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Plant Mitochondria: Fusion and Fission
Plant mitochondria have large genomes to house a small number of key genes. Most mitochondria do not contain a whole genome. To maintain the mitochondrial genes, so important for energy production, the fusion and fission of mitochondria is critical. The dynamin related proteins DRP 3A and 3B drive the fission process. Fusion is less well understood but the MIRO2 gene appears to have a significant role. Massive mitochondrial fusion and subsequent fission prior to flowering, in the enlarging zygote and at germination aids genome repair, conservation of critical genes and may give an energy boost to key stages of the life cycle.
2. Mitochondrial Fusion
2.1. Demonstration of Mitochondrial Fusion
2.2. The Mechanism of Mitochondrial Fusion
3. Significance of the Mitochondrial Fusion/Fission Cycle
3.1. Mitochondrial DNA Content per Mitochondrion Is Highly Variable
3.2. MtDNA Recombination
3.3. Cytoplasmic Male Sterility
3.4. Mitochondrial Fusion and Energetics
3.5. Mitochondrial Fusion and Evolution
4. Massive Mitochondrial Fusion (MMF)
Given that the total mtDNA of the cell must be considered as a single entity, this makes MMF or hyperfusion an important part of maintaining the integrity of the mitochondrial genome. This means that it provides an important opportunity for all the subgenomes to interact for recombination and DNA repair for the next generation. What is known currently is that MMF occurs in the SAM where flowering is initiated, in the zygote and in germination, which are key points in the life cycle. This is not to say that the fusion/fission cycle involving few mitochondria is not unimportant in the cell cycle, cell development and the functioning of the cell. In these latter cases, the importance may be in DNA replication, and ensuring transcripts, proteins and metabolites are readily available for the maintenance of functional mitochondria and their genomes.
While the fusion/fission cycle is of key importance for maintaining mitochondria and their genome, there may be other roles for MMF. In plants, there is some evidence that fusion favours high energy demand and MMF occurs at times prior to the onset of major development shifts. MMF also occurs prior to the first cell division on the path to regeneration. If there is a connection between MMF and ATP production, there may be a role for manipulating mitochondrial fusion as an approach to modulating mitochondrial performance. In mammalian cells there is evidence that the hyperfused mitochondrial reticulum in the GI/S stage of the cell cycle produces more ATP than any other stage of the cell cycle.
The entry is from 10.3390/ijms22115429
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