Demyelination Model Simulating Progressive Multiple Sclerosis
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  • Release Date: 2023-04-11
  • multiple sclerosis
  • tryptophan
  • kynurenine
  • cuprizone
  • demyelination
  • remyelination
  • translational
Video Introduction

This video is adapted from 10.3390/biomedicines11030945

In the video, researchers examined the effects of the Cuprizone toxin on the myelin sheaths in mice, which shows similar histopathological features as progressive multiple sclerosis. Specifically, researchers analyzed the tryptophan metabolites in this mouse model and found that the kynurenine metabolite profile may be a promising biomarker for progressive multiple sclerosis. This discovery could be valuable in developing personalized treatment plans, which can be difficult to formulate due to the influence of immunologic components during flare-ups.

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Tanaka, M.; Polyák, H.; Galla, Z.; Nánási, N.; Cseh, E.K.; Rajda, C.; Veres, G.; Spekker, E.; Szabó, �.; Klivényi, P.; et al. Demyelination Model Simulating Progressive Multiple Sclerosis. Encyclopedia. Available online: https://encyclopedia.pub/video/video_detail/704 (accessed on 19 April 2024).
Tanaka M, Polyák H, Galla Z, Nánási N, Cseh EK, Rajda C, et al. Demyelination Model Simulating Progressive Multiple Sclerosis. Encyclopedia. Available at: https://encyclopedia.pub/video/video_detail/704. Accessed April 19, 2024.
Tanaka, Masaru, Helga Polyák, Zsolt Galla, Nikolett Nánási, Edina Katalin Cseh, Cecília Rajda, Gábor Veres, Eleonóra Spekker, Ágnes Szabó, Péter Klivényi, et al. "Demyelination Model Simulating Progressive Multiple Sclerosis" Encyclopedia, https://encyclopedia.pub/video/video_detail/704 (accessed April 19, 2024).
Tanaka, M., Polyák, H., Galla, Z., Nánási, N., Cseh, E.K., Rajda, C., Veres, G., Spekker, E., Szabó, �., Klivényi, P., & Vécsei, L. (2023, April 11). Demyelination Model Simulating Progressive Multiple Sclerosis. In Encyclopedia. https://encyclopedia.pub/video/video_detail/704
Tanaka, Masaru, et al. "Demyelination Model Simulating Progressive Multiple Sclerosis." Encyclopedia. Web. 11 April, 2023.