Learning how to navigate autonomously in an unknown indoor environment without colliding with static and dynamic obstacles is important for mobile robots. The conventional mobile robot navigation system does not have the ability to learn autonomously. Two types of deep Q-learning agents, such as deep Q-network and double deep Q-network agents are proposed to enable the mobile robot to autonomously learn about collision avoidance and navigation capabilities in an unknown environment. For autonomous mobile robot navigation in an unknown environment, the process of detecting the target object is first carried out using a deep neural network model, and then the process of navigation to the target object is followed using the deep Q-network or double deep Q-network algorithm.