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HandWiki. CED9 (Gene). Encyclopedia. Available online: https://encyclopedia.pub/entry/37077 (accessed on 25 September 2026).
HandWiki. CED9 (Gene). Encyclopedia. Available at: https://encyclopedia.pub/entry/37077. Accessed September 25, 2026.
HandWiki. "CED9 (Gene)" Encyclopedia, https://encyclopedia.pub/entry/37077 (accessed September 25, 2026).
HandWiki. (2022, November 29). CED9 (Gene). In Encyclopedia. https://encyclopedia.pub/entry/37077
HandWiki. "CED9 (Gene)." Encyclopedia. Web. 29 November, 2022.
CED9 (Gene)
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The content is sourced from: https://handwiki.org/wiki/Biology:CED9_(gene)

Cell death abnormality gene 9 (CED-9), also known as apoptosis regulator CED-9, is a gene found in Caenorhabditis elegans that inhibits/represses programmed cell death (apoptosis). The gene was discovered while searching for mutations in the apoptotic pathway after the discovery of the apoptosis promoting genes CED-3 and CED-4. The gene gives rise to the apoptosis regulator CED-9 protein found as an Integral membrane protein in the mitochondrial membrane. The protein is homologous to the human apoptotic regulator Bcl-2 as well as all other proteins in the Bcl-2 protein family. CED-9 is involved in the inhibition of CED-4 which is the activator of the CED-3 caspase. Because of the pathway homology with humans as well as the specific protein homology, CED-9 has been used to represent the human cell apoptosis interactions of Bcl-2 in research.

programmed cell death cell apoptosis apoptosis

References

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  2. Riddle, Donald L.; Blumenthal, Thomas; Meyer, Barbara J.; Priess, James R. (1997) (in en). Genetics of Programmed Cell Death. Cold Spring Harbor Laboratory Press. https://www.ncbi.nlm.nih.gov/books/NBK20015/. 
  3. "ced-9 Apoptosis regulator ced-9 [Caenorhabditis elegans - Gene - NCBI"]. https://www.ncbi.nlm.nih.gov/gene/?term=3565776. 
  4. Hengartner, Michael O.; Horvitz, H. Robert (1994-02-25). "C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2". Cell 76 (4): 665–676. doi:10.1016/0092-8674(94)90506-1. PMID 7907274.  https://dx.doi.org/10.1016%2F0092-8674%2894%2990506-1
  5. "ced-9". http://www.wormbase.org/species/c_elegans/gene/WBGene00000423#04-9g-3. 
  6. "Family: BH4 (PF02180)". http://pfam.xfam.org/family/BH4. 
  7. "ExPASy" (in en-US). http://web.expasy.org/cgi-bin/protparam/protparam1?P41958@1-280@. 
  8. "ced-9 - Apoptosis regulator ced-9 - Caenorhabditis elegans - ced-9 gene & protein" (in en). https://www.uniprot.org/uniprot/P41958. 
  9. "SMART: Sequence analysis results for CED9_CAEEL" (in en). https://smart.embl.de/smart/show_motifs.pl?ID=P41958. 
  10. "Regulation of apoptosis by C. elegans CED-9 in the absence of the C-terminal transmembrane domain". Cell Death and Differentiation 14 (11): 1925–35. November 2007. doi:10.1038/sj.cdd.4402215. PMID 17703231.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3047747
  11. "Programmed Cell Death During Caenorhabditis elegans Development". Genetics 203 (4): 1533–62. August 2016. doi:10.1534/genetics.115.186247. PMID 27516615.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4981262
  12. "Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans". Nature 437 (7060): 831–7. October 2005. doi:10.1038/nature04002. PMID 16208361.  https://dx.doi.org/10.1038%2Fnature04002
  13. "Anti-apoptotic versus pro-apoptotic signal transduction: checkpoints and stop signs along the road to death". Oncogene 17 (11 Reviews): 1475–82. September 1998. doi:10.1038/sj.onc.1202183. PMID 9779994.  https://dx.doi.org/10.1038%2Fsj.onc.1202183
  14. "Caenorhabditis elegans EGL-1 disrupts the interaction of CED-9 with CED-4 and promotes CED-3 activation". The Journal of Biological Chemistry 273 (50): 33495–500. December 1998. doi:10.1074/jbc.273.50.33495. PMID 9837929.  https://dx.doi.org/10.1074%2Fjbc.273.50.33495
  15. "Mutations affecting programmed cell deaths in the nematode Caenorhabditis elegans". Science 220 (4603): 1277–9. June 1983. doi:10.1126/science.6857247. PMID 6857247.  https://dx.doi.org/10.1126%2Fscience.6857247
  16. "Apoptosis and disease: regulation and clinical relevance of programmed cell death". Annual Review of Medicine 48: 267–81. 1997. doi:10.1146/annurev.med.48.1.267. PMID 9046961.  https://dx.doi.org/10.1146%2Fannurev.med.48.1.267
  17. "Apoptosis in C. elegans: lessons for cancer and immunity". Frontiers in Cellular and Infection Microbiology 3: 67. 2013-10-18. doi:10.3389/fcimb.2013.00067. PMID 24151577.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3798828
  18. Lab, Mike Tyers. "ced-9 (T07C4.8) Result Summary | BioGRID" (in en). https://thebiogrid.org/533094. 
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