Erythrocytes in Atherothrombotic Stroke
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  • Release Date: 2023-03-29
  • erythrocyte
  • ischemic stroke
  • atherothrombosis
  • lipotoxicity
  • glucotoxicity
  • homocysteine
  • immunometabolism
  • neuroinflammation
Video Introduction

This video is adapted from 10.3390/neurolint15010011

Stroke constitutes the second highest cause of morbidity and mortality worldwide while also impacting the world economy, triggering substantial financial burden in national health systems. High levels of blood glucose, homocysteine, and cholesterol are causative factors for atherothrombosis. These molecules induce erythrocyte dysfunction, which can culminate in atherosclerosis, thrombosis, thrombus stabilization, and post-stroke hypoxia. Glucose, toxic lipids, and homocysteine result in erythrocyte oxidative stress. This leads to phosphatidylserine exposure, promoting phagocytosis.

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Tsiptsios, D.; Papadopoulos, C.; Anagnostopoulos, K.; Karatzetzou, S.; Liaptsi, E.; Lazaridou, I.Z.; Kokkotis, C.; Makri, E.; Ioannidou, M.; Aggelousis, N.; et al. Erythrocytes in Atherothrombotic Stroke. Encyclopedia. Available online: (accessed on 15 April 2024).
Tsiptsios D, Papadopoulos C, Anagnostopoulos K, Karatzetzou S, Liaptsi E, Lazaridou IZ, et al. Erythrocytes in Atherothrombotic Stroke. Encyclopedia. Available at: Accessed April 15, 2024.
Tsiptsios, Dimitrios, Charalampos Papadopoulos, Konstantinos Anagnostopoulos, Stella Karatzetzou, Eirini Liaptsi, Irene Zacharo Lazaridou, Christos Kokkotis, Evangelia Makri, Maria Ioannidou, Nikolaos Aggelousis, et al. "Erythrocytes in Atherothrombotic Stroke" Encyclopedia, (accessed April 15, 2024).
Tsiptsios, D., Papadopoulos, C., Anagnostopoulos, K., Karatzetzou, S., Liaptsi, E., Lazaridou, I.Z., Kokkotis, C., Makri, E., Ioannidou, M., Aggelousis, N., & Vadikolias, K. (2023, March 29). Erythrocytes in Atherothrombotic Stroke. In Encyclopedia.
Tsiptsios, Dimitrios, et al. "Erythrocytes in Atherothrombotic Stroke." Encyclopedia. Web. 29 March, 2023.