• Blood-Spinal Cord Barrier: Spinal Disorders and Therapeutic Strategies
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  • Release time: 2022-01-17
  • blood-spinal cord barrier (BSCB)
  • spinal cord injury (SCI)
  • amyotrophic lateral sclerosis (ALS)
  • degenerative cervical myelopathy (DCM)
  • peripheral nerve injury (PNI)
  • ischemia reperfusion injury (IRI)
  • multiple sclerosis (MS)
  • spinal cavernous malformations (SC
Video Introduction

The blood-spinal cord barrier (BSCB) has been long thought of as a functional equivalent to the blood-brain barrier (BBB), restricting blood flow into the spinal cord. The spinal cord is supported by various disc tissues that provide agility and has different local immune responses compared to the brain. Though physiologically, structural components of the BSCB and BBB share many similarities, the clinical landscape significantly differs. Thus, it is crucial to understand the composition of BSCB and also to establish the cause–effect relationship with aberrations and spinal cord dysfunctions.

Here, authors provide a descriptive analysis of the anatomy, current techniques to assess the impairment of BSCB, associated risk factors and impact of spinal disorders such as spinal cord injury (SCI), amyotrophic lateral sclerosis (ALS), peripheral nerve injury (PNI), ischemia reperfusion injury (IRI), degenerative cervical myelopathy (DCM), multiple sclerosis (MS), spinal cavernous malformations (SCM) and cancer on BSCB dysfunction. Along with diagnostic and mechanistic analyses, they also provide an up-to-date account of available therapeutic options for BSCB repair. Authors emphasize the need to address BSCB as an individual entity and direct future research towards it.

This video is adapted from 10.3390/neurosci3010001.

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Chopra, N.; Menounos, S.; Diwan, A.; Choi, J.P.; Hansbro, P.M.; Das, A. Blood-Spinal Cord Barrier: Spinal Disorders and Therapeutic Strategies. Encyclopedia. Available online: https://encyclopedia.pub/video/video_detail/171 (accessed on 01 July 2022).
Chopra N, Menounos S, Diwan A, Choi JP, Hansbro PM, Das A. Blood-Spinal Cord Barrier: Spinal Disorders and Therapeutic Strategies. Encyclopedia. Available at: https://encyclopedia.pub/video/video_detail/171. Accessed July 01, 2022.
Chopra, Neha, Spiro Menounos, Ashish Diwan, Jaesung Peter Choi, Philip M. Hansbro, Abhirup Das. "Blood-Spinal Cord Barrier: Spinal Disorders and Therapeutic Strategies," Encyclopedia, https://encyclopedia.pub/video/video_detail/171 (accessed July 01, 2022).
Chopra, N., Menounos, S., Diwan, A., Choi, J.P., Hansbro, P.M., & Das, A. (2022, January 17). Blood-Spinal Cord Barrier: Spinal Disorders and Therapeutic Strategies. In Encyclopedia. https://encyclopedia.pub/video/video_detail/171
Chopra, Neha, et al. ''Blood-Spinal Cord Barrier: Spinal Disorders and Therapeutic Strategies.'' Encyclopedia. Web. 17 January, 2022.
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