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HandWiki. Monomorphic Epitheliotropic Intestinal T Cell Lymphoma. Encyclopedia. Available online: https://encyclopedia.pub/entry/29616 (accessed on 26 September 2026).
HandWiki. Monomorphic Epitheliotropic Intestinal T Cell Lymphoma. Encyclopedia. Available at: https://encyclopedia.pub/entry/29616. Accessed September 26, 2026.
HandWiki. "Monomorphic Epitheliotropic Intestinal T Cell Lymphoma" Encyclopedia, https://encyclopedia.pub/entry/29616 (accessed September 26, 2026).
HandWiki. (2022, October 17). Monomorphic Epitheliotropic Intestinal T Cell Lymphoma. In Encyclopedia. https://encyclopedia.pub/entry/29616
HandWiki. "Monomorphic Epitheliotropic Intestinal T Cell Lymphoma." Encyclopedia. Web. 17 October, 2022.
Monomorphic Epitheliotropic Intestinal T Cell Lymphoma
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The content is sourced from: https://handwiki.org/wiki/Medicine:Monomorphic_epitheliotropic_intestinal_T_cell_lymphoma

Monomorphic epitheliotropic intestinal T cell lymphoma (MEITL) (formerly termed enteropathy-associated T cell lymphoma, type II) is an extremely rare peripheral T-cell lymphoma that involves the malignant proliferation of a type of lymphocyte, the T cell, in the gastrointestinal tract (i.e. GI tract). Over time, these T cells commonly spread throughout the mucosal lining of a portion of the GI tract (particularly the jejunum and ileum of the small intestine), lead to GI tract nodules and ulcerations, and cause symptoms such as abdominal pain, weight loss, diarrhea, obstruction, bleeding, and/or perforation. In 2008, the World Health Organization defined a specific type of lymphoma, enteropathy-associated T cell lymphoma (EATL), as having two different types: EATL type I, a lymphoma occurring in patients with the chronic, autoimmune GI tract disorder, celiac disease, and EATL type II, a similar bowel lymphoma that was not associated with celiac disease. However, subsequent studies found significant clinical, pathologic, and pathophysiological differences between these two types of lymphoma. Consequently, the World Health Organization (2016) redefined these lymphomas as separate entities, terming the celiac disease-associated lymphoma as enteropathy-associted T cell lymphoma (EATL) and the lymphoma not associated with celiac disease as monomorphic epitheliotropic intestinal T cell lymphoma (MEITL). MEITL is only 1/5 to 1/10 as common as EATL. The Organization (2016) also termed a third type of intestinal T cell lymphoma that could not be classified as ATL or MEITL as intestinal T cell lymphoma, not otherwise specified. MEITL is a highly aggressive GI tract lymphoma which typically has had very short survival times following its diagnosis. The disease often occurs in elderly patients who are afflicted with other ailments and consequently have little tolerance for the standard chemotherapy regimens that are used to treat other types of lymphomas. Moreover, these therapeutic regimens have shown little effectiveness in treating MEITL. To date, the best but still only marginally effective therapeutic interventions for the disease have been treatments that incorporate hematopoietic stem cell transplantation into chemotherapy plus surgical (when needed to treat local bowel issues such as obstruction or perforation) regimens.

hematopoietic stem cell lymphocyte celiac disease

References

  1. "Update on Gastrointestinal Lymphomas". Archives of Pathology & Laboratory Medicine 142 (11): 1347–1351. November 2018. doi:10.5858/arpa.2018-0275-RA. PMID 30407861.  https://dx.doi.org/10.5858%2Farpa.2018-0275-RA
  2. "Enteropathy-Associated T-Cell Lymphoma". Current Hematologic Malignancy Reports 11 (6): 504–513. December 2016. doi:10.1007/s11899-016-0357-7. PMID 27900603.  https://dx.doi.org/10.1007%2Fs11899-016-0357-7
  3. "Monomorphic epitheliotropic intestinal T-cell lymphoma may mimic intestinal inflammatory disorders". International Journal of Immunopathology and Pharmacology 33: 2058738419829387. 2019. doi:10.1177/2058738419829387. PMID 30757928.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=6376542
  4. "Recent advances in intestinal lymphomas". Histopathology 66 (1): 112–36. January 2015. doi:10.1111/his.12596. PMID 25639480.  https://dx.doi.org/10.1111%2Fhis.12596
  5. "Pathogenesis of Enteropathy-Associated T Cell Lymphoma". Current Hematologic Malignancy Reports 13 (4): 308–317. August 2018. doi:10.1007/s11899-018-0459-5. PMID 29943210.  https://dx.doi.org/10.1007%2Fs11899-018-0459-5
  6. "Enteropathy-associated T cell lymphoma subtypes are characterized by loss of function of SETD2". The Journal of Experimental Medicine 214 (5): 1371–1386. May 2017. doi:10.1084/jem.20160894. PMID 28424246.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5413324
  7. "Epstein-Barr Virus and Cancer". Annual Review of Pathology 14: 29–53. 2019. doi:10.1146/annurev-pathmechdis-012418-013023. PMID 30125149.  https://dx.doi.org/10.1146%2Fannurev-pathmechdis-012418-013023
  8. "Intestinal T-cell and NK/T-cell lymphomas: A clinicopathological study of 27 Chinese patients". Annals of Diagnostic Pathology 37: 107–117. December 2018. doi:10.1016/j.anndiagpath.2018.10.004. PMID 30317149.  https://dx.doi.org/10.1016%2Fj.anndiagpath.2018.10.004
  9. "Anaplastic large cell lymphomas: ALK positive, ALK negative, and primary cutaneous". Advances in Anatomic Pathology 22 (1): 29–49. January 2015. doi:10.1097/PAP.0000000000000047. PMID 25461779.  https://dx.doi.org/10.1097%2FPAP.0000000000000047
  10. "Peripheral T-cell lymphoma, not otherwise specified". Blood 129 (9): 1103–1112. March 2017. doi:10.1182/blood-2016-08-692566. PMID 28115372.  https://dx.doi.org/10.1182%2Fblood-2016-08-692566
  11. "Use of PEG-asparaginase in monomorphic epitheliotropic intestinal T-cell lymphoma, a disease with diagnostic and therapeutic challenges". ecancermedicalscience 11: 771. 2017. doi:10.3332/ecancer.2017.771. PMID 29062389.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5636209
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