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Wu, T.; , .; Yunyun, Y.; Zhang, M. Phenolic Compounds in Mulberry. Encyclopedia. Available online: https://encyclopedia.pub/entry/22222 (accessed on 14 June 2024).
Wu T,  , Yunyun Y, Zhang M. Phenolic Compounds in Mulberry. Encyclopedia. Available at: https://encyclopedia.pub/entry/22222. Accessed June 14, 2024.
Wu, Tao, , Yang Yunyun, Min Zhang. "Phenolic Compounds in Mulberry" Encyclopedia, https://encyclopedia.pub/entry/22222 (accessed June 14, 2024).
Wu, T., , ., Yunyun, Y., & Zhang, M. (2022, April 25). Phenolic Compounds in Mulberry. In Encyclopedia. https://encyclopedia.pub/entry/22222
Wu, Tao, et al. "Phenolic Compounds in Mulberry." Encyclopedia. Web. 25 April, 2022.
Phenolic Compounds in Mulberry
Edit

Mulberry, which belongs to the genus Morus of the Moraceae family, is an aggregated berry that is oval-shaped, rich in nutrition, sweet and soft, with a unique flavor. Mulberry is distributed in east, west and southeast Asia, southern Europe, southern North America, northwestern South America and some areas of Africa. There are 24 species of Morus and one subspecies, with at least 100 known varieties.

mulberry composition

1. Introduction

Mulberry, which belongs to the genus Morus of the Moraceae family, is an aggregated berry that is oval-shaped, rich in nutrition, sweet and soft, with a unique flavor [1][2]. Mulberry is distributed in east, west and southeast Asia, southern Europe, southern North America, northwestern South America and some areas of Africa [3]. There are 24 species of Morus and one subspecies, with at least 100 known varieties [4]. Studies have shown that mulberry is beneficial for human health, which may be related to the compounds it contains, such as phenols, amino acids and sugars [5][6]. Since ancient times, mulberries have been used as fruits and herbs and have been listed by the Chinese Ministry of Health as one of the “food and medicine” agricultural products. The fruit is a high-quality natural raw material that is used for the production of modern food and diet regimens. It is commonly eaten, often dried, or processed into wine, syrups, canned food, fruit juice, jam and beverages [3][4][7][8][9][10]. The anthocyanin content in mulberry wine is much higher than that of red wine, and regular consumption can increase immunity.
There are many varieties of mulberry, with the most common species consisting of black mulberry (Morus nigra L.), white mulberry (Morus alba L.) and red mulberry (Morus rubra L.) [11]. Some studies have revealed that black mulberry has a higher content of total phenolics, total flavonoids, total anthocyanins and more antioxidant compounds than red mulberry or white mulberry [4][12][13]. Some authors point out that the nutrient and plant chemistry of mulberry are closely related to the area in which it was cultivated [14][15][16].

2. Composition of Mulberry

Mulberry is rich in nutrients, approximately 0.5–1.4% protein and about 7.8–9% carbohydrates [17]. Mulberry contains neutral sugars such as arabinose, galactose, glucose, rhamnose, xylose, mannose and also contains a large amount of uronic acid, namely in the form of galacturonic acid and glucuronic acid [18][19][20][21]. The most abundant amino acid in mulberry is glutamate, which accounts for approximately 20%, followed by glycine and aspartate [22]. It also contains lysine, leucine, isoleucine, histidine, threonine, tryptophan and glycine, among others. Among these amino acids, leucine, threonine, isoleucine, glycine, threonine, valine, tryptophan, arginine, aspartic acid and serine are found in a higher content in white mulberry when compared with black mulberry. In contrast, the content of lysine, histidine, and proline are higher in black mulberry and lower in white mulberry [23]. The fat content of mulberry is extremely low, and linoleic acid, oleic acid, palmitic acid and stearic acid make up 69.66–78.02% of the total fatty acids [24]. The vitamins in mulberry are mainly vitamin C, vitamin A and some B groups [16]. The organic acids of mulberry are succinic acid, acetic acid, malic acid, citric acid and tartaric acid [3]. The content of titrable acid is 0.20–2.65%, and the content in black mulberry is higher than that in white mulberry [4][23][25][26][27]. The minerals in mulberry are potassium, calcium, phosphorus, sodium, zinc, copper and selenium. Studies have shown that the content of potassium in black mulberry is much higher than that in other fruits [13]. Soluble solids mainly include sugar, acid, vitamins and minerals, and their content can directly affect the taste of fruits and vegetables. The total soluble solid content of mulberry is 6.2–25.8% [4][23][25][26].
Mulberry contains many phenolic compounds, and Table 1 contains the results of the determination of total phenol and total flavonoids from recent years. In addition to the above ingredients, mulberry also contains alkaloid compounds (quinine, 1-deoxynojirimycin) and α-glucosidase inhibitors [28][29][30]. Different varieties of mulberry possess different chemical compositions and nutritional statuses, which are related to the climate, topography and soil conditions [7].
Table 1. Total phenol and total flavonoid content in mulberry.
Element Mulberry Origin Concentration Reference
Total phenolic M. alba, M. Nigra, M. rubra Olur town, Erzurum, Turkey 181–1422 mg GAE/100g FW [4]
  M. nigra L. and M. alba L. Jinhua, Zhejiang, China 879–6585 mg GAE/kg FW [12]
  8 different varieties Orihuela (latitude 38°04′08″ N × longitude 0°58′58″ W, 27 m above sea level) Alicante (South-Eastern Spain) 6.98–13.59 mg GAE/g DW [13]
  M. alba L. Qinshui County, Shanxi
province in China
23.00 mg/g MFP [15]
  22 different varieties Quanxi town, Wuyi county of Zhejiang Province, China 199.45–2330.40 μg GAE/g FW [25]
  4 different varieties northern regions of Pakistan 880–1650 mg/100 g FW [27]
  M. alba L. Taichung, Taiwan 1515.9 mg GAE/100 g FM [31]
  different varieties   7.0–2392.0 mg GAE/100 g [32]
  Morus Microphylla Buckl Yangpyeong, Korea 24.01 mg/g DW [33]
  M. nigra L. Istanbul, Turkey 1451.4 mg GAE/100 g DW [34]
  M. alba L. Silk Innovation Center,
Mahasarakham University, Thailand
104.78–213.53 mg GAE/100 g DW [35]
  Morus alba L.,
Hongguo no.2
Shaanxi, China
(34°16′–56°24′ N, 108° 4′–27°95′ E)
524.06 mg/100 g DW [36]
  M. alba L. Suncheon City, Korea 11.2 mg FAE/kg DW [37]
  10 different varieties Yinchuan, Ningxia; Zaozhuang (Shandong); Jurong (Jiangsu); Guangzhou (Guangdong) 670–7700 mg GAE/kg FW [38]
  M. alba L. National Institute
of Agricultural Science and
Technology, Suwon, Korea
959.9–2570.4 μg GAE/g dried
extracts
[39]
  M. alba L. Hangzhou, China 547.60 mg GAE/g MAE [40]
  M. nigra L. Yesilyurt, Malatya
(38.321059, 38.217478)
192.67 mg GAE/g [41]
    Guangzhou, Guangdong, China 35.53% in the proportion of dry matter [42]
  M. alba L. Anji and Fuyang,
Zhejiang, China
11.67–690.83 mg GAE/g [43]
  Dried mulberry fruits juice (Morus sp.) Xinjiang, China 3.21 mg GAE/g [44]
  M. nigra L. Puerto Real region (Spain) 1301.67 μg/g FW [45]
  11 different varieties Zhejiang province, China 100.97–586.23 mg GAE/100 g FW [46]
  M. nigra L. Ordu, Turkey 2032.87 mg GAE/100 g DW [47]
  Mulberry fruit Sang-ju Silkworm Farming
Association, Sang-ju, Korea
5.16 mg/100 g [48]
  M. alba L. Jinhua, Zhejiang, China 185–344 mg 100/g FW [49]
  M. nigra and M. rubra Turkey 1005–3488 μg GAE/g FW [50]
  M. nigra L.   1375 mg GAE/100 g DW [51]
Total flavonoids M alba, M. nigra, M. rubra Olur town, Erzurum, Turkey 29–276 mg QE/100 g FW [4]
  M. nigra L. and M. alba L. Jinhua, Zhejiang, China 663–1292 mg QE/kg FW [12]
  M. alba L. Qinshui County, Shanxi, China 3.90 mg/g MFP [15]
  M. alba L. Taichung, Taiwan 250.1 mg QE/100 g FM [31]
  Morus alba L., Hongguo no.2 Shaanxi, China
(34°16′–56°24′ N, 108° 4′–27°95′ E)
463.62 mg/100 g DW [36]
  38 different varieties all around China 0.178–2.485 mg RE/g lyophilized mulberry fruit [52]
  M. alba L. National Institute of
Agricultural Science and
Technology, Suwon, Korea
5.6–65.4 μg/g DW [39]
  M. alba L. Hangzhou, China 893.73 mg RE/g mulberry anthocyanin extract [40]
  M. nigra L. Yesilyurt, Malatya
(38.321059, 38.217478)
125.86 mg QE/g [41]
    Guangzhou, Guangdong, China 7.53% in the proportion of dry matter [42]
  M. alba L. Anji and Fuyang,
Zhejiang, China
94.53–965.63 mg RE/g [43]
  ML juice Xinjiang, China 53.85 mg QE/g [44]
  11 different varieties Zhejiang province, China 16.38–368.16 mg RE/100g FW [46]
  Mulberry fruit Sang-ju Silkworm Farming
Association, Sang-ju, Korea
9.73 mg/100g [48]
  M. nigra L.   1473 mg RE/100g DW [51]
FW: fresh weight; DW: dry weight; MAE: mulberry anthocyanin extract; RE: rutin equivalents; GAE: gallic acid equivalents; FAE: ferulic acid equivalents; FM: fresh matter; QE: equivalent of quercetin; MFP: powder of mulberry (Morus alba L.) fruit (MFP).

3. Content of Phenolic Compounds

Polyphenols play an important role in promoting human health and are the most relevant family of phytochemicals [53].

3.1. Flavonoids

Among them, flavonoids constitute a very wide range of groups and are distributed in a variety of vegetables and fruits. They have a common basic structure: C6-C3-C6, which usually forms an oxygen-containing heterocycle. Flavonoids are usually associated with sugars (glycosides), and therefore, they tend to be water-soluble.

3.2. Anthocyanins

Mulberries are especially rich in flavonoids, specifically anthocyanin [4][31][32][54][55]. Anthocyanin is the main active ingredient and chromogenic substance of mulberry, which is why mulberry is considered to be an important source of anthocyanin in the diet [33]. Its anthocyanin content is high, pigment is stable, can dissolve completely in water and has increased bioactive activity; therefore, it becomes a fruit pigment that cannot be replaced. Mulberry is an optimal source for extracting anthocyanin from pine bark, pine needles and grape seeds. Therefore, together with sea buckthorn, it is listed as a functional health food with the international development of the third generation of “fruit resources”. The most abundant anthocyanin in mulberry is cyanidin-3-glucoside (C3G), representing 53.94–78.23% of the total anthocyanins; cyanidin-3-rutinoside (C3R) accounts for 19–43.83%, and pelargonidin-3-glucoside (P3G) is measured in a proportion close to 5% [34][56][57][58][59][60]. The content of mulberry anthocyanins is shown in Table 2; white varieties do not contain any anthocyanins [24][25]. The content of anthocyanin in mulberry is related to mulberry variety, maturity, climate, soil, pruning of mulberry trees, pest control and other factors [3][7][61].
Table 2. Anthocyanin in mulberry.
Mulberry Anthocyanin Origin C3G C3R Reference
4 different
varieties
184.3–227.0 mg/100g Van province     [3]
M. alba L.   Jinhua, Zhejiang, China 1698 mg/kg FW 693 mg/kg FW [12]
M. alba L. 0.01–1.88 mg/g DW Orihuela
(latitude 38°04′08″ N × longitude 0°58′58″ W, 27 m above sea level) Alicante (South-Eastern Spain)
0.004 –1.26 mg/g DW 0.004–0.08 mg/g DW [13]
M. alba L. 0.87 mg/g Qinshui County,
Shanxi, China
    [15]
22 different varieties 306.91–1422.11μg/g Quanxi town, Wuyi county of Zhejiang Province, China     [25]
Morus Microphylla Buckl. 2.3 mg/g DW Yangpyeong, Korea     [33]
different
varieties
  Zhejiang, China 1.25–3.35 g/kg 0.25–1.50 g/kg [56]
Morus nigra L.   Istanbul,
Turkey
1221 mg/100 g DW   [34]
41 different varieties 0.87–96.08 mg/g
lyophilized mulberry fruit
all around China 0.57–62.93 mg/g
lyophilized mulberry fruit
0.05–12.70 mg/g [52]
M. alba L. 137.3–2057.3 μg/g National
Institute of Agricultural Science and Technology, Suwon, Korea
93.2–1364.9 μg/g DW 30.6–486.7 μg/g DW [39]
M. alba L. 77.9% of the whole extract Hangzhou, China     [40]
M. alba L. 24.10–383.49 mg/g Anji and Fuyang, Zhejiang, China 19.30–272.00 mg/g DW   [43]
11 different varieties 4.20–121.56 mg catechin equivalents/100 g FW Zhejiang province, China     [46]
M. nigra L.   Ordu, Turkey 1572.41 mg/100 g DW   [47]
Mulberry fruits   Sang-ju Silkworm Farming Association, Sang-ju, Korea 97.68 mg/100 g 71.18 mg/100 g [48]
M. nigra L., M. rubra L. 3–830 μg/g Turkey     [50]
M. alba L. 669 mg/100g DW   371 mg/100g DW   [51]
M. alba L.   São Paulo city, Brazil 79% of
anthocyanin
19% of
anthocyanin
[62]
  0.19–3.29 mg/g       [63]
31 kinds
cultivated mulberry
juices
147.68–2725.46 mg/L Quanxi town, Wuyi county of Zhejiang Province, China     [64]
180 different varieties 0.035–2.192 mg/g Huzhou Academy of Agricultural Sciences,
China
    [65]
FW: fresh weight; DW: dry weight.

3.3. Phenolic Acids

Mulberries contain phenolic acids (chlorogenic acid, gallic acid, protocatechuic acid, p-coumaric acid, O-coumaric acid, ferulic acid, caffeic acid, and vanillic acid), rutin, quercetin and resveratrol [3][15][56][66][67]. The main phenolic acids in mulberry are hydroxycinnamic acid derivatives [25]. Gallic acid and protocatechuic acid are the main derivatives of hydroxybenzoic acid in black mulberry [35][66]. The content of phenolic acids in mulberry is 0.02952–0.17564 mg/g fw [68]. Chlorogenic acid is the main phenolic component in black mulberry, while ruin is the dominant phenolic in white and red mulberry [3]. Chlorogenic acid is the main acid in the sugarless extract of black and white mulberry [36]. Gundogdu et al. described the concentration range of chloric acid in mulberry as 0.119–3.106 mg/g fw [3]. Butkhup et al. found that its concentration in white mulberry was 0.01 to 0.06 mg/g dw [35], and the concentration range of chlorogenic acid in white mulberry and black mulberry was reported by Sanchez-Salcedo et al. as 0.15–0.97 mg/g dw and 0.35–3.18 mg/g dw [13], respectively. The amount of chlorogenic acid in black mulberry was higher than that in white mulberry. As mulberry matures, the amount of chlorogenic acid and its isomers gradually decreases [69]. Song et al. detected resveratrol in 38 mulberry varieties from China at 0.0021–0.0053 mg/g [52]. Chon et al. found a significant difference in the total phenol content measured by different solvents [37]. The content of total phenolic compounds in mulberry is shown in Table 1, with black mulberry containing a higher amount than white mulberry [12][38].

References

  1. He, Y.; Liu, G.; Xia, C.; Chen, J.; Zhao, J.; Li, X.; Deng, J.; Wang, X.; Xiang, Z.; Zeng, P. Laxative effect of mulberry ferment on two models of constipated mice. J. Funct. Foods 2022, 90, 104971.
  2. Sedjoah, R.-C.A.-A.; Ma, Y.; Xiong, M.; Yan, H. Fast monitoring total acids and total polyphenol contents in fermentation broth of mulberry vinegar using MEMS and optical fiber near-infrared spectrometers. Spectrochim. Acta A Mol. Biomol. Spectrosc. 2021, 260, 119938.
  3. Gundogdu, M.; Muradoglu, F.; Sensoy, R.I.G.; Yilmaz, H. Determination of fruit chemical properties of Morus nigra L., Morus alba L. and Morus rubra L. by HPLC. Sci. Hortic. 2011, 132, 37–41.
  4. Ercisli, S.; Orhan, E. Chemical composition of white (Morus alba), red (Morus rubra) and black (Morus nigra) mulberry fruits. Food Chem. 2007, 103, 1380–1384.
  5. Xu, X.; Huang, Y.; Xu, J.; He, X.; Wang, Y. Anti-neuroinflammatory and antioxidant phenols from mulberry fruit (Morus alba L.). J. Funct. Foods 2020, 68, 103914.
  6. Liu, Y.; Liu, Y.; Mu, D.; Yang, H.; Feng, Y.; Ji, R.; Wu, R.; Wu, J. Preparation, structural characterization and bioactivities of polysaccharides from mulberry (Mori Fructus). Food Biosci. 2022, 46, 101604.
  7. Huang, H.P.; Ou, T.T.; Wang, C.J. Mulberry (Sang Shèn Zǐ) and its Bioactive Compounds, the Chemoprevention Effects and Molecular Mechanisms In Vitro and In Vivo. J. Tradit. Chin. Med. 2013, 3, 7–15.
  8. Zhang, L.; Fan, G.; Khan, M.A.; Yan, Z.; Beta, T. Ultrasonic-assisted enzymatic extraction and identification of anthocyanin components from mulberry wine residues. Food Chem. 2020, 323, 126714.
  9. Mirzabe, A.H.; Hajiahmad, A. Filter press optimisation for black mulberry juice extraction. Biosyst. Eng. 2022, 215, 80–103.
  10. Tomas, M.; Toydemir, G.; Boyacioglu, D.; Hall, R.D.; Beekwilder, J.; Capanoglu, E. Processing black mulberry into jam: Effects on antioxidant potential and in vitro bioaccessibility. J. Sci. Food Agric. 2017, 97, 3106–3113.
  11. Ma, G.; Chai, X.; Hou, G.; Zhao, F.; Meng, Q. Phytochemistry, bioactivities and future prospects of mulberry leaves: A review. Food Chem. 2022, 372, 131335.
  12. Li, Y.; Bao, T.; Chen, W. Comparison of the protective effect of black and white mulberry against ethyl carbamate-induced cytotoxicity and oxidative damage. Food Chem. 2018, 243, 65–73.
  13. Sánchez-Salcedo, E.M.; Mena, P.; García-Viguera, C.; Martínez, J.J.; Hernández, F. Phytochemical evaluation of white (Morus alba L.) and black (Morus nigra L.) mulberry fruits, a starting point for the assessment of their beneficial properties. J. Funct. Foods 2015, 12, 399–408.
  14. Liang, D.; Yang, Q.; Tan, B.; Dong, X.; Chi, S.; Liu, H.; Zhang, S. Dietary vitamin A deficiency reduces growth performance, immune function of intestine, and alters tight junction proteins of intestine for juvenile hybrid grouper (Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂). Fish Shellfish Immunol. 2020, 107, 346–356.
  15. Yang, X.; Yang, L.; Zheng, H. Hypolipidemic and antioxidant effects of mulberry (Morus alba L.) fruit in hyperlipidaemia rats. Food Chem. Toxicol. 2010, 48, 2374–2379.
  16. Paunović, S.M.; Mašković, P.; Milinković, M. Determination of Primary Metabolites, Vitamins and Minerals in Black Mulberry (Morus nigra) Berries Depending on Altitude. Erwerbs-Obstbau 2020, 62, 355–360.
  17. Singhal, B.K.; Khan, M.A.; Dhar, A.; Baqual, F.M.; Bindroo, B.B. Approaches to industrial exploitation of mulberry (Mulberry sp.) fruits. J. Fruit Ornam. Plant Res. 2010, 18, 83–99.
  18. Chen, C.; Zhang, B.; Fu, X.; You, L.J.; Abbasi, A.M.; Liu, R.H. The digestibility of mulberry fruit polysaccharides and its impact on lipolysis under simulated saliva, gastric and intestinal conditions. Food Hydrocoll. 2016, 58, 171–178.
  19. Choi, J.W.; Synytsya, A.; Capek, P.; Bleha, R.; Pohl, R.; Park, Y.I. Structural analysis and anti-obesity effect of a pectic polysaccharide isolated from Korean mulberry fruit Oddi (Morus alba L.). Carbohydr. Polym. 2016, 146, 187–196.
  20. Lee, J.S.; Synytsya, A.; Kim, H.B.; Choi, D.J.; Lee, S.; Lee, J.; Kim, W.J.; Jang, S.; Park, Y.I. Purification, characterization and immunomodulating activity of a pectic polysaccharide isolated from Korean mulberry fruit Oddi (Morus alba L.). Int. Immunopharmacol. 2013, 17, 858–866.
  21. Li, E.; Long, X.; Liao, S.; Pang, D.; Li, Q.; Zou, Y. Effect of mulberry galacto-oligosaccharide isolated from mulberry on glucose metabolism and gut microbiota in a type 2 diabetic mice. J. Funct. Foods 2021, 87, 104836.
  22. Lee, Y.; Hwang, K.T. Changes in physicochemical properties of mulberry fruits (Morus alba L.) during ripening. Sci. Hortic. 2017, 217, 189–196.
  23. Jiang, Y.; Nie, W.J. Chemical properties in fruits of mulberry species from the Xinjiang province of China. Food Chem. 2015, 174, 460–466.
  24. Sánchez-Salcedo, E.M.; Sendra, E.; Carbonell-Barrachina, Á.A.; Martínez, J.J.; Hernández, F. Fatty acids composition of Spanish black (Morus nigra L.) and white (Morus alba L.) mulberries. Food Chem. 2016, 190, 566–571.
  25. Chen, H.; Chen, J.; Yang, H.; Chen, W.; Gao, H.; Lu, W. Variation in total anthocyanin, phenolic contents, antioxidant enzyme and antioxidant capacity among different mulberry (Morus sp.) cultivars in China. Sci. Hortic. 2016, 213, 186–192.
  26. Calínsánchez, A.; Martíneznicolás, J.J.; Munerapicazo, S.; Carbonellbarrachina, A.A.; Legua, P.; Hernández, F. Bioactive Compounds and Sensory Quality of Black and White Mulberries Grown in Spain. Plant Foods Hum. Nutr. 2013, 68, 370–377.
  27. Imran, M.; Khan, H.; Shah, M.; Khan, R.; Khan, F. Chemical composition and antioxidant activity of certain Morus species. J. Zhejiang Univ. Sci. B. 2010, 11, 973–980.
  28. Zhao, X.L.; Fan, D.C. Review of physiological active components, extraction and detection methods and pharmacological bioactivities of mulberry. Chin. J. Pharm. Anal. 2017, 37, 378–385.
  29. Junsong, P.; Hu, C.; Zhonghuai, X.; Guangwei, Y.; Ningjia, H. Determination of 1-Deoxynojirimycin in Black Mulberry Fruit by Ultra Performance Liquid Chromatography. Food Sci. 2015, 36, 207–210.
  30. Pérez-Gregorio, M.R.; Regueiro, J.; Alonso-González, E.; Pastrana-Castro, L.M.; Simal-Gándara, J. Influence of alcoholic fermentation process on antioxidant activity and phenolic levels from mulberries (Morus nigra L.). LWT-Food Sci. Technol. 2011, 44, 1793–1801.
  31. Lin, J.Y.; Tang, C.Y. Determination of total phenolic and flavonoid contents in selected fruits and vegetables, as well as their stimulatory effects on mouse splenocyte proliferation. Food Chem. 2007, 101, 140–147.
  32. Khalifa, I.; Zhu, W.; Li, K.K.; Li, C.M. Polyphenols of mulberry fruits as multifaceted compounds: Compositions, metabolism, health benefits, and stability—A structural review. J. Funct. Foods 2018, 40, 28–43.
  33. Kim, I.; Moon, J.K.; Hur, S.J.; Lee, J. Structural changes in mulberry (Morus Microphylla. Buckl) and chokeberry (Aronia melanocarpa) anthocyanins during simulated in vitro human digestion. Food Chem. 2020, 318, 126449.
  34. Kamiloglu, S.; Capanoglu, E. Antioxidant activity and polyphenol composition of black mulberry (Morus nigra L.) products. J. Berry Res. 2013, 3, 41–51.
  35. Butkhup, L.; Samappito, W.; Samappito, S. Phenolic composition and antioxidant activity of white mulberry (Morus alba L.) fruits. Int. J. Food Sci. Technol. 2013, 48, 934–940.
  36. Wang, K.; Kang, S.; Li, F.; Wang, X.; Xiao, Y.; Wang, J.; Xu, H. Relationship between fruit density and physicochemical properties and bioactive composition of mulberry at harvest. J. Food Compos. Anal. 2022, 106, 104322.
  37. Chon, S.U.; Kim, Y.M.; Park, Y.J.; Heo, B.G.; Park, Y.S.; Gorinstein, S. Antioxidant and antiproliferative effects of methanol extracts from raw and fermented parts of mulberry plant (Morus alba L.). Eur. Food Res. Technol. 2009, 230, 231–237.
  38. Jin, Q.; Yang, J.; Ma, L.; Wen, D.; Chen, F.; Li, J. Identification of polyphenols in mulberry (genus Morus) cultivars by liquid chromatography with time-of-flight mass spectrometer. J. Food Compos. Anal. 2017, 63, 55–64.
  39. Bae, S.-H.; Suh, H.-J. Antioxidant activities of five different mulberry cultivars in Korea. LWT-Food Sci Technol. 2007, 40, 955–962.
  40. Yan, F.; Zheng, X. Anthocyanin-rich mulberry fruit improves insulin resistance and protects hepatocytes against oxidative stress during hyperglycemia by regulating AMPK/ACC/mTOR pathway. J. Funct. Foods 2017, 30, 270–281.
  41. Erden, Y. Sour black mulberry (Morus nigra L.) causes cell death by decreasing mutant p53 expression in HT-29 human colon cancer cells. Food Biosci. 2021, 42, 101113.
  42. Liu, H.; Yang, J.; Huang, S.; Liu, R.; He, Y.; Zheng, D.; Liu, C. Mulberry crude extracts induce Nrf2 activation and expression of detoxifying enzymes in rat liver: Implication for its protection against NP-induced toxic effects. J. Funct. Foods 2017, 32, 367–374.
  43. Jiang, D.Q.; Guo, Y.; Xu, D.H.; Huang, Y.S.; Yuan, K.; Lv, Z.Q. Antioxidant and anti-fatigue effects of anthocyanins of mulberry juice purification (MJP) and mulberry marc purification (MMP) from different varieties mulberry fruit in China. Food Chem. Toxicol. 2013, 59, 1–7.
  44. Chuah, H.Q.; Tang, P.L.; Ang, N.J.; Tan, H.Y. Submerged fermentation improves bioactivity of mulberry fruits and leaves. Chin. Herb. Med. 2021, 13, 565–572.
  45. Espada-Bellido, E.; Ferreiro-González, M.; Carrera, C.; Palma, M.; Barroso, C.G.; Barbero, G.F. Optimization of the ultrasound-assisted extraction of anthocyanins and total phenolic compounds in mulberry (Morus nigra) pulp. Food Chem. 2017, 219, 23–32.
  46. Bao, T.; Li, Y.; Xie, J.; Jia, Z.; Chen, W. Systematic evaluation of polyphenols composition and antioxidant activity of mulberry cultivars subjected to gastrointestinal digestion and gut microbiota fermentation. J. Funct. Foods. 2019, 58, 338–349.
  47. Turan, E.; Şimşek, A. Effects of lyophilized black mulberry water extract on lipid oxidation, metmyoglobin formation, color stability, microbial quality and sensory properties of beef patties stored under aerobic and vacuum packaging conditions. Meat Sci. 2021, 178, 108522.
  48. Lee, M.S.; Kim, Y. Mulberry Fruit Extract Ameliorates Adipogenesis via Increasing AMPK Activity and Downregulating MicroRNA-21/143 in 3T3-L1 Adipocytes. J. Med. Food 2020, 23, 266–272.
  49. Lou, H.; Hu, Y.; Zhang, L.; Sun, P.; Lu, H. Nondestructive evaluation of the changes of total flavonoid, total phenols, ABTS and DPPH radical scavenging activities, and sugars during mulberry (Morus alba L.) fruits development by chlorophyll fluorescence and RGB intensity values. LWT-Food Sci. Technol. 2012, 47, 19–24.
  50. Özgen, M.; Serçe, S.; Kaya, C. Phytochemical and antioxidant properties of anthocyanin-rich Morus nigra and Morus rubra fruits. Sci. Hortic. 2009, 119, 275–279.
  51. Tomas, M.; Toydemir, G.; Boyacioglu, D.; Hall, R.; Beekwilder, J.; Capanoglu, E. The effects of juice processing on black mulberry antioxidants. Food Chem. 2015, 186, 277–284.
  52. Song, W.; Wang, H.J.; Bucheli, P.; Zhang, P.F.; Wei, D.Z.; Lu, Y.H. Phytochemical Profiles of Different Mulberry (Morus sp.) Species from China. J. Agric. Food Chem. 2009, 57, 9133–9140.
  53. Scuto, M.; Ontario, M.L.; Salinaro, A.T.; Caligiuri, I.; Rampulla, F.; Zimbone, V.; Modafferi, S.; Rizzolio, F.; Canzonieri, V.; Calabrese, E.J.; et al. Redox modulation by plant polyphenols targeting vitagenes for chemoprevention and therapy: Relevance to novel anti-cancer interventions and mini-brain organoid technology. Free Radic. Biol. Med. 2022, 179, 59–75.
  54. Wu, Y.; Zhang, C.; Huang, Z.; Lyu, L.; Li, W.; Wu, W. Integrative analysis of the metabolome and transcriptome provides insights into the mechanisms of flavonoid biosynthesis in blackberry. Food Res. Int. 2022, 153, 110948.
  55. Wu, T.; Tang, Q.; Gao, Z.; Yu, Z.; Song, H.; Zheng, X.; Chen, W. Blueberry and mulberry juice prevent obesity development in C57BL/6 mice. PLoS ONE 2013, 8, e77585.
  56. Bao, T.; Xu, Y.; Gowd, V.; Zhao, J.; Xie, J.; Liang, W.; Chen, W. Systematic study on phytochemicals and antioxidant activity of some new and common mulberry cultivars in China. J. Funct. Foods 2016, 25, 537–547.
  57. Hassimotto, N.M.A.; Genovese, M.I.; Lajolo, F.M. Identification and Characterisation of Anthocyanins from Wild Mulberry (Morus Nigra L.) Growing in Brazil. Food Sci. Technol. Int. 2016, 13, 17–25.
  58. Ştefănuţ, M.N.; Căta, A.; Pop, R.; Moşoarcă, C.; Zamfir, A.D. Anthocyanins HPLC-DAD and MS Characterization, Total Phenolics, and Antioxidant Activity of Some Berries Extracts. Anal. Lett. 2011, 44, 2843–2855.
  59. Stefanut, M.N.; Cata, A.; Pop, R.; Tanasie, C.; Boc, D.; Ienascu, I.; Ordodi, V. Anti-hyperglycemic effect of bilberry, blackberry and mulberry ultrasonic extracts on diabetic rats. Plant Foods Hum. Nutr. 2013, 68, 378–384.
  60. Qin, C.; Li, Y.; Niu, W.; Ding, Y.; Zhang, R.; Shang, X. Analysis and characterisation of anthocyanins in mulberry fruit. Czech J. Food Sci. 2010, 28, 117–126.
  61. Mahmood, T.; Anwar, F.; Afzal, N.; Kausar, R.; Ilyas, S.; Shoaib, M. Influence of ripening stages and drying methods on polyphenolic content and antioxidant activities of mulberry fruits. J. Food Meas. Charact. 2017, 11, 2171–2179.
  62. Hassimotto, N.M.A.; Genovese, M.I.; Lajolo, F.M. Absorption and metabolism of cyanidin-3-glucoside and cyanidin-3-rutinoside extracted from wild mulberry (Morus nigra L.) in rats. Nutr. Res. 2008, 28, 198–207.
  63. Park, S.W.; Jung, Y.S.; Ko, K.C. Quantitative analysis of anthocyanins among mulberry cultivars and their pharmacological screening. J. Korean Soc. Hortic. Sci. 1997, 38, 722–724.
  64. Liu, X.; Xiao, G.; Chen, W.; Xu, Y.J.; Wu, J.J. Quantification and Purification of Mulberry Anthocyanins with Macroporous Resins. J. Biomed. Biotechnol. 2004, 2004, 713759.
  65. Huang, L.; Zhou, Y.; Meng, L.; Wu, D.; He, Y. Comparison of different CCD detectors and chemometrics for predicting total anthocyanin content and antioxidant activity of mulberry fruit using visible and near infrared hyperspectral imaging technique. Food Chem. 2017, 224, 1–10.
  66. Zadernowski, R.; Naczk, M.; Nesterowicz, J. Phenolic Acid Profiles in Some Small Berries. J. Agric. Food Chem. 2005, 53, 2118–2124.
  67. Liu, C.J.; Lin, J.Y. Anti-inflammatory effects of phenolic extracts from strawberry and mulberry fruits on cytokine secretion profiles using mouse primary splenocytes and peritoneal macrophages. Int. Immunopharmacol. 2013, 16, 165–170.
  68. Zhang, W.; Han, F.; He, J.; Duan, C. HPLC-DAD-ESI-MS/MS analysis and antioxidant activities of nonanthocyanin phenolics in mulberry (Morus alba L.). J. Food Sci. 2008, 73, 512–518.
  69. Lee, K.M.; Oh, T.J.; Kim, S.H.; Kim, H.Y.; Chung, H.; Min, D.S.; Auh, J.H.; Lee, H.J.; Lee, J.; Choi, H.K. Comprehensive metabolic profiles of mulberry fruit (Morus alba Linnaeus) according to maturation stage. Food Sci. Biotechnol. 2016, 25, 1035–1041.
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