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HandWiki. UNC. Encyclopedia. Available online: https://encyclopedia.pub/entry/29891 (accessed on 26 September 2026).
HandWiki. UNC. Encyclopedia. Available at: https://encyclopedia.pub/entry/29891. Accessed September 26, 2026.
HandWiki. "UNC" Encyclopedia, https://encyclopedia.pub/entry/29891 (accessed September 26, 2026).
HandWiki. (2022, October 18). UNC. In Encyclopedia. https://encyclopedia.pub/entry/29891
HandWiki. "UNC." Encyclopedia. Web. 18 October, 2022.
UNC
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The content is sourced from: https://handwiki.org/wiki/Biology:UNC

UNC is a set of proteins first identified through a set of screening tests in Caenorhabditis elegans, looking for roundworms with movement problems. Worms with which were un-coordinated (hence UNC) were analysed in order to identify the genetic defect. Such proteins include UNC-5, a receptor for UNC-6 which is one of the netrins. Netrins are a class of proteins involved in axon guidance. UNC-5 uses repulsion (genetics) to direct axons while the other netrin receptor UNC-40 attracts axons to the source of netrin production.

netrin unc-6 unc-5

References

  1. Hedgecock, Edward M.; Culotti, Joseph G.; Hall, David H. (1990). "The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. Elegans". Neuron 4 (1): 61–85. doi:10.1016/0896-6273(90)90444-K. PMID 2310575.  https://dx.doi.org/10.1016%2F0896-6273%2890%2990444-K
  2. Keleman, Krystyna; Dickson, Barry J. (2001). "Short- and Long-Range Repulsion by the Drosophila Unc5 Netrin Receptor". Neuron 32 (4): 605–17. doi:10.1016/S0896-6273(01)00505-0. PMID 11719202.  https://dx.doi.org/10.1016%2FS0896-6273%2801%2900505-0
  3. Kennedy, Timothy E.; Serafini, Tito; De La Torre, Josér.; Tessier-Lavigne, Marc (1994). "Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord". Cell 78 (3): 425–35. doi:10.1016/0092-8674(94)90421-9. PMID 8062385.  https://dx.doi.org/10.1016%2F0092-8674%2894%2990421-9
  4. Leung-Hagesteijn, Chungyee; Spence, Andrew M.; Stern, Brian D.; Zhou, Youwen; Su, Ming-Wan; Hedgecock, Edward M.; Culotti, Joseph G. (1992). "UNC-5, a transmembrane protein with immunoglobulin and thrombospondin type 1 domains, guides cell and pioneer axon migrations in C. Elegans". Cell 71 (2): 289–99. doi:10.1016/0092-8674(92)90357-I. PMID 1384987.  https://dx.doi.org/10.1016%2F0092-8674%2892%2990357-I
  5. Poon, Vivian Y.; Klassen, Matthew P.; Shen, Kang (2008). "UNC-6/netrin and its receptor UNC-5 locally exclude presynaptic components from dendrites". Nature 455 (7213): 669–73. doi:10.1038/nature07291. PMID 18776887.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3912858
  6. Su, M; Merz, DC; Killeen, MT; Zhou, Y; Zheng, H; Kramer, JM; Hedgecock, EM; Culotti, JG (2000). "Regulation of the UNC-5 netrin receptor initiates the first reorientation of migrating distal tip cells in Caenorhabditis elegans". Development 127 (3): 585–94. PMID 10631179. http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=10631179. 
  7. Levy-Strumpf, Naomi; Culotti, Joseph G (2007). "VAB-8, UNC-73 and MIG-2 regulate axon polarity and cell migration functions of UNC-40 in C. Elegans". Nature Neuroscience 10 (2): 161–8. doi:10.1038/nn1835. PMID 17237777.  https://dx.doi.org/10.1038%2Fnn1835
  8. Manitt, Colleen; Thompson, Katherine M.; Kennedy, Timothy E. (2004). "Developmental shift in expression of netrin receptors in the rat spinal cord: Predominance of UNC-5 homologues in adulthood". Journal of Neuroscience Research 77 (5): 690–700. doi:10.1002/jnr.20199. PMID 15352215.  https://dx.doi.org/10.1002%2Fjnr.20199
  9. Shen, K.; Cowan, C. W. (2010). "Guidance Molecules in Synapse Formation and Plasticity". Cold Spring Harbor Perspectives in Biology 2 (4): a001842. doi:10.1101/cshperspect.a001842. PMID 20452946.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2845208
  10. Low, K.; Culbertson, M.; Bradke, F.; Tessier-Lavigne, M.; Tuszynski, M. H. (2008). "Netrin-1 is a Novel Myelin-Associated Inhibitor to Axon Growth". Journal of Neuroscience 28 (5): 1099–108. doi:10.1523/JNEUROSCI.4906-07.2008. PMID 18234888.  https://dx.doi.org/10.1523%2FJNEUROSCI.4906-07.2008
  11. Colavita, A.; Krishna, S; Zheng, H; Padgett, RW; Culotti, JG (1998). "Pioneer Axon Guidance by UNC-129, a C. Elegans TGF-". Science 281 (5377): 706–9. doi:10.1126/science.281.5377.706. PMID 9685266.  https://dx.doi.org/10.1126%2Fscience.281.5377.706
  12. MacNeil, Lesley T; Hardy, W Rod; Pawson, Tony; Wrana, Jeffrey L; Culotti, Joseph G (2009). "UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways". Nature Neuroscience 12 (2): 150–5. doi:10.1038/nn.2256. PMID 19169249.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2745997
  13. Smith, Cody J; Watson, Joseph D; Vanhoven, Miri K; Colón-Ramos, Daniel A; Miller Dm, David M (2012). "Netrin (UNC-6) mediates dendritic self-avoidance". Nature Neuroscience 15 (5): 731–7. doi:10.1038/nn.3065. PMID 22426253.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3337961
  14. Yurchenco, Peter D; Wadsworth, William G (2004). "Assembly and tissue functions of early embryonic laminins and netrins". Current Opinion in Cell Biology 16 (5): 572–9. doi:10.1016/j.ceb.2004.07.013. PMID 15363809.  https://dx.doi.org/10.1016%2Fj.ceb.2004.07.013
  15. Arakawa, Hirofumi (2004). "Netrin-1 and its receptors in tumorigenesis". Nature Reviews Cancer 4 (12): 978–87. doi:10.1038/nrc1504. PMID 15573119.  https://dx.doi.org/10.1038%2Fnrc1504
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