Abstract: The worldwide prevalence of neurological and neurodegenerative disorders, such as depression or Alzheimer ’s disease, has spread extensively throughout the last decades, becoming an enormous health issue. Numerous data indicate a distinct correlation between the altered endocannabinoid signaling and different aspects of brain physiology, such as memory or neurogenesis. Moreover, the endocannabinoid system is widely regarded as a crucial factor in the development of neuropathologies. Targeting those disorders via synthetic cannabinoids, as well as phytocannabinoids, becomes a widespread research issue. Thus, this text provides a current state of knowledge of the correlation between the endocannabinoid and neuropathologies. We believe that this might contribute to finding a new preventive and therapeutic approach to both neurological and neurodegenerative disorders.