Beta-Oxidation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Lymphocytes
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  • Release Date: 2023-04-11
  • myalgic encephalomyelitis
  • chronic fatigue syndrome
  • beta-oxidation
  • fatty acid oxidation
  • Natural Killer cells
  • immunometabolism
Video Introduction

This video is adapted from 10.3390/ijms24032010

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a disabling multisystem illness in which individuals are plagued with fatigue, inflammatory symptoms, cognitive dysfunction, and the hallmark symptom, post-exertional malaise. While the cause of this disease remains unknown, there is evidence of a potential infectious component that, along with patient symptoms and common onsets of the disease, implicates immune system dysfunction. To further understanding of the state of ME/CFS lymphocytes, researchers characterized the role of fatty acids in isolated natural killer cells, CD4+ T cells, and CD8+ T cells in circulation and after overnight stimulation through implicit perturbations to fatty acid oxidation. They examined samples obtained from at least 8 and as many as 20 subjects for immune cell fatty acid characterization in a variety of experiments and found that all three isolated cell types increased their utilization of lipids and levels of pertinent proteins involved in this metabolic pathway in ME/CFS samples, particularly during higher energy demands and activation. In T cells, researchers characterized the cell populations contributing to these metabolic shifts, which included CD4+ memory cells, CD4+ effector cells, CD8+ naïve cells, and CD8+ memory cells. Researchers also discovered that patients with ME/CFS and healthy control samples had significant correlations between measurements of CD4+ T cell fatty acid metabolism and demographic data. These findings provide support for metabolic dysfunction in ME/CFS immune cells. Researchers further hypothesize about the consequences that these altered fuel dependencies may have on T and NK cell effector function, which may shed light on the illness’s mechanism of action.
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Hanson, M.; Maya, J.; Leddy, S.M.; Gottschalk, C.G.; Peterson, D.L. Beta-Oxidation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Lymphocytes. Encyclopedia. Available online: https://encyclopedia.pub/video/video_detail/707 (accessed on 15 April 2024).
Hanson M, Maya J, Leddy SM, Gottschalk CG, Peterson DL. Beta-Oxidation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Lymphocytes. Encyclopedia. Available at: https://encyclopedia.pub/video/video_detail/707. Accessed April 15, 2024.
Hanson, Maureen, Jessica Maya, Sabrina M. Leddy, C. Gunnar Gottschalk, Daniel L. Peterson. "Beta-Oxidation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Lymphocytes" Encyclopedia, https://encyclopedia.pub/video/video_detail/707 (accessed April 15, 2024).
Hanson, M., Maya, J., Leddy, S.M., Gottschalk, C.G., & Peterson, D.L. (2023, April 11). Beta-Oxidation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Lymphocytes. In Encyclopedia. https://encyclopedia.pub/video/video_detail/707
Hanson, Maureen, et al. "Beta-Oxidation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Lymphocytes." Encyclopedia. Web. 11 April, 2023.