Molecular Targets for Cannabinoids in Natural Killer Cells
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  • Release Date: 2024-04-16
  • natural killer
  • NK cells
  • cannabinoids
  • cannabinoid receptors
  • immunotherapy
Video Introduction

This video is adapted from 10.3390/receptors3020007

Recent research has emphasized the potential of natural and synthetic cannabinoids as anticancer agents. Yet it remains unclear whether and in which sense cannabinoids affect the anticancer activity of NK cells, an important branch of anticancer immunity. Similar uncertainty exists regarding NK cells-based immunotherapy. Here researchers presented an overview of multiple cannabinoid targets as canonical (mainly CB2) and non-canonical receptors, ion channels, transporters, and enzymes, expressed in NK cells, along with underlying molecular mechanisms. Through them, cannabinoids can affect viability, proliferation, migration, cytokine production, and the overall anticancer activity of NK cells. Respective holistic studies are limited, and, mostly, are phenomenological, not linking observed effects with certain molecular targets. Another problem of existing studies is the lack of standardisation, so that diverse cannabinoids at variable concentrations and ways of administration are applied, and often, instead of purified NK cells, the whole lymphocyte population is used. Therefore, there is an urgent need for more focused, systemic, and in-depth studies of the impact of the cannabinoid toolkit on NK cell function, to critically address the compatibility and potential synergies between NK activity and cannabinoid utilization in the realm of anticancer interventions.

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Olivas, M.; Gutiérrez-Iñiguez, C.; Pottosin, I.; Dobrovinskaya, O. Molecular Targets for Cannabinoids in Natural Killer Cells. Encyclopedia. Available online: https://encyclopedia.pub/video/video_detail/1210 (accessed on 26 May 2024).
Olivas M, Gutiérrez-Iñiguez C, Pottosin I, Dobrovinskaya O. Molecular Targets for Cannabinoids in Natural Killer Cells. Encyclopedia. Available at: https://encyclopedia.pub/video/video_detail/1210. Accessed May 26, 2024.
Olivas, Miguel, Cecilia Gutiérrez-Iñiguez, Igor Pottosin, Oxana Dobrovinskaya. "Molecular Targets for Cannabinoids in Natural Killer Cells" Encyclopedia, https://encyclopedia.pub/video/video_detail/1210 (accessed May 26, 2024).
Olivas, M., Gutiérrez-Iñiguez, C., Pottosin, I., & Dobrovinskaya, O. (2024, April 16). Molecular Targets for Cannabinoids in Natural Killer Cells. In Encyclopedia. https://encyclopedia.pub/video/video_detail/1210
Olivas, Miguel, et al. "Molecular Targets for Cannabinoids in Natural Killer Cells." Encyclopedia. Web. 16 April, 2024.
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