Zinc-Doped Bioactive Glass/Polycaprolactone Hybrid Scaffolds for Bone Regeneration
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  • Release Date: 2023-07-10
  • sol–gel
  • bioactive glass
  • organic-inorganic hybrid
  • additive manufacturing
  • human mesenchymal stem cells
  • bone tissue engineering
Video Introduction

This video is adapted from 10.3390/cells12131759

A novel organic-inorganic hybrid, based on SiO2-CaO-ZnO bioactive glass (BG) and polycaprolactone (PCL), associating the highly bioactive and versatile bioactive glass with clinically established PCL was examined. The BG-PCL hybrid is obtained by acid-catalyzed silica sol-gel process inside PCL solution either by direct or indirect printing. Apatite-formation tests in simulated body fluid (SBF) confirm the ion release along with the hybrid’s bone-like apatite forming. Kinetics differ significantly between directly and indirectly printed scaffolds, the former requiring longer periods to degrade, while the latter demonstrates faster calcium phosphate (CaP) formation. Remarkably, Zn diffusion and accumulation are observed at the surface within the newly formed active CaP layer. Zn release is found to be dependent on printing method and immersion medium. Investigation of BG at the atomic scale reveals the ambivalent role of Zn, capable of acting both as a network modifier and as a network former linking the BG silicate network. In addition, hMSCs viability assay proves no cytotoxicity of the Zn-hybrid. LIVE/DEAD staining demonstrates excellent cell viability and proliferation for over seven weeks. Overall, this hybrid material either non-doped or doped with a metal trace element is a promising candidate to be translated to clinical applications for bone regeneration.

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Elahpour, N.; Niesner, I.C.C.; Bossard, C.; Abdellaoui, N.; Montouillout, V.; Fayon, F.; Taviot-Guého, C.; Frankenbach, T.; Crispin, A.; Khosravani, P.; et al. Zinc-Doped Bioactive Glass/Polycaprolactone Hybrid Scaffolds for Bone Regeneration. Encyclopedia. Available online: https://encyclopedia.pub/video/video_detail/788 (accessed on 24 June 2024).
Elahpour N, Niesner ICC, Bossard C, Abdellaoui N, Montouillout V, Fayon F, et al. Zinc-Doped Bioactive Glass/Polycaprolactone Hybrid Scaffolds for Bone Regeneration. Encyclopedia. Available at: https://encyclopedia.pub/video/video_detail/788. Accessed June 24, 2024.
Elahpour, Nafise, Isabella Caroline Chiara Niesner, Cédric Bossard, Nora Abdellaoui, Valérie Montouillout, Franck Fayon, Christine Taviot-Guého, Tina Frankenbach, Alexander Crispin, Pardis Khosravani, et al. "Zinc-Doped Bioactive Glass/Polycaprolactone Hybrid Scaffolds for Bone Regeneration" Encyclopedia, https://encyclopedia.pub/video/video_detail/788 (accessed June 24, 2024).
Elahpour, N., Niesner, I.C.C., Bossard, C., Abdellaoui, N., Montouillout, V., Fayon, F., Taviot-Guého, C., Frankenbach, T., Crispin, A., Khosravani, P., Holzapfel, B.M., Jallot, E., Mayer-Wagner, S., & Lao, J. (2023, July 10). Zinc-Doped Bioactive Glass/Polycaprolactone Hybrid Scaffolds for Bone Regeneration. In Encyclopedia. https://encyclopedia.pub/video/video_detail/788
Elahpour, Nafise, et al. "Zinc-Doped Bioactive Glass/Polycaprolactone Hybrid Scaffolds for Bone Regeneration." Encyclopedia. Web. 10 July, 2023.
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