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Soyuz TM-21 was a crewed Soyuz spaceflight to Mir. The mission launched from Baikonur Cosmodrome, atop a Soyuz-U2 carrier rocket, at 06:11:34 UTC on March 14, 1995. The flight marked the first time thirteen humans were flying in space simultaneously, with three aboard the Soyuz, three aboard Mir and seven aboard Space Shuttle Endeavour, flying STS-67. The spacecraft carried expedition EO-18 to the space station. This included the first American astronaut to launch on a Soyuz spacecraft and board Mir, Norman Thagard, for the American Thagard Increment aboard the station, which was the first Increment of the Shuttle-Mir program. The three crew members it launched were relieved by Space Shuttle Atlantis during STS-71, when they were replaced by expedition EO-19. The crew returned to earth aboard Soyuz TM-21 on September 11, 1995.