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HandWiki. Aquaporin 4. Encyclopedia. Available online: https://encyclopedia.pub/entry/29000 (accessed on 27 September 2026).
HandWiki. Aquaporin 4. Encyclopedia. Available at: https://encyclopedia.pub/entry/29000. Accessed September 27, 2026.
HandWiki. "Aquaporin 4" Encyclopedia, https://encyclopedia.pub/entry/29000 (accessed September 27, 2026).
HandWiki. (2022, October 12). Aquaporin 4. In Encyclopedia. https://encyclopedia.pub/entry/29000
HandWiki. "Aquaporin 4." Encyclopedia. Web. 12 October, 2022.
Aquaporin 4
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The content is sourced from: https://handwiki.org/wiki/Biology:Aquaporin_4

Aquaporin-4, also known as AQP4, is a water channel protein encoded by the AQP4 gene in humans. AQP4 belongs to the aquaporin family of integral membrane proteins that conduct water through the cell membrane. A limited number of aquaporins are found within the central nervous system (CNS): AQP1, 3, 4, 5, 8, 9, and 11, but more exclusive representation of AQP1, 4, and 9 are found in the brain and spinal cord. AQP4 shows the largest presence in the cerebellum and spinal cord grey matter. In the CNS, AQP4 is the most prevalent aquaporin channel, specifically located at the perimicrovessel astrocyte foot processes, glia limitans, and ependyma. In addition, this channel is commonly found facilitating water movement near cerebrospinal fluid and vasculature. Aquaporin-4 was first identified in 1986. It was the first evidence of the existence of water transport channels. The method that was used to discover the existence of the transport channels was through knockout experiments. With this technique they were able to show the significant role of AQP4 in CNS injuries and brain water imbalances. In 1994 the channel was successfully cloned and initially named Mercury-Insensitive Water Channel.

cerebrospinal fluid vasculature water channel protein

References

  1. "Biology of AQP4 and anti-AQP4 antibody: therapeutic implications for NMO". Brain Pathology 23 (6): 684–95. November 2013. doi:10.1111/bpa.12085. PMID 24118484.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3890327
  2. Halsey, Andrea; Conner, Alex; Bill, Roslyn; Logan, Ann; Ahmed, Zubair (2018-10-18). "Aquaporins and Their Regulation after Spinal Cord Injury". Cells 7 (10): 174. doi:10.3390/cells7100174. ISSN 2073-4409. PMID 30340399.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=6210264
  3. "Aquaporin-4 and Cerebrovascular Diseases". International Journal of Molecular Sciences 17 (8): 1249. August 2016. doi:10.3390/ijms17081249. PMID 27529222.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5000647
  4. "Aquaporins in the Spinal Cord". International Journal of Molecular Sciences 17 (12): 2050. December 2016. doi:10.3390/ijms17122050. PMID 27941618.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5187850
  5. Mader, Simone; Brimberg, Lior (2019-01-27). "Aquaporin-4 Water Channel in the Brain and Its Implication for Health and Disease". Cells 8 (2): 90. doi:10.3390/cells8020090. ISSN 2073-4409. PMID 30691235.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=6406241
  6. "Aquaporin-4 in Astroglial Cells in the CNS and Supporting Cells of Sensory Organs-A Comparative Perspective". International Journal of Molecular Sciences 17 (9): 1411. August 2016. doi:10.3390/ijms17091411. PMID 27571065.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5037691
  7. "Aquaporin-4 water channel protein in the rat retina and optic nerve: polarized expression in Müller cells and fibrous astrocytes". The Journal of Neuroscience 18 (7): 2506–19. April 1998. doi:10.1523/JNEUROSCI.18-07-02506.1998. PMID 9502811.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=6793100
  8. "Aquaporin-4 in the central nervous system: cellular and subcellular distribution and coexpression with KIR4.1". Neuroscience 129 (4): 905–13. 2004. doi:10.1016/j.neuroscience.2004.08.053. PMID 15561407.  https://dx.doi.org/10.1016%2Fj.neuroscience.2004.08.053
  9. "The role of aquaporin-4 in synaptic plasticity, memory and disease". Brain Research Bulletin 136: 118–129. January 2018. doi:10.1016/j.brainresbull.2017.02.011. PMID 28274814.  https://dx.doi.org/10.1016%2Fj.brainresbull.2017.02.011
  10. Terris, J.; Ecelbarger, C. A.; Marples, D.; Knepper, M. A.; Nielsen, S. (1995-12-01). "Distribution of aquaporin-4 water channel expression within rat kidney". American Journal of Physiology. Renal Physiology 269 (6): F775–F785. doi:10.1152/ajprenal.1995.269.6.f775. ISSN 1931-857X. PMID 8594871.  https://dx.doi.org/10.1152%2Fajprenal.1995.269.6.f775
  11. "The aquaporin family of water channels in kidney". Nephrologie 17 (7): 409–15. 1996. PMID 8987045.  http://www.ncbi.nlm.nih.gov/pubmed/8987045
  12. "Hydrocephalus: the role of cerebral aquaporin-4 channels and computational modeling considerations of cerebrospinal fluid". Neurosurgical Focus 41 (3): E8. September 2016. doi:10.3171/2016.7.FOCUS16191. PMID 27581320.  https://dx.doi.org/10.3171%2F2016.7.FOCUS16191
  13. "Aquaporin-4 antibodies (NMO-IgG) as a serological marker of neuromyelitis optica: a critical review of the literature". Brain Pathology 23 (6): 661–83. November 2013. doi:10.1111/bpa.12084. PMID 24118483.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=8028894
  14. "Quantitative assays for anti-aquaporin-4 antibody with subclass analysis in neuromyelitis optica". Multiple Sclerosis 18 (11): 1541–51. November 2012. doi:10.1177/1352458512443917. PMID 22526930.  https://dx.doi.org/10.1177%2F1352458512443917
  15. "Clinical relevance of serum aquaporin-4 antibody levels in neuromyelitis optica". Neurochemical Research 38 (5): 997–1001. May 2013. doi:10.1007/s11064-013-1009-0. PMID 23456674.  https://dx.doi.org/10.1007%2Fs11064-013-1009-0
  16. "Aquaporin-4 in brain and spinal cord oedema". Neuroscience 168 (4): 1036–46. July 2010. doi:10.1016/j.neuroscience.2009.08.019. PMID 19682555.  https://dx.doi.org/10.1016%2Fj.neuroscience.2009.08.019
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