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HandWiki. Left-Right Asymmetry. Encyclopedia. Available online: https://encyclopedia.pub/entry/32024 (accessed on 15 October 2026).
HandWiki. Left-Right Asymmetry. Encyclopedia. Available at: https://encyclopedia.pub/entry/32024. Accessed October 15, 2026.
HandWiki. "Left-Right Asymmetry" Encyclopedia, https://encyclopedia.pub/entry/32024 (accessed October 15, 2026).
HandWiki. (2022, October 31). Left-Right Asymmetry. In Encyclopedia. https://encyclopedia.pub/entry/32024
HandWiki. "Left-Right Asymmetry." Encyclopedia. Web. 31 October, 2022.
Left-Right Asymmetry
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Left-right asymmetry (LR asymmetry) refers to differences in structure (symmetry breaking) across the mediolateral (left and right) plane in animals. This plane is defined with respect to the anteroposterior and dorsoventral axes and is perpendicular to both. Because the left-right plane is not strictly an axis (as it is not established through a morphogen gradient), to create asymmetry, the left and right sides need to be patterned separately. LR asymmetry is pervasive throughout metazoans and present throughout every major lineage. Notable examples include the large and small claws of the fiddler crab, the left offset of the vertebrate heart, asymmetrical gut coiling in Drosophila melanogaster, and dextral (clockwise) and sinistral (counterclockwise) coiling of gastropods. This asymmetry can be restricted to a specific organ or feature, as in the crab claws, or be expressed throughout the entire body as in snails.

mediolateral asymmetrical sinistral

References

  1. Levin et al. (1995). A molecular pathway determining left-right asymmetry in chick embryogenesis. Cell 82, 803-814.
  2. Coutelis, J. B., González‐Morales, N., Géminard, C., & Noselli, S. (2014). Diversity and convergence in the mechanisms establishing L/R asymmetry in metazoa. EMBO Reports, e201438972.
  3. Tee, Yee Han; Shemesh, Tom; Thiagarajan, Visalatchi; Hariadi, Rizal Fajar; Anderson, Karen L.; Page, Christopher; Volkmann, Niels; Hanein, Dorit et al. (2015). "Cellular chirality arising from the self-organization of the actin cytoskeleton". Nature Cell Biology 17 (4): 445–457. doi:10.1038/ncb3137. PMID 25799062.  https://dx.doi.org/10.1038%2Fncb3137
  4. Gros, Jerome; Feistel, Kerstin; Viebahn, Christoph; Blum, Martin; Tabin, Clifford J. (2009-05-15). "Cell Movements at Hensen's Node Establish Left/Right Asymmetric Gene Expression in the Chick". Science 324 (5929): 941–944. doi:10.1126/science.1172478. ISSN 0036-8075. PMID 19359542.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2993078
  5. Nonaka, Shigenori; Tanaka, Yosuke; Okada, Yasushi; Takeda, Sen; Harada, Akihiro; Kanai, Yoshimitsu; Kido, Mizuho; Hirokawa, Nobutaka (1998). "Randomization of Left–Right Asymmetry due to Loss of Nodal Cilia Generating Leftward Flow of Extraembryonic Fluid in Mice Lacking KIF3B Motor Protein". Cell 95 (6): 829–837. doi:10.1016/s0092-8674(00)81705-5. PMID 9865700.  https://dx.doi.org/10.1016%2Fs0092-8674%2800%2981705-5
  6. Okada, Yasushi; Nonaka, Shigenori; Tanaka, Yosuke; Saijoh, Yukio; Hamada, Hiroshi; Hirokawa, Nobutaka (1999-10-01). "Abnormal Nodal Flow Precedes Situs Inversus in iv and inv mice". Molecular Cell 4 (4): 459–468. doi:10.1016/S1097-2765(00)80197-5.  https://dx.doi.org/10.1016%2FS1097-2765%2800%2980197-5
  7. Brennan, Jane; Norris, Dominic P.; Robertson, Elizabeth J. (2002-09-15). "Nodal activity in the node governs left-right asymmetry". Genes & Development 16 (18): 2339–2344. doi:10.1101/gad.1016202. ISSN 0890-9369. PMID 12231623.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=187443
  8. Meno, Chikara; Shimono, Akihiko; Saijoh, Yukio; Yashiro, Kenta; Mochida, Kyoko; Ohishi, Sachiko; Noji, Sumihare; Kondoh, Hisato et al. (1998-08-07). "lefty-1 Is Required for Left-Right Determination as a Regulator of lefty-2 and nodal". Cell 94 (3): 287–297. doi:10.1016/S0092-8674(00)81472-5. PMID 9708731.  https://dx.doi.org/10.1016%2FS0092-8674%2800%2981472-5
  9. Levin, Michael; Thorlin, Thorleif; Robinson, Kenneth R.; Nogi, Taisaku; Mercola, Mark (2002-10-04). "Asymmetries in H+/K+-ATPase and Cell Membrane Potentials Comprise a Very Early Step in Left-Right Patterning". Cell 111 (1): 77–89. doi:10.1016/S0092-8674(02)00939-X. PMID 12372302.  https://dx.doi.org/10.1016%2FS0092-8674%2802%2900939-X
  10. Shimeld, Sebastian M.; Levin, Michael (2006-06-01). "Evidence for the regulation of left-right asymmetry in Ciona intestinalis by ion flux". Developmental Dynamics 235 (6): 1543–1553. doi:10.1002/dvdy.20792. ISSN 1097-0177. PMID 16586445.  https://dx.doi.org/10.1002%2Fdvdy.20792
  11. Molina, M Dolores; de Crozé, Noémie; Haillot, Emmanuel; Lepage, Thierry (2013-08-01). "Nodal: master and commander of the dorsal–ventral and left–right axes in the sea urchin embryo". Current Opinion in Genetics & Development. Developmental mechanisms, patterning and evolution 23 (4): 445–453. doi:10.1016/j.gde.2013.04.010. PMID 23769944.  https://dx.doi.org/10.1016%2Fj.gde.2013.04.010
  12. Nishide, Kazuhiko; Mugitani, Michio; Kumano, Gaku; Nishida, Hiroki (2012-04-15). "Neurula rotation determines left-right asymmetry in ascidian tadpole larvae". Development 139 (8): 1467–1475. doi:10.1242/dev.076083. ISSN 0950-1991. PMID 22399684.  https://dx.doi.org/10.1242%2Fdev.076083
  13. Spéder, Pauline; Ádám, Géza; Noselli, Stéphane (2006-04-06). "Type ID unconventional myosin controls left–right asymmetry in Drosophila". Nature 440 (7085): 803–807. doi:10.1038/nature04623. ISSN 0028-0836. PMID 16598259.  https://dx.doi.org/10.1038%2Fnature04623
  14. Martín-Durán, José M.; Vellutini, Bruno C.; Hejnol, Andreas (2016-12-19). "Embryonic chirality and the evolution of spiralian left–right asymmetries". Phil. Trans. R. Soc. B 371 (1710): 20150411. doi:10.1098/rstb.2015.0411. ISSN 0962-8436. PMID 27821523.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5104510
  15. Asami, Takahiro; Cowie, Robert H.; Ohbayashi, Kako (1998-01-01). "Evolution of Mirror Images by Sexually Asymmetric Mating Behavior in Hermaphroditic Snails". The American Naturalist 152 (2): 225–236. doi:10.1086/286163. PMID 18811387.  https://dx.doi.org/10.1086%2F286163
  16. Meshcheryakov, V. N.; Beloussov, L. V. (1975). "Asymmetrical rotations of blastomeres in early cleavage of gastropoda". Wilhelm Roux's Archives of Developmental Biology 177 (3): 193–203. doi:10.1007/BF00848080. ISSN 0340-0794. PMID 28304794.  https://dx.doi.org/10.1007%2FBF00848080
  17. Shibazaki, Yuichiro; Shimizu, Miho; Kuroda, Reiko (2004-08-24). "Body Handedness Is Directed by Genetically Determined Cytoskeletal Dynamics in the Early Embryo". Current Biology 14 (16): 1462–1467. doi:10.1016/j.cub.2004.08.018. PMID 15324662.  https://dx.doi.org/10.1016%2Fj.cub.2004.08.018
  18. Freeman, Gary; Lundelius, Judith W. (1982). "The developmental genetics of dextrality and sinistrality in the gastropodLymnaea peregra". Wilhelm Roux's Archives of Developmental Biology 191 (2): 69–83. doi:10.1007/BF00848443. ISSN 0340-0794. PMID 28305091.  https://dx.doi.org/10.1007%2FBF00848443
  19. Grande, Cristina; Patel, Nipam H. (2009-02-19). "Nodal signalling is involved in left–right asymmetry in snails". Nature 457 (7232): 1007–1011. doi:10.1038/nature07603. ISSN 0028-0836. PMID 19098895.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2661027
  20. Shimizu, Keisuke; Iijima, Minoru; Setiamarga, Davin HE; Sarashina, Isao; Kudoh, Tetsuhiro; Asami, Takahiro; Gittenberger, Edi; Endo, Kazuyoshi (2013-01-01). "Left-right asymmetric expression of dpp in the mantle of gastropods correlates with asymmetric shell coiling". EvoDevo 4 (1): 15. doi:10.1186/2041-9139-4-15. ISSN 2041-9139. PMID 23711320.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3680195
  21. Kurita, Yoshihisa; Wada, Hiroshi (2011-04-27). "Evidence that gastropod torsion is driven by asymmetric cell proliferation activated by TGF-β signalling". Biology Letters 7 (5): 759–762. doi:10.1098/rsbl.2011.0263. ISSN 1744-9561. PMID 21525052.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3169068
  22. Davison, Angus; McDowell, Gary S.; Holden, Jennifer M.; Johnson, Harriet F.; Koutsovoulos, Georgios D.; Liu, M. Maureen; Hulpiau, Paco; Roy, Frans Van et al. (2016). "Formin Is Associated with Left-Right Asymmetry in the Pond Snail and the Frog". Current Biology 26 (5): 654–660. doi:10.1016/j.cub.2015.12.071. PMID 26923788.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4791482
  23. Kuroda, Reiko; Fujikura, Kohei; Abe, Masanori; Hosoiri, Yuji; Asakawa, Shuichi; Shimizu, Miho; Umeda, Shin; Ichikawa, Futaba et al. (2016-10-06). "Diaphanous gene mutation affects spiral cleavage and chirality in snails". Scientific Reports 6: 34809. doi:10.1038/srep34809. ISSN 2045-2322. PMID 27708420.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5052593
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