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HandWiki. ANK2. Encyclopedia. Available online: https://encyclopedia.pub/entry/33465 (accessed on 28 September 2026).
HandWiki. ANK2. Encyclopedia. Available at: https://encyclopedia.pub/entry/33465. Accessed September 28, 2026.
HandWiki. "ANK2" Encyclopedia, https://encyclopedia.pub/entry/33465 (accessed September 28, 2026).
HandWiki. (2022, November 08). ANK2. In Encyclopedia. https://encyclopedia.pub/entry/33465
HandWiki. "ANK2." Encyclopedia. Web. 08 November, 2022.
ANK2
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Ankyrin-B, also known as Ankyrin-2, is a protein which in humans is encoded by the ANK2 gene. Ankyrin-B is ubiquitously expressed, but shows high expression in cardiac muscle. Ankyrin-B plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in cardiomyocytes, as well as in costamere structures. Mutations in ankyrin-B cause a dominantly-inherited, cardiac arrhythmia syndrome known as ankyrin-B syndrome as well as sick sinus syndrome; mutations have also been associated to a lesser degree with hypertrophic cardiomyopathy. Alterations in ankyrin-B expression levels are observed in human heart failure.

cardiac arrhythmia ankyrin-2 ankyrin-b

References

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