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Chen, K. PROK2 Gene. Encyclopedia. Available online: (accessed on 14 June 2024).
Chen K. PROK2 Gene. Encyclopedia. Available at: Accessed June 14, 2024.
Chen, Karina. "PROK2 Gene" Encyclopedia, (accessed June 14, 2024).
Chen, K. (2020, December 22). PROK2 Gene. In Encyclopedia.
Chen, Karina. "PROK2 Gene." Encyclopedia. Web. 22 December, 2020.
PROK2 Gene

prokineticin 2


1. Normal Function

The PROK2 gene provides instructions for making a protein called prokineticin 2. This protein interacts with another protein called prokineticin receptor 2 (produced from the PROKR2 gene). On the cell surface, prokineticin 2 attaches (binds) to the receptor like a key in a lock. When the two proteins are connected, they trigger a series of chemical signals within the cell that regulate various cell functions. Prokineticin 2 and its receptor are produced in many organs and tissues, including the small intestine, certain regions of the brain, and several hormone-producing (endocrine) tissues.

Prokineticin 2 and its receptor play a role in the development of a group of nerve cells that are specialized to process smells (olfactory neurons). These neurons move (migrate) from the developing nose to a structure in the front of the brain called the olfactory bulb, which is critical for the perception of odors. Prokineticin 2 and its receptor are also involved in the migration of nerve cells that produce gonadotropin-releasing hormone (GnRH). GnRH controls the production of several hormones that direct sexual development before birth and during puberty. These hormones are also important for the normal function of the ovaries in women and the testes in men.

Several additional functions of prokineticin 2 and its receptor have been discovered. These proteins help stimulate the movement of food through the intestine and are likely involved in the formation of new blood vessels (angiogenesis). They also play a role in coordinating daily (circadian) rhythms, such as the sleep-wake cycle and regular changes in body temperature. Prokineticin 2 and its receptor are active in a region of the brain called the suprachiasmatic nucleus (SCN), which acts as an internal clock that controls circadian rhythms.

2. Health Conditions Related to Genetic Changes

2.1. Kallmann syndrome

At least 16 mutations in the PROK2 gene have been identified in people with Kallmann syndrome, a disorder characterized by the combination of hypogonadotropic hypogonadism (a condition affecting the production of hormones that direct sexual development) and an impaired sense of smell. Researchers estimate that mutations in the PROK2 and PROKR2 genes together account for about 9 percent of all cases of Kallmann syndrome.

Most of the PROK2 gene mutations that cause Kallmann syndrome change single protein building blocks (amino acids) in prokineticin 2. These mutations disrupt the protein's activity, affecting its ability to bind to its receptor to send signals normally. Studies suggest that a loss of this signaling disrupts the migration and survival of olfactory neurons and GnRH-producing neurons in the developing brain. If olfactory nerve cells do not extend to the olfactory bulb, a person's sense of smell will be impaired or absent. Misplacement or premature loss of GnRH-producing neurons prevents the production of sex hormones, which interferes with normal sexual development and causes puberty to be delayed or absent.

Because the features and severity of Kallmann syndrome vary among individuals, researchers believe that additional genetic and environmental factors may be involved. Some affected individuals have mutations in one of several other genes in addition to PROK2, and these genetic changes may contribute to the varied features of the condition.

3. Other Names for This Gene

  • BV8

  • KAL4

  • MIT1

  • PK2


  • Protein Bv8 homolog


  1. Balasubramanian R, Crowley WF Jr. Isolated Gonadotropin-Releasing Hormone(GnRH) Deficiency. 2007 May 23 [updated 2017 Mar 2]. In: Adam MP, Ardinger HH,Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews®[Internet]. Seattle (WA): University of Washington, Seattle; 1993-2020. Availablefrom
  2. Cheng MY, Bullock CM, Li C, Lee AG, Bermak JC, Belluzzi J, Weaver DR, LeslieFM, Zhou QY. Prokineticin 2 transmits the behavioural circadian rhythm of thesuprachiasmatic nucleus. Nature. 2002 May 23;417(6887):405-10.
  3. Dodé C, Rondard P. PROK2/PROKR2 Signaling and Kallmann Syndrome. FrontEndocrinol (Lausanne). 2013 Apr 12;4:19. doi: 10.3389/fendo.2013.00019.
  4. Dodé C, Teixeira L, Levilliers J, Fouveaut C, Bouchard P, Kottler ML,Lespinasse J, Lienhardt-Roussie A, Mathieu M, Moerman A, Morgan G, Murat A,Toublanc JE, Wolczynski S, Delpech M, Petit C, Young J, Hardelin JP. Kallmannsyndrome: mutations in the genes encoding prokineticin-2 and prokineticinreceptor-2. PLoS Genet. 2006 Oct 20;2(10):e175.
  5. Moya-Plana A, Villanueva C, Laccourreye O, Bonfils P, de Roux N. PROKR2 andPROK2 mutations cause isolated congenital anosmia without gonadotropicdeficiency. Eur J Endocrinol. 2012 Dec 10;168(1):31-7. doi: 10.1530/EJE-12-0578. Print 2013 Jan.
  6. Ng KL, Li JD, Cheng MY, Leslie FM, Lee AG, Zhou QY. Dependence of olfactorybulb neurogenesis on prokineticin 2 signaling. Science. 2005 Jun24;308(5730):1923-7.
  7. Pitteloud N, Zhang C, Pignatelli D, Li JD, Raivio T, Cole LW, Plummer L,Jacobson-Dickman EE, Mellon PL, Zhou QY, Crowley WF Jr. Loss-of-function mutationin the prokineticin 2 gene causes Kallmann syndrome and normosmic idiopathichypogonadotropic hypogonadism. Proc Natl Acad Sci U S A. 2007 Oct30;104(44):17447-52.
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Update Date: 22 Dec 2020
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