Submitted Successfully!
To reward your contribution, here is a gift for you: A free trial for our video production service.
Thank you for your contribution! You can also upload a video entry or images related to this topic.
Version Summary Created by Modification Content Size Created at Operation
1 + 449 word(s) 449 2020-12-15 08:01:21

Video Upload Options

Do you have a full video?

Confirm

Are you sure to Delete?
Cite
If you have any further questions, please contact Encyclopedia Editorial Office.
Guo, L. MSX2 Gene. Encyclopedia. Available online: https://encyclopedia.pub/entry/3942 (accessed on 17 April 2024).
Guo L. MSX2 Gene. Encyclopedia. Available at: https://encyclopedia.pub/entry/3942. Accessed April 17, 2024.
Guo, Lily. "MSX2 Gene" Encyclopedia, https://encyclopedia.pub/entry/3942 (accessed April 17, 2024).
Guo, L. (2020, December 23). MSX2 Gene. In Encyclopedia. https://encyclopedia.pub/entry/3942
Guo, Lily. "MSX2 Gene." Encyclopedia. Web. 23 December, 2020.
MSX2 Gene
Edit

msh homeobox 2

genes

1. Introduction

The MSX2 gene provides instructions for producing a protein that is necessary for proper development of cells and tissues throughout the body. The MSX2 protein is a transcription factor, which means it attaches (binds) to specific regions of DNA and helps control the activity of certain genes. Specifically, the protein controls the activity of genes that regulate cell growth and division (proliferation), cell maturation and specialization (differentiation), and cell survival. The regulation of these functions ensures that cells start and stop growing at specific times and that they are positioned correctly during development.

The MSX2 protein is part of a chemical signaling pathway known as the bone morphogenic protein (BMP) pathway. This signaling pathway regulates various cellular processes and is involved in the growth of cells, including new bone cells. The MSX2 protein seems to be particularly critical for the development of the skull.

2. Health Conditions Related to Genetic Changes

2.1. Enlarged parietal foramina

At least 10 mutations in the MSX2 gene have been identified in people with enlarged parietal foramina type 1. This condition is characterized by enlarged openings (foramina) in the parietal bones, which are the two bones that form the top and sides of the skull. Openings in the parietal bones are normal during fetal development, but they usually close before birth. In people with this condition, the parietal foramina remain open throughout life.

The mutations that cause enlarged parietal foramina result in the production of an MSX2 protein that cannot bind to DNA, which alters the regulation of multiple genes. As a result, several cell processes are disrupted, including proliferation, differentiation, and survival. In early development, the skull seems to be particularly sensitive to changes in MSX2 protein activity and changes in cell function. Specifically, cells in the skull that are involved in bone formation (ossification) cannot function normally, leading to a lack of bone in areas of the skull and enlarged parietal foramina.

2.2. Other disorders

At least two mutations in the MSX2 gene cause a condition called craniosynostosis type 2 (also known as Boston type craniosynostosis). Craniosynostosis involves premature closure of the bones of the skull, leading to a misshapen head. People with craniosynostosis type 2 can have skull malformations including a protruding forehead (frontal bossing), a short wide head that is pointed at the top (turribrachycephaly), or a cloverleaf-shaped skull (Kleeblattschaedel deformity). Most affected people have vision problems, and a few have experienced seizures. Intelligence is typically normal.

It is unclear how changes in the MSX2 gene can cause premature closure of the skull bones in craniosynostosis type 2 and impaired bone formation in enlarged parietal foramina (described above).

3. Other Names for This Gene

  • CRS2

  • FPP

  • HOX8

  • MSH

  • msh homeobox homolog 2

  • MSX2_HUMAN

  • PFM

  • PFM1

References

  1. Florisson JM, Verkerk AJ, Huigh D, Hoogeboom AJ, Swagemakers S, Kremer A,Heijsman D, Lequin MH, Mathijssen IM, van der Spek PJ. Boston typecraniosynostosis: report of a second mutation in MSX2. Am J Med Genet A. 2013Oct;161A(10):2626-33. doi: 10.1002/ajmg.a.36126.
  2. Griessenauer CJ, Veith P, Mortazavi MM, Stewart C, Grochowsky A, Loukas M,Tubbs RS. Enlarged parietal foramina: a review of genetics, prognosis, radiology,and treatment. Childs Nerv Syst. 2013 Apr;29(4):543-7. doi:10.1007/s00381-012-1982-7.
  3. Wilkie AO, Tang Z, Elanko N, Walsh S, Twigg SR, Hurst JA, Wall SA, ChrzanowskaKH, Maxson RE Jr. Functional haploinsufficiency of the human homeobox gene MSX2causes defects in skull ossification. Nat Genet. 2000 Apr;24(4):387-90.
  4. Wu Q, Zhang L, Su P, Lei X, Liu X, Wang H, Lu L, Bai Y, Xiong T, Li D, Zhu Z, Duan E, Jiang E, Feng S, Han M, Xu Y, Wang F, Zhou J. MSX2 mediates entry ofhuman pluripotent stem cells into mesendoderm by simultaneously suppressing SOX2 and activating NODAL signaling. Cell Res. 2015 Dec;25(12):1314-32. doi:10.1038/cr.2015.118.
  5. Wuyts W, Reardon W, Preis S, Homfray T, Rasore-Quartino A, Christians H,Willems PJ, Van Hul W. Identification of mutations in the MSX2 homeobox gene infamilies affected with foramina parietalia permagna. Hum Mol Genet. 2000 May1;9(8):1251-5.
More
Information
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register :
View Times: 249
Entry Collection: MedlinePlus
Revision: 1 time (View History)
Update Date: 23 Dec 2020
1000/1000