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Forensic toxicology is the use of toxicology and disciplines such as analytical chemistry, pharmacology and clinical chemistry to aid medical or legal investigation of death, poisoning, and drug use. The primary concern for forensic toxicology is not the legal outcome of the toxicological investigation or the technology utilized, but rather the obtainment and interpretation of results. A toxicological analysis can be done to various kinds of samples. A forensic toxicologist must consider the context of an investigation, in particular any physical symptoms recorded, and any evidence collected at a crime scene that may narrow the search, such as pill bottles, powders, trace residue, and any available chemicals. Provided with this information and samples with which to work, the forensic toxicologist must determine which toxic substances are present, in what concentrations, and the probable effect of those chemicals on the person. In the United States, forensic toxicology can be separated into 3 disciplines: Postmortem toxicology, human performance toxicology, and forensic drug testing (FDT). Postmortem toxicology includes the analysis of biological specimens taken from an autopsy to identify the effect of drugs, alcohol, and poisons. A wide range of biological specimens may be analyzed including blood, urine, gastric contents, oral fluids, hair, tissues, and more. The forensic toxicologist works with pathologists, medical examiners, and coroners to help determine the cause and manner of death. In human performance toxicology, a dose-response relationship between a drug(s) present in the body and the effects on the body are examined. This field of forensic toxicology is responsible for building and implementing laws such as driving under the influence of alcohol or drugs. Lastly, forensic drug testing (FDT) is the detection of drug use among individuals in the workplace, sport doping, drug-related probation, and new job applicant screenings. Determining the substance ingested is often complicated by the body's natural processes (see ADME), as it is rare for a chemical to remain in its original form once in the body. For example: heroin is almost immediately metabolised into another substance and further to morphine, making detailed investigation into factors such as injection marks and chemical purity necessary to confirm diagnosis. The substance may also have been diluted by its dispersal through the body; while a pill or other regulated dose of a drug may have grams or milligrams of the active constituent, an individual sample under investigation may only contain micrograms or nanograms.
References
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