Submitted Successfully!
To reward your contribution, here is a gift for you: A free trial for our video production service.
Thank you for your contribution! You can also upload a video entry or images related to this topic.
Version Summary Created by Modification Content Size Created at Operation
1
Francesca Paola Sasso
 -- 1443 2022-11-30 12:45:21 |
2 format correction
Dean Liu
 Meta information modification 1443 2022-12-01 03:18:16 |

Video Upload Options

Do you have a full video?
Send video materials Upload full video

Confirm

Are you sure to Delete?
Yes No
Cite
If you have any further questions, please contact Encyclopedia Editorial Office.
Petrillo, F.;  Petrillo, A.;  Sasso, F.P.;  Schettino, A.;  Maione, A.;  Galdiero, M. Ocular Infections Caused by Viruses. Encyclopedia. Available online: https://encyclopedia.pub/entry/37337 (accessed on 27 July 2024).
Petrillo F,  Petrillo A,  Sasso FP,  Schettino A,  Maione A,  Galdiero M. Ocular Infections Caused by Viruses. Encyclopedia. Available at: https://encyclopedia.pub/entry/37337. Accessed July 27, 2024.
Petrillo, Francesco, Arianna Petrillo, Francesca Paola Sasso, Antonietta Schettino, Angela Maione, Marilena Galdiero. "Ocular Infections Caused by Viruses" Encyclopedia, https://encyclopedia.pub/entry/37337 (accessed July 27, 2024).
Petrillo, F.,  Petrillo, A.,  Sasso, F.P.,  Schettino, A.,  Maione, A., & Galdiero, M. (2022, November 30). Ocular Infections Caused by Viruses. In Encyclopedia. https://encyclopedia.pub/entry/37337
Petrillo, Francesco, et al. "Ocular Infections Caused by Viruses." Encyclopedia. Web. 30 November, 2022.
Ocular Infections Caused by Viruses
Edit
This entry is adapted from the peer-reviewed paper 10.3390/microorganisms10112224

Ocular viral infections are common and widespread globally. These infectious diseases are a major cause of acute red eyes and vision loss. The eye and its nearby tissues can be infected by several viral agents, causing infections with a short course and limited ocular implications or a long clinical progression and serious consequences for the function and structure of the ocular region. Several surveillance studies underline the increased emergence of drug resistance among pathogenic viral strains, limiting treatment options for these infections. Currently, in the event of resistant infections, topical or systemic corticosteroids are useful in the management of associated immune reactions in the eye, which contribute to ocular dysfunction. 

antiviral drug corticosteroids viral infection viruses

1. Introduction

The eye is a spheroidal organ located in the orbital cavity and protected by the eyelids and other ocular annexes [1]. Structurally, the eye consists of an internal compartment formed by the anterior and posterior chambers, iris, lens, vitreous cavity, retina, ciliary body, choroid, and intrinsic ocular muscles; and of an external compartment comprising the conjunctiva, the cornea, the sclera, and the tear film [2]. The internal compartment, physically separated from the immune system by the eye’s blood–retinal barrier, maintains a sterile environment [3]. In contrast, the outer compartment of the eye is exposed to the external environment and, therefore, is susceptible to contamination with potentially pathogenic microorganisms [4][5][6]. Mechanical, anatomical, and immunological defense mechanisms have evolved to protect the ocular surface from many external agents [7]. The stability potential of the eye plays a central role in repelling aerosol particles near the surface of the eye [8]. In order to prevent attack by pathogenic microbial species, the eye possesses several defense mechanism, such as the production of a tear film containing several antimicrobial components—including lactoferrin, defensins, and lysozymes—that help to prevent colonization by pathogens, the presence of the conjunctiva as a physical and biological barrier to external environments, the existence of an innate immune response of the ocular surface epithelium that recognizes only potential pathogens’ antigens and, finally, the presence of a commensal microbiota that constitutes the “barrier population” against pathogenic microbes [9][10][11]. The colonization of the ocular surface by commensal microorganisms has been confirmed by several studies [12][13]. The ocular surface of healthy individuals possesses a native microbiome that includes both viral and bacterial communities [14]. The ocular microbiota is widely known. Several studies have revealed a considerable complexity in the composition of the ocular microbiota, consisting of about 221 bacterial species. The most abundant phyla are represented by Proteobacteria, Actinobacteria, and Firmicutes [12][15]. Few studies have reported on the ocular virome. In the vitreous fluids of healthy individuals, the major viral families found include Myoviridae, Siphoviridae, Phycodnaviridae, Herpesviridae, Poxviridae, Iridoviridae, Podoviridae, Retroviridae, Baculoviridae, and Flaviviridae [14]. Viral and bacterial agents coexist in equilibrium with the host in immunocompetent individuals and play a crucial role in maintaining the homeostasis of the eye’s surface. The alteration of this ecosystem through various routes—such as poor hand hygiene, traumatic injuries, surgery, the transplacental route, the improper use of contact lenses, or the anatomical proximity and cellular receptor distribution between ocular and respiratory or nervous tissues—can promote the invasion of potentially pathogenic external microorganisms [16][17] and the alteration of the microbiota.
The majority of eye infections are attributed to bacteria, although viruses, fungi, and parasites can also contribute to ocular pathogenesis [18][19]. Among Gram-negative bacteria, the genus Pseudomonas is the most represented, while among the Gram-positive strains, Staphylococci are of considerable importance [20][21]. Fusarium spp. infections and Candida albicans and Aspergillus spp. endophthalmitis are also worth mentioning. With regard to viral infections, respiratory viruses such as human adenovirus (species D), avian influenza virus (H7), herpesviruses, coronaviruses, and arboviruses can cause conjunctivitis and/or keratoconjunctivitis [22][23]. The conjunctiva is therefore considered an optimal route of entry for respiratory viruses, and infected tears and conjunctival secretions can lead to the spread of infections [24].

2. Ocular Infection

Types of Ocular Infection

Blepharitis is an inflammation that affects the eyelid margin at the level of the eyelash implant; rather frequently, it tends to become chronic and relapse. Different forms have been distinguished, including hyperemic, seborrheic, scaly, and ulcerative blepharitis. The etiology is often bacterial. It is an infection of the ciliary follicle, often caused by Staphylococcus aureus or S. epidermidis, but sometimes it can be secondary to the presence of a mite (Demodex folliculorum), followed by an allergic reaction and secondary infection by bacteria that invade the hair follicle [25].
Dacryocystitis is an infection of the lacrimal sac, usually secondary to an inflammatory process of the nasal meatus or to a patency defect of the nasolacrimal duct that leads to stagnation of tear fluid. The onset of symptoms consists of copious tearing and conjunctival hyperemia, with discharge of purulent material from the lacrimal points; there may also be swelling of the lacrimal sac area [26].
Conjunctivitis is an inflammatory process of the mucous membrane that covers a large part of the anterior aspect of the eyeball and the posterior surface of the eyelids. The conjunctival sac, directly exposed to the external environment, is easily attacked by irritating factors (e.g., chemical, physical, allergens), but above all by infectious agents. Infectious conjunctivitis is very common and represents one of the most important eye diseases. The occurrence of this infectious state can be a consequence of certain erroneous behaviors (e.g., close contact with infected individuals, the possibility of touching contaminated hands, etc.) that expose the ocular conjunctiva to pathogens. A variety of evidence indicates that the rate of bacterial conjunctivitis is about 50%. Another study reported that bacteria are responsible for only 50% of cases of suspected bacterial conjunctivitis. Conversely, a study reported that up to 52% of cases treated as viral conjunctivitis turned out to be bacterial conjunctivitis following the culture examination [27].
Keratitis is an inflammatory process of the corneal tissue. Excluding forms caused by physical (e.g., UV rays) and chemical agents (e.g., acids and alkalis), most cases of keratitis (about 80%) have an infectious etiology. The causative agents of infection can be bacteria, viruses, fungi, and/or protozoa. Currently, in countries where water purified of biological pollutants is available, infections with pyogenic bacteria are rare. However, because of the spread of soft contact lenses, the frequency of infectious keratitis caused by bacteria and fungi that contaminate the containers and liquids used for storage has increased [28].
Trachoma is a severe form of chronic keratoconjunctivitis and is the leading cause of blindness in some developing countries. It is caused by Chlamydia trachomatis, and its defining pathological characteristic is the formation of inclusion bodies called Halberstaedter–Prowazek bodies [29].
Infectious scleritis is an isolated acute inflammation of the sclera—the opaque fibrous membrane that makes up five-sixths of the outer tunic of the eyeball. Clinically, it manifests with severe pain and red eye. Scleritis and episcleritis are generally rarely caused by infectious agents. Despite this, diffuse scleritis is reported in some cases of tuberculosis and herpes zoster. Episcleritis generally has a benign, self-limited course, while scleritis can result in a thinning of the sclera and, sometimes, in staphyloma [30].
Infectious endophthalmitis is a suppurative process of the vitreous body, with a tendency to abscess and spread to other eye districts. The responsible microorganisms are mainly bacteria, but also fungi [31]. Among the Gram-positive bacteria, coagulase-negative Staphylococci, S. aureus, Streptococcus spp., and Enterococcus spp. are the leading causes of endophthalmitis. Of the Gram-negative bacteria, Pseudomonas spp., K. pneumoniae, and E. coli are the most representative. Of the fungi involved in these pathologies, the genera Candida, Fusarium, and Aspergillus are involved in endophthalmitis cases.
Uveitis is an inflammation state of part or all of the middle (vascular) layer of the ocular wall. The inflammatory phenomena can be of an autoimmune or infectious nature, with simultaneous involvement of the adjacent ocular portions (i.e., the sclera, cornea, and retina). In particular, it is possible to distinguish (i) anterior uveitis, which can affect the iris (iritis), the ciliary body (cyclitis), or both (iridocyclitis); and (ii) posterior uveitis, which can involve the choroid (choroiditis), the retina (retinitis), or both (chorioretinitis). Sometimes, retinal vasculitis with possible involvement is also observed in the posterior vitreous body [32]. The sites of ocular infections and associated etiological agents were shown in Table 1.
Table 1. Sites of ocular infections and associated etiological agents.
Site Infection Etiological Agents
Ocular surface Conjunctivitis Adenovirus, HSV, Staphylococcus spp., Streptococcus spp., Clamydia trachomatis, Neisseria gonorrhoeae
Keratitis HSV, VZV, Pseudomonas aeruginosa, Staphylococcus spp., Acanthamoeba spp., Candida spp., Aspergillus spp.
Episcleritis/scleritis VZV, Mycobacterium tubercolosis
Internal eye Anterior uveitis HSV, VZV, CMV
Intermediate and posterior uveitis HSV, VZV, CMV, Mycobacterium tubercolosis, Toxoplasma gondii, Treponema pallidum
Endophthalmitis Staphylococcus spp., Streptococcus spp., Escherichia coli, Pseudomonas aeruginosa, Candida spp., Aspergillus sp., Fusarium spp.
Eye annexes Blepharitis Staphylococcus spp., Demodex folliculorum
Dacryocystitis Staphylococcus spp.

References

  1. Labelle, P. The Eye. In Pathologic Basis of Veterinary Disease; Elsevier: Amsterdam, The Netherlands, 2017; pp. 1265–1318.e1. ISBN 978-0-323-35775-3. Available online: https://linkinghub.elsevier.com/retrieve/pii/B9780323357753000217 (accessed on 19 July 2021).
  2. Wilcock, B.P.; Njaa, B.L. Special Senses. In Jubb, Kennedy & Palmer’s Pathology of Domestic Animals: Volume 1; Elsevier: Amsterdam, The Netherlands, 2016; pp. 407–508.e2. ISBN 978-0-7020-5317-7. Available online: https://linkinghub.elsevier.com/retrieve/pii/B9780702053177000059 (accessed on 19 July 2021).
  3. Lu, L.J.; Liu, J. Human Microbiota and Ophthalmic Disease. Yale J. Biol. Med. 2016, 89, 325–330.
  4. Fritz, B.; Schäfer, K.; März, M.; Wahl, S.; Ziemssen, F.; Egert, M. Eye-Catching Microbes-Polyphasic Analysis of the Microbiota on Microscope Oculars Verifies Their Role as Fomites. J. Clin. Med. 2020, 9, E1572.
  5. Szczotka-Flynn, L.B.; Pearlman, E.; Ghannoum, M. Microbial contamination of contact lenses, lens care solutions, and their accessories: A literature review. Eye Contact Lens 2010, 36, 116–129.
  6. Tamrat, L.; Gelaw, Y.; Beyene, G.; Gize, A. Microbial Contamination and Antimicrobial Resistance in Use of Ophthalmic Solutions at the Department of Ophthalmology, Jimma University Specialized Hospital, Southwest Ethiopia. Can. J. Infect. Dis. Med. Microbiol. 2019, 2019, 5372530.
  7. Akpek, E.K.; Gottsch, J.D. Immune defense at the ocular surface. Eye 2003, 17, 949–956.
  8. Zimmerman, K.; Kearns, F.; Tzekov, R. Natural protection of ocular surface from viral infections—A hypothesis. Med. Hypotheses 2020, 143, 110082.
  9. McDermott, A.M. Antimicrobial compounds in tears. Exp. Eye Res. 2013, 117, 53–61.
  10. Bolaños-Jiménez, R.; Navas, A.; López-Lizárraga, E.P.; de Ribot, F.M.; Peña, A.; Graue-Hernández, E.O.; Garfias, Y. Ocular Surface as Barrier of Innate Immunity. Open Ophthalmol. J. 2015, 9, 49–55.
  11. Galletti, J.G.; de Paiva, C.S. The ocular surface immune system through the eyes of aging. Ocul. Surf. 2021, 20, 139–162.
  12. Petrillo, F.; Pignataro, D.; Lavano, M.A.; Santella, B.; Folliero, V.; Zannella, C.; Astarita, C.; Gagliano, C.; Franci, G.; Avitabile, T.; et al. Current Evidence on the Ocular Surface Microbiota and Related Diseases. Microorganisms 2020, 8, 1033.
  13. Li, J.J.; Yi, S.; Wei, L. Ocular Microbiota and Intraocular Inflammation. Front. Immunol. 2020, 11, 609765.
  14. Arunasri, K.; Sai Prashanthi, G.; Tyagi, M.; Pappuru, R.R.; Shivaji, S. Intraocular Viral Communities Associated With Post-fever Retinitis. Front. Med. 2021, 8, 724195.
  15. Dong, K.; Xin, Y.; Cao, F.; Huang, Z.; Sun, J.; Peng, M.; Liu, W.; Shi, P. Succession of oral microbiota community as a tool to estimate postmortem interval. Sci. Rep. 2019, 9, 13063.
  16. Ozkan, J.; Willcox, M.D. The Ocular Microbiome: Molecular Characterisation of a Unique and Low Microbial Environment. Curr. Eye Res. 2019, 44, 685–694.
  17. Dell’Annunziata, F.; Martora, F.; Della Pepa, M.E.; Folliero, V.; Luongo, L.; Bocelli, S.; Guida, F.; Mascolo, P.; Campobasso, C.P.; Maione, S.; et al. Post-mortem interval assessment by MALDI-TOF mass spectrometry analysis in murine cadavers. J. Appl. Microbiol. 2021, 132, 707–714.
  18. Klotz, S.A.; Penn, C.C.; Negvesky, G.J.; Butrus, S.I. Fungal and parasitic infections of the eye. Clin. Microbiol. Rev. 2000, 13, 662–685.
  19. Rumelt, S. (Ed.) Advances in Common Eye Infections; InTech Open: London, UK, 2016; ISBN 978-953-51-2809-0. Available online: http://www.intechopen.com/books/advances-in-common-eye-infections (accessed on 19 July 2021).
  20. Teweldemedhin, M.; Gebreyesus, H.; Atsbaha, A.H.; Asgedom, S.W.; Saravanan, M. Bacterial profile of ocular infections: A systematic review. BMC Ophthalmol. 2017, 17, 212.
  21. Dell’Annunziata, F.; Folliero, V.; Giugliano, R.; De Filippis, A.; Santarcangelo, C.; Izzo, V.; Daglia, M.; Galdiero, M.; Arciola, C.R.; Franci, G. Gene Transfer Potential of Outer Membrane Vesicles of Gram-Negative Bacteria. Int. J. Mol. Sci. 2021, 22, 5985.
  22. Ghebremedhin, B. Human adenovirus: Viral pathogen with increasing importance. Eur. J. Microbiol. Immunol. 2014, 4, 26–33.
  23. Zhu, L.; Zhu, H. Ocular herpes: The pathophysiology, management and treatment of herpetic eye diseases. Virol. Sin. 2014, 29, 327–342.
  24. Sun, C.-B.; Wang, Y.-Y.; Liu, G.-H.; Liu, Z. Role of the Eye in Transmitting Human Coronavirus: What We Know and What We Do Not Know. Front. Public Health 2020, 8, 155.
  25. Dowlut, M.S.; Ahmed, Y.; Knox, A. Ocular Inflammation Associated With Fibers From Eyelash Extensions. JAMA Ophthalmol. 2018, 136, e175723.
  26. Taylor, R.S.; Ashurst, J.V. Dacryocystitis. In StatPearls; StatPearls Publishing: Treasure Island, FL, USA, 2021; Available online: http://www.ncbi.nlm.nih.gov/books/NBK470565/ (accessed on 19 July 2021).
  27. Azari, A.A.; Arabi, A. Conjunctivitis: A Systematic Review. J. Ophthalmic Vis. Res. 2020, 15, 372–395.
  28. Ting, D.S.J.; Ho, C.S.; Deshmukh, R.; Said, D.G.; Dua, H.S. Infectious keratitis: An update on epidemiology, causative microorganisms, risk factors, and antimicrobial resistance. Eye 2021, 35, 1084–1101.
  29. Satpathy, G.; Behera, H.S.; Ahmed, N.H. Chlamydial eye infections: Current perspectives. Indian J. Ophthalmol. 2017, 65, 97–102.
  30. Moshirfar, M.; Ronquillo, Y. Infectious Scleritis. In StatPearls; StatPearls Publishing: Treasure Island, FL, USA, 2021; Available online: http://www.ncbi.nlm.nih.gov/books/NBK560818/ (accessed on 19 July 2021).
  31. Vaziri, K.; Schwartz, S.G.; Kishor, K.; Flynn, H.W. Endophthalmitis: State of the art. Clin. Ophthalmol. 2015, 9, 95–108.
  32. Ebrahimiadib, N.; Maleki, A.; Fadakar, K.; Manhapra, A.; Ghassemi, F.; Foster, C.S. Vascular abnormalities in uveitis. Surv. Ophthalmol. 2021, 66, 653–667.
More
© Text is available under the terms and conditions of the Creative Commons Attribution (CC BY) license; additional terms may apply. By using this site, you agree to the Terms and Conditions and Privacy Policy.
Upload a video for this entry
Information
Subjects: Ophthalmology
Contributors MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register :
Francesco Petrillo
,
Arianna Petrillo
,
Francesca Paola Sasso
,
Antonietta Schettino
,
Angela Maione
,
Marilena Galdiero
View Times: 302
Revisions: 2 times (View History)
Update Date: 06 Dec 2022
Table of Contents
    1000/1000
    Hot Most Recent
    Video Production Service
    Feedback