Tumour-Treating Fields on Cell Division Using Live-Cell Imaging
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  • Release Date: 2022-10-13
  • oncology
  • electromagnetic fields
  • non-invasive therapies
  • human cervical carcinoma cells
Video Introduction

This video is adapted from 10.3390/cells11172712

The effects of electric fields (EFs) on various cell types have been thoroughly studied, and exhibit a well-known regulatory effect on cell processes, implicating their usage in several medical applications. While the specific effect exerted on cells is highly parameter-dependent, the majority of past research has focused primarily on low-frequency alternating fields (<1 kHz) and high-frequency fields (in the order of MHz). However, in recent years, low-intensity (1–3 V/cm) alternating EFs with intermediate frequencies (100–500 kHz) have been of topical interest as clinical treatments for cancerous tumours through their disruption of cell division and the mitotic spindle, which can lead to cell death. These aptly named tumour-treating fields (TTFields) have been approved by the FDA as a treatment modality for several cancers, such as malignant pleural mesothelioma and glioblastoma multiforme, demonstrating remarkable efficacy and a high safety profile.

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Staelens, M.;  Le, H.; Lazzari, D.; Chan, G.; Tuszynski, J. Tumour-Treating Fields on Cell Division Using Live-Cell Imaging. Encyclopedia. Available online: https://encyclopedia.pub/video/video_detail/436 (accessed on 15 June 2024).
Staelens M,  Le H, Lazzari D, Chan G, Tuszynski J. Tumour-Treating Fields on Cell Division Using Live-Cell Imaging. Encyclopedia. Available at: https://encyclopedia.pub/video/video_detail/436. Accessed June 15, 2024.
Staelens, Michael, Hoa Le, Davide Lazzari, Gordon Chan, Jack Tuszynski. "Tumour-Treating Fields on Cell Division Using Live-Cell Imaging" Encyclopedia, https://encyclopedia.pub/video/video_detail/436 (accessed June 15, 2024).
Staelens, M.,  Le, H., Lazzari, D., Chan, G., & Tuszynski, J. (2022, October 13). Tumour-Treating Fields on Cell Division Using Live-Cell Imaging. In Encyclopedia. https://encyclopedia.pub/video/video_detail/436
Staelens, Michael, et al. "Tumour-Treating Fields on Cell Division Using Live-Cell Imaging." Encyclopedia. Web. 13 October, 2022.
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