- Please check and comment entries here.
Primary Spontaneous Pneumothorax
Primary spontaneous pneumothorax is an abnormal accumulation of air in the space between the lungs and the chest cavity (called the pleural space) that can result in the partial or complete collapse of a lung. This type of pneumothorax is described as primary because it occurs in the absence of lung disease such as emphysema. Spontaneous means the pneumothorax was not caused by an injury such as a rib fracture. Primary spontaneous pneumothorax is likely due to the formation of small sacs of air (blebs) in lung tissue that rupture, causing air to leak into the pleural space. Air in the pleural space creates pressure on the lung and can lead to its collapse. A person with this condition may feel chest pain on the side of the collapsed lung and shortness of breath.
Blebs may be present on an individual's lung (or lungs) for a long time before they rupture. Many things can cause a bleb to rupture, such as changes in air pressure or a very sudden deep breath. Often, people who experience a primary spontaneous pneumothorax have no prior sign of illness; the blebs themselves typically do not cause any symptoms and are visible only on medical imaging. Affected individuals may have one bleb to more than thirty blebs. Once a bleb ruptures and causes a pneumothorax, there is an estimated 13 to 60 percent chance that the condition will recur.
Primary spontaneous pneumothorax is more common in men than in women. This condition occurs in 7.4 to 18 per 100,000 men each year and 1.2 to 6 per 100,000 women each year.
Mutations in the FLCN gene can cause primary spontaneous pneumothorax, although these mutations appear to be a very rare cause of this condition. The FLCN gene provides instructions for making a protein called folliculin. In the lungs, folliculin is found in the connective tissue cells that allow the lungs to contract and expand when breathing. Folliculin is also produced in cells that line the small air sacs (alveoli). Researchers have not determined the protein's function, but they believe it may help control the growth and division of cells. Folliculin may play a role in repairing and re-forming lung tissue following damage. Researchers have not determined how FLCN gene mutations lead to the formation of blebs and increase the risk of primary spontaneous pneumothorax. One theory is that the altered folliculin protein may trigger inflammation within the lung tissue that could alter and damage the tissue, causing blebs.
Primary spontaneous pneumothorax most often occurs in people without an identified gene mutation. The cause of the condition in these individuals is often unknown. Tall young men are at increased risk of developing primary spontaneous pneumothorax; researchers suggest that rapid growth of the chest during growth spurts may increase the likelihood of forming blebs. Long-term smoking also greatly increases the risk of developing primary spontaneous pneumothorax in both men and women.
When this condition is caused by mutations in the FLCN gene, it is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. In most cases, a person inherits the FLCN gene mutation from an affected parent. People who have an FLCN gene mutation associated with primary spontaneous pneumothorax all appear to develop blebs, but it is estimated that only 40 percent of those individuals go on to have a primary spontaneous pneumothorax.
5. Other Names for This Condition
- spontaneous pneumothorax
This entry is adapted from https://medlineplus.gov/genetics/condition/primary-spontaneous-pneumothorax
- Bintcliffe O, Maskell N. Spontaneous pneumothorax. BMJ. 2014 May 8;348:g2928. doi: 10.1136/bmj.g2928. Review. Citation on PubMed
- Chiu HT, Garcia CK. Familial spontaneous pneumothorax. Curr Opin Pulm Med.2006 Jul;12(4):268-72. Review. Citation on PubMed
- Fröhlich BA, Zeitz C, Mátyás G, Alkadhi H, Tuor C, Berger W, Russi EW. Novelmutations in the folliculin gene associated with spontaneous pneumothorax. EurRespir J. 2008 Nov;32(5):1316-20. doi: 10.1183/09031936.00132707. Epub 2008 Jun25. Citation on PubMed
- Painter JN, Tapanainen H, Somer M, Tukiainen P, Aittomäki K. A 4-bp deletionin the Birt-Hogg-Dubé gene (FLCN) causes dominantly inherited spontaneouspneumothorax. Am J Hum Genet. 2005 Mar;76(3):522-7. Epub 2005 Jan 18. Citation on PubMed or Free article on PubMed Central
- Ren HZ, Zhu CC, Yang C, Chen SL, Xie J, Hou YY, Xu ZF, Wang DJ, Mu DK, Ma DH, Wang Y, Ye MH, Ye ZR, Chen BF, Wang CG, Lin J, Qiao D, Yi L. Mutation analysis ofthe FLCN gene in Chinese patients with sporadic and familial isolated primaryspontaneous pneumothorax. Clin Genet. 2008 Aug;74(2):178-83. doi:10.1111/j.1399-0004.2008.01030.x. Epub 2008 May 25. Citation on PubMed
- Sundaram S, Tasker AD, Morrell NW. Familial spontaneous pneumothorax and lung cysts due to a Folliculin exon 10 mutation. Eur Respir J. 2009 Jun;33(6):1510-2. doi: 10.1183/09031936.00062608. Citation on PubMed
- Tschopp JM, Bintcliffe O, Astoul P, Canalis E, Driesen P, Janssen J, KrasnikM, Maskell N, Van Schil P, Tonia T, Waller DA, Marquette CH, Cardillo G. ERS taskforce statement: diagnosis and treatment of primary spontaneous pneumothorax. EurRespir J. 2015 Aug;46(2):321-35. doi: 10.1183/09031936.00219214. Epub 2015 Jun25. Review. Citation on PubMed