Fibrosis in CKD: Pathophysiology and Therapeutic Targets
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  • Release Date: 2024-05-02
  • chronic kidney disease
  • inflammation
  • nuclear factor kappa B
  • renal fibrosis
  • SGLT2 inhibitors
Video Introduction

This video is adapted from 10.3390/jcm13071881

Kidney fibrosis is characterized by accumulation of myofibroblasts, excessive deposition of extracellular matrix in the interstitial space and compromised ability to remove toxins and supply nutrients. Chronic kidney disease (CKD) is the leading cause of kidney fibrosis. CKD manifests as slow, but irreversible damage to renal tissue with scarring, declining kidney function and persistent inflammation and increased oxidative stress. This video provides insight into the roles of TGF-β signaling, diabetic nephropathy, epithelial-mesenchymal transition, serum amyloid A and Src family kinases in CKD, kidney inflammation, and fibrosis. Anti-fibrotic therapies for CKD are urgently needed to improve quality of life and prolong survival.

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Reiss, A.B.; Jacob, B.; Zubair, A.; Srivastava, A.; Johnson, M.; De Leon, J. Fibrosis in CKD: Pathophysiology and Therapeutic Targets. Encyclopedia. Available online: https://encyclopedia.pub/video/video_detail/1222 (accessed on 26 May 2024).
Reiss AB, Jacob B, Zubair A, Srivastava A, Johnson M, De Leon J. Fibrosis in CKD: Pathophysiology and Therapeutic Targets. Encyclopedia. Available at: https://encyclopedia.pub/video/video_detail/1222. Accessed May 26, 2024.
Reiss, Allison B., Berlin Jacob, Aarij Zubair, Ankita Srivastava, Maryann Johnson, Joshua De Leon. "Fibrosis in CKD: Pathophysiology and Therapeutic Targets" Encyclopedia, https://encyclopedia.pub/video/video_detail/1222 (accessed May 26, 2024).
Reiss, A.B., Jacob, B., Zubair, A., Srivastava, A., Johnson, M., & De Leon, J. (2024, May 02). Fibrosis in CKD: Pathophysiology and Therapeutic Targets. In Encyclopedia. https://encyclopedia.pub/video/video_detail/1222
Reiss, Allison B., et al. "Fibrosis in CKD: Pathophysiology and Therapeutic Targets." Encyclopedia. Web. 02 May, 2024.
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