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Chubarev, V.N.;  Beeraka, N.M.;  Sinelnikov, M.Y.;  Bulygin, K.V.;  Nikolenko, V.N.;  Mihaylenko, E.;  Tarasov, V.V.;  Mikhaleva, L.M.;  Poltronieri, P.;  Viswanadha, V.P.; et al. Gjumrakch Aliev. Encyclopedia. Available online: https://encyclopedia.pub/entry/28227 (accessed on 09 May 2024).
Chubarev VN,  Beeraka NM,  Sinelnikov MY,  Bulygin KV,  Nikolenko VN,  Mihaylenko E, et al. Gjumrakch Aliev. Encyclopedia. Available at: https://encyclopedia.pub/entry/28227. Accessed May 09, 2024.
Chubarev, Vladimir N., Narasimha M. Beeraka, Mikhail Y. Sinelnikov, Kirill V. Bulygin, Vladimir N. Nikolenko, Elizaveta Mihaylenko, Vadim V. Tarasov, Liudmila M. Mikhaleva, Palmiro Poltronieri, Vijaya Padma Viswanadha, et al. "Gjumrakch Aliev" Encyclopedia, https://encyclopedia.pub/entry/28227 (accessed May 09, 2024).
Chubarev, V.N.,  Beeraka, N.M.,  Sinelnikov, M.Y.,  Bulygin, K.V.,  Nikolenko, V.N.,  Mihaylenko, E.,  Tarasov, V.V.,  Mikhaleva, L.M.,  Poltronieri, P.,  Viswanadha, V.P.,  Somasundaram, S.G.,  Kirkland, C.E.,  Chen, K.,  Liu, J.,  Fan, R.,  Kamal, M.A.,  Mironov, A.A.,  Madhunapantula, S.V.,  Pretorius, E., ... Sukocheva, O.A. (2022, October 03). Gjumrakch Aliev. In Encyclopedia. https://encyclopedia.pub/entry/28227
Chubarev, Vladimir N., et al. "Gjumrakch Aliev." Encyclopedia. Web. 03 October, 2022.
Gjumrakch Aliev
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This entry is adapted from the peer-reviewed paper 10.3390/cancers13081965
Alzheimer disease Neuroscience Vascular Biology

1. Brief Introduction

Professor Aliev had many projects underway that he looked forward to completing to better serve the world and all of its people. The scientific community has lost a bright, multidisciplinary scientist who could connect people with similar research interests across borders and continents.
Gjumrakch (Figure 1) was the internationally recognized founder of Gally International Research Institute (http://gallyinternational.com/about/gjumrakch, accessed on 20 February 2021), a professor at the Department of Anatomy of Sechenov University (https://www.sechenov.net/department-of-human-anatomy/, accessed on 20 February 2021), chairman of the International Division of the EuroEspes Biomedical Research Center (La Coruna, Spain), leading researcher (Full Professorship) at the Institute of Physiologically Active Compounds (http://www.istc.int/en/institute/8711, accessed on 20 February 2021), “Bentham Brand Ambassador” for the Russian Federation in the United Nations Organization (UNESCAP) and the committee on Science, Technology and Innovation (STI) for UNESCAP.
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Figure 1. Professor Aliev in his Laboratory, Sechenov University, Moscow (2019).
Professor Aliev was born on 1 September 1958 in Azerbaijan, of the former USSR. He graduated from high school with Gold Medal in 1976 (Nakhichevan, USSR). In 1982, he graduated summa cum laude from the Azerbaijan Medical Institute in Baku, Azerbaijan, receiving an M.D. in general medicine and health sciences (Honor Diploma). As a student, he was interested in research work and presented at conferences. He received First Award at International and USSR Medical Students Conference and Congress (1978–1979, Moscow, 1980 Kaunas, Latvian Republic; 1981 Saratov Russia, and 1982 Sank-Petersburg, Russia). In 1989, he received his PhD summa cum laude in Cardiovascular Biology and Pathology from the Ivanovo Medical Institute while conducting his research at the Moscow State University and the Russian Cardiology Research Center. Following this, Gjumrakch received postdoctoral training under the prestigious British Heart Foundation Grant Program in the University College London (advisor Professor Geoffrey Burnstock), specializing in medicine.
Professor Aliev possessed an encyclopedic knowledge in a wide range of scientific fields; however, his main research focus was linked to the development of unique technologies and treatment protocols for age-associated diseases. He was recognized internationally for his work in the fields of gerontology [1][2][3][4][5], oncology [6][7][8][9][10][11][12][13][14][15], cardiovascular diseases [16][17][18][19], endocrinology [2][20][21], and neurodegenerative diseases [15][20][22][23][24][25][26][27][28][29][30][31][32]. His research publications on the role of vascular and mitochondrial factors in the pathogenesis of aging [2][3][5], atherosclerosis [33][34], ischemia-reperfusion [18][35][36][37], stroke [4][18][35][38], and Alzheimer’s disease (AD) [23][24][33][39][40][41][42][43] are often cited (Table 1). Additionally, Professor Aliev and his colleagues were the first to propose the role of the energy crisis as a driving force for the acceleration of aging [6][35][44]. He authored and co-authored more than 400 peer-reviewed journal articles and book chapters (https://www.researchgate.net/profile/Gjumrakch_Aliev/research (accessed on 20 February 2021)), as well as over 170 scientific abstracts of conference presentations on neurodegenerative disease research, cardio- and cerebrovascular diseases, cancer, and electron microscopy. He also had several patents and rationalizations. Prior to his passing, Professor Aliev was the Project Director and Lead Investigator of several international scientific projects.

2. Story about Notable Contributions

The idea of drug optimization in the treatment of several pathological conditions associated with aging and inflammation was the core aim of many of Prof. Aliev’s research projects. Elderly patients in all countries are prescribed a handful of drugs that often initiate side effects and provoke further prescription of additional supplements. Polypharmacy, a habit and/or a necessity to take too many drugs, is accompanied by a financial burden and health risks. Considering the advantage of less harmful and proven-to-be-beneficial chemicals, Prof. Aliev’s work strongly supports the development of oxidative stress-targeting and multi-purpose therapies as an approach to cure age-associated pathologies.
Professor Aliev had superior expertise in various aspects of microscopic analysis. Having had many years of experience in research and teaching with light microscopy, electron microscopy (EM), 2-photon microscopy, atomic force, and confocal microscopy, he produced pioneering work in different areas of EM-based techniques. These techniques included cytological in situ hybridization at the light and electron microscopic levels using non-isotopic colloidal gold probes [35][44], peroxidase-anti-peroxidase [44][45][46], and pre- and post-embedding single, double, and triple immunogold cytochemistry and quantification [37][39]. Professor Aliev’s Gally International Research Institute provided high quality scientific expertise in cellular, subcellular, functional, and biochemical assessments.
Professor Aliev enthusiastically engaged in collaborations, which led to him establishing connections among scientists all over the world. Through his cooperative and inclusive style of work, he was able to gather and link scientists with common research interests and complementary expertise from countries as diverse as China, India, USA, Russia, Singapore, Australia, and Germany. For instance, collaboration with Prof. SubbaRao V. Madhunapantula (Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR Laboratory), JSS Medical College, JSS Academy of Higher Education & Research, Karnataka, India) resulted in a successful publication of several review articles in high-impact journals, including Frontiers in Immunology [47], Seminars in Cancer Biology [48], and International Journal of Molecular Sciences [49]. In just a year, his collaboration with Prof. Madhunapantula produced a strong research breakthrough and lead to the submission of multi-centric grant proposals. For all co-authors, it was a pleasure to work with Prof. Aliev as all his colleagues could feel through email letters his warm care and attention to all their needs. We will miss his timely actions and quick responses to all e-mail communications. Was he online 24/7? It certainly looked like he was. His early death is a huge loss to the scientific community.
Professor Aliev possessed prodigious administrative skills and had excellent rapport with his colleagues, friends, employers, and subordinates. Many scientific journals will be missing his continuing contributions. Professor Aliev served as an editor and editorial board member for many prestigious journals and as a grant review board member and reviewer for international granting agencies and foundations. He was the editor-in-chief of such journals as Central Nervous System Agents in Medicinal Chemistry, Applied Cell Biology, World Journal of Neuroscience, Open Journal of Psychiatry, Journal of Aging Science, Cardiovascular and Hematological Agents in Medicinal Chemistry, and Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry. His work was cited about 25,000 times by nearly 10,000 documents (h-index 53; https://scholar.google.com/citations?user=a_TYBosAAAAJ&hl=en (accessed on 20 February 2021)) and he was among the top 2% of the world’s most-cited academic authors in the medical and health sciences (Stanford University database 2020; https://data.mendeley.com/datasets/btchxktzyw/2 (accessed on 20 February 2021)).
Professor Aliev was an active, honorable, contributing member of numerous scientific societies including American Association for the Advancement of Science (Neuroscience), International Society of Pharmacogenomics, American Association of Neuropathologist, Alzheimer Research Forum, Royal Society of Medicine (England), World Association of Neurotechnology, Science Advisory Board for Microscopy Society of Northeastern Ohio, Inc., USA, Italian Society of Electron Microscopy, Microscopy Society of America (New York Academy of Sciences), Russian Society of Microvascular Research, Russian Regional Society for Study of Atherosclerosis and Peripheral Vascular Diseases, Russian Society of Electron Microscopy, Russian Society of Atherosclerosis Investigation, and Russian Society of Anatomy, Histology and Embryology (Figure 2).
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Figure 2. Visiting Professor Aliev, Professor Nikolenko (sitting at the table in front), and staff members of Department of Human Anatomy at Sechenov Universityff, Moscow, 2020. From left to right in the first row (front): Genrik G. Verdiyan, Mariya A. Zolotareva, Ivan N. Chairkin, Olga N. Kovaleva, Ekaterina S. Klyukina, Nurgozel K. Akyeva, Yuri O. Zharikov, Kirill V. Bulygin, Karina A. Vasyanina; In the second row (behind): Anna V. Olsufieva, Angela D. Vovkogon, Inna V. Merenkova, Natalia V. Chairkina, Ivan V. Shevchuk, Andrey V. Suslov, Ruslan Z. Nurimanov, Sania N. Odinokova, Alexey E. Strizhkov.
Despite the great demands of his life’s work, Professor Aliev always found time for his family. He cared greatly for his parents, visiting his mother in Ivanovo as often as possible while she was in declining health. He was a kind and loving presence in the life of his daughter Galina and his grandson Daniel. Daniel had a special connection to his grandfather and called him the “best grandfather in the world”. Prof. Aliev’s only daughter, Galina Alieva, wrote: “My father placed a great emphasis on the importance of education in my life for which I am eternally thankful. He supported my passion for the study of foreign languages which has, in turn, allowed me to become a professional in my job today. I had a very trustworthy and caring relationship with my father throughout my life. He is greatly missed by both myself and my son Daniel, his favourite and only grandson”. Gjumrakch continued to help his relatives who remained in Azerbaijan. He will be missed not only by his family and friends, but also by his large circle of colleagues and former students.
Professor Aliev was a remarkable teacher and an invaluable resource for medical students. He was involved in the teaching and development of numerous teaching materials and courses, as shown in Table 2. He developed research and educational programs in neuroscience, neurodegeneration, mitochondrial research, cardiology, cerebrovascular pathology, anatomy, histology, cancer, electron microscopy, and others. His enthusiasm for scientific progress extended to helping young researchers get their work published in high impact factor journals, a major hurdle for non-English-speaking scientists. He was keen to nurture students in all countries and all universities where he taught. He also managed to help with the promotion of the careers of young talented scientists. Gjumrakch’s devotedly helped to prosper young researchers who struggled to publish in English. Many of Professor Aliev’s pupils have gone on to successful scientific careers and continue the development of his scientific ideas. Among his graduate students were Dr. E. Bedyaev, Dr. A. Mironov Jr., Dr. S. Gurkin, Mr. K. Arun Raina, Dr. Mark A. Obrenovich, Mr. Justin Shenk, and Mr. Gerardo Pacheco, Ms. Celia Cobb, Mr. Hector Palacios, Mrs. Brianna Walrafen, Ms. Amanda Lipsitt, and Mr. Andres Aguirre. Professor Aliev also supervised postdoctoral scientists and was involved in clinical training of recent medical graduates (2003–2020), including Dr. Dilara Seyidova, Dr. Mariana Rosca, Dr. Richard F. Silver, Dr. Ali Aliyev, Dr. Nizami Rzayev, and Dr. Andra Mardale. We sincerely apologize if we missed anybody.
Professor Aliev received numerous awards and honorable recognitions for his work, including the prestigious Upjohn Scientific Prize Award from Italian Pharmacological Society (1994; Torino, Italy), Outstanding Scholars Award/the 20th Century Honor Diploma Cambridge (1999, UK), Honorary Research Board award of Advisory of The American Biographical Institute (1999), George W. Bush Foundation Fellowship (2002), Outstanding Leadership Honor Diploma of American Biographical Institute (2003), Commemorative Medal Man of the Year 2004 American Biographical Institute, UTSA Student Organization Consul Recognition Honor Advisor Diploma (Journal of the College of Science, UTSA; 2008), Pontificia Universidad Javeriana, Facultad Ciencias Honor Diploma (Lectures Series: Theory and Practice of Modern Electron Microscopy Application for Biology and Medicine; 2008, Bogota, Colombia), and OMICS Group Special Honor diploma in Appreciation of Esteemed Editorial Support (2014, San Antonio, TX, USA).
The most recent scientific interests of Professor Aliev were in the fields of cancer cell biology, biochemistry, and the functional morphology of cells and tissues. He investigated the structure and functions of endothelial cells [33][35][44][50], smooth muscle cells [51][52], neurons [3][45][53][54], glial cells [55][56][57][58], and macrophages [47][50]. He was keen to address the most urgent health problems. Last year (2020), he generated ideas for how to target SARS-CoV-2 associated complications [47]. However, the main focus of his research was set on deciphering the mechanisms of atherogenesis, ischemia/reperfusion, tumor angiogenesis, signal transduction, mitochondrial DNA deletion, cancer growth, and metastasis [37][48][59][60][61][62][63]. His laboratory used transgenic mouse models in vivo and a large variety of cutting-edge in vitro molecular biology methods [32][35][44][46]. During the last few years, Professor Aliev was investigating the interaction of nanoparticles with tissues and cells [11][16][49][64][65]. His work aimed to elucidate the pathogenic mechanisms underlying nanoparticles’ effects and to discover potential new drug development strategies. For instance, his in vitro cancer cell model for the peptide based new drug development study showed promising results regarding the specific delivery of drugs to tumor tissues [63][65]. Another of his in vivo studies found that nanoparticles are able to cross the blood–brain barrier, which has been the biggest impediment in delivering drugs to patients with Alzheimer’s disease [16][18][64].
Prof. Aliev was named as the Primary Investigator and Co-Investigator on numerous grant applications and his research projects were supported financially as indicated by successful grant rewards in recent years. His recent projects were supported by the Russian Academy of Sciences (RSCF No. 14-23-00160P, 2 016–2020; Institute of Physiological Active Compounds, Russia), Stress Relief and Memory Center fund (New York, USA; “Stress relief and memory training in conjunction with selective natural antioxidants as an alternate method for treatment of age associated mental retardation, depression, and cancer” 2016–2019), Ministry of Science, Technology, and Innovation of Russian Federation with International Cooperation Foundation (“Unified Technology for the Evaluation of the Effectiveness of the supramolecular conjugates for the inhibition of the reverse cellular transport in Cancer and CNS Diseases”, 2018–2020), Skolkovo Foundation (Russian Skolkovo Innovation Center; 2018–2020), Nine Sigma (Japan; Project Code: 923392; 2018–2020), and Brain Tumor Foundation (USA, “Evaluation of Mitochondrial DNA Overproliferation and Deletion as an Early Diagnostic Marker and Therapeutic Target for the Brain Tumor”, 2018–2020). Unfortunately, Prof. Aliev’s company, Gally International, will continue to run his clinical projects without him. The above overview provides only a brief synopsis of his remarkable achievements.
Table 1. Top 10 Prof. Aliev’s highly cited articles in the field of Alzheimer’s disease and neuroinflammation. Source of information; https://scholar.google.com/citations?user=a_TYBosAAAAJ&hl=en (accessed on 20 March 2021).
Title, Reference # of Times Cited on 20 March 2021 Year of Publication
Oxidative damage is the earliest event in Alzheimer disease [22] 1961 2001
Mitochondrial abnormalities in Alzheimer’s disease [39] 1375
Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer’s disease [45] 449
Role of mitochondrial dysfunction in Alzheimer’s disease [23] 379 2002
Is oxidative damage the fundamental pathogenic mechanism of Alzheimer’s and other neurodegenerative diseases? [24] 358
The role of oxidative stress in the pathophysiology of cerebrovascular lesions in Alzheimer’s disease [44] 205
Microtubule reduction in Alzheimer’s disease and aging is independent of τ filament formation [66] 327 2003
Vascular oxidative stress in Alzheimer disease [67] 209 2007
Nucleic acid oxidation in Alzheimer disease [41] 210 2008
Oxidative stress mediated mitochondrial and vascular lesions as markers in the pathogenesis of Alzheimer disease [33] 148 2014
>Guidelines for the use and interpretation of assays for monitoring autophagy [68] 9455 2021
Table 2. Aliev’s Teaching Activities during 1986–2015.
Institution Years Subject, Course Title
Ivanovo Medical Institute, Russia 1986–1990 Cytology, Histology, and Embryology (Microanatomy) (Biology and Medical courses)
1988–1990 Anatomy (Biology and Medical courses)
1989–1990 Neuroscience (Biology and Medical courses)
University of Jaen, Spain 1996–1997 Cytology and Histology (Biology course)
Case Western Reserve University (CWRU) Cleveland, OH, USA 1998–1999 Cytology and Histology (Biology course)
1998–1999 Vascular Biology (Biology and Medical courses)
1998–1999 Neuroscience (Biology and Medical Students)
1999–2003 Clinical Biochemistry: Molecular Mechanisms of Cardiovascular and Neurodegenerative Disease Pathogenesis
2004–2005 General and Systemic Pathology for Medical students
2004–2006 Application of Electron Microscopy for Biology and Medicine (Biology and Medical courses)
University of Texas at San Antonio, San Antonio, TX, USA 2006–2009 Application of Electron Microscopy for Biology and Medicine (Biology and Biotechnology courses)
2008–2009 Cytoskeleton and Disease (undergraduate and graduate courses)
2008–2009 Aging and the Nervous System (undergraduate and graduate students)
Pontificia Universidad Javeriana, Bogotá, Colombia 2009–2010 Biochemistry of Aging and Aged Associated Diseases
2009–2010 Clinical Advanced Biochemistry of Cardiovascular system and CNS
2009–2010 Application of Electron Microscopy in Biology and Medicine
University of Atlanta, Atlanta, GA, USA 2010–2015 Health Sciences and Healthcare Administration: HC605; HS610; HS615 (BSc and MS students)
Further Reading
In Vivo Antidepressant Efficacy of 3-Substituted Thietane-1,1-dioxide Derivative - A Preliminary Stu New Spirocyclic Hydroxamic Acids as Effective Antiproliferative Agents Mitochondrial mutations and mitoepigenetics

References

  1. Obrenovich, M.E.; Nair, N.G.; Beyaz, A.; Aliev, G.; Reddy, V.P. The Role of Polyphenolic Antioxidants in Health, Disease, and Aging. Rejuvenation Res. 2010, 13, 631–643.
  2. Putta, S.; Peluso, I.; Yarla, N.S.; Kilari, E.K.; Bishayee, A.; Lu, D.-Y.; Barreto, G.E.; Ashraf, G.M.; Scotti, L.; Scotti, M.T.; et al. Diabetes Mellitus and Male Aging: Pharmacotherapeutics and Clinical Implications. Curr. Pharm. Des. 2017, 23, 4475–4483.
  3. Kokhan, V.S.; Kokhan, T.G.; Samsonova, A.N.; Fisenko, V.P.; Ustyugov, A.A.; Aliev, G.M. The Dopaminergic Dysfunction and Altered Working Memory Performance of Aging Mice Lacking Gamma-synuclein Gene. CNS Neurol. Disord.-Drug Targets 2018, 17, 604–607.
  4. Obrenovich, M.E.; Morales, L.A.; Cobb, C.J.; Shenk, J.C.; Méndez, G.M.; Fischbach, K.; Smith, M.A.; Qasimov, E.K.; Perry, G.; Aliev, G. Insights into cerebrovascular complications and Alzheimer disease through the selective loss of GRK2 regulation. J. Cell. Mol. Med. 2009, 13, 853–865.
  5. Obrenovich, M.E.; Li, Y.; Parvathaneni, K.; Yendluri, B.B.; Palacios, H.H.; Leszek, J.; Aliev, G. Antioxidants in Health, Disease and Aging. CNS Neurol. Disord.-Drug Targets 2011, 10, 192–207.
  6. Aliev, G.; Obrenovich, M.E.; Tabrez, S.T.; Jabir, N.R.; Reddy, V.P.; Li, Y.; Burnstock, G.; Cacabelos, R.; Kamal, M.A. Link between Cancer and Alzheimer Disease via Oxidative Stress Induced by Nitric Oxide-Dependent Mitochondrial DNA Overproliferation and Deletion. Oxidative Med. Cell. Longev. 2013, 2013, 1–19.
  7. Rayavarapu, S.; Yarla, N.S.; Kadiri, S.K.; Bishayee, A.; Vidavalur, S.; Tadikonda, R.; Basha, M.; Pidugu, V.R.; Dowluru, K.S.V.G.K.; Lakappa, D.B.; et al. Synthesis of Saccharumoside-B analogue with potential of antiproliferative and pro-apoptotic activities. Sci. Rep. 2017, 7, 1–14.
  8. Klochkov, S.G.; Neganova, M.E.; Yarla, N.S.; Parvathaneni, M.; Sharma, B.; Tarasov, V.V.; Barreto, G.; Bachurin, S.O.; Ashraf, G.M.; Aliev, G. Implications of farnesyltransferase and its inhibitors as a promising strategy for cancer therapy. Semin. Cancer Biol. 2019, 56, 128–134.
  9. Sukocheva, O.A.; Furuya, H.; Ng, M.L.; Friedemann, M.; Menschikowski, M.; Tarasov, V.V.; Chubarev, V.N.; Klochkov, S.G.; Neganova, M.E.; Mangoni, A.A.; et al. Sphingosine kinase and sphingosine-1-phosphate receptor signaling pathway in inflammatory gastrointestinal disease and cancers: A novel therapeutic target. Pharmacol. Ther. 2020, 207, 107464.
  10. Mikhaleva, L.M.; Davydov, A.I.; Patsap, O.I.; Mikhaylenko, E.V.; Nikolenko, V.N.; Neganova, M.E.; Klochkov, S.G.; Somasundaram, S.G.; Kirkland, C.E.; Aliev, G. Malignant Transformation and Associated Biomarkers of Ovarian Endometriosis: A Narrative Review. Adv. Ther. 2020, 37, 2580–2603.
  11. Tarasov, V.V.; Svistunov, A.A.; Chubarev, V.N.; Dostdar, S.A.; Sokolov, A.V.; Brzecka, A.; Sukocheva, O.; Neganova, M.E.; Klochkov, S.G.; Somasundaram, S.G.; et al. Extracellular vesicles in cancer nanomedicine. Semin. Cancer Biol. 2021, 69, 212–225.
  12. Majchrzak, M.; Brzecka, A.; Daroszewski, C.; Błasiak, P.; Rzechonek, A.; Tarasov, V.V.; Chubarev, V.N.; Kurinnaya, A.S.; Melnikova, T.I.; Makhmutova, A.; et al. Increased Pain Sensitivity in Obese Patients After Lung Cancer Surgery. Front. Pharmacol. 2019, 10.
  13. Mahalapbutr, P.; Sangkhawasi, M.; Kammarabutr, J.; Chamni, S.; Rungrotmongkol, T. Rosmarinic Acid as a Potent Influenza Neuraminidase Inhibitor: In Vitro and In Silico Study. Curr. Top. Med. Chem. 2020, 20, 2046–2055.
  14. Ejma, M.; Madetko, N.; Brzecka, A.; Guranski, K.; Alster, P.; Misiuk-Hojło, M.; Somasundaram, S.G.; Kirkland, C.E.; Aliev, G. The Links between Parkinson’s Disease and Cancer. Biomedicines 2020, 8, 416.
  15. Neganova, M.E.; Klochkov, S.G.; Aleksandrova, Y.R.; Aliev, G. The Hydroxamic Acids as a Potential Anticancer and Neuroprotective Agents. Curr. Med. Chem. 2020, 28, 1–23.
  16. Leszek, J.; Ashraf, G.M.; Tse, W.H.; Zhang, J.; Gasiorowski, K.; Avila-Rodriguez, M.F.; Tarasov, V.V.; Barreto, G.E.; Klochkov, S.G.; Bachurin, S.O.; et al. Nanotechnology for Alzheimer Disease. Curr. Alzheimer Res. 2017, 14, 1182–1189.
  17. Aliev, G.; Li, Y.; Palacios, H.H.; Obrenovich, M.E. Oxidative Stress Induced Mitochondrial DNA Deletion as a Hallmark forthe Drug Development in the Context of the Cerebrovascular Diseases. Recent Pat. Cardiovasc. Drug Discov. 2011, 6, 222–241.
  18. Leszek, J.; Mikhaylenko, E.V.; Belousov, D.M.; Koutsouraki, E.; Szczechowiak, K.; Kobusiak-Prokopowicz, M.; Mysiak, A.; Diniz, B.S.; Somasundaram, S.G.; Kirkland, C.E.; et al. The Links between Cardiovascular Diseases and Alzheimer’s Disease. Curr. Neuropharmacol. 2020, 19, 152–169.
  19. Viswanadha, V.P.; Dhivya, V.; Somasundaram, B.; Beeraka, N.M.; Huang, C.-Y.; Mikhaleva, L.M.; Achkasov, E.; Bondarev, S.; Gridin, L.; Nikolenko, V.N.; et al. The Role of Mitochondria in Piperine Mediated Cardioprotection in Isoproterenol Induced Myocardial Ischemia. Curr. Pharm. Des. 2020, 26, 1–17.
  20. Gasiorowski, K.; Brokos, B.; Leszek, J.; Tapacob, B.B.; Ashraf, G.M.; Aliev, G. Insulin Resistance in Alzheimer Disease: p53 and MicroRNAs as Important Players. Curr. Top. Med. Chem. 2017, 17, 1429–1437.
  21. Brzecka, A.; Madetko, N.; Nikolenko, V.N.; Ashraf, G.M.; Ejma, M.; Leszek, J.; Daroszewski, C.; Sarul, K.; Mikhaleva, L.M.; Somasundaram, S.G.; et al. Sleep Disturbances and Cognitive Impairment in the Course of Type 2 Diabetes—Possible Link. Curr. Neuropharmacol 2020, 19, 78–91.
  22. Nunomura, A.; Perry, G.; Aliev, G.; Hirai, K.; Takeda, A.; Balraj, E.K.; Jones, P.K.; Ghanbari, H.; Wataya, T.; Shimohama, S.; et al. Oxidative Damage Is the Earliest Event in Alzheimer Disease. J. Neuropathol. Exp. Neurol. 2001, 60, 759–767.
  23. Castellani, R.; Hirai, K.; Aliev, G.; Drew, K.L.; Nunomura, A.; Takeda, A.; Cash, A.D.; Obrenovich, M.E.; Perry, G.; Smith, M.A. Role of mitochondrial dysfunction in Alzheimer’s disease. J. Neurosci. Res. 2002, 70, 357–360.
  24. Perry, G.; Nunomura, A.; Hirai, K.; Zhu, X.; Prez, M.; Avila, J.; Castellani, R.J.; Atwood, C.S.; Aliev, G.; Sayre, L.M.; et al. Is oxidative damage the fundamental pathogenic mechanism of Alzheimer’s and other neurodegenerative diseases? Free. Radic. Biol. Med. 2002, 33, 1475–1479.
  25. Echeverria, V.; Barreto, G.E.; Avila-Rodriguezc, M.; Tarasov, V.V.; Aliev, G.; Echeverria, V. Is VEGF a Key Target of Cotinine and Other Potential Therapies Against Alzheimer Disease? Curr. Alzheimer Res. 2017, 14, 1.
  26. Bachurin, S.O.; Gavrilova, S.I.; Samsonova, A.; Barreto, G.E.; Aliev, G. Mild cognitive impairment due to Alzheimer disease: Contemporary approaches to diagnostics and pharmacological intervention. Pharmacol. Res. 2018, 129, 216–226.
  27. Brzecka, A.; Leszek, J.; Ashraf, G.M.; Ejma, M.; Ávila-Rodriguez, M.F.; Yarla, N.S.; Tarasov, V.V.; Chubarev, V.N.; Samsonova, A.N.; Barreto, G.E.; et al. Sleep Disorders Associated with Alzheimer’s Disease: A Perspective. Front. Neurosci. 2018, 12, 330.
  28. Mendoza, C.; Barreto, G.E.; Iarkov, A.; Tarasov, V.V.; Aliev, G.; Echeverria, V. Cotinine: A Therapy for Memory Extinction in Post-traumatic Stress Disorder. Mol. Neurobiol. 2018, 55, 6700–6711.
  29. Volcho, K.P.; Laev, S.S.; Ashraf, G.M.; Aliev, G.; Salakhutdinov, N.F. Application of Monoterpenoids and their Derivatives for Treatment of Neurodegenerative Disorders. Curr. Med. Chem. 2019, 25, 5327–5346.
  30. Ashraf, G.M.; Tarasov, V.V.; Makhmutova, A.; Chubarev, V.N.; Avila-Rodriguez, M.; Bachurin, S.O.; Aliev, G. The Possibility of an Infectious Etiology of Alzheimer Disease. Mol. Neurobiol. 2019, 56, 4479–4491.
  31. Bachurin, S.O.; Makhaeva, G.F.; Shevtsova, E.F.; Boltneva, N.P.; Kovaleva, N.V.; Lushchekina, S.V.; Rudakova, E.V.; Dubova, L.G.; Vinogradova, D.V.; Sokolov, V.B.; et al. Conjugates of methylene blue with γ-carboline derivatives as new multifunctional agents for the treatment of neurodegenerative diseases. Sci. Rep. 2019, 9, 4873.
  32. Nikolenko, V.N.; Gridin, L.A.; Oganesyan, M.V.; Rizaeva, N.A.; Podolskiy, Y.S.; Kudryashova, V.A.; Kochurova, E.V.; Kostin, R.K.; Tyagunova, E.E.; Mikhaleva, L.M.; et al. The Posterior Perforated Substance: A Brain Mystery Wrapped in an Enigma. Curr. Top. Med. Chem. 2020, 19, 2991–2998.
  33. Aliev, G.; Priyadarshini, M.; Reddy, V.P.; Grieg, N.; Kaminsky, Y.; Cacabelos, R.; Ashraf, G.M.; Jabir, N.; Kamal, M.A.; Nikolenko, V.; et al. Oxidative Stress Mediated Mitochondrial and Vascular Lesions as Markers in the Pathogenesis of Alzheimer Disease. Curr. Med. Chem. 2014, 21, 2208–2217.
  34. Kirichenko, T.V.; Sukhorukov, V.N.; Markin, A.M.; Nikiforov, N.G.; Liu, P.-Y.; Sobenin, I.A.; Tarasov, V.V.; Orekhov, A.N.; Aliev, G. Medicinal Plants as a Potential and Successful Treatment Option in the Context of Atherosclerosis. Front. Pharmacol. 2020, 11, 403.
  35. Aliev, G.; Seyidova, D.; Lamb, B.T.; Obrenovich, M.E.; Siedlak, S.L.; Vinters, H.V.; Friedland, R.P.; Lamanna, J.C.; Smith, M.A.; Perry, G. Mitochondria and vascular lesions as a central target for the development of Alzheimer’s disease and Alzheimer disease-like pathology in transgenic mice. Neurol. Res. 2003, 25, 665–674.
  36. De La Torre, J.C.; Aliev, G. Inhibition of Vascular Nitric Oxide after Rat Chronic Brain Hypoperfusion: Spatial Memory and Immunocytochemical Changes. Br. J. Pharmacol. 2005, 25, 663–672.
  37. Aliyev, A.; Chen, S.G.; Seyidova, D.; Smith, M.A.; Perry, G.; De La Torre, J.; Aliev, G. Mitochondria DNA deletions in atherosclerotic hypoperfused brain microvessels as a primary target for the development of Alzheimer’s disease. J. Neurol. Sci. 2005, 229-230, 285–292.
  38. Bulygin, K.V.; Beeraka, N.M.; Saitgareeva, A.R.; Nikolenko, V.N.; Gareev, I.; Beylerli, O.; Akhmadeeva, L.R.; Mikhaleva, L.M.; Solis, L.F.T.; Herrera, A.S.; et al. Can miRNAs Be Considered as Diagnostic and Therapeutic Molecules in Ischemic Stroke Pathogenesis?—Current Status. Int. J. Mol. Sci. 2020, 21, 6728.
  39. Hirai, K.; Aliev, G.; Nunomura, A.; Fujioka, H.; Russell, R.L.; Atwood, C.S.; Johnson, A.B.; Kress, Y.; Vinters, H.V.; Tabaton, M.; et al. Mitochondrial Abnormalities in Alzheimer’s Disease. J. Neurosci. 2001, 21, 3017–3023.
  40. Kosenko, E.A.; Tikhonova, L.A.; Montoliu, C.; Barreto, G.E.; Aliev, G.; Kaminsky, Y.G. Metabolic Abnormalities of Erythrocytes as a Risk Factor for Alzheimer’s Disease. Front. Neurosci. 2018, 11, 728.
  41. Moreira, P.I.; Nunomura, A.; Nakamura, M.; Takeda, A.; Shenk, J.C.; Aliev, G.; Smith, M.A.; Perry, G. Nucleic acid oxidation in Alzheimer disease. Free Radic. Biol. Med. 2008, 44, 1493–1505.
  42. Moreira, P.; Honda, K.; Liu, Q.; Santos, M.S.; Oliveira, C.; Aliev, G.; Nunomura, A.; Zhu, X.; Smith, M.; Perry, G. Oxidative Stress: The Old Enemy in Alzheimers Disease Pathophysiology. Curr. Alzheimer Res. 2005, 2, 403–408.
  43. Belousov, D.M.; Mikhaylenko, E.V.; Somasundaram, S.G.; Kirkland, C.E.; Aliev, G. The Dawn of Mitophagy: What Do We Know by Now? Curr. Neuropharmacol. 2020, 19, 170–192.
  44. Aliev, G.; Smith, M.A.; Seyidova, D.; Neal, M.L.; Lamb, B.T.; Nunomura, A.; Gasimov, E.K.; Vinters, H.V.; Perry, G.; Lamanna, J.C.; et al. The Role of Oxidative Stress in the Pathophysiology of Cerebrovascular Lesions in Alzheimer’s Disease. Brain Pathol. 2006, 12, 21–35.
  45. Zhu, X.; Raina, A.K.; Rottkamp, C.A.; Aliev, G.; Perry, G.; Boux, H.; Smith, M.A. Activation and redistribution of c-Jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer’s disease. J. Neurochem. 2001, 76, 435–441.
  46. Aliev, G.; Smith, M.A.; Obrenovich, M.E.; De La Torre, J.C.; Perry, G. Role of vascular hypoperfusion-induced oxidative stress and mitochondria failure in the pathogenesis of Alzheimer disease. Neurotox. Res. 2003, 5, 491–504.
  47. Beeraka, N.M.; Sadhu, S.P.; Madhunapantula, S.V.; Pragada, R.R.; Svistunov, A.A.; Nikolenko, V.N.; Mikhaleva, L.M.; Aliev, G. Strategies for Targeting SARS CoV-2: Small Molecule Inhibitors—The Current Status. Front. Immunol. 2020, 11.
  48. Chen, K.; Lu, P.; Beeraka, N.M.; Sukocheva, O.A.; Madhunapantula, S.V.; Liu, J.; Sinelnikov, M.Y.; Nikolenko, V.N.; Bulygin, K.V.; Mikhaleva, L.M.; et al. Mitochondrial mutations and mitoepigenetics: Focus on regulation of oxidative stress-induced responses in breast cancers. Semin. Cancer Biol. 2020.
  49. Beeraka, N.M.; Doreswamy, S.H.; Sadhu, S.P.; Srinivasan, A.; Pragada, R.R.; Madhunapantula, S.V.; Aliev, G. The Role of Exosomes in Stemness and Neurodegenerative Diseases—Chemoresistant-Cancer Therapeutics and Phytochemicals. Int. J. Mol. Sci. 2020, 21, 6818.
  50. Aliev, G.; Shi, J.; Perry, G.; Friedland, R.P.; Lamanna, J.C. Decreased constitutive nitric oxide synthase, but increased inducible nitric oxide synthase and endothelin-1 immunoreactivity in aortic endothelial cells of Donryu rats on a cholesterol-enriched diet. Anat. Rec. Adv. Integr. Anat. Evol. Biol. 2000, 260, 16–25.
  51. Aliev, G.; Seyidov, D.; Neal, M.L.; Shi, J.; Vigan, T.; Hernandez, A.; Folco, G.; Soas, A.H.; Zimina, T.V.; A Smith, M.; et al. The effect of agonists and antagonists on the morphology of non-transformed human smooth muscle cell in vitro. J. Submicrosc. Cytol. Pathol. 2001, 33, 141–149.
  52. Ashraf, G.M.; Ali, A.; Tabrez, S.; Zaidi, S.; Shakil, S.; Alam, M.; Rehan, M.; Aliev, G. Linkage of Stress with Neuromuscular Disorders. CNS Neurol. Disord.-Drug Targets 2016, 15, 1.
  53. Khan, T.; Hassan, I.; Ahmad, A.; Perveen, A.; Aman, S.; Quddusi, S.; Alhazza, I.; Ashraf, G.M.; Aliev, G. Recent updates on the dynamic association between oxidative stress and neurodegenerative disorders. CNS Neurol. Disord.-Drug Targets 2016, 15, 1.
  54. Nikolenko, V.N.; Oganesyan, M.V.; Vovkogon, A.D.; Nikitina, A.T.; Sozonova, E.A.; Kudryashova, V.A.; Rizaeva, N.A.; Cabezas, R.; Avila-Rodriguez, M.; Neganova, M.E.; et al. Current Understanding of Central Nervous System Drainage Systems: Implications in the Context of Neurodegenerative Diseases. Curr. Neuropharmacol. 2020, 18, 1054–1063.
  55. Martin-Jiménez, C.A.; García-Vega, Á.; Cabezas, R.; Aliev, G.; Echeverria, V.; González, J.; Barreto, G.E. Astrocytes and endoplasmic reticulum stress: A bridge between obesity and neurodegenerative diseases. Prog. Neurobiol. 2017, 158, 45–68.
  56. Baez-Jurado, E.; Hidalgo-Lanussa, O.; Guio-Vega, G.; Ashraf, G.M.; Echeverria, V.; Aliev, G.; Barreto, G.E. Conditioned Medium of Human Adipose Mesenchymal Stem Cells Increases Wound Closure and Protects Human Astrocytes Following Scratch Assay In Vitro. Mol. Neurobiol. 2017, 55, 5377–5392.
  57. Areiza-Mazo, N.; Robles, J.; Zamudio-Rodriguez, J.A.; Giraldez, L.; Echeverria, V.; Barrera-Bailon, B.; Aliev, G.; Sahebkar, A.; Ashraf, G.M.; Barreto, G.E. Extracts of Physalis peruviana Protect Astrocytic Cells Under Oxidative Stress With Rotenone. Front. Chem. 2018, 6, 276.
  58. Tarasov, V.V.; Svistunov, A.A.; Chubarev, V.N.; Sologova, S.S.; Mukhortova, P.; Levushkin, D.; Somasundaram, S.G.; Kirkland, C.E.; Bachurin, S.O.; Aliev, G. Alterations of Astrocytes in the Context of Schizophrenic Dementia. Front. Pharmacol. 2020, 10, 1612.
  59. Aliev, G.; A Smith, M.; Seyidova, D.; Neal, M.L.; Shi, J.; Loizidou, M.; Turmaine, M.; Friedland, R.P.; Taylor, I.; Burnstock, G.; et al. Increased expression of NOS and ET-1 immunoreactivity in human colorectal metastatic liver tumours is associated with selective depression of constitutive NOS immunoreactivity in vessel endothelium. J. Submicrosc. Cytol. Pathol. 2002, 34, 37–50.
  60. Sukocheva, O.A.; Lukina, E.; Friedemann, M.; Menschikowski, M.; Hagelgans, A.; Aliev, G. The crucial role of epigenetic regulation in breast cancer anti-estrogen resistance: Current findings and future perspectives. Semin. Cancer Biol. 2020.
  61. Chrishtop, V.V.; Tomilova, I.K.; Rumyantseva, T.A.; Mikhaylenko, E.V.; Avila-Rodriguez, M.F.; Mikhaleva, L.M.; Nikolenko, V.N.; Somasundaram, S.G.; Kirkland, C.E.; Bachurin, S.O.; et al. The Effect of Short-Term Physical Activity on the Oxidative Stress in Rats with Different Stress Resistance Profiles in Cerebral Hypoperfusion. Mol. Neurobiol. 2020, 57, 3014–3026.
  62. Gilyazova, I.R.; Beeraka, N.M.; Klimentova, E.A.; Bulygin, K.V.; Nikolenko, V.N.; Izmailov, A.A.; Gilyazova, G.R.; Pavlov, V.N.; Khusnutdinova, E.K.; Somasundaram, S.G.; et al. Novel MicroRNA Binding Site SNPs and the Risk of Clear Cell Renal Cell Carcinoma (ccRCC): A Case-Control Study. Curr. Cancer Drug Targets 2020, 20, 1–12.
  63. Beilerli, A.; Gareev, I.; Beylerli, O.; Yang, G.; Pavlov, V.; Aliev, G.; Ahmad, A. Circular RNAs as biomarkers and therapeutic targets in cancer. Semin. Cancer Biol. 2021.
  64. Aliev, G.; Ashraf, G.M.; Tarasov, V.V.; Chubarev, V.N.; Leszek, J.; Gasiorowski, K.; Makhmutova, A.; Baeesa, S.S.; Avila-Rodriguez, M.; Ustyugov, A.A.; et al. Alzheimer’s Disease—Future Therapy Based on Dendrimers. Curr. Neuropharmacol. 2019, 17, 288–294.
  65. Klochkov, S.G.; Neganova, M.E.; Nikolenko, V.N.; Chen, K.; Somasundaram, S.G.; Kirkland, C.E.; Aliev, G. Implications of nanotechnology for the treatment of cancer: Recent advances. Semin. Cancer Biol. 2021, 69, 190–199.
  66. Cash, A.D.; Aliev, G.; Siedlak, S.L.; Nunomura, A.; Fujioka, H.; Zhu, X.; Raina, A.K.; Vinters, H.V.; Tabaton, M.; Johnson, A.B.; et al. Microtubule Reduction in Alzheimer’s Disease and Aging Is Independent of τ Filament Formation. Am. J. Pathol. 2003, 162, 1623–1627.
  67. Zhu, X.; Smith, M.A.; Honda, K.; Aliev, G.; Moreira, P.I.; Nunomura, A.; Casadesus, G.; Harris, P.L.; Siedlak, S.L.; Perry, G. Vascular oxidative stress in Alzheimer disease. J. Neurol. Sci. 2007, 257, 240–246.
  68. Klionsky, D.J.; Abdalla, F.C.; Abeliovich, H.; Abraham, R.T.; Acevedo-Arozena, A.; Adeli, K.; Agholme, L.; Agnello, M.; Agostinis, P.; Aguirre-Ghiso, J.A.; et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012, 8, 445–544.
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Gjumrakch Aliev
Name: Gjumrakch Aliev
Born: Sep 1958
Died: Dec 2020
Birth
Location: Unknown
Title: Scientist
Affiliation: University of Atlanta, USA
Honor: Unknown
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Subjects: Biochemistry & Molecular Biology
Contributors MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register :
Vladimir N. Chubarev
,
Narasimha M. Beeraka
,
Mikhail Y. Sinelnikov
,
Kirill V. Bulygin
,
Vladimir N. Nikolenko
,
Elizaveta Mihaylenko
,
Vadim V. Tarasov
,
Liudmila M. Mikhaleva
,
Palmiro Poltronieri
,
Vijaya Padma Viswanadha
,
Siva G. Somasundaram
,
Cecil E. Kirkland
,
Kuo Chen
,
Junqi Liu
,
Ruitai Fan
,
Mohammad Amjad Kamal
,
Alexander A. Mironov
,
SubbaRao V. Madhunapantula
,
Etheresia Pretorius
,
Sergey V. Dindyaev
,
Cristian Muresanu
,
Olga A. Sukocheva
View Times: 496
Entry Collection: Neurodegeneration
Revisions: 2 times (View History)
Update Date: 08 Oct 2022
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