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HandWiki. Neurotensin. Encyclopedia. Available online: https://encyclopedia.pub/entry/28034 (accessed on 26 September 2026).
HandWiki. Neurotensin. Encyclopedia. Available at: https://encyclopedia.pub/entry/28034. Accessed September 26, 2026.
HandWiki. "Neurotensin" Encyclopedia, https://encyclopedia.pub/entry/28034 (accessed September 26, 2026).
HandWiki. (2022, September 29). Neurotensin. In Encyclopedia. https://encyclopedia.pub/entry/28034
HandWiki. "Neurotensin." Encyclopedia. Web. 29 September, 2022.
Neurotensin
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The content is sourced from: https://handwiki.org/wiki/Chemistry:Neurotensin

Neurotensin is a 13 amino acid neuropeptide that is implicated in the regulation of luteinizing hormone and prolactin release and has significant interaction with the dopaminergic system. Neurotensin was first isolated from extracts of bovine hypothalamus based on its ability to cause a visible vasodilation in the exposed cutaneous regions of anesthetized rats. Neurotensin is distributed throughout the central nervous system, with highest levels in the hypothalamus, amygdala and nucleus accumbens. It induces a variety of effects, including analgesia, hypothermia and increased locomotor activity. It is also involved in regulation of dopamine pathways. In the periphery, neurotensin is found in enteroendocrine cells of the small intestine, where it leads to secretion and smooth muscle contraction.

prolactin hypothalamus enteroendocrine cells

References

  1. "The amino acid sequence of a hypothalamic peptide, neurotensin". J. Biol. Chem. 250 (5): 1907–11. 1975. doi:10.1016/S0021-9258(19)41780-8. PMID 1167549. http://www.jbc.org/cgi/content/abstract/250/5/1907. 
  2. "Cloning and sequence analysis of cDNA for the canine neurotensin/neuromedin N precursor". Proc. Natl. Acad. Sci. U.S.A. 84 (10): 3516–20. 1987. doi:10.1073/pnas.84.10.3516. PMID 3472221. Bibcode: 1987PNAS...84.3516D.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=304902
  3. "The rat gene encoding neurotensin and neuromedin N. Structure, tissue-specific expression, and evolution of exon sequences". J. Biol. Chem. 263 (10): 4963–8. 1988. doi:10.1016/S0021-9258(18)68881-7. PMID 2832414. http://www.jbc.org/cgi/content/abstract/263/10/4963. 
  4. "Curcumin inhibits neurotensin-mediated interleukin-8 production and migration of HCT116 human colon cancer cells". Clin. Cancer Res. 12 (18): 5346–55. September 2006. doi:10.1158/1078-0432.CCR-06-0968. PMID 17000667.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2613866
  5. Kinkead, B, Dobner PR, Egnatashvili, V, Murray, T, Deitemeyer, N, Nemeroff, CB (2005). "Neurotensin-deficient mice have deficits in prepulse inhibition: restoration by clozapine but no haloperidol, olanzapine, or quetiapine". J. Pharmacol. Exp. Ther. 315 (1): 256–264. doi:10.1124/jpet.105.087437. PMID 15987829. http://jpet.aspetjournals.org/cgi/content/abstract/315/1/256. 
  6. Dobner, PR, Fadel, J, Deitemeyer, N, Carraway, RE, Deutch, AY (2001). "Neurotensin-deficient mice show altered responses to antipsychotic drugs". Proc. Natl. Acad. Sci. USA 98 (14): 8048–8053. doi:10.1073/pnas.141042198. PMID 11427716. Bibcode: 2001PNAS...98.8048D.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=35465
  7. "Neurotensin-induced hypothermia improves neurologic outcome after hypoxic-ischemia". Crit. Care Med. 32 (3): 806–10. March 2004. doi:10.1097/01.CCM.0000114998.00860.FD. PMID 15090966.  https://dx.doi.org/10.1097%2F01.CCM.0000114998.00860.FD
  8. Watters, Jyoti J.; Dorsa, Daniel M. (1998-09-01). "Transcriptional Effects of Estrogen on Neuronal Neurotensin Gene Expression Involve cAMP/Protein Kinase A-Dependent Signaling Mechanisms" (in en). Journal of Neuroscience 18 (17): 6672–6680. doi:10.1523/JNEUROSCI.18-17-06672.1998. ISSN 0270-6474. PMID 9712639.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=6792960
  9. Smith, Matthew J.; Wise, Phyllis M. (2001-07-01). "Neurotensin Gene Expression Increases during Proestrus in the Rostral Medial Preoptic Nucleus: Potential for Direct Communication with Gonadotropin-Releasing Hormone Neurons*". Endocrinology 142 (7): 3006–3013. doi:10.1210/endo.142.7.8256. ISSN 0013-7227. PMID 11416022.  https://dx.doi.org/10.1210%2Fendo.142.7.8256
  10. Driessen, Terri M.; Zhao, Changjiu; Whittlinger, Anna; Williams, Horecia; Gammie, Stephen C. (2014-01-08). "Endogenous CNS Expression of Neurotensin and Neurotensin Receptors Is Altered during the Postpartum Period in Outbred Mice" (in en). PLOS ONE 9 (1): e83098. doi:10.1371/journal.pone.0083098. ISSN 1932-6203. PMID 24416154.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3885409
  11. McHenry, Jenna A.; Otis, James M.; Rossi, Mark A.; Robinson, J. Elliott; Kosyk, Oksana; Miller, Noah W.; McElligott, Zoe A.; Budygin, Evgeny A. et al. (March 2017). "Hormonal gain control of a medial preoptic area social reward circuit" (in en). Nature Neuroscience 20 (3): 449–458. doi:10.1038/nn.4487. ISSN 1546-1726. PMID 28135243.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5735833
  12. Merullo, Devin P.; Asogwa, Chinweike N.; Sanchez‐Valpuesta, Miguel; Hayase, Shin; Pattnaik, Bikash R.; Wada, Kazuhiro; Riters, Lauren V. (2018). "Neurotensin and neurotensin receptor 1 mRNA expression in song-control regions changes during development in male zebra finches" (in en). Developmental Neurobiology 78 (7): 671–686. doi:10.1002/dneu.22589. ISSN 1932-846X. PMID 29569407.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=6023781
  13. Kim, Ji Tae; Weiss, Heidi L.; Evers, B. Mark (2017-06-01). "Diverse expression patterns and tumorigenic role of neurotensin signaling components in colorectal cancer cells". International Journal of Oncology 50 (6): 2200–2206. doi:10.3892/ijo.2017.3990. ISSN 1019-6439. PMID 28498396.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5435327
  14. Rodríguez, Yurena; Almeida, Teresa A.; Valladares, Francisco; Báez, Delia; Montes de Oca, Francisco; García, Candelaria; Dorta, Idaira; Hernández, Mariano et al. (2010-10-01). "Neurotensin and Neurotensin Receptor 1 Expression in Human Myometrium and Uterine Leiomyomas1". Biology of Reproduction 83 (4): 641–647. doi:10.1095/biolreprod.110.084962. ISSN 0006-3363. PMID 20592307.  https://dx.doi.org/10.1095%2Fbiolreprod.110.084962
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