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HandWiki. Margatoxin. Encyclopedia. Available online: https://encyclopedia.pub/entry/31569 (accessed on 17 October 2026).
HandWiki. Margatoxin. Encyclopedia. Available at: https://encyclopedia.pub/entry/31569. Accessed October 17, 2026.
HandWiki. "Margatoxin" Encyclopedia, https://encyclopedia.pub/entry/31569 (accessed October 17, 2026).
HandWiki. (2022, October 27). Margatoxin. In Encyclopedia. https://encyclopedia.pub/entry/31569
HandWiki. "Margatoxin." Encyclopedia. Web. 27 October, 2022.
Margatoxin
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The content is sourced from: https://handwiki.org/wiki/Biology:Margatoxin

Margatoxin (MgTX) is a peptide that selectively inhibits Kv1.3 voltage-dependent potassium channels. It is found in the venom of Centruroides margaritatus, also known as the Central American Bark Scorpion. Margatoxin was first discovered in 1993. It was purified from scorpion venom and its amino acid sequence was determined.

scorpion venom margatoxin kv1.3

References

  1. "Purification, characterization, and biosynthesis of margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channels". The Journal of Biological Chemistry 268 (25): 18866–74. September 1993. doi:10.1016/S0021-9258(17)46707-X. PMID 8360176.  https://dx.doi.org/10.1016%2FS0021-9258%2817%2946707-X
  2. "Synthetic peptides as tools to investigate the structure and pharmacology of potassium channel-acting short-chain scorpion toxins". Biochimie 80 (2): 151–4. February 1998. doi:10.1016/s0300-9084(98)80021-7. PMID 9587672.  https://dx.doi.org/10.1016%2Fs0300-9084%2898%2980021-7
  3. KCNA3
  4. "Potent suppression of vascular smooth muscle cell migration and human neointimal hyperplasia by KV1.3 channel blockers". Cardiovascular Research 89 (2): 282–9. February 2011. doi:10.1093/cvr/cvq305. PMID 20884640.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3020133
  5. "Immunomodulation of voltage-dependent K+ channels in macrophages: molecular and biophysical consequences". The Journal of General Physiology 135 (2): 135–47. February 2010. doi:10.1085/jgp.200910334. PMID 20100893.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2812499
  6. "Potassium and calcium channels in lymphocytes". Annual Review of Immunology 13: 623–53. 1995. doi:10.1146/annurev.iy.13.040195.003203. PMID 7612237.  https://dx.doi.org/10.1146%2Fannurev.iy.13.040195.003203
  7. Material Safety Data Sheet, Margatoxin: sc-3586, Santa Cruz Biotechnology, 2004
  8. "Blockade of the voltage-gated potassium channel Kv1.3 inhibits immune responses in vivo". Journal of Immunology 158 (11): 5120–8. June 1997. PMID 9164927.  http://www.ncbi.nlm.nih.gov/pubmed/9164927
  9. "Peptidyl inhibitors of shaker-type Kv1 channels elicit twitches in guinea pig ileum by blocking kv1.1 at enteric nervous system and enhancing acetylcholine release". The Journal of Pharmacology and Experimental Therapeutics 289 (3): 1517–22. June 1999. PMID 10336547.  http://www.ncbi.nlm.nih.gov/pubmed/10336547
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