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HandWiki. Strategies for Engineered Negligible Senescence. Encyclopedia. Available online: https://encyclopedia.pub/entry/31372 (accessed on 17 October 2026).
HandWiki. Strategies for Engineered Negligible Senescence. Encyclopedia. Available at: https://encyclopedia.pub/entry/31372. Accessed October 17, 2026.
HandWiki. "Strategies for Engineered Negligible Senescence" Encyclopedia, https://encyclopedia.pub/entry/31372 (accessed October 17, 2026).
HandWiki. (2022, October 26). Strategies for Engineered Negligible Senescence. In Encyclopedia. https://encyclopedia.pub/entry/31372
HandWiki. "Strategies for Engineered Negligible Senescence." Encyclopedia. Web. 26 October, 2022.
Strategies for Engineered Negligible Senescence
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The content is sourced from: https://handwiki.org/wiki/Biology:Strategies_for_Engineered_Negligible_Senescence

Strategies for Engineered Negligible Senescence (SENS) is the term coined by British biogerontologist Aubrey de Grey for the diverse range of regenerative medical therapies, either planned or currently in development, for the periodical repair of all age-related damage to human tissue with the ultimate purpose of maintaining a state of negligible senescence in the patient, thereby postponing age-associated disease for as long as the therapies are reapplied. The term "negligible senescence" was first used in the early 1990s by professor Caleb Finch to describe organisms such as lobsters and hydras, which do not show symptoms of aging. The term "engineered negligible senescence" first appeared in print in Aubrey de Grey's 1999 book The Mitochondrial Free Radical Theory of Aging. De Grey called SENS a "goal-directed rather than curiosity-driven" approach to the science of aging, and "an effort to expand regenerative medicine into the territory of aging". While many biogerontologists find it "worthy of discussion", some contend that the ultimate goals of de Grey's programme are too speculative given the current state of technology, referring to it as "fantasy rather than science".

regenerative medicine technology senescence

References

  1. de Grey, Aubrey; Rae, Michael (September 2007). Ending Aging: The Rejuvenation Breakthroughs that Could Reverse Human Aging in Our Lifetime. New York, NY: St. Martin's Press, 416 pp. ISBN:0-312-36706-6.
  2. de Grey, Aubrey D. N. J. (2003-09-01). "The foreseeability of real anti-aging medicine: focusing the debate" (in en). Experimental Gerontology 38 (9): 927–934. doi:10.1016/S0531-5565(03)00155-4. ISSN 0531-5565. http://www.sciencedirect.com/science/article/pii/S0531556503001554. 
  3. Warner (2005). "Science fact and the SENS agenda. What can we reasonably expect from ageing research?". EMBO Reports 6 (11): 1006–1008. doi:10.1038/sj.embor.7400555. PMID 16264422.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1371037
  4. Best, BP (2009). "Nuclear DNA damage as a direct cause of aging" (PDF). Rejuvenation Research 12 (3): 199–208. doi:10.1089/rej.2009.0847. PMID 19594328. http://www.benbest.com/lifeext/Nuclear_DNA_in_Aging.pdf. 
  5. "The impracticality of biomedical rejuvenation therapies: translational and pharmacological barriers". Rejuvenation Research 17 (4): 390–6. 2014. doi:10.1089/rej.2014.1588. PMID 25072550.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4142774
  6. Kyriazis, Marios (2015). "Translating laboratory anti-aging biotechnology into applied clinical practice: Problems and obstacles". World Journal of Translational Medicine 4 (2): 51–4. doi:10.5528/wjtm.v4.i2.51.  https://dx.doi.org/10.5528%2Fwjtm.v4.i2.51
  7. "The Fallacy of the Longevity Elixir: Negligible Senescence May be Achieved, but Not by Using Something Physical". Current Aging Science 8 (3): 227–34. 2015. doi:10.2174/1874609808666150702095803. PMID 26135528.  https://dx.doi.org/10.2174%2F1874609808666150702095803
  8. "The practicality or otherwise of biomedical rejuvenation therapies: a response to Kyriazis". Rejuvenation Research 17 (4): 397–400. 2014. doi:10.1089/rej.2014.1599. PMID 25072964.  https://dx.doi.org/10.1089%2Frej.2014.1599
  9. Nuland, Sherwin (1994). How We Die: Reflections on Life's Final Chapter. New York: Knopf Random House. ISBN:0-679-41461-4.
  10. Pontin, Jason (July 28, 2005). "The SENS Challenge". Technology Review. http://www.technologyreview.com/blog/pontin/14968/
  11. Pontin, Jason (March 14, 2006). "We've picked the judges for our biogerontology prize". Technology Review. http://www.technologyreview.com/Biotech/16593/
  12. Pontin, Jason (July 11, 2006). "Is Defeating Aging Only A Dream?". Technology Review. http://www2.technologyreview.com/sens/
  13. Garreau, Joel (October 31, 2007). "Invincible Man". Washington Post. https://www.washingtonpost.com/wp-dyn/content/article/2007/10/30/AR2007103002222.html?hpid=features1&hpv=nationalThe
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