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HandWiki. Glycoprotein Ib-IX-V Receptor Complex. Encyclopedia. Available online: https://encyclopedia.pub/entry/29471 (accessed on 27 September 2026).
HandWiki. Glycoprotein Ib-IX-V Receptor Complex. Encyclopedia. Available at: https://encyclopedia.pub/entry/29471. Accessed September 27, 2026.
HandWiki. "Glycoprotein Ib-IX-V Receptor Complex" Encyclopedia, https://encyclopedia.pub/entry/29471 (accessed September 27, 2026).
HandWiki. (2022, October 17). Glycoprotein Ib-IX-V Receptor Complex. In Encyclopedia. https://encyclopedia.pub/entry/29471
HandWiki. "Glycoprotein Ib-IX-V Receptor Complex." Encyclopedia. Web. 17 October, 2022.
Glycoprotein Ib-IX-V Receptor Complex
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The content is sourced from: https://handwiki.org/wiki/Biology:Glycoprotein_Ib-IX-V_Receptor_Complex

The GPIb-IX-V complex is a profuse membrane receptor complex originating in megakaryocytes and exclusively functional on the surface of platelets. It primarily functions to mediate the first critical step in platelet adhesion, by facilitating binding to von Willebrand factor (VWF) on damaged sub-endothelium under conditions of high fluid shear stress. Although the primary ligand for the GPIb-V-IX receptor is VWF, it can also bind to a number of other ligands in the circulation such as thrombin, P-selectin, factor XI, factor XII, high molecular weight kininogen as well as bacteria. GPIb-IX-V offers a critical role in thrombosis, metastasis, and the life cycle of platelets, and is implicated in a number of thrombotic pathological processes such as stroke or myocardial infarction.

platelet platelets thrombosis

References

  1. "The organizing principle of the platelet glycoprotein Ib-IX-V complex". J. Thromb. Haemost. 11 (4): 605–14. April 2013. doi:10.1111/jth.12144. PMID 23336709.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3696474
  2. "Glycoprotein Ib and glycoprotein IX are fully complexed in the intact platelet membrane". Blood 69 (5): 1524–7. May 1987. doi:10.1182/blood.V69.5.1524.1524. PMID 2436691.  https://dx.doi.org/10.1182%2Fblood.V69.5.1524.1524
  3. "Glycoprotein Ibalpha forms disulfide bonds with 2 glycoprotein Ibbeta subunits in the resting platelet". Blood 109 (2): 603–9. January 2007. doi:10.1182/blood-2006-05-024091. PMID 17008541.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1785083
  4. "Transmembrane domains are critical to the interaction between platelet glycoprotein V and glycoprotein Ib-IX complex". J. Thromb. Haemost. 10 (9): 1875–86. September 2012. doi:10.1111/j.1538-7836.2012.04841.x. PMID 22759073.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3499136
  5. "Quaternary organization of GPIb-IX complex and insights into Bernard–Soulier syndrome revealed by the structures of GPIbβ and a GPIbβ/GPIX chimera". Blood 118 (19): 5292–301. November 2011. doi:10.1182/blood-2011-05-356253. PMID 21908432.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3217411
  6. "Bernard-Soulier syndrome". Blood 91 (12): 4397–418. June 1998. doi:10.1182/blood.V91.12.4397. PMID 9616133.  https://dx.doi.org/10.1182%2Fblood.V91.12.4397
  7. Lanza F (2006). "Bernard-Soulier syndrome (hemorrhagiparous thrombocytic dystrophy)". Orphanet J Rare Dis 1: 46. doi:10.1186/1750-1172-1-46. PMID 17109744.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1660532
  8. Nurden AT (August 2005). "Qualitative disorders of platelets and megakaryocytes". J. Thromb. Haemost. 3 (8): 1773–82. doi:10.1111/j.1538-7836.2005.01428.x. PMID 16102044.  https://dx.doi.org/10.1111%2Fj.1538-7836.2005.01428.x
  9. "Sur une nouvelle variete de dystrophie thrombocythaire hemorragipare congenitale". Sem Hop Paris 24: 3217–3223. 1948. 
  10. "Synthesis of GPIb beta with novel transmembrane and cytoplasmic sequences in a Bernard–Soulier patient resulting in GPIb-defective signaling in CHO cells". J. Thromb. Haemost. 4 (1): 217–28. January 2006. doi:10.1111/j.1538-7836.2005.01654.x. PMID 16409472.  https://dx.doi.org/10.1111%2Fj.1538-7836.2005.01654.x
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