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HandWiki. Visna Virus. Encyclopedia. Available online: https://encyclopedia.pub/entry/35409 (accessed on 23 September 2026).
HandWiki. Visna Virus. Encyclopedia. Available at: https://encyclopedia.pub/entry/35409. Accessed September 23, 2026.
HandWiki. "Visna Virus" Encyclopedia, https://encyclopedia.pub/entry/35409 (accessed September 23, 2026).
HandWiki. (2022, November 21). Visna Virus. In Encyclopedia. https://encyclopedia.pub/entry/35409
HandWiki. "Visna Virus." Encyclopedia. Web. 21 November, 2022.
Visna Virus
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Visna virus (also known as visna-maedi virus, maedi-visna virus and ovine lentivirus) from the genus Lentivirus and subfamily Orthoretrovirinae, is a "prototype" retrovirus that causes encephalitis and chronic pneumonitis in sheep. It is known as visna when found in the brain, and maedi when infecting the lungs. Lifelong, persistent infections in sheep occur in the lungs, lymph nodes, spleen, joints, central nervous system, and mammary glands; The condition is sometimes known as "ovine progressive pneumonia" (OPP), particularly in the United States , or "Montana sheep disease". White blood cells of the monocyte/macrophage lineage are the main target of visna virus.

encephalitis maedi-visna virus pneumonitis

References

  1. Straub OC (January 2004). "Maedi-Visna virus infection in sheep. History and present knowledge". Comp. Immunol. Microbiol. Infect. Dis. 27 (1): 1–5. doi:10.1016/S0147-9571(02)00078-4. PMID 14656537. http://linkinghub.elsevier.com/retrieve/pii/S0147-9571(02)00078-4. 
  2. "Immune response to maedi-visna virus". Front. Biosci. 12: 1532–43. 2007. doi:10.2741/2166. PMID 17127400.  https://dx.doi.org/10.2741%2F2166
  3. "Visna, a demyelinating transmissible disease of sheep". J. Neuropathol. Exp. Neurol. 16 (3): 389–403. July 1957. PMID 13439402. "Visna of Sheep. A Slow Demyelinating Infection". Br J Exp Pathol 39 (5): 519–28. October 1958. PMID 13584702.  http://www.ncbi.nlm.nih.gov/pubmed/13439402
  4. "Nucleotide sequence of the visna lentivirus: relationship to the AIDS virus". Cell 42 (1): 369–82. August 1985. doi:10.1016/S0092-8674(85)80132-X. PMID 2410140. http://linkinghub.elsevier.com/retrieve/pii/S0092-8674(85)80132-X. 
  5. "Visna virus exhibits a complex transcriptional pattern: one aspect of gene expression shared with the acquired immunodeficiency syndrome retrovirus". J. Virol. 61 (5): 1325–31. May 1987. PMID 3033262. PMC 254106. http://jvi.asm.org/cgi/pmidlookup?view=long&pmid=3033262. 
  6. Lamontagne, L.; Roy, R.; Girard, A.; Samagh, B. S. (1983). "Seroepidemiological survey of maedi-visna virus infection in sheep and goat flocks in Quebec". Canadian Journal of Comparative Medicine 47 (3): 309–315. 
  7. Larruskain, A.; Jugo, B. M. (2013). "Retroviral Infections in Sheep and Goats: Small Ruminant Lentiviruses and Host Interaction". Viruses 5 (8): 2043–2061. doi:10.3390/v5082043.  https://dx.doi.org/10.3390%2Fv5082043
  8. "Visna/maedi virus Env protein expressed by a vaccinia virus recombinant induces cell-to-cell fusion in cells of different origins in the apparent absence of Env cleavage: role of glycosylation and of proteoglycans". Arch Virol 147 (12): 2377–2392. 2002. doi:10.1007/s00705-002-0874-7. PMID 12491104.  https://dx.doi.org/10.1007%2Fs00705-002-0874-7
  9. "Identification of a putative cellular receptor for the lentivirus visna virus". J Gen Virol 72 (8): 1905–1911. 1991. doi:10.1099/0022-1317-72-8-1905. PMID 1651984.  https://dx.doi.org/10.1099%2F0022-1317-72-8-1905
  10. "The influence of CD4 and CXCR4 on maedi-visna virus-induced syncytium formation". APMIS 110 (10): 697–708. 2002. doi:10.1034/j.1600-0463.2002.1101003.x. PMID 12583436.  https://dx.doi.org/10.1034%2Fj.1600-0463.2002.1101003.x
  11. "Identification of the ovine mannose receptor and its possible role in Visna/Maedi virus infection". Vet. Res. 42: 28. 2011. doi:10.1186/1297-9716-42-28. PMID 21314911.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3041668
  12. "C-type lectins and phagocytosis". Immunobiology 214 (7): 562–575. 2009. doi:10.1016/j.imbio.2008.11.003. PMID 19261355.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2702671
  13. "Mannose receptor and its putative ligands in normal murine lymphoid and nonlymphoid organs: In situ expression of mannose receptor by selected macrophages, endothelial cells, perivascular microglia, and mesangial cells, but not dendritic cells". J Exp Med 189 (12): 1961–1972. 1999. doi:10.1084/jem.189.12.1961. PMID 10377192.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2192961
  14. "Maedi and visna in sheep". Front Biol 44: 17–43. 1976. PMID 182560.  http://www.ncbi.nlm.nih.gov/pubmed/182560
  15. "Tropism of sheep lentiviruses for monocytes: susceptibility to infection and virus gene expression increase during maturation of monocytes to macrophages". J. Virol. 58 (1): 67–74. 1986. PMID 3005660.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=252877
  16. http://www.oie.int/doc/ged/D1226.PDF
  17. "Is caprine arthritis encephalitis virus (CAEV) transmitted vertically to early embryo development stages (morulae or blastocyst) via in vitro infected frozen semen?". Theriogenology 77 (8): 1673–8. 2012. doi:10.1016/j.theriogenology.2011.12.012. PMID 22341707.  https://dx.doi.org/10.1016%2Fj.theriogenology.2011.12.012
  18. de Boer G. F.; Terpstra C.; Houwers D. J.; Hendriks J. (1979). "Studies in epidemiology of maedi/visna in sheep". Res.Vet.Sci. 26: 202–208. 
  19. Russo P.; Vitu C.; Guiguen F. (1991). "La maladie maedi-visna du mouton: revue et perspectives". Point Vét. 23: 33–38. 
  20. Houwers, D. J. Epidemiology, diagnosis and control of SRLVinfections. Universidad de Zaragoza. 1997. Jaca - Spain, Universidad de Zaragoza. Badiola, J. J., Gonzalez, L., Lujan, L., Amorena, B., and Juste, R. A. Universidad de Zaragoza. 3rd. European Workshop on Ovine and Caprine Retroviruses. Jaca, Spain. 2–5 March 1997.
  21. "Maedi-visna virus infection in sheep: a review.". Veterinary research 29 (3): 341–367. 1998. PMID 9689746.  http://www.ncbi.nlm.nih.gov/pubmed/9689746
  22. Lechat, E., Milhau, N., Brun., P., Bellaton, C., Greenland, T., Mornex, J., Le Jan, C., 2005. Goat endothelial cells may be infected in vitro by transmigration of caprine arthritis encephalitis virus infected leukocytes. Vet. J. Immunol. Immunopathol. 104, 257‐263.
  23. Thormar H (2005). "Maedi-visna virus and its relationship to human immunodeficiency virus". AIDS Rev 7 (4): 233–45. PMID 16425963.  http://www.ncbi.nlm.nih.gov/pubmed/16425963
  24. "Regulation of the visna virus long terminal repeat in macrophages involves cellular factors that bind sequences containing AP-1 sites.". Molecular and Cellular Biology 9 (6): 2728–2733. 1989. PMID 2548087.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=362346
  25. "Sequences in the visna virus long terminal repeat that control transcriptional activity and respond to viral trans-activation: involvement of AP-1 sites in basal activity and trans-activation.". J. Virol. 63 (7): 3001–30015. 1989. PMID 2542608.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=250855
  26. "Targeting of the Visna Virus Tat Protein to AP-1 Sites: Interactions with the bZIP Domains of Fos and Jun In Vitro and In Vivo". J. Virol. 73 (1): 37–45. 1999. PMID 9847304.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=103805
  27. "Duplicated sequence motif in the long terminal repeat of maedi-visna virus extends cell tropism and is associated with neurovirulence". J. Virol. 81 (8): 4052–4057. 2007. doi:10.1128/jvi.02319-06. PMID 17287273.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1866131
  28. "Visna virus dUTPase is dispensable for neuropathogenicity.". J. Virol. 72 (2): 1657–1661. 1998. PMID 9445073.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=124651
  29. "Visna virus Tat protein: a potent transcription factor with both activator and suppressor domains.". J. Virol. 68 (10): 6137–6146. Oct 1994. PMID 8083955.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=237033
  30. "Maedi-Visna Virus and Caprine Arthritis Encephalitis Virus Genomes Encode a Vpr-Like but No Tat Protein". J. Virol. 77 (17): 9632–9638. 2003. doi:10.1128/jvi.77.17.9632-9638.2003. PMID 12915575.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=187391
  31. "Visna virus encodes a post-transcriptional regulator of viral structural gene expression.". Proc. Natl. Acad. Sci. USA 87 (19): 7497–7501. 1990. doi:10.1073/pnas.87.19.7497. PMID 2170981.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=54774
  32. "Structural and functional analysis of the visna virus Rev-response element.". J. Virol. 66 (6): 3609–3615. 1992. PMID 1316470.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=241143
  33. "Identification and subcellular localization of the Q gene product of visna virus.". J. Virol. 189 (2): 734–739. Aug 1992. doi:10.1016/0042-6822(92)90596-h. PMID 1322597.  https://dx.doi.org/10.1016%2F0042-6822%2892%2990596-h
  34. "The vif gene of maedi-visna virus is essential for infectivity in vivo and in vitro.". J. Virol. 318 (1): 350–359. Jan 2004. doi:10.1016/j.virol.2003.09.044. PMID 14972560.  https://dx.doi.org/10.1016%2Fj.virol.2003.09.044
  35. "Infection of Dendritic Cells by the Maedi-Visna Lentivirus". J. Virol. 74 (21): 10096–103. November 2000. doi:10.1128/JVI.74.21.10096-10103.2000. PMID 11024138. PMC 102048. http://jvi.asm.org/cgi/pmidlookup?view=long&pmid=11024138. 
  36. Gonda, MA; Wong-Staal, F; Gallo, RC; Clements, JE; Narayan, O; Gilden, RV (Jan 1985). "Sequence homology and morphologic similarity of HTLV-III and visna virus, a pathogenic lentivirus.". Science 227 (4683): 173–7. doi:10.1126/science.2981428. PMID 2981428.  https://dx.doi.org/10.1126%2Fscience.2981428
  37. "Why is HIV a pathogen?". Trends Microbiol. 16 (12): 555–60. December 2008. doi:10.1016/j.tim.2008.09.004. PMID 18977141. http://linkinghub.elsevier.com/retrieve/pii/S0966-842X(08)00227-8. 
  38. Adv Pharmacol. 2000;49:315-85. "HIV-1-associated central nervous system dysfunction." Krebs FC, Ross H, McAllister J, Wigdahl B.
  39. "Visna virus as an in vitro model for human immunodeficiency virus and inhibition by ribavirin, phosphonoformate, and 2',3'-dideoxynucleosides". Antimicrob. Agents Chemother. 31 (9): 1369–74. September 1987. doi:10.1128/aac.31.9.1369. PMID 2445282. PMC 174944. http://aac.asm.org/cgi/pmidlookup?view=long&pmid=2445282. 
  40. "Maedi-visna virus, a model for in vitro testing of potential anti-HIV drugs". Comp. Immunol. Microbiol. Infect. Dis. 24 (2): 113–22. April 2001. doi:10.1016/S0147-9571(00)00021-7. PMID 11247044. http://linkinghub.elsevier.com/retrieve/pii/S0147-9571(00)00021-7. 
  41. "Adenine and deazaadenine nucleoside and deoxynucleoside analogues: inhibition of viral replication of sheep MVV (in vitro model for HIV) and bovine BHV-1". Bioorg. Med. Chem. 10 (9): 2973–80. September 2002. doi:10.1016/S0968-0896(02)00131-1. PMID 12110319. http://linkinghub.elsevier.com/retrieve/pii/S0968089602001311. 
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