Submitted Successfully!
To reward your contribution, here is a gift for you: A free trial for our video production service.
Thank you for your contribution! You can also upload a video entry or images related to this topic.
Version Summary Created by Modification Content Size Created at Operation
1 -- 1416 2022-11-18 08:45:46 |
2 format correct Meta information modification 1416 2022-11-22 07:26:49 | |
3 format correct + 2 word(s) 1418 2022-11-22 07:27:14 | |
4 format correct + 4 word(s) 1422 2022-11-24 06:40:09 |

Video Upload Options

Do you have a full video?

Confirm

Are you sure to Delete?
Cite
If you have any further questions, please contact Encyclopedia Editorial Office.
Pinazo-Bandera, J.M.;  García-Cortés, M.;  Segovia-Zafra, A.;  Lucena, M.I.;  Andrade, R.J. Herbal and Hepatocellular Cancer. Encyclopedia. Available online: https://encyclopedia.pub/entry/35284 (accessed on 27 July 2024).
Pinazo-Bandera JM,  García-Cortés M,  Segovia-Zafra A,  Lucena MI,  Andrade RJ. Herbal and Hepatocellular Cancer. Encyclopedia. Available at: https://encyclopedia.pub/entry/35284. Accessed July 27, 2024.
Pinazo-Bandera, José M., Miren García-Cortés, Antonio Segovia-Zafra, María Isabel Lucena, Raúl J. Andrade. "Herbal and Hepatocellular Cancer" Encyclopedia, https://encyclopedia.pub/entry/35284 (accessed July 27, 2024).
Pinazo-Bandera, J.M.,  García-Cortés, M.,  Segovia-Zafra, A.,  Lucena, M.I., & Andrade, R.J. (2022, November 18). Herbal and Hepatocellular Cancer. In Encyclopedia. https://encyclopedia.pub/entry/35284
Pinazo-Bandera, José M., et al. "Herbal and Hepatocellular Cancer." Encyclopedia. Web. 18 November, 2022.
Herbal and Hepatocellular Cancer
Edit

Cirrhosis is the most important risk factor for the development of Hepatocellular cancer (HCC). Thus, it is estimated that one out of three patients with cirrhosis will suffer from HCC during their lifetime. Although chronic viral hepatitis, chronic alcohol intake and metabolic-associated fatty liver disease (MAFLD) are responsible for most cases of cirrhosis, any other cause of cirrhosis (such as herbal causes) might result in hepatocellular carcinoma.

recreational drugs illicit drugs herbals

1. Introduction

Hepatocellular cancer (HCC) is the sixth most frequently diagnosed cancer and the third cause of cancer-related death worldwide, according to the recent registries. In 2020, approximately 724,800 new cases of HCC were diagnosed, with a total of 664,000 deaths in 185 countries from all over the world [1]. Therefore, HCC represents a sizeable contributor to the global cancer-related burden [2]. The incidence of HCC increases substantially in advanced aging population, with a peak in seventh decade of life, except for Chinese and black African patients, whose mean ages at diagnosis are considerably low [3][4]. Regarding the sex preponderance, there is a ratio of around 2.5:1 (male:female) [1]. Only 10% of HCCs occur in patients without any known etiology of liver disease, whilst approximately 90% are associated mainly with chronic viral hepatitis, alcohol abuse, aflatoxin exposure and metabolic-associated fatty liver disease (MAFLD) [5]. Nowadays, hepatitis B (HBV) infection has become the main cause of HCC, accounting for roughly 54% of cases globally. Nevertheless, the incidence and prevalence of MAFLD-related HCC are expected to rise dramatically due the growing obesity pandemic [5][6]. The estimated annual incidence of HCC among patients with non-alcoholic-steatohepatitis-related cirrhosis is 0.5–2.6%. Thus, MAFLD may soon become the foremost global cause of HCC [6].
Cirrhosis is the most important risk factor for the development of HCC [7]. Thus, it is estimated that one out of three patients with cirrhosis will suffer from HCC during their lifetime [7]. Although chronic viral hepatitis, chronic alcohol intake and MAFLD are responsible for most cases of cirrhosis, any other cause of cirrhosis (e.g., drugs or herbal causes) might result in hepatocellular carcinoma [4]. It is well-known that chronic liver damage caused by conventional drugs can lead to severe liver fibrosis and even liver cirrhosis. Once this state has been reached, it is not unlikely to develop into HCC due to the patient’s natural history of cirrhosis [8]. However, neither in the case of conventional medications nor the illicit use of recreational drug or herbs is there robust evidence regarding their associations with the risk of HCC.
Illicit drug and tobacco use, together with alcohol intake, are major contributors to the universal morbidity rate worldwide [9]. Despite the well-known risks of systemic diseases (such as malignancies, lung and cardiovascular disorders, etc.), tobacco consumption remains a serious public health concern [10]. According to World Health Organization (WHO), cigarette smoking kills more of the European population than any other preventable cause [10]. Likewise, substance use disorders, along with mental illnesses, are the first cause of the health burden in young people, accounting for nearly 20% of all disability-adjusted life years. Furthermore, illicit substance consumption carries the risk of significant physical and social disturbances, such as traffic accidents, violent behaviors, and increased suicide rates, among others [11][12]. Thus, among injection drug addicts, the proportion of chronic hepatitis cases is not negligible, causing an important burden of liver cirrhosis and, consequently, of virus-related hepatocellular carcinoma [13].
On the other hand, in modern society, physical appearance is increasingly acquiring an overestimated value, favoring the popularity of illegal and illicit substances used to strengthen and enlarge the muscles for aesthetic purposes [14]. Anabolic androgenic steroids (AAS), nowadays, have very limited medical indications [15]. However, AAS are typically used by 20–40-year-old people, predominantly males, who illicitly consume these drugs for recreational purposes in the context of gym practice or weight training [16][17].

2. Herbal and HCC

2.1. Khat and HCC

Khat (Catha edulis) is a plant with psychoactive effects similar to those of amphetamine. Indeed, it is popularly known as the “natural amphetamine”. Specifically, this herb is one of the most widely consumed herbs in the whole world, with users usually chewing its leaves [18]. The mean age of khat users is approximately the second decade of life, with a significant predominance of the male gender [19]. Khat is a legal and socially accepted substance used recreationally in East African and Middle Eastern countries (mainly Somalia, Ethiopia and Yemen) [19]. It is estimated that it has a daily consumption by more than 20 million people [20]. However, Khat is considered a drug of abuse by the WHO, and its sale is forbidden in almost all Western countries, including the United States of America (USA) and European Union [19].
Khat is a well-established hepatotoxic agent, with case reports and case series implicating the herb in acute and chronic liver injury, and it is defined as category B in terms of its hepatotoxicity potential in LiverTox (this xenobiotic has been reported and is known or highly likely to cause idiosyncratic liver damage, with 12–50 previously published cases) [21][22]. Although it is not clear whether this toxic potential is due to its constituents or a direct effect of the pesticides/preservatives used for cultivating and transporting the herb [23]. The mechanism of khat-related liver injury remains to be elucidated. Animal model studies have shown that khat can cause acute hepatitis, and that chronic active hepatitis and fibrotic liver disease are linked to long-term khat exposure in rats [24]. On the other hand, vasoconstriction due to cathinone, one of its components, has been suggested as a plausible mechanism of the liver injury [25]. It is worth mentioning that, in humans, the pattern of liver damage associated with khat typically has autoimmune features, with frequent autoantibody presentation and, histologically, chronic hepatitis and fibrosis [26][27][28][29][30]. Indeed, a cross-sectional study carried out in Ethiopia—one of the countries with the highest prevalence of khat intake—showed, interestingly, an eye-catching ratio of cirrhosis of apparently unexplained causes (55%). The authors noted that the widespread consumption of khat in this area, together with histological features of toxic injury in the liver biopsy performed among a subgroup of patients without an established etiology, suggest a probable causal association [31]. Similar data have been published in other regions with a high prevalence of khat use, such as Somaliland [32]. Nonetheless, a careful review of all the published reports on khat-induced liver injury does not provide sufficient evidence to link khat consumption with the development of HCC [21][23][26][27][28][29][31][32][33][34][35][36].

2.2. Kava and HCC

Kava (or kava-kava) is a herb extracted from the roots of the plant named Piper methysticum. Kava has been taken as a recreational beverage in Oceania for centuries, and more recently, it has been used in its concentrated form or as an infusion to alleviate anxiety disorders [37][38].
The hepatotoxicity of kava has been recognized in recent decades, with an important fraction of sever and fatal cases, and it is thus included in category A (highest hepatotoxic potential) in LiverTox (the xenobiotic is well-known, with more than 50 cases published in the literature) [39][40]. Several experimental studies on in vivo mouse models have shown the liver oncogenic potential of kava. In 2011, Behl et al. found an increase in the incidence of hepatoblastoma (dose-dependent) in male mice and an increment in hepatocellular carcinoma and adenoma detection (non-dose-related) in female mice. Moreover, non-neoplastic lesions (such as hepatocellular hypertrophy) were detected in the livers of mice, and such findings were confirmed in an independent study, which also identified a considerable rise in the rates of liver cancer and non-malignant liver lesions in mice of both sexes after kava exposure [41][42]. In contrast, in humans, there is no convincing published evidence linking kava intake to HCC thus far [39][43][44][45][46][47][48][49][50][51][52][53][54]. This apparent discrepancy could be related to the low quality of the design of these studies (observational, lacking long-term follow-up) that precluded the drawing of firm conclusions.

2.3. Other Herbs and HCC

Other herbs have been associated with chronic liver damage, even causing liver fibrosis and cirrhosis. In a recent review of the published case reports on herbal-induced liver injury in Latin America, a case of chronic hepatitis with a cholestatic and granulomatous pattern and cirrhotic processing due to Centella asiatica was identified [55][56]. Centella asiatica (or Gotu kola) is a traditional Chinese plant frequently used in Southeast Asia that occasionally is taken to facilitate weight loss, among other applications [57]. In the same systematic review, another case of herb-induced hepatotoxicity with a chronic course due to Crotalaria juncea was also included [55]. This herb is traditionally used as household remedy for several medical conditions, and it is known to cause sinusoidal obstruction syndrome [58]. Crotalaria juncea contains pyrrolizidine alkaloids among its components [55], which have been clearly related to veno-occlusive disease and, hence, to cirrhosis [55][59]. Nevertheless, there is no published evidence to associate these herbs with the risk of HCC.

References

  1. Sung, H.; Ferlay, J.; Siegel, R.L.; Laversanne, M.; Soerjomataram, I.; Jemal, A.; Bray, F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 2021, 71, 209–249.
  2. Forouzanfar, M.H.; Afshin, A.; Alexaner, L.T.; Anderson, H.R.; Bhutta, Z.A.; Biryukov, S.; Brauer, M.; Burnett, R.; Cercy, K.; Charlson, F.J.; et al. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks of clusters of risks, 1990–2015: A systematic analysis for the Global Burden of Disease Study 2015. Lancet 2016, 3388, 1659–1724.
  3. White, D.L.; Thrift AP: Kanwal, F.; Davila, J.; El-Serag, H.B. Incidence of Hepatocellular Carcinoma in All 50 United States, From 2000 Through 2012. Gastroenterology 2017, 152, 812–820.
  4. Galle, P.R.; Forner, A.; Llovet, J.M.; Mazzaferro, V.; Piscaglia, F.; Raoul, J.L.; Schirmacher, P.; Vilgrain, V. EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma. J. Hepatol. 2018, 69, 182–236.
  5. Akinyemiju, T.; Abera, S.; Ahmed, M.; Alam, N.; Alemayohu, M.A.; Allen, C.; Al-Raddadi, R.; Alvis-Guzman, N.; Amoako, Y.; Artaman, A. The burden of primary liver cancer and underlying etiologies from 1990 to 2015 at the global, regional, and national level. JAMA Oncol. 2017, 3, 1683–1691.
  6. Huang, D.Q.; El-Serag, H.B.; Loomba, R. Global epidemiology of NAFLD-related HCC: Trends, predictions, risk factors and prevention. Nat. Rev. Gastroenterol. Hepatol. 2021, 18, 223–238.
  7. Sangiovanni, A.; Prati, G.M.; Fasani, P.; Ronchi, P.; Romeo, R.; Manini, M.; Del Nino, E.; Morabito, A.; Colombo, M. The natural history of compensated cirrhosis due to hepatitis C virus: A 17-year cohort study of 214 patients. Hepatology 2006, 43, 1303–1310.
  8. Björnsson, E.S.; Andrade, R.J. Long-term sequelae of drug induced liver injury. J. Hepatol. 2022, 76, 435–445.
  9. Degenhardt, L.; Whiteford, H.A.; Ferrari, A.J.; Baxter, A.J.; Charlson, F.J.; Hall, W.D.; Freedman, G.; Burstein, R.; Johns, N.; Engell, R.E.; et al. Global burden of disease attributable to illicit drug use and dependence: Findings from the Global Buden of Disease Study 2010. Lancet 2013, 382, 1564–1574.
  10. Machii, R.; Saika, K. Mortality attributable to tobacco by region based on the WHO Global Report. Jpn. J. Clin. Oncol. 2012, 42, 464–465.
  11. Degenhardt, L.; Stockings, E.; Patton, G.; Hall, W.D.; Lynskey, M. The increasing global health priority of substance use in young people. Lancet Psychiatr. 2016, 3, 251–264.
  12. Guvendeger, D.N.; Zahmacioglu, O.; Ciftci, D.A.; Kocaman, G.M.; Erdogan, A. Association of suicide attempts and non-suicidal self-injury behaviors with substance use and family characteristics among children and adolescents seeking treatment for substance use disorder. Subst. Use Misuse 2017, 52, 604–613.
  13. Reimer, J.; Lorenzen, J.; Baetz, B.; Fischer, B.; Rehm, J.; Haasen, C.; Backmund, M. Multiple viral hepatitis in injection drug users and associated risk factors. J. Gastroenterol. Hepatol. 2007, 22, 80–85.
  14. Brennan, R.; Wells, J.S.G.; Van Hout, M.C. The injecting use of image and performance-enhancing drugs (IPED) in the general population: A systematic review. Health Soc. Care Community 2017, 25, 1459–1531.
  15. Shahidi, N.T. A review of the chemistry, biological action, and clinical applications of anabolic-androgenic steroids. Clin. Ther. 2001, 23, 1355–1390.
  16. Mullen, C.; Whalley, B.J.; Schifano, F.; Baker, J.S. Anabolic androgenic steroid abuse in the United Kingdom: An update. Br. J. Pharmacol. 2020, 177, 2180–2198.
  17. Ip, E.J.; Barnett, M.J.; Tenerowicz, M.J.; Perry, P.J. The Anabolic 500 survey: Characteristics of male users versus nonusers of anabolic-androgenic steroids for strength training. Pharmacotherapy 2011, 31, 757–766.
  18. Balint, E.E.; Falkay, G.; Balint, G.A. Khat—A controversial plant. Wien. Klin. Wochenschr. 2009, 121, 604–614.
  19. El-Menyar, A.; Mekkodathil, A.; Al-Thani, H.; Al-Motarreb, A. Khat use: History and heart failure. Oman Med. J. 2015, 30, 77–82.
  20. Patel, N.B. “Natural Amphetamine” Khat: A cultural tradition or a drug of abuse? Int. Rev. Neurobiol. 2015, 120, 235–255.
  21. Coton, T.; Simon, F.; Oliver, M.; Kraemer, P. Hepatotoxicity of khat chewing. Liver Int. 2011, 31, 434.
  22. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury; National Institute of Diabetes and Digestive and Kidney Disease: Bethesda, MD, USA, 2012. Available online: https://www.ncbi.nlm.nih.gov/books/NBK548707 (accessed on 17 June 2022).
  23. Patel, H.; Kumar, K.; Essrani, R.K.; Niazi, M.; Makker, J.; Nayudu, S.K. Acute Hepatitis in a Yemeni Immigrant Associated with Khat: A “Biological Amphetamine” Carried in Cultures. Clin. Pract. 2021, 11, 167–173.
  24. Valente, M.J.; Araújo, A.M.; Bastos, M.L.; Fernandes, E.; Carvalho, F.; De Pinho, P.G.; Carvalho, M. Editor’s Highlight: Characterization of Hepatotoxicity Mechanisms Triggered by Designer Cathinone Drugs (β-Keto Amphetamines). Toxicol. Sci. 2016, 153, 89–102.
  25. Alkadi, H.O.; Al-Kamarany, M.; Al-Kadi, H.; Lyoussi, B.; Khalil, K.A. Khat-aspirin interaction. Yemen J. Pharm. Biol. Sci. 2008, 2, e39.
  26. Riyaz, S.; Imran, M.; Gleeson, D.; Karajeh, M.A. Khat (Catha Edulis) as a possible cause of autoimmune hepatitis. World J. Hepatol. 2014, 6, 150–154.
  27. Alhaddad, O.M.; Elsabaawy, M.M.; Rewisha, E.A.; Salman, T.A.; Kohla, M.A.; Ehsan, N.A.; Waked, I.A. Khat-induced liver injuries: A report of two cases. Arab. J. Gastroenterol. 2016, 17, 45–48.
  28. Peevers, C.G.; Moorghen, M.; Collins, P.L.; Gordon, F.H.; McCune, C.A. Liver disease and cirrhosis because of Khat chewing in UK Somali men: A case series. Liver Int. 2010, 30, 1242–1243.
  29. Stuyt, R.J.; Willems, S.M.; Wagtmans, M.J.; Van Hoek, B. Chewing khat and chronic liver disease. Liver Int. 2011, 31, 434–436.
  30. Björnsson, E.S.; Medina-Caliz, I.; Andrade, R.J.; Lucena, M.I. Setting up criteria for drug-induced autoimmune-like hepatitis through a systematic analysis of published reports. Hepatol. Commun. 2022, 6, 1895–1909.
  31. Orlien, S.M.S.; Ismael, N.Y.; Ahmed, T.A.; Berhe, N.; Lauritzen, T.; Roald, B.; Goldin, R.D.; Sten-Johansen, K.; Dyrhol-Riise, A.M.; Gundersen, S.G.; et al. Unexplained chronic liver disease in Ethiopia: A cross-sectional study. BMC Gastroenterol. 2018, 18, 27.
  32. Mahamoud, H.D.; Muse, S.M.; Roberts, L.R.; Fischer, P.R.; Torbenson, M.S.; Fader, T. Khat chewing and cirrhosis in Somaliland: Case series. Afr. J. Prim. Health Care Fam. Med. 2016, 8, e1–e4.
  33. Jenkins, M.G.; Handslip, R.; Kumar, M.; Mahadeva, U.; Lucas, S.; Yamamoto, T.; Wood, D.M.; Wong, T.; Dargan, P.I. Reversible khat-induced hepatitis: Two case reports and review of the literature. Frontline Gastroenterol. 2013, 4, 278–281.
  34. Chapman, M.H.; Kajihara, M.; Borges, G.; O´Beirne, J.; Patch, D.; Dhillon, A.P.; Crozier, A.; Morgan, M.Y. Severe, acute liver injury and khat leaves. N. Engl. J. Med. 2010, 362, 1642–1644.
  35. Forbes, M.P.; Raj, A.S.; Martin, J.; Lampe, G.; Powell, E.E. Khat-associated hepatitis. Med. J. Aust. 2013, 199, 498–499.
  36. Teisen, E.; Vainer, B.; Ytting, H. Hepatitis after chewing of khat leaves. Ugeskr. Laeger. 2016, 178, V02160124.
  37. Sarris, J. Herbal medicines in the treatment of psychiatric disorders. 10-year updated review. Phytother. Res. 2018, 32, 1147–1162.
  38. Pantano, F.; Tittarelli, R.; Mannocchi, G.; Zaami, S.; Ricci, S.; Giorgetti, R.; Terranova, D.; Busardo, F.P.; Marinelli, E. Hepatotoxicity Induced by “the 3Ks”: Kava, Kratom and Khat. Int. J. Mol. Sci. 2016, 17, 580.
  39. Teshke, R. Kava hepatotoxicity. A clinical review. Ann. Hepatol. 2010, 9, 251–265.
  40. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury; National Institute of Diabetes and Digestive and Kidney Disease: Bethesda, MD, USA, 2012. Available online: www.ncbi.nlm.nih.gov/books/NBK548637/ (accessed on 20 June 2022).
  41. Behl, M.; Nyska, A.; Chhabra, R.S.; Travlos, G.S.; Fomby, L.M.; Sparrow, B.R.; Hejtmanicik, M.R.; Chan, P.C. Liver toxicity and carcinogenicity in F344/N rats and B6C3F1 mice exposed to Kava Kava. Food Chem. Toxicol. 2011, 49, 2820–2829.
  42. National Toxicology Program. Toxicology and carcinogenesis studies of kava kava extract (CAS No. 9000-38-8) in F344/N rats and B6C3F1 mice (Gavage Studies). Natl. Toxicol. Progr. Tech. Rep. Ser. 2012, 571, 1–186.
  43. Strahl, S.; Ehret, V.; Dahm, H.H.; Maier, K.P. Necrotising hepatitis after taking herbal remedies. Dtsch. Med. Wschr. 1998, 123, 1410–1414.
  44. Escher, M.; Desmeules, J.; Giostra, E.; Mentha, G. Hepatitis associated with kava, a herbal remedy for anxiety. Br. Med. J. 2001, 322, 139.
  45. Kraft, M.; Spahn, T.W.; Menzel, J.; Senninger, N.; Dietl, K.H.; Herbst, H.; Domschke, W.; Lerch, M.M. Fulminant liver failure after administration of the herbal antidepressant Kava-Kava. Dtsch. Med. Wschr. 2001, 126, 970–972.
  46. Russmann, S.; Lauterburg, B.H.; Helbling, A. Kava hepatotoxicity. Ann. Intern. Med. 2001, 135, 68–69.
  47. Bujanda, L.; Palacios, A.; Silvariño, R.; Sánchez, A.; Muñoz, C. Hepatitis aguda icterica secundaria a kava. Gastroenterol. Hepatol. 2002, 25, 434–435.
  48. Denham, A.; McIntyre, M.; Whitehouse, J. Kava—The unfolding story: Report on a work-in-progress. J. Altern. Complement. Med. 2002, 8, 237–263.
  49. Gow, P.J.; Connelly, N.J.; Hill, R.L.; Crowley, P.; Angus, P.W. Fatal fulminant hepatic failure induced by a natural therapy containing kava. Med. J. Aust. 2003, 178, 442–443.
  50. Humberston, C.L.; Akhtar, J.; Krenzelok, E.P. Acute hepatitis induced by kava kava. J. Toxicol./Clin. Toxicol. 2003, 41, 109–113.
  51. Russmann, S.; Barguil, Y.; Cabalion, P.; Kritsanida, M.; Duhet, D.; Lauterburg, B.H. Hepatic injury due to traditional aqueous extracts of kava root in New Caledonia. Eur. J. Gastroenterol. Hepatol. 2003, 15, 1033–1036.
  52. Stickel, F.; Baumu¨ller, H.M.; Seitz, K.; Vasilakis, D.; Seitz, G.; Seitz, H.K.; Schuppan, D. Hepatitis induced by kava (Piper methysticum rhizoma). J. Hepatol. 2003, 39, 62–67.
  53. Teschke, R.; Schwarzenboeck, A.; Hennermann, K.H. Kava hepatotoxicity: A clinical survey and critical analysis of 26 suspected cases. Eur. J. Gastroenterol. Hepatol. 2008, 20, 1182–1193.
  54. Christl, S.U.; Seifert, A.; Seeler, D. Toxic hepatitis after consumption of traditional kava preparation. Int. Soc. Travel Med. 2009, 16, 55–56.
  55. Santos, G.; Gasca, J.; Parana, R.; Nunes, V.; Schinnoni, M.; Medina-Caliz, I.; Cabello, M.R.; Lucena, M.I.; Andrade, R.J. Profile of herbal and dietary supplements induced liver injury in Latin America: A systematic review of published reports. Phytother. Res. 2021, 35, 6–19.
  56. Jorge, O.A.; Jorge, A.D. Hepatotoxicity associated with the ingestion of Centella asiatica. Rev. Esp. Enf. Dig. 2005, 97, 115–124.
  57. Sun, B.; Wu, L.; Wu, Y.; Zhang, C.; Qin, L.; Hayashi, M.; Kudo, M.; Gao, M.; Liu, T. Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review. Front. Pharmacol. 2020, 11, 568032.
  58. Lyford, C.L.; Vergara, G.G.; Moeller, D.D. Hepatic venoocclusive disease originating in Ecuador. Gastroenterology 1976, 70, 105–108.
  59. Zhuge, Y.; Liu, Y.; Xie, W. Chinese Society of Gastroenterology Committee of Hepatobiliary Disease. Expert consensus on the clinical management of pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome. J. Gastroenterol. Hepatol. 2019, 34, 634–642.
More
Information
Contributors MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : , , , ,
View Times: 306
Revisions: 4 times (View History)
Update Date: 24 Nov 2022
1000/1000
Video Production Service