Your browser does not fully support modern features. Please upgrade for a smoother experience.
Submitted Successfully!
Thank you for your contribution! You can also upload a video entry or images related to this topic. For video creation, please contact our Academic Video Service.
Version Summary Created by Modification Content Size Created at Operation
1 handwiki Dean Liu -- 2326 2022-11-08 01:31:53

Video Upload Options

We provide professional Academic Video Service to translate complex research into visually appealing presentations. Would you like to try it?
No, upload directly Yes
Cite
If you have any further questions, please contact Encyclopedia Editorial Office.
HandWiki. Meso-Zeaxanthin. Encyclopedia. Available online: https://encyclopedia.pub/entry/37872 (accessed on 30 September 2026).
HandWiki. Meso-Zeaxanthin. Encyclopedia. Available at: https://encyclopedia.pub/entry/37872. Accessed September 30, 2026.
HandWiki. "Meso-Zeaxanthin" Encyclopedia, https://encyclopedia.pub/entry/37872 (accessed September 30, 2026).
HandWiki. (2022, December 02). Meso-Zeaxanthin. In Encyclopedia. https://encyclopedia.pub/entry/37872
HandWiki. "Meso-Zeaxanthin." Encyclopedia. Web. 02 December, 2022.
Meso-Zeaxanthin
Edit
The content is sourced from: https://handwiki.org/wiki/Chemistry:Meso-zeaxanthin

Meso-zeaxanthin (3R,3´S-zeaxanthin) is a xanthophyll carotenoid, as it contains oxygen and hydrocarbons, and is one of the three stereoisomers of zeaxanthin. Of the three stereoisomers, meso-zeaxanthin is the second most abundant in nature after 3R,3´R-zeaxanthin, which is produced by plants and algae. To date, meso-zeaxanthin has been identified in specific tissues of marine organisms and in the macula lutea, also known as the "yellow spot", of the human retina.

xanthophyll meso-zeaxanthin zeaxanthin

References

  1. Maoka, Takashi; Arai, Akihiro; Shimizu, Minoru; Matsuno, Takao (1986). "The first isolation of enantiomeric and meso-zeaxanthin in nature". Comparative Biochemistry and Physiology Part B: Comparative Biochemistry 83 (1): 121–124. doi:10.1016/0305-0491(86)90341-X. PMID 3943294.  https://dx.doi.org/10.1016%2F0305-0491%2886%2990341-X
  2. Bhosale, Prakash; Serban, Bogdan; Zhao, Da You; Bernstein, Paul S. (2007-08-07). "Identification and metabolic transformations of carotenoids in ocular tissues of the Japanese quail Coturnix japonica". Biochemistry 46 (31): 9050–9057. doi:10.1021/bi700558f. ISSN 0006-2960. PMID 17630780.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2531157
  3. Rasmussen, Helen M.; Muzhingi, Tawanda; Eggert, Emily M. R.; Johnson, Elizabeth J. (2012-09-01). "Lutein, zeaxanthin, meso-zeaxanthin content in egg yolk and their absence in fish and seafood". Journal of Food Composition and Analysis 27 (2): 139–144. doi:10.1016/j.jfca.2012.04.009.  https://dx.doi.org/10.1016%2Fj.jfca.2012.04.009
  4. Nolan, J. M.; Meagher, K.; Kashani, S.; Beatty, S. (2013-08-01). "What is meso-zeaxanthin, and where does it come from?". Eye (London, England) 27 (8): 899–905. doi:10.1038/eye.2013.98. ISSN 1476-5454. PMID 23703634.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3740325
  5. Prado-Cabrero, Alfonso; Beatty, Stephen; Stack, Jim; Howard, Alan; Nolan, John M. (2016). "Quantification of zeaxanthin stereoisomers and lutein in trout flesh using chiral high-performance liquid chromatography-diode array detection". Journal of Food Composition and Analysis 50: 19–22. doi:10.1016/j.jfca.2016.05.004. PMID 27721557.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5055101
  6. Khachik, Frederick; Moura, Fabiana F. de; Zhao, Da-You; Aebischer, Claude-Pierre; Bernstein, Paul S. (2002-11-01). "Transformations of Selected Carotenoids in Plasma, Liver, and Ocular Tissues of Humans and in Nonprimate Animal Models". Investigative Ophthalmology & Visual Science 43 (11): 3383–3392. ISSN 1552-5783. PMID 12407147. http://iovs.arvojournals.org/article.aspx?articleid=2123268. 
  7. Schiedt, Katharina; Vecchi, Max; Glinz, Ernst (1986-01-01). "Astaxanthin and its metabolites in wild rainbow trout (Salmo gairdneri R.)". Comparative Biochemistry and Physiology B 83 (1): 9–12. doi:10.1016/0305-0491(86)90324-X.  https://dx.doi.org/10.1016%2F0305-0491%2886%2990324-X
  8. Prado-Cabrero, Alfonso; Beatty, Stephen; Howard, Alan; Stack, Jim; Bettin, Philipp; Nolan, John M. (2016). "Assessment of lutein, zeaxanthin and meso-zeaxanthin concentrations in dietary supplements by chiral high-performance liquid chromatography" (in en). Eur Food Res Technol 242 (4): 599–608 242(4). doi:10.1007/s00217-015-2569-9. ISSN 1438-2377. PMID 27069419.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4788689
  9. Bone, R. A.; Landrum, J. T.; Friedes, L. M.; Gomez, C. M.; Kilburn, M. D.; Menendez, E.; Vidal, I.; Wang, W. (1997-02-01). "Distribution of lutein and zeaxanthin stereoisomers in the human retina". Experimental Eye Research 64 (2): 211–218. doi:10.1006/exer.1996.0210. ISSN 0014-4835. PMID 9176055.  https://dx.doi.org/10.1006%2Fexer.1996.0210
  10. Li, Binxing; Ahmed, Faisal; Bernstein, Paul S. (2010-12-01). "Studies on the singlet oxygen scavenging mechanism of human macular pigment". Archives of Biochemistry and Biophysics 504 (1): 56–60. doi:10.1016/j.abb.2010.07.024. ISSN 1096-0384. PMID 20678467.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2957523
  11. Akuffo, K. O.; Nolan, J. M.; Howard, A. N.; Moran, R.; Stack, J.; Klein, R.; Klein, B. E.; Meuer, S. M. et al. (2015-07-01). "Sustained supplementation and monitored response with differing carotenoid formulations in early age-related macular degeneration". Eye (London, England) 29 (7): 902–912. doi:10.1038/eye.2015.64. ISSN 1476-5454. PMID 25976647.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4506345
  12. Loughman, James; Nolan, John M.; Howard, Alan N.; Connolly, Eithne; Meagher, Katie; Beatty, Stephen (2012-11-01). "The impact of macular pigment augmentation on visual performance using different carotenoid formulations". Investigative Ophthalmology & Visual Science 53 (12): 7871–7880. doi:10.1167/iovs.12-10690. ISSN 1552-5783. PMID 23132800.  https://dx.doi.org/10.1167%2Fiovs.12-10690
  13. Meagher, Katherine A.; Thurnham, David I.; Beatty, Stephen; Howard, Alan N.; Connolly, Eithne; Cummins, Wayne; Nolan, John M. (2013-07-28). "Serum response to supplemental macular carotenoids in subjects with and without age-related macular degeneration". The British Journal of Nutrition 110 (2): 289–300. doi:10.1017/S0007114512004837. ISSN 1475-2662. PMID 23211762.  https://dx.doi.org/10.1017%2FS0007114512004837
  14. Nolan, John M.; Akkali, Mukunda C.; Loughman, James; Howard, Alan N.; Beatty, Stephen (2012-08-01). "Macular carotenoid supplementation in subjects with atypical spatial profiles of macular pigment". Experimental Eye Research 101: 9–15. doi:10.1016/j.exer.2012.05.006. ISSN 1096-0007. PMID 22652506. https://arrow.dit.ie/otpomart/36. 
  15. Sabour-Pickett, Sarah; Beatty, Stephen; Connolly, Eithne; Loughman, James; Stack, Jim; Howard, Alan; Klein, Ronald; Klein, Barbara E. et al. (2014-09-01). "Supplementation with three different macular carotenoid formulations in patients with early age-related macular degeneration". Retina (Philadelphia, Pa.) 34 (9): 1757–1766. doi:10.1097/IAE.0000000000000174. ISSN 1539-2864. PMID 24887490. https://arrow.dit.ie/otpomart/39. 
  16. Thurnham, David I.; Nolan, John M.; Howard, Alan N.; Beatty, Stephen (2015-08-01). "Macular response to supplementation with differing xanthophyll formulations in subjects with and without age-related macular degeneration". Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie 253 (8): 1231–1243. doi:10.1007/s00417-014-2811-3. ISSN 1435-702X. PMID 25311651.  https://dx.doi.org/10.1007%2Fs00417-014-2811-3
  17. Torres-Cardona, M.D., Torres-Quiroga, J., (1996). Process for the isomerization of lutein. Industrial Organica, S.A. de C.V., Monterrey, Mexico, US.
  18. Andrewes, A.G., (1974). Isomerization of epsilon-carotene to beta-carotene and of Lutein to Zeaxanthin. Acta Chemica Scandinavica B 28(1), 137-138.
  19. Andrewes, A.G., Borch, G.L., Liaaen-Jensen, S., (1974). Carotenoids of Higher Plants 7. * On the Absolute Configuration of Lutein. Acta Chemica Scandinavica B 28(1), 139-140.
  20. Thurnham, David I.; Howard, Alan N. (2013). "Studies on meso-zeaxanthin for potential toxicity and mutagenicity". Food and Chemical Toxicology 59: 455–463. doi:10.1016/j.fct.2013.06.002. PMID 23819916.  https://dx.doi.org/10.1016%2Fj.fct.2013.06.002
  21. Xu, Xinde; Zhang, Lihua; Shao, Bin; Sun, Xiaoxia; Ho, Chi-Tang; Li, Shiming (2013). "Safety evaluation of meso-zeaxanthin". Food Control 32 (2): 678–686. doi:10.1016/j.foodcont.2013.02.007.  https://dx.doi.org/10.1016%2Fj.foodcont.2013.02.007
  22. Chang, (2006). Thirteen-week oral (gavage) toxicity of meso-zeaxanthin in Han Wistar rats with a 4-week recovery.
  23. Bone, RA; Landrum, JT; Cao, Y; Howard, AN; Alvarez-Calderon, F (2007). "Macular pigment response to a supplement containing meso-zeaxanthin, lutein and zeaxanthin". Nutr Metab (Lond) 4: 12. doi:10.1186/1743-7075-4-12. PMID 17498306.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1872023
  24. Connolly, EE; Beatty, S; Loughman, J; Howard, AN; Louw, MS; Nolan, JM (2011). "Supplementation with all three macular carotenoids: response, stability, and safety". Invest Ophthalmol Vis Sci 52 (12): 9207–17. doi:10.1167/iovs.11-8025. PMID 21979997.  https://dx.doi.org/10.1167%2Fiovs.11-8025
  25. Sabour-Pickett, S; Beatty, S; Connolly, E; Loughman, J; Stack, J; Howard, A; Klein, R; Klein, BE et al. (2014). "Supplementation with three different macular carotenoid formulations in patients with early age-related macular degeneration". Retina (Philadelphia, Pa.) 34 (9): 1757–66. doi:10.1097/IAE.0000000000000174. PMID 24887490. https://arrow.dit.ie/otpomart/39. 
  26. Connolly, EE; Beatty, S; Thurnham, DI; Loughman, J; Howard, AN; Stack, J; Nolan, JM (2010). "Augmentation of macular pigment following supplementation with all three macular carotenoids: an exploratory study". Curr Eye Res 35 (4): 335–51. doi:10.3109/02713680903521951. PMID 20373901. http://repository.wit.ie/1546/1/Connolly2010.pdf. 
  27. Nolan, John M.; Power, Rebecca; Stringham, Jim; Dennison, Jessica; Stack, Jim; Kelly, David; Moran, Rachel; Akuffo, Kwadwo O. et al. (2016-06-01). "Enrichment of Macular Pigment Enhances Contrast Sensitivity in Subjects Free of Retinal Disease: Central Retinal Enrichment Supplementation Trials – Report 1". Investigative Ophthalmology & Visual Science 57 (7): 3429–3439. doi:10.1167/iovs.16-19520. ISSN 1552-5783. PMID 27367585.  https://dx.doi.org/10.1167%2Fiovs.16-19520
  28. Akuffo, Kwadwo Owusu; Beatty, Stephen; Peto, Tunde; Stack, Jim; Stringham, Jim; Kelly, David; Leung, Irene; Corcoran, Laura et al. (2017-10-01). "The Impact of Supplemental Antioxidants on Visual Function in Nonadvanced Age-Related Macular Degeneration: A Head-to-Head Randomized Clinical Trial". Investigative Ophthalmology & Visual Science 58 (12): 5347–5360. doi:10.1167/iovs.16-21192. ISSN 1552-5783. PMID 29053808.  https://dx.doi.org/10.1167%2Fiovs.16-21192
More
©Text is available under the terms and conditions of the Creative Commons-Attribution ShareAlike (CC BY-SA) license; additional terms may apply. By using this site, you agree to the Terms and Conditions and Privacy Policy.
Upload a video for this entry
Information
Subjects: Others
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register :
HandWiki
View Times: 1.9K
Entry Collection: HandWiki
Revision: 1 time (View History)
Update Date: 02 Dec 2022
Table of Contents
    Notice
    You are not a member of the advisory board for this topic. If you want to update advisory board member profile, please contact office@encyclopedia.pub.
    OK
    Confirm
    Only members of the Encyclopedia advisory board for this topic are allowed to note entries. Would you like to become an advisory board member of the Encyclopedia?
    Yes
    No
    ${ textCharacter }/${ maxCharacter }
    Submit
    Cancel
    There is no comment~
    ${ textCharacter }/${ maxCharacter }
    Submit
    Cancel
    ${ selectedItem.replyTextCharacter }/${ selectedItem.replyMaxCharacter }
    Submit
    Cancel
    Confirm
    Are you sure to Delete?
    Yes No
    Academic Video Service
    Feedback