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Khan, A.; Khan, M.; , .; Xiao, J.; Chen, T.; Liu, S.; Wang, Y.; Cao, Z. Selenium/Vitamins E/B9 in Bovine Mastitis during Periparturient Period. Encyclopedia. Available online: https://encyclopedia.pub/entry/22900 (accessed on 21 December 2024).
Khan A, Khan M,  , Xiao J, Chen T, Liu S, et al. Selenium/Vitamins E/B9 in Bovine Mastitis during Periparturient Period. Encyclopedia. Available at: https://encyclopedia.pub/entry/22900. Accessed December 21, 2024.
Khan, Adnan, Muhammad Khan,  , Jianxin Xiao, Tianyu Chen, Shuai Liu, Yajing Wang, Zhijun Cao. "Selenium/Vitamins E/B9 in Bovine Mastitis during Periparturient Period" Encyclopedia, https://encyclopedia.pub/entry/22900 (accessed December 21, 2024).
Khan, A., Khan, M., , ., Xiao, J., Chen, T., Liu, S., Wang, Y., & Cao, Z. (2022, May 13). Selenium/Vitamins E/B9 in Bovine Mastitis during Periparturient Period. In Encyclopedia. https://encyclopedia.pub/entry/22900
Khan, Adnan, et al. "Selenium/Vitamins E/B9 in Bovine Mastitis during Periparturient Period." Encyclopedia. Web. 13 May, 2022.
Selenium/Vitamins E/B9 in Bovine Mastitis during Periparturient Period
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This entry is adapted from the peer-reviewed paper 10.3390/antiox11040657

Mastitis (inflammation of the mammary gland) commonly occurs in dairy cattle during the periparturient period (transition period), in which dairy cattle experience physiological and hormonal changes and severe negative energy balance, followed by oxidative stress. The periparturient period in dairy cattle is critical and predisposes them to mastitis. Key factors leading to the susceptibility of dairy cattle to mastitis during the transition period are negative energy balance, followed by excessive lipid mobilization, oxidative stress, and consequent abnormal regulation of immunity and inflammation. Dairy cattle experience severe deficiency of some key nutrients (vitamin E, folic acid, and selenium) during the perinatal period, which predisposes them to mastitis. Vitamin (E and folic acid) and Se supplementation positively impact immunoregulation and relieve the oxidative and inflammatory status in dairy cattle during the periparturient phase. 

oxidative stress periparturient period bovine mastitis vitamins selenium

1. Introduction

The three weeks before and after calving are known as the periparturient period (transition period) in dairy cattle [1][2]. The periparturient period is characterized by negative energy balance, low dry matter intake, metabolic stress [3], physiological and hormonal changes, increased oxidative stress, immune suppression, and abnormal regulation of inflammation in dairy cattle [4][5][6]. During the transition period, excessive lipid mobilization, physiological changes, oxidative stress, inflammation, and immune dysfunction are key biological function processes that expose dairy cattle to various economic diseases, including mastitis [7][8][9][10].
Dry matter intake and energy demands decrease to maintain successful lactation in dairy cattle. Moreover, more oxygen utilization is required for cellular respiration, leading to oxidative stress [11][12][13]. In addition to fulfilling energy requirements, dairy cattle utilize the fat of their adipose tissues. Excessive fat mobilization may lead to overproduction of reactive oxygen species (ROS) and reactive nitrogen species (RNS) [14]. High concentrations of nonesterified fatty acids (NEFA) [15] and β-hydroxybutyric acid (BHB) are among the critical factors that also provoke ROS overproduction [16]. In addition, a high body condition score (BCS) (body condition score > 3.5/5) is another key factor in determining susceptibility to oxidative stress (OS) during the periparturient phase in dairy cattle [17]. Consistently, it has been documented that excessive loss of BCS causes high concentrations of NEFA and overproduction of OS [18].
Se, vitamin E, and folic acid (B9) have been targeted to improve metabolism, relieve oxidative stress, and enhance the immunity and anti-inflammatory status of perinatal dairy cattle [19][20][21].

1.1. Oxidative Stress and Its Association with Mastitis in Periparturient Dairy Cattle

Oxidative stress is considered one of the primary variables during the periparturient period, which is associated with the susceptibility of dairy cattle to various diseases such as mammary edema and mastitis [12][13][16][22][23][24][25]. Increased oxidative stress compromises immunity and elevates the susceptibility of dairy cattle to mastitis during the perinatal phase [22][26]. Consistently, Aiken et al. reported that the expression of antioxidant-associated enzymes was significantly low in periparturient dairy cattle [23]. Guan et al. documented higher concentrations of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and a lower concentration of malondialdehyde (MDA) in periparturient cows with low SCC and vice versa [27], which is supported by other published studies [28][29]. OS is associated with abnormal regulation of immunity and inflammation before and after parturition, which has been proven in dairy cattle to coliform mastitis [30][31][32][33][34].

1.2. Metabolic Alternation and Its Association with Mastitis in Periparturient Dairy Cattle

Negative energy balance and physiological and metabolic changes aggravate immunosuppression in dairy cattle during the periparturient period [35][36]. High milk production stress, hormonal changes, pregnancy burden, and endocrine and metabolic changes may lead to NEB during the periparturient period in dairy cattle [37]. Negative energy balance triggers the increase in lipid fat mobilization, followed by elevation of NEFA and BHB levels, which promotes the abnormal production of ROS and results in oxidative stress in perinatal dairy cattle [27][28][29]. Higher levels of NEFA and BHB are associated with oxidative stress, which disrupts the immune system and enhances the inflammatory status, including lower expression of IL-10, increased blood neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), and higher levels of IL-6, TNF-α, and p-selectin glycoprotein ligand-1 (PSGL-1) in cattle with the high level of SCC [27]. Consequently, higher levels of NEFA and BHB also suppress bovine peripheral blood mononuclear cells (PBMCs), disrupt the function of polymorphonuclear leukocytes (PMNLs), and inhibit the production of interferon-γ, which exposes dairy cattle to mastitis during the periparturient period [38][39][40]. Consistently, other studies have also documented that a high concentration of NEFA may cause severe inhibition of interferon-gamma (IFN-γ) levels, which has antibacterial activity, thus increasing the chances of mammary infections in periparturient dairy cattle [15][19].

1.3. Association of Immune System Suppression and Increased Inflammatory Status with Mastitis in Periparturient Dairy Cattle

Hormonal, digestive, and immunological changes in periparturient dairy cattle interfere with immune function, causing immunosuppression and subsequent mastitis [41][42][43]. The periparturient period is regarded as an infection-prone period for dairy cattle due to immunosuppression [44][45]. Moreover, during the first week of lactation, the bactericidal ability of phagocytes and blood PMNLs is significantly reduced, which predisposes dairy cattle to mammary gland infections [46]. C

2. Role of Se and Vitamins E and B9 in Overcoming Oxidative Stress, Immune Suppression, Metabolic Imbalance, and Inflammatory Status Associated with Mastitis

2.1. Antioxidant Properties of Se and Their Role in Mastitis Alleviation in Periparturient Dairy Cattle

It has been reported that the reduction of hydrogen peroxide and lipid hydroperoxides is catalyzed by plasma glutathione peroxidase (GPx-3), which is a selenocysteine-containing extracellular antioxidant protein [47]. In addition, GPx plays a key role in the antioxidant defense system of dairy cattle [48]. Milk lactoserum has shown undefined antibacterial activity in Se-supplemented dairy cattle [49]. Although the exact mechanism for this antimicrobial activity remains unknown, an increased level of GSH-Px has been found in the blood of dairy cattle treated with Se [50][51]. To prevent oxidative stress, Se has been reported to regulate key antioxidant-associated genes (TOAX, GPX, CAT, SOD, and GSH) [52]. Consistently, a studies have experimentally proved that superoxide dismutase-1 (SOD1) and catalase (CAT) protect cells from oxidative damage induced by heat stress in bovine granulosa cells [53][54]. Due to its immunological and antioxidant properties, Se has been widely targeted in mastitis control research in dairy cattle.
Mastitis is more common in high-yielding periparturient dairy cattle due to oxidative stress, which promotes changes in the expression of genes associated with proinflammatory factors [23]. Miranda et al. [55] reported that low levels of Se and GPx activity promote oxidative stress in the mammary gland, which is associated with a decrease in mammary epithelial cell numbers. However, in mammary epithelial cells, a balanced level of Se lowers the concentration of hydrogen peroxide [55]. Thus, by lowering hydrogen peroxide levels in mammary epithelial cells, the oxidative status can be eased, resulting in a reduction in apoptotic cells.
Twelve out of twenty-five selenoproteins in animals have shown strong immunological and antioxidant ability [56][57], suggesting that they could be useful options in preventing mastitis in dairy cattle [58]. The level of Se in dairy cattle is associated with the sensitivity of the mammary gland to bacteria [59]. Ali-Vehmas et al. [60] have documented that Se treatment significantly enhances the antibacterial activity, and GSH-Px level of milk. Moreover, the SCC level and mastitis-causing bacteria such as Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), Streptococcus agalactiae, and Streptococcus uberis (S. uberis) growth were significantly reduced in response to Se treatment in the milk of dairy cattle [60]. Oxidative stress was restricted by enhancing the level of GSH-Px by selenium in dairy cattle [61][62]. Moreover, it has been documented that Se supplementation reduces the chances of udder infections in dairy cattle [61].

2.2. Role of Folic Acid (Vitamin B9) in Mastitis Alleviation of Periparturient Dairy Cattle

In recently published studies, it has been well studied that folic acid plays a key role in the metabolism [2], enhanced immunity, and antioxidant status of periparturient dairy cattle [19]. During the periparturient period, folic acid deficiency may compromise the immunity of dairy cattle [19]. With a key role in immunity and anti-inflammation, folic acid has been targeted in bovine mastitis alleviation in periparturient dairy cattle [63][64][65]. Folic acid supplementation by suppressing MAPK and NF-κB activation maintains the anti-inflammatory status and prevents mastitis [65]. Consistently, a study documented that folic acid supplementation (120 mg/500 kg body weight) for 21 days downregulated all genes associated with immune function and inflammation (PIM1, SOCS3, ATP12A, KIT, LPL NFKBIA, DUSP4, ZC3H12, ESPNL, TNFAIP3) [19] that were found to be upregulated in S. aureus-induced mastitis during the periparturient period in dairy cattle [66][67]. In addition, it found that folic acid supplementation significantly regulated glutathione metabolism signaling and its related genes (LAP3, GSR, G6PD, GSTA4, GCLC, GPX3, PGD, IDH1, GGT1, GPX7, MGST1, and MGST2) in periparturient dairy cattle [2]. Furthermore, it documented that folic acid could enhance the antioxidant ability of dairy cattle and improve their resistance to mammary gland infection during the periparturient period. Consistently, Mi et al. [68] recently proved experimentally that S. aureus induced mastitis in MAC-T cells by downregulating the expression of progenitor renewal associated noncoding RNA (PRANCR). However, in folic-acid-treated MAC-T cells, the expression was higher, showing that folic acid could be the best therapeutic agent in mastitis prevention [68]. Treatment with 5 μg/mL FA significantly reduced apoptosis in Mac-T cells and produced a strong defense against MRSA treatment by improving cytosolic DNA sensing and tight junction signaling [63][69]. They found the upregulation of ZBP1, IRF3, IRF7, and IFNAR2 within the cytosolic DNA-sensing pathway in FA-treated MAC-T cells. ZTP1 was reported to be associated with milk SCC [68] and also plays a key role in the activation of anti-pathogen mechanisms and inflammation [70][71].

2.3. Role of Vitamin E in Periparturient Dairy Cattle Mastitis Alleviation

Vitamin E, a fat-soluble vitamin, protects the cell membrane from the action of lipid peroxidation chain reaction [72][73]. Consistently, a study documented that the polyunsaturated fatty acids in cell membranes of immune cells made them vulnerable to the action of lipid peroxidation by ROS [72][74]. In brief, vitamin E neutralizes peroxyl radicals and prevents polyunsaturated fatty acid oxidation (PUFA). Peroxyl radicals react with α-tocopherol instead of lipid hydroperoxide in the presence of vitamin E, halting the chain reaction of peroxyl radical generation and preventing further oxidation of PUFAs in the membrane [75].
A considerable decrease in the level of vitamin E has been observed during the transition period in dairy cattle [76]. It has been reported that vitamin E supplementation enhances the anti-inflammatory ability, immunity, and antioxidative ability and reduces mammary infections during the perinatal period in dairy cows [77]. Vitamin E in combination with Se has shown more profitable outcomes in preventing intramammary infections, including mastitis, in dairy cattle [78][79]. Morgante and coauthors [79] also found that somatic cell counts in milk were considerably reduced in response to vitamin E and Se therapy, demonstrating their efficacy in preventing mastitis. Parenteral vitamin E (2100 mg) injections for two weeks before and on calving day have consistently been shown to reduce the incidence of mastitis in dairy cows [79]. 

References

  1. Drackley, J.K. Biology of dairy cows during the transition period: The final frontier. J. Dairy Sci. 1999, 82, 2259–2273.
  2. Khan, M.Z.; Liu, L.; Zhang, Z.; Khan, A.; Wang, D.; Mi, S.; Usman, T.; Liu, G.; Guo, G.; Li, X.; et al. Folic acid supplementation regulates milk production variables, metabolic associated genes and pathways in perinatal Holsteins. J. Anim. Physiol. Anim. Nutr. 2020, 104, 483–492.
  3. LeBlanc, S. Monitoring metabolic health of dairy cattle in the transition period. J. Reprod. Dev. 2010, 56, 29–35.
  4. Sordillo, L.M. Nutritional strategies to optimize dairy cattle immunity. J. Dairy Sci. 2016, 99, 4967–4982.
  5. Gärtner, T.; Gernand, E.; Gottschalk, J.; Donat, K. Relationships between body condition, body condition loss and serum metabolites during the transition period in primiparous and multiparous cows. J. Dairy Sci. 2019, 102, 9187–9199.
  6. Surai, P.F.; Kochish, I.I.; Fisinin, V.I.; Juniper, D.T. Revisiting oxidative stress and the use of organic Selenium in dairy cow nutrition. Animals 2019, 9, 462.
  7. Baumgard, L.H.; Collier, R.J.; Bauman, D.E. A 100-Year Review: Regulation of nutrient partitioning to support lactation. J. Dairy Sci. 2017, 100, 10353–10366.
  8. Sordillo, L.; Mavangira, V. The nexus between nutrient metabolism, oxidative stress and inflammation in transition cows. Anim. Prod. Sci. 2014, 54, 1204–1214.
  9. Contreras, G.A.; Sordillo, L.M. Lipid mobilization and inflammatory responses during the transition period of dairy cows. Comp. Immunol. Microbiol. Infect. Dis. 2011, 34, 281–289.
  10. Sordillo, L.M.; Raphael, W. Significance of metabolic stress, lipid mobilization, and inflammation on transition cow disorders. Vet. Clin. N. Am. Food Anim. Pract. 2013, 29, 267–278.
  11. Celi, P.; Gabai, G. Oxidant/Antioxidant Balance in Animal Nutrition and Health: The Role of Protein Oxidation. Front. Vet. Sci. 2015, 2, 48.
  12. Castillo, C.; Hernández, J.; Valverde, I.; Pereira, V.; Sotillo, J.; Alonso, M.L.; Benedito, J.L. Plasma malonaldehyde (MDA) and total antioxidant status (TAS) during lactation in dairy cows. Res. Vet. Sci. 2006, 80, 133–139.
  13. Castillo, C.; Hernandez, J.; Bravo, A.; Lopez-Alonso, M.; Pereira, V.; Benedito, J.L. Oxidative status during late pregnancy and early lactation in dairy cows. Vet. J. 2005, 169, 286–292.
  14. Contreras, G.A.; Strieder-Barboza, C.; Raphael, W. Adipose tissue lipolysis and remodeling during the transition period of dairy cows. J. Anim. Sci. Biotechnol. 2017, 8, 41.
  15. Ster, C.; Loiselle, M.C.; Lacasse, P. Effect of postcalving serum nonesterified fatty acids concentration on the functionality of bovine immune cells. J. Dairy Sci. 2012, 95, 708–717.
  16. Ospina, P.A.; McArt, J.; Overton, T.; Stokol, T.; Nydam, D. Using nonesterified fatty acids and β-hydroxybutyrate concentrations during the transition period for herd-level monitoring of increased risk of disease and decreased reproductive and milking performance. Vet. Clin. N. Am. Food Anim. Pract. 2013, 29, 387–412.
  17. Bernabucci, U.; Ronchi, B.; Lacetera, N.; Nardone, A. Influence of Body Condition Score on Relationship Between Metabolic Status and Oxidative Stress in Periparturient Dairy Cows. J. Dairy Sci. 2005, 88, 2017–2026.
  18. Hoedemaker, M.; Prange, D.; Gundelach, Y. Body condition change ante- and postpartum, health and reproductive per-formance in German Holstein cows. Reprod. Domest. Anim. 2010, 44, 167–173.
  19. Khan, M.Z.; Zhang, Z.; Liu, L.; Wang, D.; Mi, S.; Liu, X.; Liu, G.; Guo, G.; Li, X.; Wang, Y.; et al. Folic acid supplementation regulates key immunity-associated genes and pathways during the periparturient period in dairy cows. Asian-Australas. J. Anim. Sci. 2020, 33, 1507–1519.
  20. Khan, M.Z.; Khan, A.; Xiao, J.; Dou, J.; Liu, L.; Yu, Y. Overview of folic acid supplementation alone or in combination with vitamin B12 in dairy cattle during periparturient period. Metabolites 2020, 10, 263.
  21. Xiao, J.; Khan, M.Z.; Ma, Y.; Alugongo, G.M.; Ma, J.; Chen, T.; Khan, A.; Cao, Z. The Antioxidant Properties of Selenium and Vitamin E; Their Role in Periparturient Dairy Cattle Health Regulation. Antioxidants 2021, 10, 1555.
  22. Sordillo, L.M.; Aitken, S.L. Impact of oxidative stress on the health and immune function of dairy cattle. Vet. Immunol. Immunopathol. 2009, 128, 104–109.
  23. Aitken, S.L.; Karcher, E.L.; Rezamend, P.; Gandy, J.C.; VandeHaar, M.J.; Capuco, A.V.; Sorgidillo, L.M. Evaluation of an-tioxidant and proinflammatory gene expression in bovine mammary tissue during the periparturient period. J. Dairy Sci. 2009, 92, 589–598.
  24. Bouwstra, R.J.; Nielen, M.; Newbold, J.R.; Jansen, E.H.; Jelinek, H.F.; van Werven, T. Vitamin E supplementation during the dry period in dairy cattle. Part II: Oxidative stress following vitamin E supplementation may increase clinical mastitis incidence postpartum. J. Dairy Sci. 2010, 93, 5696–5706.
  25. Bouwstra, R.J.; Goselink, R.M.A.; Dobbelaar, P.; Nielen, M.; Newbold, J.R.; van Werven, T. The relationship between oxidative damage and vitamin E concentration in blood, milk, and liver tissue from vitamin E supplemented and nonsupplemented periparturient heifers. J. Dairy Sci. 2008, 91, 977–987.
  26. Sordillo, L.M. Factors affecting mammary gland immunity and mastitis susceptibility. Livest. Prod. Sci. 2005, 98, 89–99.
  27. Guan, R.W.; Wang, D.M.; Wang, B.B.; Jiang, L.Y.; Liu, J.X. Prognostic potential of pre-partum blood biochemical and immune variables for postpartum mastitis risk in dairy cows. BMC Vet. Res. 2020, 16, 136.
  28. Colakoglu, H.E.; Yazlik, M.O.; Kaya, U.; Colakoglu, E.C.; Kurt, S.; Oz, B.; Bayramoglu, R.; Vural, M.R.; Kuplul, S. MDA and GSH-Px activity in transition dairy cows under seasonal variations and their relationship with reproductive performance. J. Vet. Res. 2017, 61, 497–502.
  29. Turk, R.; Juretić, D.; Gereš, D.; Svetina, A.; Turk, N.; Flegar-Meštrić, Z. Influence of oxidative stress and metabolic adaptation on PON1 activity and MDA level in transition dairy cows. Anim. Reprod. Sci. 2008, 108, 98–106.
  30. Walker, C.C.; Brester, J.L.; Sordillo, L.M. Flunixin Meglumine Reduces Milk Isoprostane Concentrations in Holstein Dairy Cattle Suffering from Acute Coliform Mastitis. Antioxidants 2021, 10, 834.
  31. Mavangira, V.; Mangual, M.J.; Gandy, J.C.; Sordillo, L.M. 15-F2t-isoprostane concentrations and oxidant status in lactating dairy cattle with acute coliform mastitis. J. Vet. Intern. Med. 2016, 30, 339–347.
  32. Mavangira, V.; Kuhn, M.J.; Abuelo, A.; Morisseau, C.; Hammock, B.D.; Sordillo, L.M. Activity of sEH and oxidant status during systemic bovine coliform mastitis. Antioxidants 2021, 10, 812.
  33. Mavangira, V.; Gandy, J.C.; Zhang, C.; Ryman, V.E.; Jones, A.D.; Sordillo, L.M. Polyunsaturated fatty acids influence differential biosynthesis of oxylipids and other lipid mediators during bovine coliform mastitis. J. Dairy Sci. 2015, 98, 6202–6215.
  34. Sordillo, L.M. Symposium review: Oxylipids and the regulation of bovine mammary inflammatory responses. J. Dairy Sci. 2018, 101, 5629–5641.
  35. Dänicke, S.; Meyer, U.; Kersten, S.; Frahm, J. Animal models to study the impact of nutrition on the immune system of the transition cow. Res. Vet. Sci. 2018, 116, 15–27.
  36. Jacob, S.K.; Ramnath, V.; Philomina, P.T.; Raghunandhanan, K.V.; Kannan, A. Assessment of physiological stress in periparturient cows and neonatal calves. Indian J. Physiol. Pharmacol. 2001, 45, 233–238.
  37. Sammad, A.; Khan, M.Z.; Abbas, Z.; Hu, L.; Ullah, Q.; Wang, Y.; Zhu, H.; Wang, Y. Major Nutritional Metabolic Alterations Influencing the Reproductive System of Postpartum Dairy Cows. Metabolites 2022, 12, 60.
  38. Hammon, D.S.; Evjen, I.M.; Dhiman, T.R.; Goff, J.P.; Walters, J.L. Neutrophil function and energy status in Holstein cows with uterine health disorders. Vet. Immunol. Immunopathol. 2006, 113, 21–29.
  39. Bai, H.; Talukder, M.S.; Hiroki, K.; Tsukino, I.; Manabu, K.; Masashi, T. Evaluation of the immune status of peripheral blood monocytes from dairy cows during the periparturition period. J. Reprod. Dev. 2019, 65, 313–318.
  40. Lacetera, N.; Scalia, D.; Franci, O.; Bernabucci, U.; Ronchi, B.; Nardone, A. Effects of nonesterified fatty acids on lymphocyte function in dairy heifers. J. Dairy Sci. 2004, 87, 1012–1014.
  41. Gonzalez, M.; Yabuta, A.K.; Galindo, F. Behaviour and adrenal activity of first parturition and multiparous cows under a competitive situation. Appl. Anim. Behav. Sci. 2003, 83, 259–266.
  42. Meglia, G.E.; Johannisson, A.; Agenas, S.; Holtenius, K.; Waller, K.P. Effects of feeding intensity during the dry period on leukocyte and lymphocyte sub-populations, neutrophil function and health in periparturient dairy cows. Vet. J. 2005, 169, 376–384.
  43. Kulberg, S.; Storset, A.K.; Heringstad, B.; Larsen, H.J.S. Reduced levels of total leukocytes and neutrophils in Norwegian cattle selected for decreased mastitis incidence. J. Dairy Sci. 2002, 85, 3470–3475.
  44. Lacetera, N.; Scalia, D.; Bernabucci, U.; Ronchi, B.; Pirazzi, D.; Nardone, A. Lymphocyte functions in overconditioned cows around parturition. J. Dairy Sci. 2005, 88, 2010–2016.
  45. Mulligan, F.J.; Doherty, M.L. Production diseases of the transition cow. Vet. J. 2008, 176, 3–9.
  46. Nonnecke, B.J.; Kimura, K.; Goff, J.P.; Kehrli, M.E. Effects of the mammary gland on functional capacities of blood mononuclear leukocyte populations from periparturient cows 1. J. Dairy Sci. 2003, 86, 2359–2368.
  47. Ottaviano, F.G.; Tang, S.-S.; Handy, D.E.; Loscalzo, J. Regulation of the extracellular antioxidant selenoprotein plasma glutathione peroxidase (GPx-3) in mammalian cells. Mol. Cell. Biochem. 2009, 327, 111–126.
  48. Pilarczyk, B.; Jankowiak, D.; Tomza-Marciniak, A.; Pilarczyk, R.; Sablik, P.; Drozd, R.; Tylkowska, A.; Skólmowska, M. Selenium Concentration and Glutathione Peroxidase (GSH-Px) Activity in Serum of Cows at Different Stages of Lactation. Biol. Trace Elem. Res. 2012, 147, 91–96.
  49. Salman, S.; Khol-Parisini, A.; Schafft, H.; Lahrssen-Wiederholt, M.; Hulan, H.W.; Dinse, D.; Zentek, J. The role of dietary selenium in bovine mammary gland health and immune function. Anim. Health Res. Rev. 2009, 10, 21–34.
  50. Hall, J.A.; Bobe, G.; Vorachek, W.R.; Kasper, K.; Traber, M.G.; Mosher, W.D.; Pirelli, G.J.; Gamroth, M. Effect of su-pranutritional organic selenium supplementation on postpartum blood micronutrients, antioxidants, metabolites, and in-flammation biomarkers in selenium-replete dairy cows. Biol. Trace Elem. Res. 2014, 161, 272–287.
  51. Diyabalanage, S.; Dangolla, A.; Mallawa, C.; Rajapakse, S.; Chandrajith, R. Bioavailability of selenium (Se) in cattle pop-ulation in Sri Lanka based on qualitative determination of glutathione peroxidase (GSH-Px) activities. Environ. Geochem. Health. 2020, 42, 617–624.
  52. Ahmadi, K.; Roshan-Milani, S.; Asgharzadeh, F.; Pourjabali, M.; Fard, A.A. In Vitro and In Vivo Pretreatment with Selenium Mitigates Tetrahydrocannabinol-Induced Testicular Cell Apoptosis: The Role of AKT and p53 Pathways. Biol. Trace Elem. Res. 2021, 199, 2278–2287.
  53. Khan, A.; Khan, M.Z.; Dou, J.; Xu, H.; Liu, L.; Zhu, H.; Wang, Y. SOD1 Gene Silencing Promotes Apoptosis and Suppresses Proliferation of Heat-Stressed Bovine Granulosa Cells via Induction of Oxidative Stress. Vet. Sci. 2021, 8, 326.
  54. Khan, A.; Khan, M.Z.; Dou, J.; Umer, S.; Xu, H.; Sammad, A.; Zhu, H.B.; Wang, Y. RNAi-Mediated silencing of catalase gene promotes apoptosis and impairs proliferation of bovine granulosa cells under heat stress. Animals 2020, 10, 1060.
  55. Miranda, S.; Wang, Y.J.; Purdie, N.G.; Osborne, V.R.; Coomber, B.L.; Cant, J.P. Selenomethionine stimulates expression of glutathione peroxidase 1 and 3 and growth of bovine mammary epithelial cells in primary culture. J. Dairy Sci. 2009, 92, 2670–2683.
  56. Avery, J.; Hoffmann, P. Selenium, Selenoproteins, and immunity. Nutrients 2018, 10, 1203.
  57. Wang, N.; Tan, H.; Li, S.; Xu, Y.; Guo, W.; Feng, Y. Supplementation of micronutrient selenium in metabolic diseases: Its role as an antioxidant. Oxidative Med. Cell. Longev. 2017, 2017, 7478523.
  58. Jing, H.; Chen, Y.; Qiu, C.; Guo, M.Y. LncRNAs Transcriptome Analysis Revealed Potential Mechanisms of Selenium to Mastitis in Dairy Cows. Biol. Trace Elem. Res. 2022, 1–9.
  59. Wang, D.; Jia, D.; He, R.; Lian, S.; Wang, J.; Wu, R. Association Between Serum Selenium Level and Subclinical Mastitis in Dairy Cattle. Biol. Trace Elem. Res. 2021, 199, 1389–1396.
  60. Ali-Vehmas, T.; Vikerpuur, M.; Fang, W.; Sandholm, M. Giving selenium supplements to dairy cows strengthens the inflammatory response to intramammary infection and induces a growth-suppressing effect on mastitis pathogens in whey. J. Vet. Med. Ser. A 1997, 44, 559–571.
  61. Malbe, M.; Klaassen, E.; Kaartinen, L.; Attila, M.; Atroshi, F. Effects of oral selenium supplementation on mastitis markers and pathogens in Estonian cows. Vet. Ther. Res. Appl. Vet. Med. 2003, 4, 145–154.
  62. Malbe, M.; Attila, M.; Atroshi, F. Possible involvement of Selenium in Staphylococcus aureus inhibition in cow’s whey. J. Anim. Physiol. Anim. Nutr. 2006, 90, 159–164.
  63. Mi, S.; Tang, Y.; Shi, L.; Liu, X.; Si, J.; Yao, Y.; Augustino, S.M.A.; Fang, L.; Yu, Y. Protective Roles of Folic Acid in the Responses of Bovine Mammary Epithelial Cells to Different Virulent Staphylococcus aureus Strains. Biology 2021, 10, 1164.
  64. Miszewski, S.G.; Trott, J.F.; Berryhill, G.E.; Tat, L.; Green, R.; Borowsky, A.D.; Miller, J.W.; Hovey, R.C. Folate Deficiency Inhibits Development of the Mammary Gland and its Associated Lymphatics in FVB Mice. Ann. N. Y. Acad. Sci. 2016, 1372, 53–64.
  65. Feng, D.; Zhou, Y.; Xia, M.; Ma, J. Folic acid inhibits lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages by suppressing MAPKs and NF-κB activation. Inflamm. Res. 2011, 60, 817–822.
  66. Fang, L.; Hou, Y.; An, J.; Li, B.; Song, M.; Wang, X.; Sørensen, P.; Dong, Y.; Liu, C.; Wang, Y.; et al. Genome-wide transcriptional and post-transcriptional regulation of innate immune and defense responses of bovine mammary gland to Staphylococcus aureus. Front. Cell. Infect. Microbiol. 2016, 6, 193.
  67. Kosciuczuk, E.M.; Lisowski, P.; Jarczak, J.; Majewska, A.; Rzewuska, M.; Zwierzchowski, L.; Bagnicka, E. Transcriptome profiling of Staphylococci-infected cow mammary gland parenchyma. BMC Vet. Res. 2017, 13, 161.
  68. Mi, S.; Tang, Y.; Dari, G.; Shi, Y.; Zhang, J.; Zhang, H.; Liu, X.; Liu, Y.; Tahir, U.; Yu, Y. Transcriptome sequencing analysis for the identification of stable lncRNAs associated with bovine Staphylococcus aureus mastitis. J. Anim. Sci. Biotechnol. 2021, 12, 120.
  69. Bae, D.; Chon, J.-W.; Kim, D.-H.; Kim, H.; Seo, K.-H. Effect of folic acid supplementation on proliferation and apoptosis in bovine mammary epithelial (MAC-T) cells. Anim. Biotechnol. 2022, 33, 13–21.
  70. Momota, M.; Lelliott, P.; Kubo, A.; Kusakabe, T.; Kobiyama, K.; Kuroda, E.; Imai, Y.; Akira, S.; Coban, C.; Ishii, K.J. ZBP1 governs the inflammasome-independent IL-1α and neutrophil inflammation that play a dual role in anti-influenza virus im-munity. Int. Immunol. 2020, 32, 203–212.
  71. Lin, J.; Kumari, S.; Kim, C.; Van, T.M.; Wachsmuth, L.; Polykratis, A.; Pasparakis, M. RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation. Nat. Cell Biol. 2016, 540, 124–128.
  72. Sontag, T.J.; Parker, R.S. Influence of major structural features of tocopherols and tocotrienols on their ω-oxidation by tocopherol-ω-hydroxylase. J. Lipid Res. 2007, 48, 1090–1098.
  73. Kamal-Eldin, A.; Appelqvist, L.Å. The chemistry and antioxidant properties of tocopherols and tocotrienols. Lipids 1996, 31, 671–701.
  74. Yoshida, Y.; Niki, E.; Noguchi, N. Comparative study on the action of tocopherols and tocotrienols as antioxidant: Chemical and physical effects. Chem. Phys. Lipids. 2003, 123, 63–75.
  75. Lee, G.Y.; Han, S.N. The role of vitamin E in immunity. Nutrients 2018, 10, 1614.
  76. Haga, S.; Ishizaki, H.; Roh, S. The Physiological Roles of Vitamin E and Hypovitaminosis E in the Transition Period of High-Yielding Dairy Cows. Animals 2021, 11, 1088.
  77. Krueger, L.A.; Beitz, D.C.; Onda, K.; Osman, M.R.; O’Neil, M.; Lei, S.; Wattoo, F.H.; Stuart, R.L.; Tyler, H.D.; Nonnecke, B. Effects of d-α-tocopherol and dietary energy on growth and health of preruminant dairy calves. J. Dairy Sci. 2014, 97, 3715–3727.
  78. Bourne, N.; Wathes, D.C.; Lawrence, K.E.; McGowan, M.; Laven, R.A. The effect of parenteral supplementation of vitamin E with Selenium on the health and productivity of dairy cattle in the UK. Vet. J. 2008, 177, 381–387.
  79. Morgante, M.; Beghelli, D.; Pauselli, M.; Dall’Ara, P.; Capuccella, M.; Ranucci, S. Effect of Administration of Vitamin E and Selenium During the Dry Period on Mammary Health and Milk Cell Counts in Dairy Ewes. J. Dairy Sci. 1999, 82, 623–631.
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Subjects: Agriculture, Dairy & Animal Science
Contributors MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register :
Adnan Khan
,
Muhammad Khan
,
,
Jianxin Xiao
,
Tianyu Chen
,
shuai liu
,
Yajing Wang
,
Zhijun Cao
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Revisions: 2 times (View History)
Update Date: 16 May 2022
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