SARS-CoV-2 Virus on Psoriasis

Version	Summary	Created by	Modification	Content Size	Created at	Operation
1		Andrzej Bożek	+ 1325 word(s)	1325	2021-08-27 12:10:23	\|
2	format corrected.	Beatrix Zheng	+ 154 word(s)	1479	2021-08-30 06:02:40	\|

This entry is adapted from the peer-reviewed paper 10.3390/medicina57090881

Biological treatment is an important and effective therapy for psoriasis. During the COVID-19 pandemic, it remains unclear whether this type of therapy affects the course of SARS-CoV-2 infection. The aim of the study was to observe patients with psoriasis undergoing biological or other systemic treatment in relation to the impact of SARS-CoV-2 infection on the course of psoriasis and the COVID-19 disease itself. Materials and methods: A one-year observational study included 57 patients with diagnosed psoriasis who qualified for biological treatment and a group of 68 similar patients who were administered a different systemic treatment. Patients were analyzed monthly for psoriasis (including Psoriasis Area Severity Index (PASI) assessment) and constantly for SARS-CoV-2 infection (telephone contact). Cases of COVID-19 were confirmed by Polymerase Chain Reaction (PCR) at the study center. Results: SARS-CoV-2 infection was confirmed by a positive Real Time Polymerase Chain Reaction (RT-PCR) test in eight patients (14.0%) with psoriasis on biological therapy. None of the cases in this group required hospitalization for COVID-19. Similar data were obtained in the control group. Specifically, 11 (16%) patients were confirmed to be infected with SARS-CoV-2. These results were statistically comparable (p > 0.05). In the group of patients undergoing biological treatment, six (75%) of eight patients developed an exacerbation of psoriasis during SARS-CoV-2 infection, and similar results were noted in the control group, with eight (72%) patients experiencing an exacerbation of psoriasis. Conclusions: Patients with psoriasis who were administered biological treatment or other systemic therapy may experience a mild course of SARS-CoV-2 infection but might also experience a temporary exacerbation of skin lesions.

psoriasis psoriatic arthritis COVID-19 biological drugs

1. Introduction

Psoriasis is a chronic, immune-mediated inflammatory skin disease. It is estimated that approximately 5–30% of patients with psoriasis vulgaris suffer from psoriatic arthritis (PsA) ^[1]. Psoriasis treatment includes the use of external preparations and systemic medications ^[1]. The use of biological drugs represents an important breakthrough in the treatment of psoriasis. These drugs inhibit effector cytokines, such as TNF-alpha, IL-12, IL-17, and IL-23, that play a key role in the pathomechanism of psoriasis ^[2].

Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The first cases were reported in Wuhan, China, in December 2019 ^[3]. This new virus has spread rapidly to many countries, and the ongoing SARS-CoV-2 pandemic presents us with new diagnostic and therapeutic challenges. Patients with severe psoriasis require the use of biologics to control disease severity, but it is unclear whether the achieved immunosuppression increases the risk of SARS-CoV-2 infection ^[4]. The aim of this study was to monitor patients with severe psoriasis who were administered biological therapy during the COVID-19 pandemic. Two key questions of this study were as follows: could the use of biological drugs have an impact on the course of COVID-19 infection? Could the use of biological drugs prevent symptomatic/asymptomatic SARS-CoV-2 infection?

2. Analysis on Results

In the group of patients under biological treatment, SARS-CoV-2 infection was confirmed by a positive RT-PCR test in eight patients (14.0%). All of these patients had mild clinical symptoms, including anosmia, cough, mild breathing difficulties, and fever. Hospitalization due to COVID-19 did not occur in this group. Similar data were obtained in the control group: 11 (16%) patients were confirmed to be infected with SARS-CoV-2. In this group, only mild disease was observed, and hospitalization was not required for any patient. These results were statistically comparable (p > 0.05). In the group of patients undergoing biological treatment, six (75%) of eight patients developed an exacerbation of psoriasis during SARS-CoV-2 infection (example of a patient before and immediately after SARS-CoV-2 infection: Figure 1 and Figure 2). A similar relationship was observed in the control group, in which 8 (72%) of 11 patients with SARS-CoV-2 infection experienced an exacerbation of psoriasis. Detailed data are presented in Table 1. In any described patients, psoriasis therapy was not suspended in the case of SARS-CoV-2 infection. In all patients with an exacerbation of psoriasis, the condition resolved within 4–6 weeks from the diagnosis of COVID-19 and did not require intensification of systemic treatment (local treatment was increased), with the exception of two patients on cyclosporin for whom the dose was temporarily increased (4–6 weeks) by 50%. There was no situation in which the patients themselves modified their psoriasis treatment.

Figure 1. Patient before COVID-19 during biological therapy.

Figure 2. The same patient just after SARS-Co-V-2 infection.

Table 1. Characteristics of psoriasis patients who developed SARS-CoV-2 infection.

N S/C	Sex	Age	Type of Psoriasis According to ICD-10	Drug Name	Exacerbation of Psoriasis PASI Score before vs. after	Concomitant Diseases	Time of Exacerbation (days)
1S	M	72	L40.0	adalimumab	No 32–28	Arterial hypertension	-
2S	M	60	L40.0	secukinumab	No 29–31	-	-
3S	W	50	L40.0	ustekinumab	Yes 4–64	Obesity	12
4S	M	44	L40.0	ustekinumab	Yes 23–51	-	24
5S	W	43	L40.5	adalimumab	Yes 18–33	-	28
6S	M	50	L40.0	risankizumab	Yes 4–31	Arterial hypertension	28
7S	W	52	L40.0	ustekinumab	Yes 8–44	-	21
8S	W	52	L40.0	adalimumab	Yes 15–25	-	36
1C	M	51	L40.5	cyclosporin	No 17–15	-	-
2C	M	42	L40.5	PUVA	Yes 32–46	Arterial hypertension	24
3C	M	45	L40.0	cyclosporin	Yes 28–39	-	38
4C	W	62	L40.0	PUVA	Yes 12–54	-	42
5C	W	55	L40.0	cyclosporin	No 19–42	-	-
6C	M	54	L40.5	cyclosporin	Yes 33–63	Arterial hypertension	32
7C	M	46	L40.0	methotrexate	No 8–7	-	-
8C	W	69	L40.0	methotrexate	Yes 5–26	Diabetes Arterial hypertension	25
9C	M	38	L40.0	cyclosporin	Yes 9–52	-	60
10C	M	44	L40.0	PUVA	Yes 12–33	-	24
11C	W	49	L40.0	methotrexate	Yes 25–38	-	32

Legend: S—study group, C—control group, M: man, W: woman.

3. Current Insights

With the onset of the COVID-19 pandemic, there were alarming case reports of exacerbation of psoriasis after SARS-CoV-2 infection in patients not being treated with biological therapy ^[5]^[6]^[7].

The impact of SARS-CoV-2 infection on biologically treated patients with moderate to severe psoriasis is currently unclear. The primary immune response is satisfactory and leads to a decrease in viral load. Unfortunately, for reasons that remain unclear, the secondary immune response (the so-called “cytokine storm”) may be excessive and may be a factor leading to tissue integrity disorders, respiratory failure, or exacerbation of skin lesions. We cannot exclude the notion that biologics may reduce the production of pro-inflammatory cytokines, thereby reducing the negative impact of COVID-19 on the symptoms of psoriasis ^[5]^[6]^[7]^[8]^[9]^[10].

The presented work documents that all patients undergoing biological treatment had a mild course of COVID-19 and did not require hospitalization. Earlier studies also confirmed that the use of biological drugs by patients with psoriasis was associated with a much lower risk of hospitalization, although other factors, such as a patient’s age or comorbidities, should not be overlooked ^[11]^[12]^[13]. The current Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) guidelines recommend that biological treatments for psoriasis and psoriatic arthritis should not be discontinued or reduced during the pandemic, or when SARS-COV-2 virus infection is diagnosed. Research indicates that inappropriate treatment modification or discontinuation of treatment may worsen symptoms and reduce the response to re-treatment ^[14]^[15].

There are no conclusive data on the safety of initiating biological therapy in patients with psoriasis. In addition, a joint decision by a patient and their physician on the initiation of treatment is recommended, given that delayed treatment of psoriasis can seriously affect a patient’s physical and mental health ^[14]^[15]^[16].

The observed control group reacted in a similar manner to SARS-CoV-2 infection as patients on biological treatment. Specifically, no severe cases of COVID-19 and no cases requiring hospitalization were noted in either group. All patients were only symptomatically treated and did not require systemic steroids, heparin, or oxygen therapy. The patients only used antipyretic drugs.

None of our patients modified or suspended psoriasis treatment during SARS-Co-V-2 infection, and this excludes any additional impact on the course of psoriasis during COVID-19. This is different from other observations in which patients themselves decided to change or suspend such treatment ^[17]. It should be emphasized that, in the studied group of patients, a smaller than expected effect was observed in several patients after one year of biological treatment, which was often due to poor adherence (limitations related to the COVID-19 pandemic). It seems that completely uncontrolled psoriasis in individual patients could lead to instability during SARS-Co-V-19 infection.

It can be assumed that the transient exacerbations of psoriasis are associated with viral infection as a non-specific factor, which is similar to what is often observed with other infections in patients with psoriasis. However, due to the small study group, it was difficult to assess the impact of drugs on the course of SARS-CoV-2 infection. This is a significant limitation of this study. However, a similar observational study in patients with atopic dermatitis and immunosuppressive therapy also found no effect on the severity of COVID-19 ^[18]. The possible negative effects of this type of therapy should be emphasized. In the case of biological treatment, there are indications of an increased risk of infection in adult psoriasis patients treated with biological drugs. An analysis of data from 11,466 adults with psoriasis in the Psoriasis Longitudinal Assessment and Registry revealed an increased risk of serious infections with adalimumab and infliximab compared with and without non-biological systemic therapy. The rates of serious infections among patients treated with infliximab, adalimumab, etanercept, and ustekinumab were 2.49, 1.97, 1.47, and 0.83 per 100 patient-years, respectively ^[19]. No similar infections were recorded in the follow-up.

References

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1. Introduction

2. Analysis on Results

3. Current Insights

References