, Yamaguchi M, Takahashi H, Shoda Y, Mitsuma T, Tsuda K, Nishida E, Togawa Y, Nakajima K, Sakakibara A, Kawachi S, Shimizu M, Ito Y,Takeichi T, Kono M, Ogawa Y, Muro Y, Ishida-Yamamoto A, Sano S, Matsue H, Morita A, Mizutani H, Iizuka H, Muto M, Akiyama M. The majority of generalized pustular psoriasis without psoriasis vulgaris is caused by deficiency of interleukin-36receptor antagonist. J Invest Dermatol. 2013 Nov;133(11):2514-2521. doi:10.1038/jid.2013.230.
  8. Sugiura K. The genetic background of generalized pustular psoriasis: IL36RNmutations and CARD14 gain-of-function variants. J Dermatol Sci. 2014Jun;74(3):187-92. doi: 10.1016/j.jdermsci.2014.02.006.
  9. Takeichi T, Kobayashi A, Ogawa E, Okuno Y, Kataoka S, Kono M, Sugiura K,Okuyama R, Akiyama M. Autosomal dominant familial generalized pustular psoriasis caused by a CARD14 mutation. Br J Dermatol. 2017 Oct;177(4):e133-e135. doi:10.1111/bjd.15442.
  10. Tauber M, Bal E, Pei XY, Madrange M, Khelil A, Sahel H, Zenati A, Makrelouf M,Boubridaa K, Chiali A, Smahi N, Otsmane F, Bouajar B, Marrakchi S, Turki H,Bourrat E, Viguier M, Hamel Y, Bachelez H, Smahi A. IL36RN Mutations AffectProtein Expression and Function: A Basis for Genotype-Phenotype Correlation inPustular Diseases. J Invest Dermatol. 2016 Sep;136(9):1811-1819. doi:10.1016/j.jid.2016.04.038.
  11. Wang Y, Cheng R, Lu Z, Guo Y, Yan M, Liang J, Huang P, Li M, Yao Z. Clinicalprofiles of pediatric patients with GPP alone and with different IL36RNgenotypes. J Dermatol Sci. 2017 Mar;85(3):235-240. doi:10.1016/j.jdermsci.2016.11.008.
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