Your browser does not fully support modern features. Please upgrade for a smoother experience.
Submitted Successfully!
Thank you for your contribution! You can also upload a video entry or images related to this topic. For video creation, please contact our Academic Video Service.
Version Summary Created by Modification Content Size Created at Operation
1 handwiki Vivi Li -- 1171 2022-11-04 01:47:32

Video Upload Options

We provide professional Academic Video Service to translate complex research into visually appealing presentations. Would you like to try it?
Cite
If you have any further questions, please contact Encyclopedia Editorial Office.
HandWiki. Exercise Induced Anaphylaxis. Encyclopedia. Available online: https://encyclopedia.pub/entry/32873 (accessed on 25 September 2026).
HandWiki. Exercise Induced Anaphylaxis. Encyclopedia. Available at: https://encyclopedia.pub/entry/32873. Accessed September 25, 2026.
HandWiki. "Exercise Induced Anaphylaxis" Encyclopedia, https://encyclopedia.pub/entry/32873 (accessed September 25, 2026).
HandWiki. (2022, November 04). Exercise Induced Anaphylaxis. In Encyclopedia. https://encyclopedia.pub/entry/32873
HandWiki. "Exercise Induced Anaphylaxis." Encyclopedia. Web. 04 November, 2022.
Exercise Induced Anaphylaxis
Edit

Exercise-Induced Anaphylaxis (EIAn) is a rare condition in which anaphylaxis, a serious or life-threatening allergic response, is brought on by physical activity. Approximately 5-15% of all reported cases of anaphylaxis are thought to be exercise-induced. The exact proportion of the population with EIAn is unknown, but a 2001 study of 76,229 Japanese junior high students showed that the frequency of EIAn was 0.031%. EIAn is not a widely known or understood condition, with the first research on the disorder only having been conducted in the past 40 years. A case report in 1979 on EIAn was the first research of its kind, where a patient was described to experience anaphylactic shock related to exercise 5–24 hours following the consumption of shellfish. The condition is thought to be more prevalent in women, with two studies of EIAn patients reporting a ratio of 2:1 for females:males with the disorder. There is, however, thought to be no link to race. Survey results from EIAn patients have shown that the average number of attacks per year is 14.5. However, most sufferers of EIAn report that both severity and frequency of attacks decrease over time.

physical activity anaphylactic shock anaphylaxis

References

  1. "Anaphylaxis Campaign". https://www.anaphylaxis.org.uk/. 
  2. Shadick, N. A.; Liang, M. H.; Partridge, A. J.; Bingham III, C. O.; Bingham, C.; Wright, E.; Fossel, A. H.; Sheffer, A. L. (July 1999). "The natural history of exercise-induced anaphylaxis: survey results from a 10-year follow-up study". The Journal of Allergy and Clinical Immunology 104 (1): 123–127. doi:10.1016/s0091-6749(99)70123-5. ISSN 0091-6749. PMID 10400849.  https://dx.doi.org/10.1016%2Fs0091-6749%2899%2970123-5
  3. Barg, Wojciech; Medrala, Wojciech; Wolanczyk-Medrala, Anna (February 2011). "Exercise-Induced Anaphylaxis: An Update on Diagnosis and Treatment". Current Allergy and Asthma Reports 11 (1): 45–51. doi:10.1007/s11882-010-0150-y. ISSN 1529-7322. PMID 20922508.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3020292
  4. Wade, J. P.; Liang, M. H.; Sheffer, A. L. (1989). "Exercise-induced anaphylaxis: epidemiologic observations". Progress in Clinical and Biological Research 297: 175–182. ISSN 0361-7742. PMID 2587584.  http://www.worldcat.org/issn/0361-7742
  5. Sheffer, A. L.; Austen, K. F. (August 1980). "Exercise-induced anaphylaxis". The Journal of Allergy and Clinical Immunology 66 (2): 106–111. doi:10.1016/0091-6749(80)90056-1. ISSN 0091-6749. PMID 7400473.  https://dx.doi.org/10.1016%2F0091-6749%2880%2990056-1
  6. Aihara, Y.; Takahashi, Y.; Kotoyori, T.; Mitsuda, T.; Ito, R.; Aihara, M.; Ikezawa, Z.; Yokota, S. (December 2001). "Frequency of food-dependent, exercise-induced anaphylaxis in Japanese junior-high-school students". The Journal of Allergy and Clinical Immunology 108 (6): 1035–1039. doi:10.1067/mai.2001.119914. ISSN 0091-6749. PMID 11742285.  https://dx.doi.org/10.1067%2Fmai.2001.119914
  7. Romano, A.; Di Fonso, M.; Giuffreda, F.; Papa, G.; Artesani, M. C.; Viola, M.; Venuti, A.; Palmieri, V. et al. (July 2001). "Food-dependent exercise-induced anaphylaxis: clinical and laboratory findings in 54 subjects". International Archives of Allergy and Immunology 125 (3): 264–272. doi:10.1159/000053825. ISSN 1018-2438. PMID 11490160.  https://dx.doi.org/10.1159%2F000053825
  8. Morita, Eishin; Kunie, Kohno; Matsuo, Hiroaki (August 2007). "Food-dependent exercise-induced anaphylaxis". Journal of Dermatological Science 47 (2): 109–117. doi:10.1016/j.jdermsci.2007.03.004. ISSN 0923-1811. PMID 17507204.  https://dx.doi.org/10.1016%2Fj.jdermsci.2007.03.004
  9. Morita, Eishin; Matsuo, Hiroaki; Chinuki, Yuko; Takahashi, Hitoshi; Dahlström, Jörgen; Tanaka, Akira (December 2009). "Food-dependent exercise-induced anaphylaxis -importance of omega-5 gliadin and HMW-glutenin as causative antigens for wheat-dependent exercise-induced anaphylaxis-". Allergology International 58 (4): 493–498. doi:10.2332/allergolint.09-RAI-0125. ISSN 1440-1592. PMID 19847096.  https://dx.doi.org/10.2332%2Fallergolint.09-RAI-0125
  10. Du Toit, George (2008). "Food-dependent exercise-induced anaphylaxis in childhood". Pediatric Allergy and Immunology 18 (5): 455–463. doi:10.1111/j.1399-3038.2007.00599.x. ISSN 0905-6157. PMID 17617816.  https://dx.doi.org/10.1111%2Fj.1399-3038.2007.00599.x
  11. Exercise-Induced Anaphylaxis: Background, Pathophysiology, Epidemiology. 2017-11-20. https://emedicine.medscape.com/article/886641-overview. Retrieved 2018-09-22. 
  12. Feldweg, Anna M. (May 2015). "Exercise-induced anaphylaxis". Immunology and Allergy Clinics of North America 35 (2): 261–275. doi:10.1016/j.iac.2015.01.005. ISSN 1557-8607. PMID 25841550.  https://dx.doi.org/10.1016%2Fj.iac.2015.01.005
  13. Lewis, J.; Lieberman, P.; Treadwell, G.; Erffmeyer, J. (December 1981). "Exercise-induced urticaria, angioedema, and anaphylactoid episodes". The Journal of Allergy and Clinical Immunology 68 (6): 432–437. doi:10.1016/0091-6749(81)90197-4. ISSN 0091-6749. PMID 7310010.  https://dx.doi.org/10.1016%2F0091-6749%2881%2990197-4
  14. Sheffer, A. L.; Soter, N. A.; McFadden, E. R.; Austen, K. F. (March 1983). "Exercise-induced anaphylaxis: a distinct form of physical allergy". The Journal of Allergy and Clinical Immunology 71 (3): 311–316. doi:10.1016/0091-6749(83)90085-4. ISSN 0091-6749. PMID 6826991.  https://dx.doi.org/10.1016%2F0091-6749%2883%2990085-4
  15. Sheffer, A. L.; Tong, A. K.; Murphy, G. F.; Lewis, R. A.; McFadden, E. R.; Austen, K. F. (April 1985). "Exercise-induced anaphylaxis: a serious form of physical allergy associated with mast cell degranulation". The Journal of Allergy and Clinical Immunology 75 (4): 479–484. doi:10.1016/s0091-6749(85)80021-x. ISSN 0091-6749. PMID 3980883.  https://dx.doi.org/10.1016%2Fs0091-6749%2885%2980021-x
  16. Hanakawa, Y.; Tohyama, M.; Shirakata, Y.; Murakami, S.; Hashimoto, K. (May 1998). "Food-dependent exercise-induced anaphylaxis: a case related to the amount of food allergen ingested". The British Journal of Dermatology 138 (5): 898–900. doi:10.1046/j.1365-2133.1998.02254.x. ISSN 0007-0963. PMID 9666843.  https://dx.doi.org/10.1046%2Fj.1365-2133.1998.02254.x
  17. Matsuo, H.; Morimoto, K.; Akaki, T.; Kaneko, S.; Kusatake, K.; Kuroda, T.; Niihara, H.; Hide, M. et al. (April 2005). "Exercise and aspirin increase levels of circulating gliadin peptides in patients with wheat-dependent exercise-induced anaphylaxis". Clinical & Experimental Allergy 35 (4): 461–466. doi:10.1111/j.1365-2222.2005.02213.x. ISSN 0954-7894. PMID 15836754.  https://dx.doi.org/10.1111%2Fj.1365-2222.2005.02213.x
  18. Palosuo, Kati; Varjonen, Elina; Nurkkala, Jenni; Kalkkinen, Nisse; Harvima, Rauno; Reunala, Timo; Alenius, Harri (June 2003). "Transglutaminase-mediated cross-linking of a peptic fraction of omega-5 gliadin enhances IgE reactivity in wheat-dependent, exercise-induced anaphylaxis". The Journal of Allergy and Clinical Immunology 111 (6): 1386–1392. doi:10.1067/mai.2003.1498. ISSN 0091-6749. PMID 12789243.  https://dx.doi.org/10.1067%2Fmai.2003.1498
  19. Cooper, Dan Michael; Radom-Aizik, Shlomit; Schwindt, Christina; Zaldivar, Frank (August 2007). "Dangerous exercise: lessons learned from dysregulated inflammatory responses to physical activity". Journal of Applied Physiology 103 (2): 700–709. doi:10.1152/japplphysiol.00225.2007. ISSN 8750-7587. PMID 17495117. https://escholarship.org/content/qt5gh9q1vt/qt5gh9q1vt.pdf?t=pqczy9. 
  20. Robson-Ansley, Paula; Toit, George Du (August 2010). "Pathophysiology, diagnosis and management of exercise-induced anaphylaxis". Current Opinion in Allergy and Clinical Immunology 10 (4): 312–317. doi:10.1097/ACI.0b013e32833b9bb0. ISSN 1473-6322. PMID 20543674.  https://dx.doi.org/10.1097%2FACI.0b013e32833b9bb0
  21. Welle, M. (March 1997). "Development, significance, and heterogeneity of mast cells with particular regard to the mast cell-specific proteases chymase and tryptase". Journal of Leukocyte Biology 61 (3): 233–245. doi:10.1002/jlb.61.3.233. ISSN 0741-5400. PMID 9060446.  https://dx.doi.org/10.1002%2Fjlb.61.3.233
More
Upload a video for this entry
Information
Subjects: Others
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register :
View Times: 671
Entry Collection: HandWiki
Revision: 1 time (View History)
Update Date: 04 Nov 2022
Notice
You are not a member of the advisory board for this topic. If you want to update advisory board member profile, please contact office@encyclopedia.pub.
OK
Confirm
Only members of the Encyclopedia advisory board for this topic are allowed to note entries. Would you like to become an advisory board member of the Encyclopedia?
Yes
No
${ textCharacter }/${ maxCharacter }
Submit
Cancel
There is no comment~
${ textCharacter }/${ maxCharacter }
Submit
Cancel
${ selectedItem.replyTextCharacter }/${ selectedItem.replyMaxCharacter }
Submit
Cancel
Confirm
Are you sure to Delete?
Yes No
Academic Video Service