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HandWiki. Deleted in Colorectal Cancer. Encyclopedia. Available online: https://encyclopedia.pub/entry/28446 (accessed on 29 September 2026).
HandWiki. Deleted in Colorectal Cancer. Encyclopedia. Available at: https://encyclopedia.pub/entry/28446. Accessed September 29, 2026.
HandWiki. "Deleted in Colorectal Cancer" Encyclopedia, https://encyclopedia.pub/entry/28446 (accessed September 29, 2026).
HandWiki. (2022, October 08). Deleted in Colorectal Cancer. In Encyclopedia. https://encyclopedia.pub/entry/28446
HandWiki. "Deleted in Colorectal Cancer." Encyclopedia. Web. 08 October, 2022.
Deleted in Colorectal Cancer
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The content is sourced from: https://handwiki.org/wiki/Biology:Deleted_in_Colorectal_Cancer

An Error has occurred retrieving Wikidata item for infobox Deleted in Colorectal Carcinoma, also known as DCC, is a protein which in humans is encoded by the DCC gene. DCC has long been implicated in colorectal cancer. While the official, full name of this gene is Deleted in Colorectal Carcinoma, it is almost universally called Deleted in Colorectal Cancer. The protein product of DCC is a single transmembrane receptor also known as DCC, and it has the same interchangeable name. Since it was first discovered in a colorectal cancer study in 1990, DCC has been the focus of a significant amount of research. DCC held a controversial place as a tumour suppressor gene for many years, and is well known as an axon guidance receptor that responds to netrin-1. More recently DCC has been characterized as a dependence receptor, and many hypotheses have been put forward that have revived interest in DCC's candidacy as a tumour suppressor gene, as it may be a ligand-dependent suppressor that is frequently epigenetically silenced.

colorectal cancer axon guidance epigenetically

References

  1. "Identification of a chromosome 18q gene that is altered in colorectal cancers". Science 247 (4938): 49–56. January 1990. doi:10.1126/science.2294591. PMID 2294591. Bibcode: 1990Sci...247...49F.  https://dx.doi.org/10.1126%2Fscience.2294591
  2. "Deleted in Colorectal Cancer (DCC) encodes a netrin receptor". Cell 87 (2): 175–85. October 1996. doi:10.1016/S0092-8674(00)81336-7. PMID 8861902.  https://dx.doi.org/10.1016%2FS0092-8674%2800%2981336-7
  3. "Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene". Nature 386 (6627): 796–804. April 1997. doi:10.1038/386796a0. PMID 9126737. Bibcode: 1997Natur.386..796F.  https://dx.doi.org/10.1038%2F386796a0
  4. "The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis". Nature 395 (6704): 801–4. October 1998. doi:10.1038/27441. PMID 9796814. Bibcode: 1998Natur.395..801M.  https://dx.doi.org/10.1038%2F27441
  5. AceView: Homo sapiens complex locus DCC, encoding deleted in colorectal carcinoma"AceView: a comprehensive cDNA-supported gene and transcripts annotation". Genome Biol. 7 (Suppl 1): S12.1–14. 2006. doi:10.1186/gb-2006-7-s1-s12. PMID 16925834.  https://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?c=geneid&org=9606&l=1630
  6. Human Protein Reference Database: DCC http://www.hprd.org/summary?protein=00391&isoform_id=00391_1&isoform_name=
  7. "Deleted in colorectal carcinoma (DCC) binds heparin via its fifth fibronectin type III domain". J Biol Chem 272 (43): 26940–6. October 1997. doi:10.1074/jbc.272.43.26940. PMID 9341129.  https://dx.doi.org/10.1074%2Fjbc.272.43.26940
  8. "Netrin-1/DCC signaling in commissural axon guidance requires cell-autonomous expression of heparan sulfate". J. Neurosci. 27 (16): 4342–50. April 2007. doi:10.1523/JNEUROSCI.0700-07.2007. PMID 17442818.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=6672322
  9. "Tyrosine phosphorylation of netrin receptors in netrin-1 signaling". Neurosignals 16 (2–3): 235–45. 2008. doi:10.1159/000111566. PMID 18253061.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3812529
  10. "The dependence receptor hypothesis". Apoptosis 9 (1): 37–49. January 2004. doi:10.1023/B:APPT.0000012120.66221.b2. PMID 14739597.  https://dx.doi.org/10.1023%2FB%3AAPPT.0000012120.66221.b2
  11. "Making the case for DCC and UNC5C as tumor-suppressor genes in the colon". Gastroenterology 133 (6): 2045–9. December 2007. doi:10.1053/j.gastro.2007.10.034. PMID 18054576.  https://dx.doi.org/10.1053%2Fj.gastro.2007.10.034
  12. "Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo/DCC receptor complex". Science 291 (5510): 1928–38. March 2001. doi:10.1126/science.1058445. PMID 11239147. Bibcode: 2001Sci...291.1928S.  https://dx.doi.org/10.1126%2Fscience.1058445
  13. "DCC association with lipid rafts is required for netrin-1-mediated axon guidance". J Cell Sci 118 (Pt 8): 1687–92. April 2005. doi:10.1242/jcs.02296. PMID 15811950.  https://dx.doi.org/10.1242%2Fjcs.02296
  14. "The dependence receptor DCC requires lipid raft localization for cell death signaling". Proc Natl Acad Sci USA 103 (11): 4128–33. March 2006. doi:10.1073/pnas.0507864103. PMID 16537496. Bibcode: 2006PNAS..103.4128F.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1449658
  15. "Netrins and DCC in the guidance of migrating neural crest-derived cells in the developing bowel and pancreas". Dev. Biol. 258 (2): 364–84. June 2003. doi:10.1016/S0012-1606(03)00136-2. PMID 12798294.  https://dx.doi.org/10.1016%2FS0012-1606%2803%2900136-2
  16. "The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation". Proc Natl Acad Sci USA 98 (6): 3416–21. March 2001. doi:10.1073/pnas.051378298. PMID 11248093. Bibcode: 2001PNAS...98.3416F.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=30668
  17. "Netrin-1 and its receptors in tumorigenesis". Nature Reviews Cancer 4 (12): 978–87. December 2004. doi:10.1038/nrc1504. PMID 15573119.  https://dx.doi.org/10.1038%2Fnrc1504
  18. "Colorectal cancer: genetics of development and metastasis". J. Gastroenterol. 41 (3): 185–92. March 2006. doi:10.1007/s00535-006-1801-6. PMID 16699851.  https://dx.doi.org/10.1007%2Fs00535-006-1801-6
  19. "Limiting the location of putative human prostate cancer tumor suppressor genes on chromosome 18q". Oncogene 20 (18): 2273–80. April 2001. doi:10.1038/sj.onc.1204310. PMID 11402322.  https://dx.doi.org/10.1038%2Fsj.onc.1204310
  20. "Expression and mutational analysis of the DCC, DPC4, and MADR2/JV18-1 genes in neuroblastoma". Cancer Res. 57 (17): 3772–8. 1 September 1997. PMID 9288786. http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=9288786. 
  21. "Deleted in colorectal cancer is a putative conditional tumor-suppressor gene inactivated by promoter hypermethylation in head and neck squamous cell carcinoma". Cancer Res. 66 (19): 9401–7. October 2006. doi:10.1158/0008-5472.CAN-06-1073. PMID 17018594.  https://dx.doi.org/10.1158%2F0008-5472.CAN-06-1073
  22. "A systematic review and meta-analysis of the relationship between chromosome 18q genotype, DCC status and colorectal cancer prognosis". Eur J Cancer 41 (14): 2060–70. September 2005. doi:10.1016/j.ejca.2005.04.039. PMID 16125380.  https://dx.doi.org/10.1016%2Fj.ejca.2005.04.039
  23. "Genetic changes and histopathological types in colorectal tumors from patients with familial adenomatous polyposis". Cancer Res. 50 (22): 7166–73. 15 November 1990. PMID 1977514. http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=1977514. 
  24. "Opposing roles of netrin-1 and the dependence receptor DCC in cancer cell invasion, tumor growth and metastasis". Oncogene 26 (38): 5615–25. August 2007. doi:10.1038/sj.onc.1210347. PMID 17334389.  https://dx.doi.org/10.1038%2Fsj.onc.1210347
  25. "Regulation of netrin-1 receptors by amphetamine in the adult brain". Neuroscience 150 (4): 764–73. December 2007. doi:10.1016/j.neuroscience.2007.09.069. PMID 17996376.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4880477
  26. "Mediation of the DCC apoptotic signal by DIP13 alpha". J. Biol. Chem. 277 (29): 26281–5. Jul 2002. doi:10.1074/jbc.M204679200. PMID 12011067.  https://dx.doi.org/10.1074%2Fjbc.M204679200
  27. "Isolation and identification of L-dopa decarboxylase as a protein that binds to and enhances transcriptional activity of the androgen receptor using the repressed transactivator yeast two-hybrid system". Biochem. J. 375 (Pt 2): 373–83. Oct 2003. doi:10.1042/BJ20030689. PMID 12864730.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1223690
  28. "The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation". Proc. Natl. Acad. Sci. U.S.A. 98 (6): 3416–21. Mar 2001. doi:10.1073/pnas.051378298. PMID 11248093. Bibcode: 2001PNAS...98.3416F.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=30668
  29. "Interaction of Myc-associated zinc finger protein with DCC, the product of a tumor-suppressor gene, during the neural differentiation of P19 EC cells". Biochem. Biophys. Res. Commun. 286 (5): 1087–97. Sep 2001. doi:10.1006/bbrc.2001.5469. PMID 11527412.  https://dx.doi.org/10.1006%2Fbbrc.2001.5469
  30. "Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin". J. Biol. Chem. 278 (35): 32561–8. Aug 2003. doi:10.1074/jbc.M302943200. PMID 12810718.  https://dx.doi.org/10.1074%2Fjbc.M302943200
  31. "Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas". Cell Growth Differ. 10 (1): 35–42. Jan 1999. PMID 9950216.  http://www.ncbi.nlm.nih.gov/pubmed/9950216
  32. "Focal adhesion kinase in netrin-1 signaling". Nat. Neurosci. 7 (11): 1204–12. Nov 2004. doi:10.1038/nn1330. PMID 15494733.  https://dx.doi.org/10.1038%2Fnn1330
  33. "The DCC gene suppresses the malignant phenotype of transformed human epithelial cells". Oncogene 10 (8): 1581–6. April 1995. PMID 7731713.  http://www.ncbi.nlm.nih.gov/pubmed/7731713
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