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HandWiki. Thalidomide Scandal. Encyclopedia. Available online: https://encyclopedia.pub/entry/33611 (accessed on 04 October 2026).
HandWiki. Thalidomide Scandal. Encyclopedia. Available at: https://encyclopedia.pub/entry/33611. Accessed October 04, 2026.
HandWiki. "Thalidomide Scandal" Encyclopedia, https://encyclopedia.pub/entry/33611 (accessed October 04, 2026).
HandWiki. (2022, November 09). Thalidomide Scandal. In Encyclopedia. https://encyclopedia.pub/entry/33611
HandWiki. "Thalidomide Scandal." Encyclopedia. Web. 09 November, 2022.
Thalidomide Scandal
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In the late 1950s and early 1960s, the use of thalidomide in pregnant women in 46 countries resulted in the "biggest man‐made medical disaster ever," with over 10,000 children born with a range of severe deformities, such as phocomelia, and thousands of miscarriages. Thalidomide was introduced in 1956 and was aggressively marketed by the German pharmaceutical company Chemie Grünenthal as a medication for anxiety, trouble sleeping, "tension", and morning sickness. It was introduced as a sedative and medication for morning sickness without having been tested on pregnant women. While initially deemed to be safe in pregnancy, concerns regarding birth defects were noted in 1961, and the medication was removed from the market in Europe that year.

thalidomide phocomelia pregnancy

References

  1. Thomas, Katie (2020-03-23). "The Unseen Survivors of Thalidomide Want to Be Heard" (in en-US). The New York Times. ISSN 0362-4331. https://www.nytimes.com/2020/03/23/health/thalidomide-survivors-usa.html. 
  2. Miller, Marylin T. (1991). "Thalidomide Embryopathy: A Model for the Study of Congenital Incomitant Horizontal Strabismus". Transactions of the American Ophthalmological Society 81: 623–674. PMID 1808819.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1298636
  3. "Thalidomide Monograph for Professionals" (in en). https://www.drugs.com/monograph/thalidomide.html. Retrieved 14 November 2019. 
  4. Cuthbert, Alan (2003). The Oxford Companion to the Body. Oxford University Press. p. 682. doi:10.1093/acref/9780198524038.001.0001. ISBN 9780198524038. https://archive.org/details/oxfordcompaniont0000unse_z0k4/page/682. 
  5. Loue, Sana; Sajatovic, Martha (2004) (in en). Encyclopedia of Women's Health. Springer Science & Business Media. p. 644. ISBN 9780306480737. https://books.google.ca/books?id=LbHWgd-mDbsC&pg=PA644. 
  6. "Thalidomide: The Fifty Year Fight (no longer available)". BBC. 15 May 2014. https://www.youtube.com/watch?v=_NLbhOyLLMY. 
  7. Zimmer C (15 March 2010). "Answers Begin to Emerge on How Thalidomide Caused Defects". New York Times. https://www.nytimes.com/2010/03/16/science/16limb.html?ref=science&pagewanted=all. "As they report in the current issue of Science, a protein known as cereblon latched on tightly to the thalidomide" 
  8. "Apology for thalidomide survivors". BBC News. 14 January 2010. http://news.bbc.co.uk/1/hi/health/8458855.stm. 
  9. null
  10. Flintoff, John-Paul (23 March 2008). "Thalidomide: the battle for compensation goes on". The Sunday Times (London: Times Newspapers Ltd.). http://www.timesonline.co.uk/tol/life_and_style/health/article3602694.ece. 
  11. "Thalidomide survivors to get £20m". BBC News. 23 December 2009. http://news.bbc.co.uk/1/hi/8428838.stm. 
  12. "About Us". https://www.thalidomidetrust.org/about-us/. Retrieved 21 April 2020. 
  13. "Thalidomide survivors to get £20m". BBC News. 23 December 2009. http://news.bbc.co.uk/1/hi/8428838.stm. 
  14. Scott, Caroline; Haupt, Oliver (3 May 2015). "The forgotten victims". The Sunday Times Magazine: pp. 12–19. http://www.thesundaytimes.co.uk/sto/Magazine/article1551306.ece. 
  15. Swan, Norman (28 June 2018). "Dr William McBride: The Flawed Character Credited with Linking Thalidomide to Birth Defects." ABC.net.au. Retrieved 29 May 2019. http://www.abc.net.au/news/health/2018-06-29/thalidomide-william-mcbride-flawed-character-norman-swan/9920608
  16. Anon. "Widukind Lenz". who name it?. Ole Daniel Enersen. http://www.whonamedit.com/doctor.cfm/1002.html. 
  17. Anon (7 June 2002). "Thalidomide:40 years on". BBC news (BBC). http://news.bbc.co.uk/1/hi/uk/2031459.stm. 
  18. "Report of Thalidomide at University of New South Wales". Embryology.med.unsw.edu.au. http://embryology.med.unsw.edu.au/Defect/page5i.htm. 
  19. Millikin, Robert (20 February 1993). "'Thalidomide Doctor' Guilty of Medical Fraud: William McBride, Who Exposed the Danger of One Anti-Nausea Drug, Has Been Disgraced by Experiments with Another." The Independent. Retrieved 28 May 2019. https://www.independent.co.uk/news/world/thalidomide-doctor-guilty-of-medical-fraud-william-mcbride-who-exposed-the-danger-of-one-anti-nausea-1474190.html
  20. "The foetal toxicity of thalidomide". Proc. European Soc. Study Drug Toxicity 1: 49. 1963. 
  21. King, C.T.G.; Kendrick, F.J. (1962). "Teratogenic effects of thalidomide in the Sprague Dawley rat". The Lancet 280 (7265): 409–17. doi:10.1016/S0140-6736(62)90822-X. PMID 14288814.  https://dx.doi.org/10.1016%2FS0140-6736%2862%2990822-X
  22. "Effect of some therapeutic agents on the developing rat fetus". Toxicology and Applied Pharmacology 7 (7265): 409–17. 1965. doi:10.1016/S0140-6736(62)90822-X. PMID 14288814.  https://dx.doi.org/10.1016%2FS0140-6736%2862%2990822-X
  23. Botting, Jack (April 2015). "Chapter 18". Animals and Medicine: The Contribution of Animal Experiments to the Control of Disease. OpenBook Publishers. ISBN 9781783741175. http://www.openbookpublishers.com/htmlreader/978-1-78374-117-5/Ch-18.xhtml#_idTextAnchor074. Retrieved 12 August 2015. 
  24. "Australian thalidomide victims win right for hearing". ABC News. 19 December 2011. http://www.abc.net.au/news/2011-12-19/australian-thalidomide-victims-win-hearing-bid/3738116. 
  25. Petrie, Andrea (19 July 2012). "Landmark thalidomide payout offers hope for thousands". The Sydney Morning Herald. http://www.smh.com.au/national/landmark-thalidomide-payout-offers-hope-for-thousands-20120718-22apa.html. 
  26. Farnsworth, Sarah (7 February 2014). "Supreme Court formally approves $89m compensation payout for Thalidomide victims". Australian Broadcasting Corporation. http://www.abc.net.au/news/2014-02-07/supreme-court-formally-approves-2489m-class-action-for-thalido/5245034. 
  27. Australian Associated Press (7 February 2014). "Thalidomide survivors' compensation approved". The Sunday Star-Times. http://www.stuff.co.nz/national/health/9698482/Thalidomide-survivors-compensation-approved. 
  28. "DDR-Bürger schliefen ohne Contergan" (in German). Neues Deutschland. 4 November 2007. https://www.neues-deutschland.de/artikel/120351.html. Retrieved June 6, 2013. 
  29. Thomann, Klaus-Dieter (2007). "Die Contergan-Katastrophe: Die trügerische Sicherheit der "harten" Daten" (in German). Deutsches Ärzteblatt 104 (41): A–2778 / B–2454 / C–2382. http://www.aerzteblatt.de/archiv/57224/. Retrieved June 6, 2013.  Alt URL
  30. (in German) Die Contergankatastrophe eine Bilanz nach 40 Jahren. Darmstadt: Steinkopff. 2005. ISBN 978-3-7985-1479-9. 
  31. "Canadian Thalidomide Experience". Canadian Medical Association Journal 89: 987–92. November 1963. PMID 14076167.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1921912
  32. "Turning Points of History–Prescription for Disaster". History Television. http://www.history.ca/ontv/titledetails.aspx?titleid=21267. 
  33. "On-line sources of toxicological information in Canada". Toxicology 190 (1–2): 3–14. August 2003. doi:10.1016/S0300-483X(03)00192-6. PMID 12909394.  https://dx.doi.org/10.1016%2FS0300-483X%2803%2900192-6
  34. "The plight of the thalidomide 'sample babies' who don't qualify for gov't compensation". W5. http://www.ctvnews.ca/w5/the-plight-of-the-thalidomide-sample-babies-who-don-t-qualify-for-gov-t-compensation-1.3176590. 
  35. "Living in a world with thalidomide: a dose of reality". FDA Consumer 35 (2): 40. 2001. PMID 11444250. http://permanent.access.gpo.gov/lps1609/www.fda.gov/fdac/departs/2001/201_word.html. 
  36. "TVAC and its mission - Thalidomide". June 24, 2009. http://www.thalidomide.ca/tvac-mission/. 
  37. "Thalidomide". Lancet 363 (9423): 1802–11. May 2004. doi:10.1016/S0140-6736(04)16308-3. PMID 15172781. https://zenodo.org/record/1259793. 
  38. Bren L (28 February 2001). "Frances Oldham Kelsey: FDA Medical Reviewer Leaves Her Mark on History". FDA Consumer (U.S. Food and Drug Administration). http://permanent.access.gpo.gov/lps1609/www.fda.gov/fdac/features/2001/201_kelsey.html. 
  39. Braun, Whitny (29 December 2015). "Thalidomide: The Connection Between a Statue in Trafalgar Square, a 1960s Children's Show Host and the Abortion Debate". https://www.huffingtonpost.com/whitny-braun/thalidomide-the-connectio_b_8881702.html. 
  40. Mekdeci, Betty. "Bendectin Part 1: How a Commonly Used Drug Caused Birth Defects". http://www.birthdefects.org/research/bendectin_1.php. 
  41. "Click - Debating Reproductive Rights - Reproductive Rights and Feminism, History of Abortion Battle, History of Abortion Debate, Roe v. Wade and Feminists". https://www.cliohistory.org/click/body-health/reproduction/. 
  42. Harris, Gardiner (13 September 2010). "The Public's Quiet Savior From Harmful Medicines". The New York Times. https://www.nytimes.com/2010/09/14/health/14kelsey.html?_r=1&8dpc. 
  43. "Dr. Helen Brooke Taussig", Bethesda, MD: U.S. National Library of Medicine (3 June 2015): https://cfmedicine.nlm.nih.gov/physicians/biography_316.html
  44. "10.000 Fälle von Missbildungen" (in German). ORF. http://orf.at/070930-17124/index.html. 
  45. "Speech on the occasion of the inauguration of Thalidomide-Memorial". http://www.contergan.grunenthal.info/grt-ctg/GRT-CTG/Stellungnahme/Rede_anlaesslich_Einweihung_des_Contergan-Denkmals/224600963.jsp. 
  46. "Thalidomide apology insulting, campaigners say". BBC News. September 1, 2012. https://www.bbc.com/news/health-19448046. 
  47. Tamplin, Harley (12 June 2015). "Mid Sussex residents honoured by Queen". Mid Sussex Times. http://www.midsussextimes.co.uk/news/local/mid-sussex-residents-honoured-by-queen-1-6795898. 
  48. "Orpheus lives: A small good thing in Quastoff". The Portland Phoenix. April 19, 2002. http://www.portlandphoenix.com/archive/music/02/04/19/classical_Orpheus.html. 
  49. "NoBody's Perfect (2008): Release Info". IMDB. https://www.imdb.com/title/tt1266093/releaseinfo. 
  50. Brussat, Frederic; Brussat, Mary Ann. "Film Review: NoBody's Perfect". Spirituality & Practice. http://www.spiritualityandpractice.com/films/films.php?id=19559. 
  51. "Outstanding eight to receive honorary doctorates at Convocation". Windsor, Ontario, Canada: University of Windsor. 9 June 2016. http://www.uwindsor.ca/dailynews/2016-06-07/outstanding-eight-receive-honorary-doctorates-convocation. 
  52. "Exploitations of embodiment: Born Freak and the academic bally plank.". Disability Studies Quarterly 25 (3). June 2005. doi:10.18061/dsq.v25i3.575. http://www.dsq-sds.org/article/view/575/752. 
  53. "50 Years: The Kefauver-Harris Amendments". Food and Drug Administration (United States). https://www.fda.gov/Drugs/NewsEvents/ucm320924.htm. 
  54. "Thalidomide". National Health Service (England). http://www.crncc.nihr.ac.uk/workforce_development/learning_and_development/gcp/gcp_resource/research_standards/history/thalidomide. 
  55. "Unlicensed and off label drug use in neonates". Archives of Disease in Childhood: Fetal and Neonatal Edition 80 (2): F142–4; discussion F144–5. March 1999. doi:10.1136/fn.80.2.F142. PMID 10325794.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1720896
  56. "The evolution of pharmacy, Theme E, Level 3 Thalidomide and its aftermath". Royal Pharmaceutical Society. 2011. https://www.rpharms.com/museum-pdfs/e3a-thalidomide-and-its-aftermath-2011.pdf. 
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