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HandWiki. Mir-137. Encyclopedia. Available online: https://encyclopedia.pub/entry/37450 (accessed on 27 September 2026).
HandWiki. Mir-137. Encyclopedia. Available at: https://encyclopedia.pub/entry/37450. Accessed September 27, 2026.
HandWiki. "Mir-137" Encyclopedia, https://encyclopedia.pub/entry/37450 (accessed September 27, 2026).
HandWiki. (2022, December 01). Mir-137. In Encyclopedia. https://encyclopedia.pub/entry/37450
HandWiki. "Mir-137." Encyclopedia. Web. 01 December, 2022.
Mir-137
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The content is sourced from: https://handwiki.org/wiki/Biology:Mir-137

In molecular biology, miR-137 (or microRNA-137) is a short non-coding RNA molecule that functions to regulate the expression levels of other genes by various mechanisms. miR-137 is located on human chromosome 1p22 and has been implicated to act as a tumor suppressor in several cancer types including colorectal cancer, squamous cell carcinoma and melanoma via cell cycle control. Recent genome-wide association studies (GWAS) have provided evidence to suggest that single nucleotide polymorphisms in the vicinity of the MIR137 gene are statistically associated with schizophrenia and other psychiatric disorders. miR-137 is shown to regulate neural stem cell proliferation and differentiation in mouse embryonic stem cells, and neuronal maturation, including regulation of dendrite length, branch points, end points, and spine density in mouse adult hippocampal neuroprogenitor-derived and mouse fetal hippocampus neurons. Decreased spine density has also been observed in the dorsolateral cortex of patients with schizophrenia. miR-137 belongs to the miR-137 clan (a clan is group of two or more RNA families that have arisen from a single evolutionary origin, as derived from their related structure and function). The miR-137 clan contains two members: miR-137 and miR-234; the total number of RNA domains in the clan is 112.

neural stem cell squamous cell carcinoma cell cycle

References

  1. "MicroRNA-137 targets microphthalmia-associated transcription factor in melanoma cell lines.". Cancer Res 68 (5): 1362–8. 2008. doi:10.1158/0008-5472.CAN-07-2912. PMID 18316599.  https://dx.doi.org/10.1158%2F0008-5472.CAN-07-2912
  2. "MicroRNA miR-137 regulates neuronal maturation by targeting ubiquitin ligase Mind Bomb-1". Stem Cells 28 (6): 1060–70. 2010. doi:10.1002/stem.431. PMID 20506192.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3140955
  3. "Epigenetic silencing of miR-137 is an early event in colorectal carcinogenesis". Cancer Res 70 (16): 6609–18. 2010. doi:10.1158/0008-5472.CAN-10-0622. PMID 20682795.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2922409
  4. Kozaki K (2008). "Exploration of tumour-suppressive microRNAs silenced by DNA hypermethylation in oral cancer". Cancer Res 68 (7): 2094–2105. doi:10.1158/0008-5472.can-07-5194. PMID 18381414.  https://dx.doi.org/10.1158%2F0008-5472.can-07-5194
  5. Ando T (2009). "DNA methylation of microRNA genes in gastric mucosae of gastric cancer patients: its possible involvement in the formation of epigenetic field defect". Int J Cancer 124 (10): 2367–2374. doi:10.1002/ijc.24219. PMID 19165869.  https://dx.doi.org/10.1002%2Fijc.24219
  6. Vrba, L; Muñoz-Rodríguez, JL; Stampfer, MR; Futscher, BW (2013). "miRNA Gene Promoters Are Frequent Targets of Aberrant DNA Methylation in Human Breast Cancer.". PLOS ONE 8 (1): e54398. doi:10.1371/journal.pone.0054398. PMID 23342147.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3547033
  7. "MicroRNA-137 promoter methylation in oral rinses from patients with squamous cell carcinoma of the head and neck is associated with gender and body mass index". Carcinogenesis 31 (5): 864–70. May 2010. doi:10.1093/carcin/bgq051. PMID 20197299.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2864416
  8. "miR-137 targets Cdc42 expression, induces cell cycle G1 arrest and inhibits invasion in colorectal cancer cells". Int J Cancer 128 (6): 1269–79. 2010. doi:10.1002/ijc.25452. PMID 20473940.  https://dx.doi.org/10.1002%2Fijc.25452
  9. "miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells". BMC Med 6: 14. 2008. doi:10.1186/1741-7015-6-14. PMID 18577219.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2443372
  10. "Epigenetics, MicroRNAs, and Carcinogenesis: Functional Role of MicroRNA-137 in Uveal Melanoma". Invest Ophthalmol Vis Sci 52 (3): 1193–1199. November 2010. doi:10.1167/iovs.10-5272. PMID 21051724.  https://dx.doi.org/10.1167%2Fiovs.10-5272
  11. "miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells". FASEB J. 24 (9): 3255–63. September 2010. doi:10.1096/fj.09-152207. PMID 20439489.  https://dx.doi.org/10.1096%2Ffj.09-152207
  12. Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium; Sanders, Alan R; Kendler, Kenneth S; Levinson, Douglas F; Sklar, Pamela; Holmans, Peter A; Lin, Dan-Yu; Duan, Jubao et al. (2011). "Genome-wide association study identifies five new schizophrenia loci". Nature Genetics 43 (10): 969–76. doi:10.1038/ng.940. PMID 21926974.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3303194
  13. Agarwal, Vikram; Bell, George W.; Nam, Jin-Wu; Bartel, David P. (2015-08-12). "Predicting effective microRNA target sites in mammalian mRNAs". eLife 4: e05005. doi:10.7554/eLife.05005. ISSN 2050-084X. PMID 26267216.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4532895
  14. Neault, Mathieu; Mallette, Frédérick A.; Richard, Stéphane (2016-03-01). "miR-137 Modulates a Tumor Suppressor Network-Inducing Senescence in Pancreatic Cancer Cells". Cell Reports 14 (8): 1966–1978. doi:10.1016/j.celrep.2016.01.068. ISSN 2211-1247. PMID 26904954.  https://dx.doi.org/10.1016%2Fj.celrep.2016.01.068
  15. Mallette, Frédérick A.; Richard, Stéphane (2012-11-29). "JMJD2A promotes cellular transformation by blocking cellular senescence through transcriptional repression of the tumor suppressor CHD5". Cell Reports 2 (5): 1233–1243. doi:10.1016/j.celrep.2012.09.033. ISSN 2211-1247. PMID 23168260.  https://dx.doi.org/10.1016%2Fj.celrep.2012.09.033
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