Coronary Artery Bypass Graft Surgery Improves Diastolic Recovery
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  • Release Date: 2023-04-06
  • hibernating myocardium
  • diastolic dysfunction
  • mesenchymal stem cell
  • ischemic heart disease
  • cardiac MRI
  • CABG
  • PGC1α
Video Introduction

This video is adapted from 10.3390/ijms24065475

Diastolic dysfunction persists despite coronary artery bypass graft surgery (CABG) in patients with hibernating myocardium (HIB). Researchers studied whether the adjunctive use of a mesenchymal stem cells (MSCs) patch during CABG improves diastolic function by reducing inflammation and fibrosis. HIB was induced in juvenile swine by placing a constrictor on the left anterior descending (LAD) artery, causing myocardial ischemia without infarction. At 12 weeks, CABG was performed using the left-internal-mammary-artery (LIMA)-to-LAD graft with or without placement of an epicardial vicryl patch embedded with MSCs, followed by four weeks of recovery. The animals underwent cardiac magnetic resonance imaging (MRI) prior to sacrifice, and tissue from septal and LAD regions were collected to assess for fibrosis and analyze mitochondrial and nuclear isolates. During low-dose dobutamine infusion, diastolic function was significantly reduced in HIB compared to the control, with significant improvement after CABG + MSC treatment.

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Aggarwal, R.; Potel, K.N.; Shao, A.; So, S.W.; Swingen, C.; Reyes, C.P.; Rose, R.; Wright, C.; Stone, L.L.H.; Mcfalls, E.O.; et al. Coronary Artery Bypass Graft Surgery Improves Diastolic Recovery. Encyclopedia. Available online: https://encyclopedia.pub/video/video_detail/686 (accessed on 13 April 2024).
Aggarwal R, Potel KN, Shao A, So SW, Swingen C, Reyes CP, et al. Coronary Artery Bypass Graft Surgery Improves Diastolic Recovery. Encyclopedia. Available at: https://encyclopedia.pub/video/video_detail/686. Accessed April 13, 2024.
Aggarwal, Rishav, Koray N. Potel, Annie Shao, Simon W. So, Cory Swingen, Christina P. Reyes, Rebecca Rose, Christin Wright, Laura L. Hocum Stone, Edward O. Mcfalls, et al. "Coronary Artery Bypass Graft Surgery Improves Diastolic Recovery" Encyclopedia, https://encyclopedia.pub/video/video_detail/686 (accessed April 13, 2024).
Aggarwal, R., Potel, K.N., Shao, A., So, S.W., Swingen, C., Reyes, C.P., Rose, R., Wright, C., Stone, L.L.H., Mcfalls, E.O., Butterick, T.A., & Kelly, R.F. (2023, April 06). Coronary Artery Bypass Graft Surgery Improves Diastolic Recovery. In Encyclopedia. https://encyclopedia.pub/video/video_detail/686
Aggarwal, Rishav, et al. "Coronary Artery Bypass Graft Surgery Improves Diastolic Recovery." Encyclopedia. Web. 06 April, 2023.