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1 Further research on the association between headache disorders and vascular changes in children is needed to clarify this issue. + 1773 word(s) 1773 2020-10-24 19:47:54

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Sordyl, J.; Sarecka-Hujar, B. Headache. Encyclopedia. Available online: https://encyclopedia.pub/entry/2782 (accessed on 29 March 2024).
Sordyl J, Sarecka-Hujar B. Headache. Encyclopedia. Available at: https://encyclopedia.pub/entry/2782. Accessed March 29, 2024.
Sordyl, Joanna, Beata Sarecka-Hujar. "Headache" Encyclopedia, https://encyclopedia.pub/entry/2782 (accessed March 29, 2024).
Sordyl, J., & Sarecka-Hujar, B. (2020, October 24). Headache. In Encyclopedia. https://encyclopedia.pub/entry/2782
Sordyl, Joanna and Beata Sarecka-Hujar. "Headache." Encyclopedia. Web. 24 October, 2020.
Headache
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Headaches are common complaints in children. The International Classification of Headache Disorders, 3rd edition (beta version), defines more than 280 types of headaches. Primary headaches refer to independent conditions that cause pain and include migraine, tension-type headaches (TTH) and trigeminal autonomic cephalalgias (TACs). Several agents are involved in the pathogenesis of headaches. The factors associated with predisposition to atherosclerosis seem to be particularly important from the clinical point of view. The influence of obesity on the incidence of headaches has been well established. Moreover, idiopathic headaches, especially migraine, are thought to be one of the first signs of disorders in lipid metabolism and atherosclerosis. The risk of migraine increases with increasing obesity in children. Another factor that seems to be involved in both obesity and headaches is the adiponectin level.This review presents the current knowledge on the relationship between obesity and adiponectin and primary headaches.

atherosclerosis headache idiopathic headache inflammation child dyslipidaemia paediatric obesity

1. Introduction

Headache is one of the most frequent complaints in primary care practices and a very common condition reported by children, adolescents, and young adults [1][2][3][4]. However, headache phenotypes differ depending on the age group. In the pediatric population, the incidence of headaches increases with age. Conicella et al. observed headaches in 66% of school-age children [5]. The authors demonstrated that 93% of the analyzed children presented a recent onset of headache, whereas medium- and late-onset headaches were reported by 3% and 4% of all patients, respectively [5]. The overall headache prevalence has been reported to be as high as 56% in children under 10 years of age and 91% in early adulthood [3][6]. Additionally, a relationship between gender and the frequency of headaches was observed in pediatric patients. Abu-Arafeh et al. described odds ratio (OR) equal to 1.53 and 1.67 for the prevalence of headache and migraine in female and male patients, respectively [3][6]. During puberty, headaches are more common in girls, whereas in prepuberty, the frequency of headaches is similar in males and females [6][7]. On the other hand, in a large group of adult patients from the USA, migraine was more common among females, but in the case of other severe headaches, no sex difference was observed [2][8]. In some patients, headaches may become a long-lasting health problem as they tend to persist into adulthood. Most patients from Nova Scotia, Canada, having pediatric headaches suffered from headaches in adulthood (i.e., twenty years after diagnosis), whereas 27% were headache-free [9].

Headache classification is a complex issue due to the multi-faceted pathophysiology of this disorder. Possible etiological factors include, inter alia, neuronal, vascular, immunological, and psychological agents [10]. Nowadays, more than 280 headache types and subtypes are defined and categorized in the International Classification of Headache Disorders, 3rd edition, created by the International Headache Society (ICHD-3). The classification consists of four sections: primary headaches, secondary headaches, neuropathies, and appendix [10].

The group of primary headaches includes migraine, tension-type headaches (TTH), trigeminal autonomic cephalalgias (TACs), and other primary headache disorders [10].

The diagnosis of primary headache is strongly related to the patient`s medical history and typical characteristics of headaches described in ICHD-3. A thorough medical history and physical examination are crucial for identifying the etiology [3][10][11].

The treatment of headaches in children and adolescents requires a balanced approach to personalize therapy depending on the kind, frequency, and severity of symptoms as well as the limitations in daily life activities due to pain. The main goal of headache therapy in children is quick resolution with minimal side effects. The multi-faceted effort includes three general stages: lifestyle modification, psychotherapy, and pharmacotherapy [12][13].

A number of risk factors for headache have been demonstrated. Predisposition to atherosclerosis in idiopathic headaches seems to be particularly important from the clinical point of view. Migraine was suggested to be one of the first signs of disorders in lipid metabolism [14]. Elevated lipid concentrations were widely observed in adult migraineurs as well as in a few clinical studies conducted in pediatric patients [14][15][16]. The risk of migraine was also suggested to increase with increasing obesity in children [17][18][19][20].

Recent data suggest that some risk factors for atherosclerosis and platelet aggregation (i.e., brain-derived neurotrophic factor (BDNF), sCD40L (soluble CD40 ligand), serpin E1/PAI I (endothelial plasminogen activator inhibitor), and vascular endothelial growth factor (VEGFO)) may be involved in the underlying processes of idiopathic headaches [21][22][23][24][25][26][27][28][29][30].

The knowledge on the correlation between headaches and factors, which may increase the risk of atherosclerosis, and consequently, premature coronary artery disease, may be of particular importance, especially in the pediatric population.

2. Body Mass Index (BMI)

The available data support the relationship between obesity and headaches in children and adolescents [17][18][19][20][31][32][4][33][34][35][36][37][38][39][40][41][42]. Previous data demonstrated that obesity is associated with more frequent headaches in children and adolescents [17][18][19][20][38][39][41]. According to Pinhas-Hamiel et al., obese girls had a 4-fold increase in headaches compared to lean controls [17]. In the adult population, Peterlin et al. found that obese individuals had an 81% greater risk of episodic migraine than subjects with normal weight. The risk was particularly high in younger adults (below 50 years of age) and in females [38].

BMI percentile correlated not only with the frequency of headaches, but also with headache-related disability. However, no correlation between obesity and headache severity and duration was found [18][20]. The body mass index of children with headaches correlates not only with the incidence of this ailment, but also with the tendency to relapse and everyday functioning disruptions [18]. Verotti et al. reported that a change of mean BMI from 32.9 kg/m2 at baseline to 29.9 kg/m2 after 12 months of an intervention program caused a significant reduction in the headache frequency in obese Italian children and adolescents [43]. Similar data were obtained in the study evaluating the obesity–headache relationship in adolescents (13–18 years). Obese adolescent girls and boys were more likely to have recurrent headaches [43]. In contrast, some authors have reported no correlation between migraine and increased BMI in children [40].

Data on the relationship between obesity and TTH in children are insufficient and controversial, and the obtained results are often contradictory [19][39][40][41]. Pinhas-Hamiel et al. suggested that slightly overweight and obese patients more often fulfilled the TTH criteria than normal-weight children [17][18][39].

The mechanism involved in migraine in obese children is not known and several hypotheses have been suggested. The pathways involved in feeding regulation and those implicated in migraine are consistent in many central and peripheral points, for example, in hypothalamic activation, in the release of adiponectin, serotonin, or other immune modulators and inflammatory neurotransmitters [38][44][45]. Other possible factors involved in the migraine–obesity relationship are lifestyle and habits including migraine medications that could modulate body weight as well as diet and physical exercise of patients [40][44][45][46][47].

3. Adiponectin

Adiponectin is a protein post-translationally modified into various multimers and secreted into the circulation from adipocytes [48]. It shows anti-inflammatory properties and also protects cells from apoptosis. Adiponectin receptors are expressed in the cortex, hypothalamus, brainstem, circumventricular organs, and on the endothelium of the cerebral microvasculature. Several signal transduction mechanisms were found to be activated by adiponectin, of which some are implicated in migraine including nuclear factor kappa beta (NFkβ), AMP-activated protein kinase (AMPK), mitogen-activated protein kinase (MAPK), or endothelial nitric oxide synthase (e-NOS) [49][50]. Previous research demonstrated that obese children had low adiponectin levels, whereas the markers of inflammation and proinflammatory cytokines were elevated [51]. The study by Asayama et al. showed that the levels of adiponectin in obese children were correlated inversely with the visceral adipose tissue area and their serum levels were decreased. Low levels of adiponectin are associated with platelet aggregation as well as proinflammatory cytokine release [52]. The above-mentioned mediators can trigger the following cascade of events: they affect frequency, severity, and duration of migraine attacks, which, especially when repeated, may cause central sensitization, and eventually permanent neuronal damage. Duarte et al. reported significantly higher levels of adiponectin in patients with migraine than in the controls [53]. However, no relation was observed when patients with episodic vs. chronic migraine as well as migraine patients with aura vs. without aura were compared [53]. On the other hand, a Brazilian study revealed a statistical difference in adiponectin levels between migraine patients and tension-type headaches [54]. The study by Dearborn et al. demonstrated that total adiponectin levels were significantly higher in women compared to men [55].

4. Dyslipoproteinemia

Dyslipoproteinemia, just like obesity, is a common, well-known risk factor for cerebrovascular and cardiovascular diseases [56][57]. Data from large groups of subjects revealed how common the problem of lipid disturbances in children is. In a study by Reuter et al., 42% (out of n = 1243) of healthy Brazilian children and adolescents had dyslipidemia, which was more prevalent in girls than in boys [15]. Almost 20% of Korean children and adolescents aged 10–18 years were reported to have at least one abnormal lipid profile [16].

Elevated lipid levels were observed in adults with idiopathic headaches, but there are only a few small clinical studies showing a relationship between disturbances in lipid levels and migraine in pediatric patients [14][22][58][59][60][61]. A significant positive correlation between the frequency and intensity of migraine and the levels of total cholesterol as well as low-density lipoprotein (LDL) cholesterol was observed in an Italian study. Moreover, in patients treated for migraine prophylaxis, a decreased number and intensity of episodes correlated significantly with a reduction in total cholesterol and LDL levels [14]. Glueck and Bates showed a similar relation between severe migraine headaches and LDL levels in boys with primary and familial dyslipoproteinemias [59]. In a large group of Brazilian adults, the relation between migraine and lipid sub-fraction was assessed [60]. The authors indicated a positive correlation between migraine without aura and the highest tertiles of very-low-density lipoprotein (VLDL) cholesterol in females. On the other hand, in men, a positive association was observed between migraine with aura and the highest tertile of VLDL3 cholesterol [60].

Nevertheless, some authors deny the correlation between lipid levels and the occurrence of primary headaches in children. A large and representative American sample showed no differences in the values of lipid levels by headache status. However, boys with headaches had lower high-density lipoprotein (HDL) levels than asymptomatic patients of the same sex [22].

In contrast, Winsvold et al. reported that total cholesterol levels may be even lower in adults suffering from migraine than in non-migraine controls. In this study, HDL cholesterol showed a similar tendency toward decreased values [61].

Moreover, according to Sacher et al., migraine correlates with an increased risk of ischemic stroke in adult patients in comparison to the healthy population [62][63]. Studies performed in children did not confirm this correlation, but some authors reported a higher prevalence of migraine among young individuals with medical history of stroke, silent infarct-like brain lesions, and cerebrovascular disorders during headache attacks [64][65][66]. The study by Sarecka-Hujar et al. demonstrated that about 40% of children with arterial ischemic stroke had hypertriglyceridemia [67]. Moreover, the data from the International Pediatric Stroke Study (IPSS) demonstrated that 41% of children with arterial ischemic stroke had elevated levels of TG, whereas 36% of children were dyslipidemic [68].

References

  1. William P Whitehouse; Shakti Agrawal; Management of children and young people with headache. Archives of disease in childhood - Education & practice edition 2016, 102, 58-65, 10.1136/archdischild-2016-311803.
  2. Lars Jacob Stovner; Emma Nichols; Timothy J Steiner; Foad Abd-Allah; Ahmed Abdelalim; Rajaa M Al-Raddadi; Mustafa Geleto Ansha; Aleksandra Barac; Isabela M Bensenor; Linh Phuong Doan; et al.Dumessa EdessaMatthias EndresKyle J ForemanFortune Gbetoho GankpeGururaj GopalkrishnaAlessandra C GoulartRahul GuptaGraeme J HankeySimon I HayMohamed I HegazyEsayas Haregot HilaweAmir KasaeianDessalegn H KassaIbrahim KhalilYoung-Ho KhangJagdish KhubchandanYun Jin KimYoshihiro KokuboMohammed A MohammedMaziar Moradi-LakehHuong Lan Thi NguyenYirga Legesse NirayoMostafa QorbaniAnna RantaKedir T RobaSaeid SafiriItamar S SantosMaheswar SatpathyMonika SawhneyMekonnen Sisay ShiferawIvy ShiueMari SmithCassandra E I SzoekeNu Thi TruongNarayanaswamy VenketasubramanianKidu Gidey WeldegwergsRonny WestermanTissa WijeratneBach Xuan TranNaohiro YonemotoValery L FeiginTheo VosChristopher J L Murray Global, regional, and national burden of migraine and tension-type headache, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet Neurology 2018, 17, 954-976, 10.1016/s1474-4422(18)30322-3.
  3. Rizzoli, P.; Mullally, W.J.; Headache. J. Med. 2018, 131, 17-24.
  4. Çiçek Wöber-Bingöl; Epidemiology of Migraine and Headache in Children and Adolescents. Current Pain and Headache Reports 2013, 17, 1-11, 10.1007/s11916-013-0341-z.
  5. Elena Conicella; Umberto Raucci; Nicola Vanacore; Federico Vigevano; Antonino Reale; Nicola Pirozzi; Massimiliano Valeriani; The Child With Headache in a Pediatric Emergency Department. Headache: The Journal of Head and Face Pain 2008, 48, 1005-1011, 10.1111/j.1526-4610.2007.01052.x.
  6. Ishaq Abu-Arafeh; Sheik Razak; Baskaran Sivaraman; Catriona Graham; Prevalence of headache and migraine in children and adolescents: a systematic review of population-based studies. Developmental Medicine & Child Neurology 2010, 52, 1088-1097, 10.1111/j.1469-8749.2010.03793.x.
  7. D. W. Lewis; S. Ashwal; G. Dahl; D. Dorbad; D. Hirtz; A. Prensky; I. Jarjour; Practice parameter: Evaluation of children and adolescents with recurrent headaches: Report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology 2002, 59, 490-498, 10.1212/wnl.59.4.490.
  8. Dawn C. Buse; Elizabeth W. Loder; Jennifer A. Gorman Ms; Walter F. Stewart; Michael L. Reed; Kristina M. Fanning; Daniel Serrano; Richard B. Lipton; Sex Differences in the Prevalence, Symptoms, and Associated Features of Migraine, Probable Migraine and Other Severe Headache: Results of the American Migraine Prevalence and Prevention (AMPP) Study. Headache: The Journal of Head and Face Pain 2013, 53, 1278-1299, 10.1111/head.12150.
  9. Paula Brna; Joseph Dooley; Kevin Gordon; Tammie Dewan; The Prognosis of Childhood Headache. Archives of Pediatrics & Adolescent Medicine 2005, 159, 1157-1160, 10.1001/archpedi.159.12.1157.
  10. Headache Classification Committee of the International Headache Society (IHS); Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia 2018, 38, 1-211, 10.1177/0333102417738202.
  11. Jasmin M. Dao; William Qubty; Headache Diagnosis in Children and Adolescents. Current Pain and Headache Reports 2018, 22, 17, 10.1007/s11916-018-0675-7.
  12. Marina Khrizman; Ann Pakalnis; Management of Pediatric Migraine: Current Therapies. Pediatric Annals 2018, 47, e55-e60, 10.3928/19382359-20180129-02.
  13. P. Barbanti; L. Grazzi; G. Egeo; Pharmacotherapy for acute migraines in children and adolescents. Expert Opinion on Pharmacotherapy 2018, 20, 455-463, 10.1080/14656566.2018.1552941.
  14. Claudio Tana; Francesca Santilli; Paolo Martelletti; Angelo Di Vincenzo; Francesco Cipollone; Giovanni Davì; Maria Adele Giamberardino; Correlation between Migraine Severity and Cholesterol Levels. Pain Practice 2014, 15, 662-670, 10.1111/papr.12229.
  15. Cézane Priscila Reuter; Priscila Tatiana Da Silva; Jane Dagmar Pollo Renner; Elza Daniel De Mello; Andréia Rosane De Moura Valim; Luiza Pasa; Rafaela Da Silva; Miria Suzana Burgos; Dyslipidemia is Associated with Unfit and Overweight-Obese Children and Adolescents. Arquivos Brasileiros de Cardiologia 2016, 106, 188-93, 10.5935/abc.20160025.
  16. Seung Yang; Jin Soon Hwang; Hong Kyu Park; Hae Sang Lee; Hae Soon Kim; Eun Young Kim; Jung Sub Lim; Serum Lipid Concentrations, Prevalence of Dyslipidemia, and Percentage Eligible for Pharmacological Treatment of Korean Children and Adolescents; Data from the Korea National Health and Nutrition Examination Survey IV (2007–2009). PLoS ONE 2012, 7, e49253, 10.1371/journal.pone.0049253.
  17. Orit Pinhas-Hamiel; Katia Frumin; Lidia Gabis; Kineret Mazor-Aronovich; Dalit Modan-Moses; Brian Reichman; Liat Lerner-Geva; Headaches in Overweight Children and Adolescents Referred to a Tertiary-care Center in Israel. Obesity 2008, 16, 659-663, 10.1038/oby.2007.88.
  18. Andrew D. Hershey; Scott W. Powers; Timothy D. Nelson; Marielle A. Kabbouche; Paul Winner; Marcy Yonker; Steven L. Linder; Alma Bicknese; Michael K. Sowel; William McClintock; et al.The American Headache Society Pediatric Adolescent Section Obesity in the Pediatric Headache Population: A Multicenter Study. Headache: The Journal of Head and Face Pain 2009, 49, 170-177, 10.1111/j.1526-4610.2008.01232.x.
  19. Sarit Ravid; Eli Shahar; Aharon Schiff; Shirie Gordon; Obesity in Children With Headaches: Association With Headache Type, Frequency, and Disability. Headache: The Journal of Head and Face Pain 2013, 53, 954-961, 10.1111/head.12088.
  20. Kinik, S.T.; Alehan, F.; Erol, I.; Kanra, A.R.; Obesity and pediatric migraine. Cephalalgia 2010, 30, 105-109.
  21. George Nikov Chaldakov; Marco Fiore; Mariana G Hristova; L. Aloe; Metabotrophic potential of neurotrophins:implication in obesity and related diseases?. Medical Science Monitor 2003, 9, 19-21.
  22. Karin B. Nelson; Amanda Kalaydjian Richardson; Jianping He; Tarranum M. Lateef; Suzan Khoromi; Kathleen R. Merikangas; Headache and Biomarkers Predictive of Vascular Disease in a Representative Sample of US Children. Archives of Pediatrics & Adolescent Medicine 2010, 164, 358-362, 10.1001/archpediatrics.2010.17.
  23. F. Blandini; L Rinaldi; C Tassorelli; G Sances; M Motta; A Samuele; R Fancellu; G Nappi; A Leon; Peripheral Levels of BDNF and NGF in Primary Headaches. Cephalalgia 2006, 26, 136-142, 10.1111/j.1468-2982.2005.01006.x.
  24. Marco Túlio A. Tanure; Rodrigo S. Gomez; Rubens Carlos L. Hurtado; Antônio L. Teixeira; Renan Barros Domingues; Increased serum levels of brain-derived neurotropic factor during migraine attacks: a pilot study. The Journal of Headache and Pain 2010, 11, 427-430, 10.1007/s10194-010-0233-0.
  25. Marlene Fischer; Georg Wille; Stephanie Klien; Hind Shanib; Dagny Holle; Charly Gaul; Gregor Broessner; Brain-derived neurotrophic factor in primary headaches. The Journal of Headache and Pain 2012, 13, 469-475, 10.1007/s10194-012-0454-5.
  26. Sibel Guldiken; Baburhan Guldiken; Muzaffer Demir; Levent Kabayel; Hulya Ozkan; Nilda Turgut; Remziye Hunkar; Selahattin Kat; Soluble CD40 ligand and prolactin levels in migraine patients during interictal period. The Journal of Headache and Pain 2011, 12, 355-360, 10.1007/s10194-011-0306-8.
  27. Dawei Han; Association of serum levels of calcitonin gene-related peptide and cytokines during migraine attacks. Annals of Indian Academy of Neurology 2019, 22, 277-281, 10.4103/aian.aian_371_18.
  28. A Bianchi; G Pitari; V Amenta; F Giuliano; M Gallina; R Costa; S Ferlito; Endothelial, haemostatic and haemorheological modifications in migraineurs.. Artery 1996, 22, 93-100.
  29. Nanna Arngrim; Henrik Winther Schytz; Josefine Britze; Faisal Mohammad Amin; Mark Bitsch Vestergaard; Anders Hougaard; Frauke Wolfram; Patrick J. H. De Koning; Karsten S. Olsen; Niels H. Secher; et al.Henrik Bo Wiberg LarssonJes OlesenMessoud Ashina Migraine induced by hypoxia: an MRI spectroscopy and angiography study. Brain 2015, 139, 723-737, 10.1093/brain/awv359.
  30. Xiana Rodríguez-Osorio; Tomás Sobrino; David Brea; Francisco Martínez; José Castillo; Rogelio Leira; Endothelial progenitor cells: A new key for endothelial dysfunction in migraine. Neurology 2012, 79, 474-479, 10.1212/wnl.0b013e31826170ce.
  31. M. S. Linet; An epidemiologic study of headache among adolescents and young adults. JAMA 1989, 261, 2211-2216, 10.1001/jama.261.15.2211.
  32. I. Abu-Arefeh; G. Russell; Prevalence of headache and migraine in schoolchildren.. BMJ 1994, 309, 765-769.
  33. M J Mortimer; J Kay; A Jaron; Epidemiology of headache and childhood migraine in an urban general practice using Ad Hoc, Vahlquist and IHS criteria.. Developmental Medicine & Child Neurology 1992, 34, 1095-1101.
  34. Valquist, B.; Migraine in children. Int Arch Allergy 1955, 7, 348–355.
  35. Matti Sillanpaa; PREVALENCE OF MIGRAINE AND OTHER HEADACHE IN FINNISH CHILDREN STARTING SCHOOL. Headache: The Journal of Head and Face Pain 1976, 15, 288-290, 10.1111/j.1526-4610.1976.hed1504288.x.
  36. Scott W. Powers; Susana R. Patton; Kevin A. Hommel; Andrew D. Hershey; Quality of Life in Childhood Migraines: Clinical Impact and Comparison to Other Chronic Illnesses. Pediatrics 2003, 112, e1-e5, 10.1542/peds.112.1.e1.
  37. Kevin Hawkins; Sara Wang; Marcia Rupnow; Direct Cost Burden Among Insured US Employees With Migraine. Headache: The Journal of Head and Face Pain 2008, 48, 553-563, 10.1111/j.1526-4610.2007.00990.x.
  38. B. Lee Peterlin; Andrea L. Rosso; Michelle A. Williams; Jason R. Rosenberg; Jennifer A. Haythornthwaite; Kathleen R. Merikangas; Rebecca F. Gottesman; Dale S. Bond; Jian-Ping He; Alan B. Zonderman; et al. Episodic migraine and obesity and the influence of age, race, and sex. Neurology 2013, 81, 1314-1321, 10.1212/wnl.0b013e3182a824f7.
  39. 41. Robberstad, L.; Dyb, G.; Hagen, K.; Stovner, L.J.; Holmen, T.L.; Zwart, J.A.; An unfavourable lifestyle and recurrent headaches among adolescents: the HUNT study. Neurology 2010, 75, 712–717.
  40. 42. Pakalnis, A.; Kring, D.; Chronic daily headache, medication overuse, and obesity in children andadolescents. J Child Neurol 2012, 27, 577–580.
  41. 43. Lu, S.R.; Fuh, J.L.; Wang, S.J.; Juang, K.D.; Chen, S.P.; Liao, Y.C. et al.; Incidence and Risk Factors of Chronic Daily Headache in Young Adolescents: A School Cohort Study. Pediatrics 2013, 132, 9-16, 10.1542/peds.2012-1909d.
  42. Fatma Hancı; Nimet Kabakuş; Sevim Türay; Keziban A. Bala; Mustafa Dilek; The role of obesity and vitamin D deficiency in primary headaches in childhood. Acta Neurologica Belgica 2019, 120, 1123-1131, 10.1007/s13760-019-01134-2.
  43. A. Verrotti; S. Agostinelli; Claudia D’Egidio; A. Di Fonzo; M. Carotenuto; Battistella Pa; M. Esposito; E. Tozzi; V. Belcastro; A. Mohn; et al.P. A. Battistella Impact of a weight loss program on migraine in obese adolescents. European Journal of Neurology 2012, 20, 394-397, 10.1111/j.1468-1331.2012.03771.x.
  44. Nu Cindy Chai; Ann I. Scher; Abhay Moghekar; Dale S. Bond; B. Lee Peterlin Do; Obesity and Headache: Part I - A Systematic Review of the Epidemiology of Obesity and Headache. Headache: The Journal of Head and Face Pain 2014, 54, 219-234, 10.1111/head.12296.
  45. Nu Cindy Chai; Dale S. Bond; Abhay Moghekar; Ann I. Scher; B. Lee Peterlin Do; Obesity and Headache: Part II - Potential Mechanism and Treatment Considerations. Headache: The Journal of Head and Face Pain 2014, 54, 459-471, 10.1111/head.12297.
  46. Frederick R Taylor; Weight change associated with the use of migraine-preventive medications. Clinical Therapeutics 2008, 30, 1069-1080, 10.1016/j.clinthera.2008.06.005.
  47. Eric H. W. Kossoff; J Huffman; Z Turner; J Gladstein; Use of the modified Atkins diet for adolescents with chronic daily headache.. Cephalalgia 2010, 30, 1014-1016, 10.1111/j.1468-2982.2009.02016.x.
  48. Han Fang; Robert L. Judd; Adiponectin Regulation and Function. Comprehensive Physiology 2018, 8, 1031-1063, 10.1002/cphy.c170046.
  49. Nu Cindy Chai; Bizu Gelaye; Gretchen E. Tietjen; Paul D. Dash; Barbara A. Gower; Linda W. White; Thomas N. Ward; Ann I Scher; B. Lee Peterlin; Ictal adipokines are associated with pain severity and treatment response in episodic migraine.. Neurology 2015, 84, 1409-18, 10.1212/WNL.0000000000001443.
  50. B. Lee Peterlin Do; Simona Sacco; Claudia Bernecker; Ann I. Scher; Adipokines and Migraine: A Systematic Review. Headache: The Journal of Head and Face Pain 2016, 56, 622-644, 10.1111/head.12788.
  51. Alison N Jeffery; Michael J. Murphy; B. S. Metcalf; Joanne Hosking; Linda D Voss; Patrick English; Naveed Sattar; T J Wilkin; Adiponectin in childhood. Pediatric Obesity 2008, 3, 130-140, 10.1080/17477160801954538.
  52. Kohtaro Asayama; Hidemasa Hayashibe; Kazushige Dobashi; Norihiko Uchida; Takaya Nakane; Kohji Kodera; Akira Shirahata; Matsuo Taniyama; Decrease in Serum Adiponectin Level Due to Obesity and Visceral Fat Accumulation in Children. Obesity Research 2003, 11, 1072-1079, 10.1038/oby.2003.147.
  53. Halina Duarte; Antonio L. Teixeira; Natália P. Rocha; Renan B. Domingues; Increased serum levels of adiponectin in migraine. Journal of the Neurological Sciences 2014, 342, 186-188, 10.1016/j.jns.2014.04.035.
  54. Renan B. Domingues; Halina Duarte; Carlos Senne; Gustavo Bruniera; Fernando Brunale; Natália P. Rocha; Antonio L. Teixeira; Serum levels of adiponectin, CCL3/MIP-1α, and CCL5/RANTES discriminate migraine from tension-type headache patients. Arquivos de Neuro-Psiquiatria 2016, 74, 626-631, 10.1590/0004-282x20160096.
  55. Jennifer L. Dearborn; Andrea L.C. Schneider; Rebecca F. Gottesman; Tobias Kurth; James S. Pankow; David J. Couper; Kathryn M. Rose; Michelle A. Williams; B. Lee Peterlin; Adiponectin and leptin levels in migraineurs in the Atherosclerosis Risk in Communities Study. Neurology 2014, 83, 2211-2218, 10.1212/wnl.0000000000001067.
  56. Huige Li; Sven Horke; Ulrich Förstermann; Vascular oxidative stress, nitric oxide and atherosclerosis. Atherosclerosis 2014, 237, 208-219, 10.1016/j.atherosclerosis.2014.09.001.
  57. Arturo Zárate; Leticia Manuel-Apolinar; Renata Saucedo; Marcelino Hernández-Valencia; Lourdes Basurto; Hypercholesterolemia As a Risk Factor for Cardiovascular Disease: Current Controversial Therapeutic Management. Archives of Medical Research 2016, 47, 491-495, 10.1016/j.arcmed.2016.11.009.
  58. C J Glueck; S R Bates; Migraine in children: association with primary and familial dyslipoproteinemias.. Pediatrics 1986, 77, 316-21.
  59. Joanna Sordyl; Ilona Kopyta; Beata Sarecka-Hujar; Tomasz Francuz; Paweł Matusik; Ewa Małecka-Tendera; Lipid levels and selected biomarkers of vascular changes in children with idiopathic headaches – a preliminary report. Archives of Medical Science 2019, 15, 120-125, 10.5114/aoms.2018.73983.
  60. Alessandra C Goulart; Paulo Lotufo; Itamar S Santos; Márcio S Bittencourt; Raul D Santos; Michael J Blaha; Steven Jones; Peter P Toth; Krishnaji Kulkarni; Isabela M Benseñor; et al. The relationship between migraine and lipid sub-fractions among individuals without cardiovascular disease: A cross-sectional evaluation in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Cephalalgia 2017, 38, 528-542, 10.1177/0333102417699181.
  61. Bendik Slagsvold Winsvold; K. Hagen; A. H. Aamodt; L. J. Stovner; J. Holmen; J.-A. Zwart; Headache, migraine and cardiovascular risk factors: The HUNT study. European Journal of Neurology 2010, 18, 504-511, 10.1111/j.1468-1331.2010.03199.x.
  62. Ann I. Scher; Migraine Headache in Middle Age and Late-Life Brain Infarcts. JAMA 2009, 301, 2563-2570, 10.1001/jama.2009.932.
  63. Chia-Kuang Tsai; Chung-Hsing Chou; Pei-Jung Lee; Jiu-Haw Yin; Shao-Yuan Chen; Chun-Chieh Lin; Yueh-Feng Sung; Fu-Chi Yang; Chi-Hsiang Chung; Wu-Chien Chien; et al.Jiunn-Tay Lee The potential impact of primary headache disorders on stroke risk. The Journal of Headache and Pain 2016, 17, 1-7, 10.1186/s10194-016-0701-2.
  64. Davinia Larrosa; César Ramón-Carbajo; Marta Para-Prieto; Sergio Calleja-Puerta; Eva Cernuda-Morollón; Julio Pascual; [Migraine as a vascular risk factor].. Revista de Neurología 2012, 55, 349-358.
  65. Marta Guillán; Araceli Alonso-Canovas; Jaime Gonzalez-Valcarcel; Nuria García Barragán; Juan García Caldentey; Ignacio Hernández-Medrano; Alicia DeFelipe-Mimbrera; Victor Sanchez-Gonzalez; Elena Terecoasa; María Alonso De Leciñana; et al.Jaime Masjuan Stroke Mimics Treated with Thrombolysis: Further Evidence on Safety and Distinctive Clinical Features. Cerebrovascular Diseases 2012, 34, 115-120, 10.1159/000339676.
  66. Sonia Partap; Stroke and Cerebrovascular Complications in Childhood Cancer Survivors. Seminars in Pediatric Neurology 2012, 19, 18-24, 10.1016/j.spen.2012.02.012.
  67. Sarecka-Hujar, B.; Kopyta, I.; Machnikowska-Sokołowska, M.; Gruszczyńska, K.; Raczkiewicz, D.; Lipid and coagulation profiles in children with arterial ischemic stroke depending on the presence of focal cerebral arteriopathy. Eur. J. Med. Technol. 2018, 1, 41-50.
  68. Sally Sultan; Michael Dowling; Adam Kirton; Gabrielle DeVeber; Alexandra Linds; Mitchell S. V. Elkind; Tim Bernard; Marta Hernandez; Michael Rivkin; Ilona Kopyta; et al.Rebecca IchordSusan BenedictMark MackayDimitrios ZafeiriouMonica TroncosoJerome YagerLisa AbrahamWarren LoVeronica GonzalezMontri SaengpattrachaiAnthony ChanAbdallah AbdallahVesna Brankovic-SreckovicAnneli KolkJessica CarpenterGordana KovacevicCatherine Amlie-LefondMaja SteinlinJuliann PaolicchiMonroe CarellBruce BjornsonBarry KosofskyVirginia WongPaola PergamiNeil FriedmanYang GuangPeter HumphreysUlrike Nowak-GöttlDonna FerrieroFrederico XavierRobert FryerLucila Andrade AlvealDiana AltunaRyan FellingSteven PavlakisEric GrabowskiMeredith GolombMichael NoetzelChaouki KhouryNorma LernerAmanda BlairMubeen Rafay Dyslipidemia in Children With Arterial Ischemic Stroke: Prevalence and Risk Factors. Pediatric Neurology 2018, 78, 46-54, 10.1016/j.pediatrneurol.2017.09.019.
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