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HandWiki. SLC7A11. Encyclopedia. Available online: https://encyclopedia.pub/entry/27777 (accessed on 22 September 2026).
HandWiki. SLC7A11. Encyclopedia. Available at: https://encyclopedia.pub/entry/27777. Accessed September 22, 2026.
HandWiki. "SLC7A11" Encyclopedia, https://encyclopedia.pub/entry/27777 (accessed September 22, 2026).
HandWiki. (2022, September 28). SLC7A11. In Encyclopedia. https://encyclopedia.pub/entry/27777
HandWiki. "SLC7A11." Encyclopedia. Web. 28 September, 2022.
SLC7A11
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The content is sourced from: https://handwiki.org/wiki/Biology:SLC7A11

An Error has occurred retrieving Wikidata item for infobox Cystine/glutamate transporter is an antiporter that in humans is encoded by the SLC7A11 gene. The SLC7A11 gene codes for a sodium-independent cystine-glutamate antiporter that is chloride dependent, known as system Xc- or xCT. It regulates synaptic activity by stimulating extrasynaptic receptors and performs nonvesicular glutamate release. This gene is highly expressed by astrocytes and couples the uptake of one molecule of cystine with the release of one molecule of glutamate. The dimer cystine gets taken up by glial cells and the monomer of cystine, cysteine, is taken up by neurons. The expression of Xc- was detected throughout the brain with higher expression found in the basolateral amygdala and the prefrontal cortex. The inhibition of system Xc- has been found to alter a number of behaviors, which suggests that it plays a key role in excitatory signaling.

glial cells basolateral amygdala glutamate

References

  1. "Behavioral assessment of acute inhibition of system xc (-) in rats". Psychopharmacology 231 (24): 4637–47. December 2014. doi:10.1007/s00213-014-3612-4. PMID 24828877.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4474164
  2. "Regulation of xCT expression and system x (c) (-) function in neuronal cells". Amino Acids 42 (1): 171–9. January 2012. doi:10.1007/s00726-011-0862-x. PMID 21369940.  https://dx.doi.org/10.1007%2Fs00726-011-0862-x
  3. "The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities". Antioxidants & Redox Signaling 18 (5): 522–55. February 2013. doi:10.1089/ars.2011.4391. PMID 22667998.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3545354
  4. "System xc⁻ cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS". British Journal of Pharmacology 165 (1): 20–34. January 2012. doi:10.1111/j.1476-5381.2011.01480.x. PMID 21564084.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3252963
  5. "Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis". eLife 3: e02523. May 2014. doi:10.7554/eLife.02523. PMID 24844246.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4054777
  6. "Mechanisms of ferroptosis". Cellular and Molecular Life Sciences 73 (11–12): 2195–209. June 2016. doi:10.1007/s00018-016-2194-1. PMID 27048822.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4887533
  7. "Thinking outside the cleft to understand synaptic activity: contribution of the cystine-glutamate antiporter (System xc-) to normal and pathological glutamatergic signaling". Pharmacological Reviews 64 (3): 780–802. July 2012. doi:10.1124/pr.110.003889. PMID 22759795.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3400835
  8. "Decreased mRNA expression for the two subunits of system xc(-), SLC3A2 and SLC7A11, in WBC in patients with schizophrenia: Evidence in support of the hypo-glutamatergic hypothesis of schizophrenia". Journal of Psychiatric Research 72: 58–63. January 2016. doi:10.1016/j.jpsychires.2015.10.007. PMID 26540405.  https://dx.doi.org/10.1016%2Fj.jpsychires.2015.10.007
  9. "Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways". Nature Neuroscience 5 (5): 405–14. May 2002. doi:10.1038/nn835. PMID 11953750.  https://dx.doi.org/10.1038%2Fnn835
  10. "Therapeutic targeting of the pathological triad of extrasynaptic NMDA receptor signaling in neurodegenerations". The Journal of Experimental Medicine 214 (3): 569–578. March 2017. doi:10.1084/jem.20161673. PMID 28209726.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5339681
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