| Version | Summary | Created by | Modification | Content Size | Created at | Operation |
|---|---|---|---|---|---|---|
| 1 | Sirius Huang | -- | 6654 | 2022-11-09 01:37:43 |
A COVID‑19 vaccine is a hypothetical vaccine in development against coronavirus disease 2019 (COVID‑19). Although no candidate has completed clinical trials to prove its safety and efficacy, there are multiple efforts in progress to develop one. As of July 2020, there are 24 vaccine candidates planned or undergoing clinical trials, with two beginning Phase III and seven in Phase I-II. Previous attempts to develop a vaccine against the coronavirus diseases SARS and MERS established considerable knowledge about the structure and function of coronaviruses – which accelerated rapid development during early 2020 of varied technology platforms for a COVID‑19 vaccine – but all the previous coronavirus vaccine candidates failed in early-stage clinical trials, with none being advanced to licensing. The Coalition for Epidemic Preparedness Innovations (CEPI) – which is organizing a US$2 billion worldwide fund for rapid investment and development of vaccine candidates – indicated in April that a vaccine may be available under emergency use protocols in less than 12 months or by early 2021. On 4 May 2020, the WHO organized a telethon which received US$8.1 billion in pledges from forty countries to support rapid development of vaccines to prevent COVID‑19 infections. At the same time, the WHO also announced deployment of an international "Solidarity trial" for simultaneous evaluation of several vaccine candidates reaching Phase II-III clinical trials.