Shingles with an Immunostimulatory Vaccine Virus and Acyclovir
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  • Release Date: 03 Apr 2023
  • herpes
  • shingles
  • herpes zoster ophtalmicus
  • acyclovir
  • infectious bursal disease virus
  • IBDV
  • adjunct therapy
  • superinfection
  • interferons
  • varicella zoster virus
  • VZV
Video Introduction

This video is adapted from 10.3390/ph16020226

Practically the entire global population is infected by herpesviruses that establish lifelong latency and can be reactivated. Alpha-herpesviruses, herpes simplex viruses 1 and 2 (HSV-1/HSV-2) and varicella zoster virus (VZV), establish latency in sensory neurons and then reactivate to infect epithelial cells in the mucosa or skin, resulting in a vesicular rash. Licensed antivirals inhibit virus replication, but do not affect latency. On reactivation, VZV causes herpes zoster, also known as shingles. The 76-year-old first author of this paper published an autobiography of his own severe herpes zoster ophthalmicus (HZO) infection with orbital edema, which is considered an emergency condition. Acyclovir (ACV) treatment was complemented with an immunostimulatory viral therapy, which resolved most symptoms within a few days. The orally administered live-attenuated infectious bursal disease vaccine virus (IBDV) delivers its double-stranded RNA (dsRNA) cargo to host cells and activates the natural antiviral interferon (IFN) gene defense system from within the host cells. IBDV has already been demonstrated to be safe and effective against five different families of viruses, hepatitis A virus (HAV), hepatitis B and C virus (HBV/HCV), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and varicella zoster virus (VZV). Here researchers propose a short phase I/II trial in elderly shingles patients who will be assigned to receive either ACV monotherapy or ACV combined with R903/78, an attenuated immunostimulatory IBDV strain. The primary endpoints will be safety, but the efficacy of the combination therapy against the ACV monotherapy also will be assessed.

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Bakacs, T.; Sandig, V.; Kovesdi, I. Shingles with an Immunostimulatory Vaccine Virus and Acyclovir. Encyclopedia. Available online: https://encyclopedia.pub/video/video_detail/680 (accessed on 23 February 2024).
Bakacs T, Sandig V, Kovesdi I. Shingles with an Immunostimulatory Vaccine Virus and Acyclovir. Encyclopedia. Available at: https://encyclopedia.pub/video/video_detail/680. Accessed February 23, 2024.
Bakacs, Tibor, Volker Sandig, Imre Kovesdi. "Shingles with an Immunostimulatory Vaccine Virus and Acyclovir" Encyclopedia, https://encyclopedia.pub/video/video_detail/680 (accessed February 23, 2024).
Bakacs, T., Sandig, V., & Kovesdi, I. (2023, April 03). Shingles with an Immunostimulatory Vaccine Virus and Acyclovir. In Encyclopedia. https://encyclopedia.pub/video/video_detail/680
Bakacs, Tibor, et al. "Shingles with an Immunostimulatory Vaccine Virus and Acyclovir." Encyclopedia. Web. 03 April, 2023.