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Maniaci, A.; Cocuzza, S.; Mantia, I.L.; , .; Iannella, G.; Vicini, C.; Privitera, E.; Lechien, J. Treatment of Obsessive-Compulsive Disorder in PANS/PANDAS in Children. Encyclopedia. Available online: https://encyclopedia.pub/entry/21655 (accessed on 27 July 2024).
Maniaci A, Cocuzza S, Mantia IL,  , Iannella G, Vicini C, et al. Treatment of Obsessive-Compulsive Disorder in PANS/PANDAS in Children. Encyclopedia. Available at: https://encyclopedia.pub/entry/21655. Accessed July 27, 2024.
Maniaci, Antonino, Salvatore Cocuzza, Ignazio La Mantia,  , Giannicola Iannella, Claudio Vicini, Elio Privitera, Jerome Lechien. "Treatment of Obsessive-Compulsive Disorder in PANS/PANDAS in Children" Encyclopedia, https://encyclopedia.pub/entry/21655 (accessed July 27, 2024).
Maniaci, A., Cocuzza, S., Mantia, I.L., , ., Iannella, G., Vicini, C., Privitera, E., & Lechien, J. (2022, April 12). Treatment of Obsessive-Compulsive Disorder in PANS/PANDAS in Children. In Encyclopedia. https://encyclopedia.pub/entry/21655
Maniaci, Antonino, et al. "Treatment of Obsessive-Compulsive Disorder in PANS/PANDAS in Children." Encyclopedia. Web. 12 April, 2022.
Treatment of Obsessive-Compulsive Disorder in PANS/PANDAS in Children
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This entry is adapted from the peer-reviewed paper 10.3390/children9020155

Several treatment options have been proposed for pediatric acute-onset neuropsychiatric syndrome/pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANS/PANDAS). Still, no clear therapeutic protocol has been recognized to prevent these neuropsychiatric diseases. 

PANDAS adenotonsillectomy ENT OCD behavioral disorders orobuccal disorders infection

1. Introduction

Post-infectious autoimmune and neuro-inflammatory events have been recognized to cause acute childhood neuropsychiatric disorders and have been designed with different terms, but all presented with similar clinical-pathogenetic manifestations. These disorders were previously indicated as paediatric infection-triggered autoimmune neuropsychiatric disorder (PITND); pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANDAS); paediatric acute-onset neuropsychiatric syndrome (PANS); and childhood acute neuropsychiatric syndrome (CANS) [1][2][3][4][5].
The clinical recommendations of the PANS Consensus Conference clarified the clinical evaluation and diagnostic criteria of patients with young pediatric acute-onset neuropsychiatric syndrome (PANS) [3].
PANS describes a clinical situation defined by the sudden and dramatic onset of obsessive-compulsive disorders or severely restricted food intake, associated with acute onset neuropsychiatric symptoms such as anxiety, emotional lability and/or depression, irritability, aggression, and/or strongly oppositional behavior behavioral regression (development), deterioration in school performance or memory impairment. On the other hand, the PANDAS subgroup is defined by an acute prepubertal onset of tics or OCD symptoms associated with GAS infection and specific neuropsychiatric symptoms. It is distinguished from PANS by a sudden onset, and episodic course and tics have an “off/on” and increasing/decreasing course. While PANDAS has a specific infectious pathogen responsible, PANS foresee different microbes possibly implicated in the genesis of the disorders postinfectious neurological such as H1N1 influenza, Epstein Barr virus, and Borrelia burgdorferi (Lyme) disease [4][6][7][8].
The term PANS/PANDAS has been connected with a clinical condition in children and adolescents presenting with a sudden onset of various neuropsychiatric disorders, including obsessive-compulsive disorder (OCD), severely restricted food intake, anxiety, and inattention deficit hyperactivity disorder (ADHD). Therefore, diagnostic criteria have been proposed in order to allow a clear identification of individuals affected by PANS/PANDAS and consist of the onset of childhood/adolescent-related obsessive-compulsive disorder or severe restrictive eating, associated with at least two of the following neuropsychiatric disorders such as anxiety, emotional lability, and depression, irritability, aggression or strongly oppositional behavior, behavioral and developmental regression [5]. Other disturbances may include a deterioration in school performance, sensory or motor difficulties, somatic signs or symptoms, including sleep disturbance, enuresis, or increased urinary frequency. These disturbances should not be better explained or be related to a known neurologic or medical disorder [4][5][6][7][8][9][10].
The simultaneous presence of additional neuropsychiatric symptoms has been associated with similarly severe and acute onset, such as anxiety, emotional lability or depression, irritability, aggression, and severely oppositional behaviors, and sensory or motor difficulties [11][12]. In addition, somatic signs or symptoms may also be reported, including sleep disturbances, enuresis, or urinary frequency [12].
At the diagnosis of PANS/PANDAS, several types of treatment have been proposed and used according to the prevalent clinical signs and the severity of the disturbances. Antibiotics (penicillin V, azithromycin), anti-inflammatory drugs (cyclooxygenase (COX) inhibitors, corticosteroids), immunomodulating treatments (intravenous immunoglobulin –IVIG. plasma exchange) are the most applied treatment singularly or in association [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27].

2. Treatment of Obsessive-Compulsive Disorder in PANS/PANDAS in Children

The PANDAS concept was first stated by Sweedo et al. in 1998 [1]. Among the various diagnostic hypotheses reported in the literature, streptococcal and other infections have been shown to trigger the development of symptoms such as OCD, tics and behavioral disturbances [2][3][5]. Therefore, numerous studies have been performed on neurological outcomes in PANDAS patients undergoing medical or surgical treatments, with the principle of adenotonsillar infection as the primary target [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29]. Pavone et al. examined whether adenotonsillectomy could impact both disease remission and affect the clinical course, streptococcal antibody titers, neuronal antibodies, or the clinical severity of the obsessive-compulsive disorder (OCD) [13]. Surgery did not affect symptom progression, streptococcal and neuronal antibodies or clinical severity of neuropsychiatric symptoms with comparable results for remission (17 surgical vs. 14 non-surgical; p = 0.29) and disease recurrence (39 surgical vs. 50 controls; p = 0.09) [14]. Conversely, promising results have been reported later by Demesh et al. [22]. They noted that nine surgically treated patients achieved clinically significant relief, including those who had no response to antibiotic therapy alone (p = 0.03). However, the sample of enrolled patients constitutes a limitation for the reported research, reducing the significance of the evidence demonstrated.

Prasad et al. attempted to compare the outcomes achieved through surgical treatment alone versus those obtained from the combined surgical approach with intravenous immunoglobulins [23]. However, they enrolled a small group of patients, dividing them into three different treatment arms: tonsillectomy and adenoidectomy (AT) (n = 28), AT plus intravenous immunoglobulin (IVIG) (n = 22), or non-surgical treatment (n = 10). Although caregivers did not report a decrease in symptom frequency depending on the type of treatment except choreiform movement (p = 0.0296), TA was shown to be the treatment with the greatest symptom impact for patients (p = 0.05).

Another issue of concern remains the effectiveness of surgical treatment on disease prevention by influencing the onset of neuropsychiatric symptoms.

In this regard, Murphy et al. reported in 2013 poor prevention of neuropsychiatric symptoms (e.g., OCD or tics) based on patient surgical status (p = 0.71), inferring a mismatch between tonsillectomy and course of OCD/tics or concentration of streptococcal antibodies [28].

Using the same etiopathogenetic principle, antibiotic therapy has been proposed as a treatment for PANDAS patients, boasting a dual purpose, acting both on the prevention of the disease and relapses [15][16][20][21]. Murphy et al. in 2002 reported promising medical therapy results, with a rapid resolution of the symptoms of OCD, anxiety and tics that occur after 14 days of appropriate antibiotic treatment in 6/12 patients with PANDAS [21]. They put forward an interesting point of view regarding the management of related symptoms. GABHS serological tests have been used as an objective evaluation of response to treatment and the eradication of the germ by antibiotics has shown efficacy in the resolution of OCD symptoms as well as any relapse after acute streptococcal infection.

In reverse, different studies instead focus on the limits of the efficacy of antibiotics in prophylaxis, affirming instead the therapeutic benefits during acute episodes. Snider et al. reported a significantly reduced number of exacerbations of neuropsychiatric symptoms in both penicillin and azithromycin-treated patients (p < 0.01 for both) [15]. Subsequently, the possible role of antibiotic therapy was hypothesized by a research comparing the severity of OCD on the Clinical Global Impression Scale (CGI-S). However, it should be noted that the scholars in this case did not correctly correlate the number of exacerbation and the eradication of the germ to the reduction of specific symptoms.

In 2017 Murphy et al. comparing two different medical treatment for PANDAS patients, demonstrated significant reductions in the azithromycin group (n = 17) matched to the placebo group (n = 14) (p = 0.003) [16].
Other scholars have instead evaluated the effects of reducing oropharyngeal and nasosinus inflammation after treatment with non-steroidal anti-inflammatory drugs in an attempt to improve neuropsychiatric symptoms, reporting unpromising results [18][19]. The lack of efficacy has probably been interpreted in the role of the eradication of the germ in the resolution of the pathology, regardless of the reduction of the episodes of inflammation.
In response to a Group A Streptococcal infection, cross-reactive antibodies have been hypothesized in the etiology and pathogenesis of PANDAS in susceptible individuals by reacting to cell wall components and neuronal proteins of the basal ganglia [30][31][32][33][34]. For this reason, some studies have tested the possible role of intravenous immunoglobulins (IVIG) on the clinical course of the disease [19][24].
Although Williams et al. demonstrated that IVIG was safe and well-tolerated, differences between groups in the double-blind comparison did not demonstrate the superiority of IVIG over placebo [19][24]. In this regard, the reported outcomes certainly suffered from the disadvantage of small sample sizes and the lack of specific biomarkers predicting a positive response to immunotherapy.
Exploiting the same concept of higher concentrations of cross-reactive antibodies in acute serum samples, therapeutic plasmapheresis (TPE) has been proposed as an alternative treatment. However, the support for the plasmapheresis use remains limited to a few reports and controlled-placebo trials with a lessened population, demonstrating symptom improvements mainly in the short-term follow-up.
Latimer et al. proposed therapeutic plasmapheresis (TPE) to treat 35 severely ill children and adolescents with PANDAS disorders [34]. They reported an average improvement of 65% at six months post-TPE and 78% at long-term follow-up. However, the sample enrolled was not homogeneous, with possible confounding variables not adequately identified.
The therapeutic effect of corticosteroids, also proposed in the treatment of PANDAS, seems to be affected by the timing of drug administration. Indeed, while early administration appears to be associated with shorter flare-up periods (p < 0.001) [35], longer administrations are associated with better control of neuropsychiatric symptoms (p = 0.014) [18]. The probable therapeutic hypothesis is the stabilization of the chronic inflammatory state induced by the streptococcal infection and the maintenance of a low antibody titre, although in the literature there are insufficient data in this regard.
At the overall pooled analysis performed for the subgroup of medical patients, the improvement in OCD was recorded in 150/263 (57.03%) patients. However, at the subsequent meta-analysis of the data by subgroup fixed effects modeling although an OR of 1.86 was found [95% CI 0.81, 4.28], the overall effect Z score 1.47 (p < 0.14) heterogeneity I2 = 0% (p = 0.41) were not significant. It should be noted that several medical approaches have been adopted without any standardized protocol, which represents a major limitation for the pooled analysis of the studies included.

3. Conclusions

Although PANS/PANDAS are disorders with well-defined diagnostic criteria, the proposed therapeutic protocols report conflicting data to date. Furthermore, the effectiveness of medical and surgical approaches on movements and behavioral disorders often does not reach significant differences and is frequently affected by the timing of administration. Finally, it is necessary to consider that the evidence in the literature does not follow a unified therapeutic protocol, leading to poor enrolled samples and unsatisfactory results.

References

  1. Swedo, S.E.; Leonard, H.L.; Garvey, M.; Mittleman, B.; Allen, A.J.; Perlmutter, S.; Lougee, L.; Dow, S.; Zamkoff, J.; Dubbert, B.K. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: Clinical description of the first 50 cases. Am. J. Psychiatry 1998, 155, 264–271.
  2. Swedo, S.E.; Leckman, J.F.; Rose, N.R. From Research Subgroup to Clinical Syndrome: Modifying the PANDAS Criteria to Describe PANS (Pediatric Acute-onset Neuropsychiatric Syndrome). Pediatr. Ther. 2012, 2, 113.
  3. Chang, K.; Frankovich, J.; Cooperstock, M.; Cunningham, M.W.; Latimer, M.E.; Murphy, T.K.; Pasternack, M.; Thienemann, M.; Williams, K.; Walter, J.; et al. Clinical Evaluation of Youth with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS): Recommendations from the 2013 PANS Consensus Conference. J. Child Adolesc. Psychopharmacol. 2015, 25, 3–13.
  4. Pavone, P.; Ceccarelli, M.; Marino, S.; Caruso, D.; Falsaperla, R.; Berretta, M.; Rullo, E.V.; Nunnari, G. SARS-CoV-2 related paediatric acute-onset neuropsychiatric syndrome. Lancet Child Adolesc. Heal. 2021, 5, e19–e21.
  5. Thienemann, M.; Murphy, T.; Leckman, J.; Shaw, R.; Williams, K.; Kapphahn, C.; Frankovich, J.; Geller, D.; Bernstein, G.; Chang, K.; et al. Clinical Management of Pediatric Acute-Onset Neuropsychiatric Syndrome: Part I-Psychiatric and Behavioral Interventions. J. Child Adolesc. Psychopharmacol. 2017, 27, 566–573.
  6. Ercan, T.E.; Ercan, G.; Severge, B.; Arpaozu, M.; Karasu, G. Mycoplasma pneumoniae Infection and Obsessive-Compulsive Disease: A Case Report. J. Child Neurol. 2008, 23, 338–340.
  7. Caruso, J.M.; Tung, G.A.; Gascon, G.G.; Rogg, J.; Davis, L.; Brown, W.D. Persistent Preceding Focal Neurologic Deficits in Children With Chronic Epstein-Barr Virus Encephalitis. J. Child Neurol. 2000, 15, 791–796.
  8. Fallon, B.A.; Kochevar, J.M.; Gaito, A.; Nields, J.A. The underdiagnosis of neuropsychiatric Lyme disease in children and adults. Psychiatr. Clin. N. Am. 1998, 21, 693–703.
  9. Gamucci, A.; Uccella, S.; Sciarretta, L.; D’Apruzzo, M.; Calevo, M.G.; Mancardi, M.M.; Veneselli, E.; De Grandis, E. PANDAS and PANS: Clinical, Neuropsychological, and Biological Characterization of a Monocentric Series of Patients and Proposal for a Diagnostic Protocol. J. Child Adolesc. Psychopharmacol. 2019, 29, 305–312.
  10. Sigra, S.; Hesselmark, E.; Bejerot, S. Treatment of PANDAS and PANS: A systematic review. Neurosci. Biobehav. Rev. 2018, 86, 51–65.
  11. Wilbur, C.; Bitnun, A.; Kronenberg, S.; Laxer, R.M.; Levy, D.M.; Logan, W.J.; Shouldice, M.; Yeh, E.A. PANDAS/PANS in childhood: Controversies and evidence. Paediatr. Child Heal. 2018, 24, 85–91.
  12. Tipton, P.W. Searching for tics. Neurol. Neurochir. Polska 2019, 53, 315–316.
  13. Pavone, P.; Rapisarda, V.; Serra, A.; Nicita, F.; Spalice, A.; Parano, E.; Rizzo, R.; Maiolino, L.; Di Mauro, P.; Vitaliti, G.; et al. Pediatric Autoimmune Neuropsychiatry Disorder Associated with Group a Streptococcal Infection: The Role of Surgical Treatment. Int. J. Immunopathol. Pharmacol. 2014, 27, 371–378.
  14. Brown, K.D.; Farmer, C.; Freeman, G.M.; Spartz, E.; Farhadian, B.; Thienemann, M.; Frankovich, J. Effect of Early and Prophylactic Nonsteroidal Anti-Inflammatory Drugs on Flare Duration in Pediatric Acute-Onset Neuropsychiatric Syndrome: An Observational Study of Patients Followed by an Academic Community-Based Pediatric Acute-Onset Neuropsychiatric Syndrome Clinic. J. Child Adolesc. Psychopharmacol. 2017, 27, 619–628.
  15. Snider, L.A.; Lougee, L.; Slattery, M.; Grant, P.; Swedo, S.E. Antibiotic prophylaxis with azithromycin or penicillin for childhood-onset neuropsychiatric disorders. Biol. Psychiatry 2005, 57, 788–792.
  16. Murphy, T.K.; Brennan, E.M.; Johnco, C.; Parker-Athill, E.C.; Miladinovic, B.; Storch, E.A.; Lewin, A.B. A Double-Blind Randomized Placebo-Controlled Pilot Study of Azithromycin in Youth with Acute-Onset Obsessive–Compulsive Disorder. J. Child Adolesc. Psychopharmacol. 2017, 27, 640–651.
  17. Spartz, E.J.; Freeman, G.M., Jr.; Brown, K.; Farhadian, B.; Thienemann, M.; Frankovich, J. Course of Neuropsychiatric Symptoms After Introduction and Removal of Nonsteroidal Anti-Inflammatory Drugs: A Pediatric Observational Study. J Child Adolesc. Psychopharmacol. 2017, 27, 652–659.
  18. Brown, K.; Farmer, C.; Farhadian, B.; Hernandez, J.; Thienemann, M.; Frankovich, J. Pediatric Acute-Onset Neuropsychiatric Syndrome Response to Oral Corticosteroid Bursts: An Observational Study of Patients in an Academic Community-Based PANS Clinic. J. Child Adolesc. Psychopharmacol. 2017, 27, 629–639.
  19. Williams, K.A.; Swedo, S.E.; Farmer, C.; Grantz, H.; Grant, P.J.; D’Souza, P.; Hommer, R.; Katsovich, L.; King, R.A.; Leckman, J.F. Randomized, Controlled Trial of Intravenous Immunoglobulin for Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections. J. Am. Acad. Child Adolesc. Psychiatry 2016, 55, 860–867.e2.
  20. Hesselmark, E.; Bejerot, S. Patient Satisfaction and Treatments Offered to Swedish Patients with Suspected Pediatric Acute-Onset Neuropsychiatric Syndrome and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections. J. Child Adolesc. Psychopharmacol. 2019, 29, 634–641.
  21. Murphy, M.L.; Pichichero, M.E. Prospective Identification and Treatment of Children With Pediatric Autoimmune Neuropsychiatric Disorder Associated With Group A Streptococcal Infection (PANDAS). Arch. Pediatr. Adolesc. Med. 2002, 156, 356–361.
  22. Demesh, D.; Virbalas, J.M.; Bent, J.P. The Role of Tonsillectomy in the Treatment of Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections (PANDAS). JAMA Otolaryngol. Neck Surg. 2015, 141, 272–275.
  23. Prasad, N.; Johng, S.; Powell, D.; Williams, M.; Latimer, E.; Harley, E. Role of tonsillectomy and adenoidectomy in parental satisfaction of treatments for PANDAS. Am. J. Otolaryngol. 2021, 42, 102963.
  24. Perlmutter, S.J.; Leitman, S.F.; Garvey, M.A.; Hamburger, S.; Feldman, E.; Leonard, H.L.; Swedo, S.E. Therapeutic plasma exchange and intravenous immunoglobulin for obsessive-compulsive disorder and tic disorders in childhood. Lancet 1999, 354, 1153–1158.
  25. Storch, E.A.; Murphy, T.K.; Geffken, G.R.; Mann, G.; Adkins, J.; Merlo, L.J.; Duke, D.; Munson, M.; Swaine, Z.; Goodman, W.K. Cognitive-Behavioral Therapy for PANDAS-Related Obsessive-Compulsive Disorder: Findings From a Preliminary Waitlist Controlled Open Trial. J. Am. Acad. Child Adolesc. Psychiatry 2006, 45, 1171–1178.
  26. Nadeau, J.M.; Jordan, C.; Selles, R.R.; Wu, M.S.; King, M.A.; Patel, P.D.; Hanks, C.E.; Arnold, E.B.; Lewin, A.B.; Murphy, T.K.; et al. A Pilot Trial of Cognitive-Behavioral Therapy Augmentation of Antibiotic Treatment in Youth with Pediatric Acute-Onset Neuropsychiatric Syndrome-Related Obsessive-Compulsive Disorder. J. Child Adolesc. Psychopharmacol. 2015, 25, 337–343.
  27. Moher, D.; Shamseer, L.; Clarke, M.; Ghersi, D.; Liberati, A.; Petticrew, M.; Shekelle, P.; Stewart, L.A.; PRISMA-P Group. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst. Rev. 2015, 4, 1.
  28. Murphy, T.K.; Lewin, A.B.; Parker-Athill, E.C.; Storch, E.A.; Mutch, P.J. Tonsillectomies and Adenoidectomies Do Not Prevent the Onset of Pediatric Autoimmune Neuropsychiatric Disorder Associated With Group A Streptococcus. Pediatr. Infect. Dis. J. 2013, 32, 834–838.
  29. Farhood, Z.; Ong, A.A.; Discolo, C.M. PANDAS: A systematic review oftreatment options. Int. J. Pediatr Otorhinolaryngol. 2016, 89, 149–153.
  30. Kirvan, C.A.; Swedo, S.E.; Snider, L.A.; Cunningham, M.W. Antibody-mediated neuronal cell signaling in behavior and movement disorders. J. Neuroimmunol. 2006, 179, 173–179.
  31. Kirvan, C.A.; Cox, C.; Swedo, S.E.; Cunningham, M. Tubulin Is a Neuronal Target of Autoantibodies in Sydenham’s Chorea. J. Immunol. 2007, 178, 7412–7421.
  32. Hallett, J.J.; Harling-Berg, C.J.; Knopf, P.M.; Stopa, E.G.; Kiessling, L.S. Anti-striatal antibodies in Tourette syndrome cause neuronal dysfunction. J. Neuroimmunol. 2000, 111, 195–202.
  33. Dileepan, T.; Smith, E.; Knowland, D.; Hsu, M.; Platt, M.; Bittner-Eddy, P.; Cohen, B.; Southern, P.; Latimer, E.; Harley, E.; et al. Group A Streptococcus intranasal infection promotes CNS infiltration by streptococcal-specific Th17 cells. J. Clin. Investig. 2015, 126, 303–317.
  34. Latimer, M.E.; L’Etoile, N.; Seidlitz, J.; Swedo, S.E. Therapeutic Plasma Apheresis as a Treatment for 35 Severely Ill Children and Adolescents with Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections. J. Child Adolesc. Psychopharmacol. 2015, 25, 70–75.
  35. Jonasson, G.; Wilkinson, S.R. Prednisolone-induced obsessive-compulsive behavior in a child. Tidsskr. Den Nor. Legeforen. 1993, 113, 3162–3163.
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Subjects: Pediatrics
Contributors MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register :
Antonino Maniaci
,
Salvatore Cocuzza
,
Ignazio La Mantia
,
,
GIANNICOLA IANNELLA
,
Claudio Vicini
,
Elio Privitera
,
Jerome Lechien
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Update Date: 13 Apr 2022
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