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HandWiki. Binary Fission. Encyclopedia. Available online: (accessed on 19 June 2024).
HandWiki. Binary Fission. Encyclopedia. Available at: Accessed June 19, 2024.
HandWiki. "Binary Fission" Encyclopedia, (accessed June 19, 2024).
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HandWiki. "Binary Fission." Encyclopedia. Web. 31 October, 2022.
Binary Fission

Fission, in biology, is the division of a single entity into two or more parts and the regeneration of those parts to separate entities resembling the original. The object experiencing fission is usually a cell, but the term may also refer to how organisms, bodies, populations, or species split into discrete parts. The fission may be binary fission, in which a single organism produces two parts, or multiple fission, in which a single entity produces multiple parts.

regeneration biology fission

1. Binary Fission

Schematic diagram of cellular growth (elongation) and binary fission of bacilli. Blue and red lines indicate old and newly generated bacterial cell wall, respectively. (1) growth at the centre of the bacterial body. e.g. Bacillus subtilis, E. coli, and others. (2) apical growth. e.g. Corynebacterium diphtheriae. This is bacterial proliferation.

Organisms in the domains of Archaea and Bacteria reproduce with binary fission. This form of asexual reproduction and cell division is also used by some organelles within eukaryotic organisms (e.g., mitochondria). Binary fission results in the reproduction of a living prokaryotic cell (or organelle) by dividing the cell into two parts, each with the potential to grow to the size of the original.

1.1. Fission of Prokaryotes

The single DNA molecule first replicates, then attaches each copy to a different part of the cell membrane. When the cell begins to pull apart, the replicated and original chromosomes are separated. The consequence of this asexual method of reproduction is that all the cells are genetically identical, meaning that they have the same genetic material (barring random mutations). Unlike the processes of mitosis and meiosis used by eukaryotic cells, binary fission takes place without the formation of a spindle apparatus on the cell. Like in mitosis (and unlike in meiosis), the parental identity is lost.

Process of FtsZ-dependent fission

Binary fission in a prokaryote.

FtsZ is homologous to β-tubulin, the building block of the microtubule cytoskeleton used during mitosis in eukaryotes.[1] FtsZ is thought to be the first protein to localize to the site of future division in bacteria, and it assembles into a Z ring, anchored by FtsZ-binding proteins and defines the division plane between the two daughter cells.[1][2] MinC and MinD function together as division inhibitors, blocking formation of the FtsZ ring. MinE stops the MinCD activity midcell, allowing FtsZ to take over for binary fission.[3]

More specifically, the following steps occur:

  1. The bacterium before binary fission is when the DNA is tightly coiled.
  2. The DNA of the bacterium has uncoiled and duplicated.
  3. The DNA is pulled to the separate poles of the bacterium as it increases the size to prepare for splitting.
  4. The growth of a new cell wall begins to separate the bacterium (triggered by FtsZ polymerization and "Z-ring" formation)[4]
  5. The new cell wall (septum) fully develops, resulting in the complete split of the bacterium.
  6. The new daughter cells have tightly coiled DNA rods, ribosomes, and plasmids; these are now brand-new organisms.

Studies of bacteria made to not produce a cell wall, called L-form bacteria, shows that FtsZ requires a cell wall to work. Little is known about how bacteria that naturally don't grow a cell wall divides, but it is thought to resemble the L-form's budding-like division process of extrusion and separation.[5][6]

Speed of FtsZ-dependent Fission

Binary fission is generally rapid though its speed varies between species. For E. coli, cells typically divide about every 20 minutes at 37 °C.[7] Because the new cells will, in turn, undergo binary fission on their own, the time binary fission requires is also the time the bacterial culture requires to double in the number of cells it contains. This time period can, therefore, be referred to as the doubling time. Some species other than E. coli may have faster or slower doubling times: some strains of Mycobacterium tuberculosis may have doubling times of nearly 100 hours.[8] Bacterial growth is limited by factors including nutrient availability and available space, so binary fission occurs at much lower rates in bacterial cultures once they enter the stationary phase of growth.

In archaea

Thermoproteota (formerly Crenarchaeota) possess neither a cell wall nor the FtsZ mechanism. They use a primitive version of the eukaryotic ESCRT-III system (also known as Cdv) to manipulate the membrane into separating, specifically by coming into the middle of the two soon-to-be daughter cells.[6][9] "Euryarchaeota" use FtsZ like bacteria do.[1][10]

1.2. Fission of Organelles

Some organelles in eukaryotic cells reproduce using binary fission. Mitochondrial fission occurs frequently within the cell, even when the cell is not actively undergoing mitosis, and is necessary to regulate the cell's metabolism.[11] All chloroplasts and some mitochrondria (not in animals), both organelles derived from endosymbiosis of bacteria, also use FtsZ in a bacteria-like fashion.[1][12]

1.3. Types of Binary

Binary fission in organisms can occur in four ways, irregular, longitudinal, transverse, oblique.i.e.left oblique & right oblique

  1. Irregular: In this fission, cytokinesis may take place along any plane but it is always perpendicular to the plane of karyokinesis (nuclear division). e.g. amoeba
  2. Longitudinal: Here cytokinesis takes place along the longitudinal axis. e.g. in flagellates like Euglena.
  3. Transverse: Here cytokinesis takes place along the transverse axis. e.g. in ciliate protozoans like Paramecium.
  4. Oblique: In this type of binary fission cytokinesis occurs obliquely. Example Ceratium

Binary fission means "division into two". It is the simplest and most common method of asexual reproduction.

2. Multiple Fission

2.1. Fission of Protists

Multiple fission at the cellular level occurs in many protistists, e.g. sporozoans and algae. The nucleus of the parent cell divides several times by amitosis, producing several nuclei. The cytoplasm then separates, creating multiple daughter cells.[13][14][15]

Some parasitic, single-celled organisms undergo a multiple fission-like process to produce numerous daughter cells from a single parent cell. Isolates of the human parasite Blastocystis hominis were observed to begin such a process within 4 to 6 days.[16] Cells of the fish parasite Trypanosoma borreli have also been observed participating in both binary and multiple fission.[17]

Fission of apicomplexans

In the apicomplexans, a phylum of parasitic protists, multiple fission, or schizogony, is manifested either as merogony, sporogony or gametogony. Merogony results in merozoites, which are multiple daughter cells, that originate within the same cell membrane,[18][19] sporogony results in sporozoites, and gametogony results in microgametes.

Fission of green algae

Green algae can divide into more than two daughter cells. The exact number of daughter cells depends on the species of algae and is an effect of temperature and light.[20]

2.2. Multiple Fission of Bacteria

Most species of bacteria primarily undergo binary reproduction. Some species and groups of bacteria may undergo multiple fission as well, sometimes beginning or ending with the production of spores.[21] The species Metabacterium polyspora, a symbiont of guinea pigs, has been found to produce multiple endospores in each division.[22] Some species of cyanobacteria have also been found to reproduce through multiple fission.[23]

3. Plasmotomy

Some protozoans reproduce by yet another mechanism of fission called as plasmotomy. In this type of fission, a multinucleate adult parent undergoes cytokinesis to form two multinucleate (or coenocytic) daughter cells. The daughter cells so produced undergo further mitosis.

Opalina and Pelomyxa reproduce in this way.

4. Clonal Fragmentation

Fragmentation in multicellular or colonial organisms is a form of asexual reproduction or cloning, where an organism is split into fragments. Each of these fragments develop into mature, fully grown individuals that are clones of the original organism. In echinoderms, this method of reproduction is usually known as fissiparity.[24]

5. Population Fission

Any splitting of a single population of individuals into discrete parts may be considered fission. A population may undergo fission process for a variety of reasons, including migration or geographic isolation. Since the fission leads to genetic variance in the newly isolated, smaller populations, population fission is a precursor to speciation.[25][26]


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  2. "9.1 How Microbes Grow". Microbiology. OpenStax. ISBN 978-1-947172-23-4. 
  3. "Effect of minCD on FtsZ ring position and polar septation in Bacillus subtilis". Journal of Bacteriology 180 (22): 6048–51. November 1998. doi:10.1128/JB.180.22.6048-6051.1998. PMID 9811667.
  4. "Targeting Bacterial Cell Division: A Binding Site-Centered Approach to the Most Promising Inhibitors of the Essential Protein FtsZ". Antibiotics 9 (2): 69. February 2020. doi:10.3390/antibiotics9020069. PMID 32046082.
  5. "Life without a wall or division machine in Bacillus subtilis". Nature 457 (7231): 849–53. February 2009. doi:10.1038/nature07742. PMID 19212404. Bibcode: 2009Natur.457..849L.
  6. "FtsZ-less cell division in archaea and bacteria". Current Opinion in Microbiology 13 (6): 747–52. December 2010. doi:10.1016/j.mib.2010.10.005. PMID 21050804.
  7. "Escherichia coli physiology in Luria-Bertani broth". Journal of Bacteriology 189 (23): 8746–9. December 2007. doi:10.1128/JB.01368-07. PMID 17905994.
  8. "Mycobacterial virulence. Virulent strains of Mycobacteria tuberculosis have faster in vivo doubling times and are better equipped to resist growth-inhibiting functions of macrophages in the presence and absence of specific immunity". The Journal of Experimental Medicine 177 (6): 1723–33. June 1993. doi:10.1084/jem.177.6.1723. PMID 8496688.
  9. "Ancient ESCRTs and the evolution of binary fission". Trends in Microbiology 17 (11): 507–13. November 2009. doi:10.1016/j.tim.2009.08.003. PMID 19783442.
  10. "Evolution of diverse cell division and vesicle formation systems in Archaea". Nature Reviews. Microbiology 8 (10): 731–41. October 2010. doi:10.1038/nrmicro2406. PMID 20818414.
  11. "Mechanisms of mitochondrial fission and fusion". Cold Spring Harbor Perspectives in Biology 5 (6): a011072. June 2013. doi:10.1101/cshperspect.a011072. PMID 23732471.
  12. "An ancestral bacterial division system is widespread in eukaryotic mitochondria". Proceedings of the National Academy of Sciences of the United States of America 112 (33): 10239–46. August 2015. doi:10.1073/pnas.1421392112. PMID 25831547. Bibcode: 2015PNAS..11210239L.
  13. "Reproduction - Binary fission: Multiple fission". Encyclopædia Britannica. 
  14. Britannica Educational Publishing (2011). Fungi, Algae, and Protists. The Rosen Publishing Group. ISBN 978-1-61530-463-9. Retrieved 2016-12-21. 
  15. Animal Forms And Functions: Invertebrata. Sarup & Sons. 2007. ISBN 978-81-7625-791-6. Retrieved 2016-12-21. 
  16. "A multiple fission-like mode of asexual reproduction in Blastocystis hominis". Parasitology Research 80 (6): 523–7. 1994. doi:10.1007/BF00932701. PMID 7809004.
  17. "Growth, morphology and division of flagellates of the genus Trypanoplasma (Protozoa, Kinetoplastida) in vitro". Parasitology Research 76 (7): 553–8. 1990. doi:10.1007/BF00932559. PMID 2217113.
  18. Illustrated glossary of protoctista: vocabulary of the algae, apicomplexa, ciliates, foraminifera, microspora, water molds, slime molds, and the other protoctists. Jones & Bartlett Learning. 1993. ISBN 978-0-86720-081-2. Retrieved 2016-12-21. 
  19. Insect pathology. Gulf Professional Publishing. 1993. ISBN 978-0-12-683255-6. Retrieved 2016-12-21. 
  20. "Cell-cycle regulation in green algae dividing by multiple fission". Journal of Experimental Botany 65 (10): 2585–602. June 2014. doi:10.1093/jxb/ert466. PMID 24441762.
  21. "Alternatives to binary fission in bacteria". Nature Reviews. Microbiology 3 (3): 214–24. March 2005. doi:10.1038/nrmicro1096. PMID 15738949.
  22. "Propagation by sporulation in the guinea pig symbiont Metabacterium polyspora". Proceedings of the National Academy of Sciences of the United States of America 95 (17): 10218–23. August 1998. doi:10.1073/pnas.95.17.10218. PMID 9707627. Bibcode: 1998PNAS...9510218A.
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