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Winter, L.; Zrelski, M.; , . Muscle-Related Plectinopathies. Encyclopedia. Available online: https://encyclopedia.pub/entry/21452 (accessed on 18 July 2025).
Winter L, Zrelski M,  . Muscle-Related Plectinopathies. Encyclopedia. Available at: https://encyclopedia.pub/entry/21452. Accessed July 18, 2025.
Winter, Lilli, Michaela Zrelski,  . "Muscle-Related Plectinopathies" Encyclopedia, https://encyclopedia.pub/entry/21452 (accessed July 18, 2025).
Winter, L., Zrelski, M., & , . (2022, April 07). Muscle-Related Plectinopathies. In Encyclopedia. https://encyclopedia.pub/entry/21452
Winter, Lilli, et al. "Muscle-Related Plectinopathies." Encyclopedia. Web. 07 April, 2022.
Muscle-Related Plectinopathies
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This entry is adapted from the peer-reviewed paper 10.3390/cells10092480

Plectin is a giant cytoskeletal crosslinker and intermediate filament stabilizing protein. Mutations in the human plectin gene (PLEC) cause several rare diseases that are grouped under the term plectinopathies. The most common disorder is autosomal recessive disease epidermolysis bullosa simplex with muscular dystrophy (EBS-MD), which is characterized by skin blistering and progressive muscle weakness. Besides EBS-MD, PLEC mutations lead to EBS with nail dystrophy, EBS-MD with a myasthenic syndrome, EBS with pyloric atresia, limb-girdle muscular dystrophy type R17, or EBS-Ogna.

plectin muscular dystrophy myopathology desmin intermediate filaments sarcomere structure

1. Introduction

Cardiac and skeletal striated muscles are elaborately organized machines designated for contraction. Sarcomeres, the smallest functional units of muscle contraction, comprise precisely organized filament systems including thin (actin) and thick (myosin) filaments, titin, and nebulin [1] and build up the myofibrillar apparatus. Desmin intermediate filaments (IFs), which are structurally organized by plectin in myoblasts (Figure 1A) and muscle fibers, constitute the principal component of the extrasarcomeric cytoskeleton. Plectin, a giant (>500 kDa) multi-modular cytolinker of the plakin protein family [2], may be considered as the universal cross-linking element of the cytoskeleton. Possessing binding sites for all types of IF subunit proteins, it networks and anchors them to sites of strategic importance for the organization and performance of cells, such as transmembrane junctional complexes, the nuclear envelope, and cytoplasmic organelles [3]. In addition, plectin harbors a functional actin-binding domain (ABD); binds to microtubule-associated proteins (MAPs); and interacts with transmembrane receptors, proteins of the subplasma membrane protein skeleton, components of the nuclear envelope, and several kinases with known roles in the migration, proliferation, and energy metabolism of cells (Figure 1B) [4][5]. Plectin’s functional versatility is not only due to its multi-domain structure enabling a broad range of interactions, but it is also due to an unusual transcript diversity that is largely based on at least nine different, relatively short N-terminal sequences. Encoded by alternatively spliced first exons [6], individual plectin isoforms are differentially targeted to distinct cellular locations where they function as universal IF-docking sites, thus enabling them to fulfill distinct functions in different cell types and tissues [4][5]. In muscle tissue, the four most prominently isoforms expressed (plectin isoform 1d (P1d), P1f, P1b, and P1) are crucial for myofiber integrity by anchoring desmin IFs to Z-disks, costameres, mitochondria, and the nuclear/sarcoplasmic reticulum membrane system, respectively [7][8][9]. Thus, plectin acts as a multi-functional linker and signaling scaffold, centrally orchestrating the structural and functional organization of filamentous cytoskeletal networks and thereby substantially contributing to the fundamental biomechanical properties of stress-bearing tissues such as muscle.
Figure 1. Subcellular localization of plectin in a myoblast and schematic representation of plectin and its binding partners, with a special focus on direct interaction partners identified in myoblasts and/or skeletal muscle. (A) Immunofluorescence microscopy of a human primary myoblast using antibodies to plectin (in red) and desmin (in green). The nucleus was visualized using DAPI (blue in the merged image). Note the co-localization of plectin and desmin. Scale bar: 15 µm. (B) Schematic domain map of the protein. The tripartite structure of plectin comprises a central rod domain (encoded by exon 31) flanked by N- and C-terminal domains. The N terminus harbors differentially spliced first exons (star), an actin-binding domain (ABD, exons 2–8), and a plakin domain (exons 9–30), while the C terminus comprises six plectin repeat domains (PRD), each containing a conserved core (plectin module) and a linker region. An intermediate filament binding domain (IFBD) is located between modules 5 and 6 (green). Binding partners are indicated below the scheme; binding partners which were experimentally found in myoblasts/skeletal muscle are highlighted in bold. * Interaction was shown for isoform P1f. ** Interaction was shown for isoform P1.

2. Human Plectinopathies

The proposed concept that plectin contributes to the stability and coherence of cells was confirmed by showing that mutations in the human plectin gene (PLEC, NM_000445) on chromosome 8q24 cause a variety of human disorders referred to as “plectinopathies”. Plectinopathies belong to the group of rare diseases with an incidence of less than 5 affected individuals for every 10,000 people. As of today, almost 100 disease-causing PLEC gene alterations comprising missense, frame-shift, and splice site mutations as well as small in-frame deletions have been reported. Most PLEC mutations cause epidermolysis bullosa simplex with muscular dystrophy (EBS-MD, MIM #226670), an autosomal recessive skin blistering disorder associated with progressive muscle weakness [4]. A plethora of additional symptoms has been described for EBS-MD patients in recent years, including cardiac pathology, nail deformation, tooth decay, erosive lesions on the oral or laryngeal mucosa, hoarseness, respiratory complications during infant life, and urethral strictures. In addition to EBS-MD, PLEC mutations have been shown to lead to EBS-MD with a myasthenic syndrome (EBS-MD-MyS) or EBS with pyloric atresia (EBS-PA, MIM #612138) [4]. Autosomal dominant PLEC mutations (c.5998C > T, p.R2000W; c.8668A > T, p.T2890S; and c.10579C > T, p.R3527C) cause EBS-Ogna (MIM #131950), where the patients suffer from generalized skin blistering or fragile skin without showing any muscular symptoms [10][11][12]. Recently, the first mutations in alternative first exons have been described. A homozygous 9 bp deletion (c.1_9del1f) containing the initiation codon of exon 1f (and therefore resulting in the loss of isoform P1f) was identified in several patients suffering from limb-girdle muscular dystrophy (LGMDR17, previously denoted as LGMD2Q [13], MIM #613723); however, these patients did not show any overt signs of an epidermolytic skin disease [14][15]. Since then, another exon 1f-specific mutation (c.58G > T, p.E20X) has been reported, where three siblings suffered from MD and respiratory problems but who did not present with any skin involvement [16]. Likewise, a homozygous nonsense mutation in exon 1a (c.46C > T), leading to a premature termination codon p.R16X and therefore to the disruption of P1a, an isoform that is hardly expressed in muscle, resulted in a skin-only EBS phenotype without muscle involvement (EBS with nail dystrophy, EBSND, MIM #616487) [17]. Taken together, plectinopathies emerge as complex multi-systemic disorders, primarily affecting tissues exposed to great mechanical stress such as skin and muscle but including more and more additional symptoms and disease manifestations.

3. Clinical Phenotypes and Muscle-Related Disease Manifestations of Human Plectinopathies

3.1. EBS-MD, the Most Common Muscle-Related Plectinopathy

While EBS-MD patients usually suffer from skin blistering early in life, muscle-specific symptoms can occur between early infancy up to the fourth decade of life, with first signs such as gross developmental motor delays (e.g., delayed independent walking), fatigability, muscle weakness, predominantly affecting proximal upper and lower muscle groups, and ptosis. Disease progression is relatively slow; most affected individuals noted the first signs of distal or proximal muscle weakness in the second decade of life. Loss of ambulation was reported for EBS-MD patients between 14 and 47 years of age. Out of 53 EBS-MD cases with genetically determined PLEC mutations (see Table 1), muscular symptoms have been described for 37 patients (~70%) at the time of publication. No muscular symptoms were reported for the remaining 16 cases at the time of publication, but one might anticipate that these patients will likely also develop muscular weakness later in life. Blood serum creatine kinase (CK) levels have been reported for five EBS-MD cases, with two patients showing normal and three showing increased values [18][19][20][21][22]. Electromyography (EMG) in EBS-MD patients revealed a myopathic pattern with short duration, polyphasic, and low-amplitude motor unit potentials [19][23][24][25]. Furthermore, fibrillation potentials, positive sharp waves, and pseudomyotonic/myotonic discharges have been reported, whereas nerve conduction and neuromuscular transmission appeared to be normal [19].
Table 1. Patients with genetically determined PLEC mutations associated with muscle-related disease manifestations.
Ref Mutation 1 Mutation 2 Geno- MD Sex MB
  DNA Protein DNA Protein Type (Onset)    
EBS-MD
[25] 906 + 19_40del * V303_P313ins11 906 + 19_40del * V303_P313ins11 hom. adolescence F no
[26] 954_956dupGCT L319dup 4222C > T Q1408X c.het. MD not dev. at 4 years; but histological changes M yes
[26] 954_956dupGCT L319dup 4222C > T Q1408X c.het. N/A M no
[27] 956T > C L319P 2807G > A W936X c.het. MD not dev. at 18 years M no
[27] 956T > C L319P 6955C > T R2319X c.het. MD not dev. at 31 years F no
[28] 968G > A R323Q 4840G > T E1614X c.het. twenties M yes
[28] 968G > A R323Q 4840G > T E1614X c.het. MD not dev. at 9 years F no
[29] 1530_1531ins36 A510_I511ins12 2677_2685del Q893_A895del c.het. 42 years F N/A
[30] 1648C > G R500G 1648C > G R500G hom. MD not dev. at 2 years M no
[21] 2264_2266del F755del 2264_2266del F755del hom. twenties F n.s.
[24] 2264_2266del F755del 3119_3210del K1040RfsX c.het. 27 years M yes
[31] 2264_2266del F755del 9194dup S3066EfsX55 c.het. MD not dev. at 3 years M no
[32][33] 2677_2685del Q893_A895del 2677_2685del Q893_A895del hom. early thirties F no
[32][33] 2677_2685del Q893_A895del 2677_2685del Q893_A895del hom. early thirties F no
[19] 2677_2685del Q893_A895del 4930C > T Q1644X c.het. 28 years M yes
[34] 2694−9_2705del N/A 5032delG V1678WfsX65 c.het. MD not dev. at 5 months F no
[33][35][36] 3157C > T Q1053X 5806C > T Q1936X c.het. infancy M no
[37] 3341 + 1G > T N/A 6955C > T R2319X c.het. MD not dev. at 1.5 years - no
[37] 4126−4A > G N/A 7804C > T Q2602X c.het. 18 years - no
[37] 4216C > T Q1421X 4216C > T Q1421X hom. teens - no
[38] 4294_4306dup V1436GfsX40 4365delC S1456RfsX93 c.het. 20 years M N/A
[36][39] 4348C > T Q1450X 4348C > T Q1450X hom. 19 years F no
[40] 4549C > T R1517X 4549C > T R1517X hom. MD not dev. at 24 years M no
[36] 4643_4667dup K1558GfsX89 7120C > T Q2374X c.het. MD not dev. at 7 years M no
[41] 4840G > T E1614X 4840G > T E1614X hom. teens - no
[24][42] 5018_5036del L1673RfsX64 5018_5036del L1673RfsX64 hom. MD not dev. at 5 years F yes
[43] 5105_5112del R1702QfsX14 5105_5112del R1702QfsX14 hom. 10 years M n.s.
[44] 5137C > T Q1713X 7051C > T R2351X c.het. MD not dev. at 4 years M no
[45] 5254C > T Q1752X 7285C > T R2429X c.het. adolescence F n.s.
[18] 5257dupG E1753GfsX17 5257dupG E1753GfsX17 hom. MD not dev. at 3 years F no
[46] 5410G > T E1804X 5410G > T E1804X hom. 17 years M no
[46] 5410G > T E1804X 5410G > T E1804X hom. 15 years M n.s.
[47][48] 5728C > T Q1910X 5728C > T Q1910X hom. infancy F yes
[47][48] 5728C > T Q1910X 5728C > T Q1910X hom. infancy F n.s.
[37] 5770C > T Q1924X N/A N/A N/A 30 years - no
[32][33][36][49] 5815delC L1939WfsX6 5815delC L1939WfsX6 hom. late twenties F yes
[50] 5849_5856dup E1953WfsX8 5849_5856dup E1953WfsX8 hom. infancy M n.s.
[42][49] 5854_5855del E1952GfsX60 5854_5855del E1952GfsX60 hom. MD not dev. at 3 years F yes
[22] 5902_5093del K1968GfsX44 9109_9125del V3037CfsX78 c.het. 8 years M n.s.
[34] 6013G > T E2005X 13378A > T K4460X c.het. MD not dev. at 6 months M no
[51] 6622C > T Q2208X 8119C > T Q2707X c.het. 6 years M no
[36] 6549_6582del L2184RfsX21 13040dupG I4348HfsX8 c.het. 10 years F no
[37] 6682C > T Q2228X 10456C > T Q3486X c.het. 5 years - no
[52] 6955C > T R2319X 6955C > T R2319X hom. 25 years F no
[20] 7100C > T R2351X 7100C > T R2351X hom. teens M no
[53] 7159G < T E2387X 7159G < T E2387X hom. adolescence F no
[33][35][36] 7261C > T R2421X 12578_12581dup Y4195DfsX41 c.het. 5 years M no
[41] 7261C > T R2421X N/A N/A N/A childhood - no
[41][49][50] 7393C > T R2465X 7393C > T R2465X hom. early childhood M yes
[54] 7468C > T Q2490X 7468C > T Q2490X hom. MD not dev. at 4 years M no
[55] 10909C > T R3637C 10909C > T R3637C hom. yes (onset N/A) M no
[55] 10909C > T R3637C 10909C > T R3637C hom. yes (onset N/A) M no
[23][24] 13459_13474dup E4492GfsX48 13459_13474dup E4492GfsX48 hom. 4 years F yes
EBS-MD-MyS
[56] IVS11 + 2T > G N/A 10187_10190del K3395GfsX11 c.het. birth M yes
[57] 1500_1501ins36 R500_V501ins12 1500_1501ins36 R500_V501ins12 hom. childhood F yes
[57] 1500_1501ins36 R500_V501ins12 1500_1501ins36 R500_V501ins12 hom. childhood M no
[58] 2539−2A > G N/A 11737delC R3913VfsX30 c.het. 25 years M yes
[59] 3086G > A R1029H 9679_9766del D3229VfsX21 c.het. N/A F no
[59] 3086G > A R1029H 9679_9766del D3229VfsX21 c.het. N/A M no
[59] 3086G > A R1029H 9679_9766del D3229VfsX21 c.het. N/A M no
[60][61] 6169C > T Q2057X 12043dupG E4015GfsX69 c.het. 9 years F yes
[61] 6955C > T R2319X 12043dupG E4015GfsX69 c.het. 3 years M yes
EBS-PA
[62] 913C > T Q305X 913C > T Q305X hom. N/A M no
[63] 913C > T Q305X 1344G > A N/A c.het. N/A M no
[62] 1563_1567del G522WfsX11 1563_1567del G522WfsX11 hom. N/A F no
[64] 2680_2693del E894AfsX84 2680_2693del E894AfsX84 hom. N/A F no
[62] 2769_2788del W923CfsX53 2769_2788del W923CfsX53 hom. N/A M no
[40] 2888dupT F963PfsX19 N/A Q2367X c.het. MD not dev. at 6 years F no
[37] 3342−2A > G N/A 3902_3903del Q1301LfsX8 c.het. N/A - no
[63] 3565C > T R1189X 3565C > T7612C > T R1189XQ2538X hom.& c.het N/A F no
[37] 4119_4120del N/A 12499C > T R4167X c.het. MD not dev. at 12 years - no
[39] 7396C > T Q2466X 7633C > T Q2545X c.het. N/A M no
[62] 9085C > T R3029X 9085C > T R3029X hom. N/A F no
[65] 11912del K3971Ter 12499C > T R4167X c.het. birth M no
[66] 10984C > T E3662X 11453_11462del I3818RfsX90 c.het. birth M no
LGMDR17 (P1f mutation)
[14] 1_9del ** - 1_9del ** - hom. 3 years M yes
[14] 1_9del ** - 1_9del ** - hom. early childhood M no
[14] 1_9del ** - 1_9del ** - hom. early childhood F no
[14] 1_9del ** - 1_9del ** - hom. early childhood F no
[14] 1_9del ** - 1_9del ** - hom. 2 years M yes
[14] 1_9del ** - 1_9del ** - hom. early childhood M n.s.
[15] 1_9del ** - 1_9del ** - hom. 6 years F n.s.
[15] 1_9del ** - 1_9del ** - hom. 26 years F n.s.
[15] 1_9del ** - 1_9del ** - hom. early childhood F n.s.
[15] 1_9del ** - 1_9del ** - hom. early childhood F yes
[16] 58G > T ** E20X 58G > T ** E20X hom. early childhood M yes
[16] 58G > T ** E20X 58G > T ** E20X hom. N/A M no
[16] 58G > T ** E20X 58G > T ** E20X hom. N/A F no
Other MD-related plectinopathy reports
[67] 3064C > T Q1022Ter 11503G > A G3835S c.het. 4 years F no
[67] 3064C > T Q1022Ter 11503G > A G3835S c.het. 16 years F no
[68] 6118C > T R2040W 10063T > A F3355I c.het. 2 years M yes
Ref = Reference, MD = muscular dystrophy, MB = muscle biopsy, EBS = epidermolysis bullosa simplex, dup = duplication, del = deletion, hom. = homozygous, c.het. = compound heterozygous, dev. = developed, F = female, M = male, N/A = not available, n.s. = biopsy performed, but data not shown in the respective publication, MyS = myasthenic syndrome, PA = pyloric athresia, LGMDR17 = limb girdle musculyr dystrophy type R17. Plectin mutations are listed according to the respective plectinopathy phenotype and position within the gene. Mutations are assigned to the common reference sequence, P1c (also referred to as transcript variant 1 in the databases; GenBank accession no. NM_000445). * Intronic deletion resulting in alternative splicing. ** Mutations in exon 1f, resulting in a lack of P1f and not affecting other plectin isoforms.

3.2. Other Skeletal Muscle-Associated Plectinopathy Disease Manifestations

In addition to EBS-MD, skeletal muscle-related disease manifestations have been described for patients suffering from EBS-MD-MyS, EBS-PA, or LGMDR17. To date, myasthenic features in combination with EBS-MD have been reported for seven plectinopathy patients, resulting in the narration of “EBS-MD-MyS” [56][58][59][60][61]. Early onset bilateral ptosis; progressive ocular, facial, limb, and truncal weakness; and fatigability were present in all cases. In addition to muscular symptoms, which mostly appeared within the first decade of life, EBS-MD-MyS patients suffered from hypotension, alopecia totalis, hoarseness, and feeding difficulties. Significantly elevated (2–10 times) serum CK levels were reported for all patients [56][58][60][61], except for one patient with normal CK values [59]. While EMG did not show any abnormalities in a 2-year-old patient [56], it revealed a myopathic pattern in conjunction with fibrillation potentials, positive sharp waves, and complex repetitive discharges in other EBS-MD-MyS patients. Neuromuscular transmission studies using radial nerve stimulation (RNS) revealed a pathological decremental response in all patients. Tests for the presence of anti-acetylcholine receptor (AChR)- and anti-muscle-specific-kinase (MuSK)-antibodies were negative. Treatment with the cholinesterase inhibitor pyridostigmine and/or the potassium channel blocker 3,4-diaminopyridine (DAP) led to a significant improvement in some but not all EBS-MD-MyS patients. In addition, two siblings carrying a homozygous PLEC mutation as well as a mutation in the CHRNE gene, which encodes a subunit of the AChR, were described with EBD-MD-MyS [57].
Initially, for EBS-PA patients, who generally showed a more severe phenotype that included generalized skin blistering, aplasia cutis congenita, and pyloric atresia usually died within few months after birth, no signs of MD were reported [4]. However, it was reasonable to assume that these patients, if they survived longer, would have also developed MD at later points in life. In 2010, an EBS-PA patient was reported, who, based on clinical features and laboratory data, was postnatally diagnosed with MD [66]. Elevated levels of muscle enzymes, including CK and aldolase, persisted over the course of his life of three months [66]. Another case with EBS-PA experienced significant urological abnormalities and showed slightly increased CK levels at the age of 6 but demonstrated no clinical signs of MD at this age [40]. More recently, a patient with non-lethal EBS-PA and progressive MD was published [65]. This patient showed growth and motor developmental delays and started to walk and stand at the age of 20 months. CK values for this patient with EBS-MD-PA were reported for different times in life [65], with a CK peak of 1468 U/L (normal range <350 U/L) five days after birth and decreased levels over time (184 U/L and 206 U/L at 14 and 17 months of age, respectively). Since, at least in this case, the CK levels reached their peak at a very early age and before the onset of muscular symptoms, it would be advisable to also perform the corresponding measurements in plectinopathy patients at early time points.
Up until now, 13 cases with LGMDR17 due to mutations in exon 1f have been published [14][15][16]. In general, most LGMDR17 patients suffered from early onset limb-girdle syndrome followed by several years of plateau. They presented with delayed motor milestones, difficulties in walking and climbing stairs, easy fatigability, and muscle cramps. A routine EMG examination, performed on the index patient in the initial study, was clearly myopathic [14]. CK levels were markedly elevated (10- to 20-fold). Interestingly, while the first studies did not report any myasthenic features, the LGMDR17 patients presented by Mroczek et al., originating from four unrelated families, presented myasthenic symptoms such as mild ptosis from early on [15]. All four patients had high jitter in single-fiber EMG. Two patients, who had milder weakness, had a decremental response of over 10% in RNS. Moreover, two patients were reported to be negative for anti-AChR and anti-MuSK antibodies [15]. In addition to LGMDR17 caused by mutations in exon 1f, one patient suffering from severe MD with no obvious skin disorder was diagnosed with LGMDR17 due to compound heterozygous PLEC mutations in exons 31 and 32 (c.5995C > T, p.R1999W; c.9940T > A, p.F3314I), comparable to “classical” EBS-MD-causing PLEC mutations and not restricted to skeletal muscle-specific isoforms [68]. This patient developed the first signs of muscle weakness at 2 years of age (e.g., delayed independent walking, occasional falls, and difficulties climbing stairs), and muscle hypertrophy was reported at 7 years of age, including >10 times-increased serum CK levels [68]. Two more patients were diagnosed with LGMDR17 and myasthenic symptoms without any skin involvement caused by compound heterozygous PLEC mutations in exons 25 and 32 (c.3064C > T, p.Q1022Ter; c.11503G > A, p.G3835S), showing progressive limb and ocular muscle weakness with ptosis and dysphagia [67]. In these patients, serum CK levels were reported to be elevated, evaluation for anti-AChR antibody was negative, and EMG examinations showed a myopathic pattern, but nerve conduction studies revealed normal results [67].

3.3. Emerging Cardiac Pathologies in Plectinopathy Patients

The clinical phenotypes of human plectinopathies with the predominant involvement of skin and skeletal muscle highlight the notion that plectin centrally contributes to the fundamental biomechanical properties of stress-bearing tissues. Accordingly, plectin-related disease manifestations affecting the heart, a striated muscle organ with a high mechanical workload, are indeed plausible. The concept of an importance of plectin in cardiac tissue was further substantiated by several EBS-MD case studies, which reported on cardiac disease manifestations including left ventricular hypertrophy of the heart [23], atrial fibrillation in conjunction with reduced ejection fraction and hypokinetic left ventricular cardiac walls [69], biventricular dilated cardiomyopathy [28], and left ventricular non-compaction cardiomyopathy [20]. In another EBS-MD patient, a postoperative paroxysmal atrial fibrillation after a surgery was noted [19]. In 2016, an EBS-MD patient was reported, who, in addition to the typical skin and skeletal muscle involvement, developed a dilated cardiomyopathy and life-threatening episodes of cardiac arrhythmias necessitating the implantation of a single-chamber cardioverter defibrillator [24]. This work was the first report indicating that life-threatening cardiac disease manifestations may occur before the onset of skeletal muscle symptoms, underscoring the importance of routine cardiological evaluation including electrophysiological and cardiac imaging studies that should be part of the diagnostic work-up of all EBS-MD and EBS-MD-MyS patients. This is also in line with another study, in which a family with several cases of fatal cardiomyopathy was reported, and PLEC mutations were finally identified for the index patient [25]. Recently, out of a family with three siblings suffering from LGMDR17 due to a mutation in exon 1f, one patient died from sudden cardiac death after spontaneous pneumothorax [16]. Finally, the role of a PLEC missense variant as a risk factor for atrial fibrillation has been controversially discussed [70][71]. Despite its clear clinical relevance, data on plectin in normal and diseased human hearts is very scarce. Up until now, only a single publication exists in which the pathological consequences of PLEC mutations on human cardiac tissue have been described [28]. In the reported EBS-MD patient with progressive biventricular cardiomyopathy due to compound heterozygous PLEC mutations, an aberrant plectin staining with the loss of the normal plectin-desmin colocalization at intercalated disks and Z-disks as well as a sarcoplasmic protein aggregation pathology were found.

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