Your browser does not fully support modern features. Please upgrade for a smoother experience.
Submitted Successfully!
Thank you for your contribution! You can also upload a video entry or images related to this topic. For video creation, please contact our Academic Video Service.
Version Summary Created by Modification Content Size Created at Operation
1 handwiki Dean Liu -- 1605 2022-11-02 01:32:51

Video Upload Options

We provide professional Academic Video Service to translate complex research into visually appealing presentations. Would you like to try it?
No, upload directly Yes
Cite
If you have any further questions, please contact Encyclopedia Editorial Office.
HandWiki. Postmenopausal Confusion. Encyclopedia. Available online: https://encyclopedia.pub/entry/32965 (accessed on 22 September 2026).
HandWiki. Postmenopausal Confusion. Encyclopedia. Available at: https://encyclopedia.pub/entry/32965. Accessed September 22, 2026.
HandWiki. "Postmenopausal Confusion" Encyclopedia, https://encyclopedia.pub/entry/32965 (accessed September 22, 2026).
HandWiki. (2022, November 04). Postmenopausal Confusion. In Encyclopedia. https://encyclopedia.pub/entry/32965
HandWiki. "Postmenopausal Confusion." Encyclopedia. Web. 04 November, 2022.
Postmenopausal Confusion
Edit
The content is sourced from: https://handwiki.org/wiki/Medicine:Postmenopausal_confusion

Postmenopausal confusion, also commonly referred to as postmenopausal brain fog, is a group of symptoms of menopause in which women report problems with cognition at a higher frequency during postmenopause than before. Multiple studies on cognitive performance following menopause have reported noticeable declines of greater than 60%. The common issues presented included impairments in reaction time and attention, difficulty recalling numbers or words, and forgetting reasons for involvement in certain behaviors. Association between subjective cognitive complaints and objective measures of performance show a significant impact on health-related quality of life for postmenopausal women. Treatment primarily involves symptom management through non-pharmacological treatment strategies. This includes involvement in physical activity and following medically supervised diets, especially those that contain phytoestrogens or resveratrol. Pharmacological interventions in treating postmenopausal confusion are currently being researched. Hormone therapy is currently not indicated for the treatment of postmenopausal confusion due to inefficacy. The use of hormone replacement therapy for approved indications has identified no significant negative effect on postmenopausal cognition. Although much of the literature references women, it is important to understand that all people who undergo menopause, including those who do not self-identify as women, may experience symptoms of postmenopausal confusion.

resveratrol postmenopausal physical activity

References

  1. El Khoudary, Samar R.; Greendale, Gail; Crawford, Sybil L.; Avis, Nancy E.; Brooks, Maria M.; Thurston, Rebecca C.; Karvonen-Gutierrez, Carrie; Waetjen, L. Elaine et al. (2019). "The menopause transition and women's health at midlife: a progress report from the Study of Women's Health Across the Nation (SWAN)" (in en). Menopause Publish Ahead of Print (10): 1213–1227. doi:10.1097/GME.0000000000001424. ISSN 1530-0374. PMID 31568098.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=6784846
  2. Mott, Natasha N.; Toni R. Pak (2013). "Estrogen Signaling and the Aging Brain: Context-Dependent Consideration for Postmenopausal Hormone Therapy". ISRN Endocrinology 2013: 1–16. doi:10.1155/2013/814690. PMID 23936665.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3725729
  3. Sheikh, Knvul. "Hormone Therapy May Not Prevent Postmenopausal Brain Fog" (in en). https://www.scientificamerican.com/article/hormone-therapy-may-not-prevent-postmenopausal-brain-fog/. 
  4. Gava, Giulia; Orsili, Isabella; Alvisi, Stefania; Mancini, Ilaria; Seracchioli, Renato; Meriggiola, Maria Cristina (2019). "Cognition, Mood and Sleep in Menopausal Transition: The Role of Menopause Hormone Therapy" (in en). Medicina 55 (10): 668. doi:10.3390/medicina55100668. ISSN 1648-9144. PMID 31581598.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=6843314
  5. Grimm, A.; Y. Lim; A.G. Mensah-Nyagan; J. Götz; A. Eckert (2012). "Alzheimer's disease, oestrogen and mitochondria: an ambiguous relationship". Molecular Neurobiology 46 (1): 151–160. doi:10.1007/s12035-012-8281-x. PMID 22678467.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3443477
  6. Borrelli, Francesca; Ernst, Edzard (2008). "Black cohosh (Cimicifuga racemosa) for menopausal symptoms: A systematic review of its efficacy" (in en). Pharmacological Research 58 (1): 8–14. doi:10.1016/j.phrs.2008.05.008. ISSN 1043-6618. PMID 18585461. https://www.sciencedirect.com/science/article/abs/pii/S1043661808000996. 
  7. "Postmenopause" (in en). https://healthcare.utah.edu/womenshealth/gynecology/menopause/postmenopause.php. 
  8. Henderson, Victor W. (2008). "Cognitive Changes After Menopause: Influence of Estrogen". Clinical Obstetrics and Gynecology 51 (3): 618–626. doi:10.1097/GRF.0b013e318180ba10. ISSN 0009-9201. PMID 18677155.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2637911
  9. Miller, Kathleen B.; Miller, Virginia M.; Barnes, Jill N. (2019). "Pregnancy History, Hypertension, and Cognitive Impairment in Postmenopausal Women". Current Hypertension Reports 21 (12): 93. doi:10.1007/s11906-019-0997-9. PMID 31741134.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=6861362
  10. Volgman, Annabelle Santos; Bairey Merz, C. Noel; Aggarwal, Neelum T.; Bittner, Vera; Bunch, T. Jared; Gorelick, Philip B.; Maki, Pauline; Patel, Hena N. et al. (2019). "Sex Differences in Cardiovascular Disease and Cognitive Impairment: Another Health Disparity for Women?". Journal of the American Heart Association 8 (19): e013154. doi:10.1161/JAHA.119.013154. PMID 31549581.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=6806032
  11. Sliwinski, Jim R; Johnson, Aimee K; Elkins, Gary R (2014). "Memory Decline in Peri- and Post-menopausal Women: The Potential of Mind–Body Medicine to Improve Cognitive Performance". Integrative Medicine Insights 9: 17–23. doi:10.4137/IMI.S15682. ISSN 1177-3936. PMID 25125972.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4125424
  12. Georgakisa, Marios; Beskou-Konto, Theano; Theodoridis, Ioannis; Skalkidou, Alkistis; Petridou, Eleni (2019). "Surgical menopause in association with cognitive function and risk of dementia: A systematic review and meta-analysis". Psychoneuroendocrinology 106: 9–19. doi:10.1016/j.psyneuen.2019.03.013. PMID 30928686.  https://dx.doi.org/10.1016%2Fj.psyneuen.2019.03.013
  13. Dalal, PronobK; Agarwal, Manu (2015). "Postmenopausal syndrome" (in en). Indian Journal of Psychiatry 57 (6): S222-32. doi:10.4103/0019-5545.161483. ISSN 0019-5545. PMID 26330639. PMC 4539866. http://www.indianjpsychiatry.org/text.asp?2015/57/6/222/161483. 
  14. Lethaby, Anne; Hogervorst, Eva; Richards, Marcus; Yesufu, Amina; Yaffe, Kristine (2008). "Hormone replacement therapy for cognitive function in postmenopausal women". Cochrane Database of Systematic Reviews (1): CD003122. doi:10.1002/14651858.CD003122.pub2. PMID 18254016.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=6599876
  15. Maki, PM (2005). "Estrogen effects on the hippocampus and frontal lobes". International Journal of Fertility and Women's Medicine 50 (2): 67–71. PMID 16334413.  http://www.ncbi.nlm.nih.gov/pubmed/16334413
  16. Wnuk, A.; D.L. Korol; K.I. Erickson (2012). "Estrogens, hormone therapy, and hippocampal volume in postmenopausal women". Maturitas 73 (3): 186–190. doi:10.1016/j.maturitas.2012.07.001. PMID 22858056.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3576699
  17. Rizzo, Maria Rosaria; Fasano, Renata; Paolisso, Giuseppe (2020). "Adiponectin and Cognitive Decline". International Journal of Molecular Sciences 21 (6): 2010. doi:10.3390/ijms21062010. ISSN 1422-0067. PMID 32188008.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=7139651
  18. University of Pennsylvania (2017). Attention & Memory Impairments in Menopausal Women: A Possible Role for Vyvanse?. Shire. https://clinicaltrials.gov/ct2/show/study/NCT01324024. 
  19. Epperson, C. Neill; Pittman, Brian; Czarkowski, Kathryn A.; Bradley, Jeanette; Quinlan, Donald M.; Brown, Thomas E. (2015). "Impact of atomoxetine on subjective attention and memory difficulties in perimenopausal and postmenopausal women" (in en). Menopause 18 (5): 542–548. doi:10.1097/gme.0b013e3181fcafd6. ISSN 1072-3714. PMID 21293309. PMC 4076798. https://dx.doi.org/10.1097/gme.0b013e3181fcafd6. 
  20. Davis, Courtney; Bryan, Janet; Hodgson, Jonathan; Murphy, Karen (2015). "Definition of the Mediterranean Diet; A Literature Review" (in en). Nutrients 7 (11): 9139–9153. doi:10.3390/nu7115459. PMID 26556369.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4663587
  21. Lehert, P.; Villaseca, P.; Hogervorst, E.; Maki, P. M.; Henderson, V. W. (2015). "Individually modifiable risk factors to ameliorate cognitive aging: a systematic review and meta-analysis". Climacteric 18 (5): 678–689. doi:10.3109/13697137.2015.1078106. ISSN 1369-7137. PMID 26361790.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5199766
  22. Cheng, Peng-Fei; Chen, Jian-Jun; Zhou, Xin-Yu; Ren, Yi-Fei; Huang, Wen; Zhou, Jing-Jing; Xie, Peng (2015). "Do soy isoflavones improve cognitive function in postmenopausal women? A meta-analysis" (in en-US). Menopause 22 (2): 198–206. doi:10.1097/GME.0000000000000290. ISSN 1530-0374. PMID 25003621. https://dx.doi.org/10.1097/GME.0000000000000290. 
  23. Leach, Matthew J; Moore, Vivienne (2012). "Black cohosh (Cimicifuga spp.) for menopausal symptoms". The Cochrane Database of Systematic Reviews 2012 (9): CD007244. doi:10.1002/14651858.CD007244.pub2. ISSN 1469-493X. PMID 22972105.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=6599854
  24. Maki, Pauline M.; Rubin, Leah H.; Fornelli, Deanne; Drogos, Lauren; Banuvar, Suzanne; Shulman, Lee P.; Geller, Stacie E. (2009). "Effects of botanicals and combined hormone therapy on cognition in postmenopausal women" (in en). Menopause 16 (6): 1167–1177. doi:10.1097/gme.0b013e3181ace484. ISSN 1072-3714. PMID 19590458. PMC 2783198. https://dx.doi.org/10.1097/gme.0b013e3181ace484. 
  25. Thaung Zaw, Jay Jay; Howe, Peter Ranald Charles; Wong, Rachel Heloise Xiwen (2018). "Postmenopausal health interventions: Time to move on from the Women's Health Initiative?" (in en). Ageing Research Reviews 48: 79–86. doi:10.1016/j.arr.2018.10.005. ISSN 1568-1637. PMID 30355506. https://www.sciencedirect.com/science/article/pii/S1568163718301612. 
  26. Clement, Yuri N.; Onakpoya, Igho; Hung, Shao K.; Ernst, Edzard (2011). "Effects of herbal and dietary supplements on cognition in menopause: A systematic review" (in en). Maturitas 68 (3): 256–263. doi:10.1016/j.maturitas.2010.12.005. ISSN 0378-5122. PMID 21237589. https://www.sciencedirect.com/science/article/abs/pii/S0378512210004536. 
  27. Goel, Rachna M.; Cappola, Anne R. (2011). "Dehydroepiandrosterone sulfate and postmenopausal women" (in en-US). Current Opinion in Endocrinology, Diabetes and Obesity 18 (3): 171–176. doi:10.1097/MED.0b013e3283461818. ISSN 1752-296X. PMID 21478748. https://dx.doi.org/10.1097/MED.0b013e3283461818. 
  28. Pluchino, N.; Drakopoulos, P.; Bianchi-Demicheli, F.; Wenger, J.M.; Petignat, P.; Genazzani, A.R. (2015). "Neurobiology of DHEA and effects on sexuality, mood and cognition" (in en). The Journal of Steroid Biochemistry and Molecular Biology 145: 273–280. doi:10.1016/j.jsbmb.2014.04.012. ISSN 0960-0760. PMID 24892797. https://www.sciencedirect.com/science/article/abs/pii/S0960076014000983. 
  29. Anderson, Debra; Seib, Charlotte; Rasmussen, Laura (2014). "Can physical activity prevent physical and cognitive decline in postmenopausal women?" (in en). Maturitas 79 (1): 14–33. doi:10.1016/j.maturitas.2014.06.010. PMID 25008420. https://linkinghub.elsevier.com/retrieve/pii/S0378512214002060. 
More
©Text is available under the terms and conditions of the Creative Commons-Attribution ShareAlike (CC BY-SA) license; additional terms may apply. By using this site, you agree to the Terms and Conditions and Privacy Policy.
Upload a video for this entry
Information
Subjects: Others
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register :
HandWiki
View Times: 1.7K
Entry Collection: HandWiki
Revision: 1 time (View History)
Update Date: 04 Nov 2022
Table of Contents
    Notice
    You are not a member of the advisory board for this topic. If you want to update advisory board member profile, please contact office@encyclopedia.pub.
    OK
    Confirm
    Only members of the Encyclopedia advisory board for this topic are allowed to note entries. Would you like to become an advisory board member of the Encyclopedia?
    Yes
    No
    ${ textCharacter }/${ maxCharacter }
    Submit
    Cancel
    There is no comment~
    ${ textCharacter }/${ maxCharacter }
    Submit
    Cancel
    ${ selectedItem.replyTextCharacter }/${ selectedItem.replyMaxCharacter }
    Submit
    Cancel
    Confirm
    Are you sure to Delete?
    Yes No
    Academic Video Service
    Feedback